Human Geneticist Answers DNA Questions From Twitter | Tech Support | WIRED

[@mastod0n1]

I've said it before and I'll say it again; the producers and creative team at Wired are doing an incredible job finding these experts. Whatever subject matter it is, I find myself intrigued.

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@surveytaker4059]

@@lipstick318 because telomeres need to be kept short... longer telomeres means that cell is cancerous

[@TheWade822]

@@lipstick318 Because there are tens of trillions of cells in the human body, and you’d need to extend the telomeres on each one, or you still risk cancerous cell growth later in life. It would be more feasible to modify gametes and embryos, but the ethics of genetically modifying these cells are a massive barrier.

[@datguy7250]

@@lipstick318 also longer life = a more painful life with higher chances of developing mutations which can cause non-infectious diseases like cancer

[@anotherjewishsharpnicholas9425]

He starts off with neo-nazism that denies genetic research.

[@nayan3066]

How smoothly the man explained the complex concepts. Commendable.

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@WilliamParkerer]

@@lipstick318 One of the primary reasons cells have telomeres is to prevent uncontrolled cell division. In many cancers, cells reactivate the enzyme telomerase, which rebuilds telomeres and allows the cells to continue dividing indefinitely, leading to tumor growth. Using CRISPR to extend telomeres might inadvertently increase the risk of developing cancer.

[@PhysioAl1]

Yup

[@cavman7]

He's been genetically modified to do so. :)

[@antoniohaddad8816]

Did you just assume his gender?😲🤣🤣

[@sanskritibarman4928]

As a biochemist, it's commendable how he makes such complex phenomena so easy to grasp and process.

[@notsoberoveranalyzer8264]

Being able to articulate your thoughts effectively, simplify complicated subjects, and being able to do so with those who have no prior knowledge of the subject are such incredible skills.

[@tomato-v8x]

⁠​⁠@@notsoberoveranalyzer8264That’s just called being a professional. If you can’t explain a concept in simple terms, you probably don’t have a complete understanding of it.

[@sanskritibarman4928]

@@yann2850_ and you're pissed about what, for people to make harmless comments?🤡🤧

[@stultum]

@@yann2850_ im sure they worked hard for their degree better flex it on the plebeians

[@kennysproat3747]

It helps when you don’t include the more complex parts like not talking about SNPs and NHEJ

[@marcmariano1428]

You can tell if someone is really knowledgeable in their field if they can explain it in terms everyone can understand

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@marcmariano1428]

@@lipstick318 probably they are still working on it?

[@saranaila5905]

​@@lipstick318maybe they already are.

[@nickv1212]

​@lipstick318 They are. Scientists are starting to consider aging as something like a disorder that can be treated, figuring out how to protect or regrow our telomeres is essential in that.

[@jkaustok]

The second you start putting in jargon when you don't need to, you've lost your teachers license in my view because you aren't trying to help someone understand you're trying to show how smart you are.

[@rolandvien5886]

The way this guy speaks just shows how intelligent he is. I'm baffled by his clear and elaborate answers.

[@backintimealwyn5736]

that's not how you evaluate intellgence....

[@miguelpadeiro762]

​@@backintimealwyn5736Actually a great way to acess intelligence overall (including emotional intelligence) The ability not only to understanc really complex topics BUT also the ability to grab these complex topics and grind them down into easily understandable yet still factual information for anyone to digest, even if they don't have the years of professional and/or academic experience you have

[@necromancer___3054]

Because he’s researched the questions answers before he answers him just like everyone else… if you think this is a measure of intelligence, I got news for you.

[@agustinbarquero8898]

That's not how you evaluate intelligence

[@TiffanyHoL]

This geneticist was the entire reason why I'm studying genetics in undergrad at the moment. I remember his video on CRISPR-Cas9, the one about explaining the concept at 5 different levels wayyy back in middle school and it just stuck haha

[@defaultname992]

How is it going ?

[@sprout-abelle6067]

Omg me too!! Im studying genetics and microbiology

[@wavewatcher_]

That’s so cool! I hope he sees your comment

[@winterkeptuswarm]

This is so wholesome. I hope he sees this.

[@jordanlunsford9214]

That is so cool! Hope you’re doing well!!

[@CellRus]

Please do one for cell biology! Cell support! We have a lot of genetics and neurobiology but never have one for cell biology, which arguably one of the most diverse field in biology.

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@aLime404]

@@lipstick318 Because the relationship between aging and telomeres is extremely complex, not fully understood, and certainly not able to be reduced down to “long telomere = long life”. And like the geneticist said, we are currently focused on genetically simple, but terrible diseases like the examples he gave. There are a limited number of scientists working on this, and limited money. We are essentially doing triage on human health, so we start with severe, simpler problems.

[@feynstein1004]

@@aLime404 It's a bot. I noticed that it's made the same reply to every comment in the comment section

[@jovicagasic98]

​@@lipstick318 aLime answered you very well, but just to add more. When you add a protein/genetic trait to lengthen telomeres to human cells in a lab they often become cancerous. Its been a while since I took my genetics course, so I don't remember why this explicitly happens but interesting nonetheless.

[@myuniemew]

as someone who’s abt to take a cell bio class next school year, i need it 😹

[@kamiladjellal345]

As a biotechnology Engineer , I wish I had this man as a teacher back when I was in uni

[@michaelag8256]

Dude same.

[@stultum]

i heard its pretty terrible being a professor, its much more competitive than you would think and the pay isnt great

[@ChopsTV]

Dude hitting on the ethics at the end! All new technological developments should pass the Ian Malcolm test: "Your scientists were so preoccupied with whether or not they could, they didnt stop to think if they should". Just because you can, that doesnt mean you should.

[@njrom2975]

Yes focus on the better good first . That’s we should use science for . What an honorable man

[@veramae4098]

Humans used to be able to make their own vitamin C. Sometime early a mutation took place and that DNA sequence was broken. Would be nice to repair that, and I think it clears the Malcolm test.

[@darkermatter125.35]

I very often see these topics veer into the realm of eugenics when the layperson imagines the changes they could do. I've heard so many ask about getting rid of autism and down syndrome and a bunch of other disabilities. I am really glad they chose the mars question so that they could address some of the more.... playing god questions, vs medicine, without diving into that complex and emotional debate.

[@Droid6689]

But we definitely should

[@wizardsuth]

@@veramae4098 Having to continue eating fruits and vegetables is a small price to pay for being able to prevent cystic fibrosis or muscular dystrophy. We can always repair the citric acid gene(s) after such serious congenital defects have been eliminated.

[@laurenmoffