Synthetic Biology and Materials Science Part 2: Nature-Made Plastics

[@glennpearson9348]

As an environmental and civil engineer married to a microbiologist, I am super-excited to see this technology continue to be explored and developed. I hope I live long enough to experience the benefits.

[@scienceisall2632]

Wow, awesome couple. You can connect in a way most people can’t even have conversations about. Sexy stuff

[@glennpearson9348]

@@scienceisall2632, it does make for interesting "pillow talk" sometimes.

[@scienceisall2632]

@@glennpearson9348 Sweet man, that’s magical stuff

[@Ryan6.022]

Yay I love the idea of bioengineered materials.

[@Mr.Plecostomus]

This is completely off topic to what the video is about, but I just love how brilliant your responses are, you must have thousands of reply’s replying to people who either have a great question or responding to people never made it past kindergarten, I just love it!

[@biochemicalracketeering3018]

*pheenol. Also I'm a junior in biochemical engineering so I greatly appreciate this series

[@ProfessorDaveExplains]

Nah, it's pronounced as I said it.

[@scienceisall2632]

@@ProfessorDaveExplains How do you know so damn much professor Dave. It’s like you’re an expert in so many areas

[@GameOver-qk2ys]

Best channel on youtube🔥🔥🔥

[@97Lacko]

Science is like magic, but real.

[@YouMockMe]

Magic is real, science is magic.

[@manavparikh1918]

@@YouMockMe No. Magic is science we can't understand yet.

[@YouMockMe]

@@manavparikh1918 Let's do the math of "Magic is science"..... (prof Dave t-shirt?!) Magic = science = real = theories = magic

[@manavparikh1918]

@@YouMockMe XD haha

[@Traumbewusstsein]

This is so fascinating and promising from an ecological perspective. I wonder though, would such modified bacteria be able to escape the vats and somehow start turning normal soil into plastics?

[@AA-gl1dr]

you’re teaching exactly what I’ve been wanting to learn about for so long. Thank you! unfortunately plant based material still requires a lot of hydrocarbons to procure the mineral salts from the earth.

[@YouMockMe]

Love this channel....love it.

[@kevinmoore2501]

Always good vids, Dave.

[@tophatv2902]

I dont understand how someone is willing to make this for free and with great qulity.

[@backstreetfan2887]

I think KZbin advertisements are what makes that possible (and maybe Patreon too), but it is amazing isn't it? I am really grateful for content like this!

[@aaronkorkegian3706]

Some think that science outreach is its own reward because they believe that it will help build a better world.

[@backstreetfan2887]

@@aaronkorkegian3706 yep, for sure

[@bruvmariia]

Idk why, but professor Dave gives a Gen-z kind of humour whne making these videos. Is it just me who notices?

[@shahabbaloch8338]

Outstanding content

[@brittanyjacobson5199]

very nice

[@bapman1231]

Love the video, very informative a clear! If you want to learn more about about enzyme engineering methods for synthectic biology needs, you should look up rational design and directed evolution (or maybe Dave could make a video covering the subject ;)

[@frankchen4229]

STEM History series when?!?!?!!?

[@nixx9232]

thanks for thanking me for watching

[@brainandrain3848]

Please make one episode about the gene synthesis :) and about designing software !

[@bradhilton2283]

Well Professor Dave that was both informative and interesting all in a nut shell .

[@backstreetfan2887]

hooray, a new video!

[@backstreetfan2887]

amazing

[@reecelawson4718]

Hi again, could you make a video explaining the difference between the centre of mass and centre of gravity and how they affect stability please?

[@ilham6030]

Thanksss dave jesus

[@Nivola1953]

Just Amazing what knowledge can do. I remember an old sci fi story, but not the book title, sorry 😞, where a bacteria evolved that could break down the plastic material used for sealing pressure vessels like o-rings and such, causing airplanes pressurisation to fail and other industrial mishaps. Can the plastic polymerisation be reversed by enzymes, like in this scenario?

[@aaronkorkegian3706]

Andromeda Strain?

[@rakeshmehra6354]

Wow great explaination Please upload in Hindi language or Hindi Subtitles

[@angrydoggy9170]

Anything that resembles brewing beer has my approval.

[@TrapperAaron]

Yesss! Bioshock is real! I call the fire and lightning plasmids

[@scienceisall2632]

I just bought that game today lol

[@MisterItchy]

I'm gonna try to follow along with this one but I am not holding out hope. It started out okay but got too much for me! Interesting, though.

[@fromaggio7654]

cool vid!

[@scienceisall2632]

I wonder if a computer can extrapolate a design of an enzyme/protein/structure which would ordinarily be thermodynamically/evolutionarily unable to escape the local minimum or make it through any non viable intermediates. I wonder if it just takes an extreme amount of simulations, or it just takes more of an insight approach to skip the evolution and get to the design

[@aaronkorkegian3706]

I think its important to recognize that computers are tools and that like any tool it only really excels in the hands of skilled craftsmen. Yes, there is nothing that would prohibit computational searches outside local minima, in fact protein design algorithms are typically built to occasionally take hops to more thoroughly sample the space to hopefully find global minima rather than get stuck in whatever local minima they happen to fall into. However what defines a minima is also driven by the computer so its accuracy is also dependent on the means in which it is calculating the energy. As you pointed out, at some point you are limited by how much is reasonable to do. An exhaustive search is not feasible no matter how powerful computers become, and a detailed energy function is going to drastically shrink your search space...so at somepoint intelligent decisions need to factor in. Both intelligence at the level of designing the computational tool and intelligence at the level of using the right computational tool for the job and intelligence at the level of handling that tool skillfully. Not to be overly sentimental but there is an art to it...not to mention luck. I'd say we are to the point where if a skilled practitioner keeps at it you will likely see results given sufficient investment.

[@scienceisall2632]

@@aaronkorkegian3706 Wow, you are smart, and that made sense. Thanks! It sounds to me like you work in the field with practical experience. I know there are so many cool designs and improvements in all areas of understanding coming thanks to the predictive analytics revolution. Everything is just going to accelerate so much, like the singularity university people talk about. I just hope the power of all this is not abused, so we don’t end up like China or westworld

[@bapman1231]

@@scienceisall2632 there are many ways to design new proteins, if you're interested you should read up on rational design and directed evolution, two really promising and interesting topics of biology :)

[@SamSam-ir7ux]

Do you care for bioethics?

[@SamSam-ir7ux]

Amazing video btw.

[@HeyCariTahu]

Thanksss ssso muucchh

[@blackfeathercrafts]

You mentioned tulips-and I started thinking of giant flower farms in Minecraft. I think I’ve been playing Minecraft too much.

[@TWFDeadzoneII]

Came trying to learn how to make nanobots, and i am not disappointed.

[@bryceyoung325]

0:05

[@JohnTheStun]

Hey bro, I don't know if you did this already, but can you make a video that roasts anti vaxxer logic in these times of insanity where even celebs are spreading misinformation and conspiracies about the vaccine? Love your stuff man. All the best

[@ProfessorDaveExplains]

I did! A couple months ago.

[@JohnTheStun]

​@@ProfessorDaveExplains GREAT! For a more "viral" reaction, maybe you should do a reaction video to Russell Brand's recent (moronic) video.. I think he accidentally swallowed 2 red pills...

[@annehettick8285]

Mad scientists

[@vivacristorey4728]

Please expose this video from string on temple science

[@old_house_1906]

polymethyl methacrylate, adorable. 1:51

[@surrrey]

Early

[@Yunus-hu2ih]

What if we just bio engineered a slave creatures to do our biding.

[@Yunus-hu2ih]

@@spatrk6634 they wouldn't know. For them it would be their life purpose. They would feel fulfilled serving us

[@Tacticalerth]

The subject is hard

[@monev25]

i hope its not synthetic at all..

[@omanoman-nb8zz]

Ask them How can japan and south america west side at one day laight or same dark night in flat earth map ? 🤣🤣

[@brd8764]

Nature be like 100-1 =99. Idealsim not idea-l-o. #(99+1)=(100)+1\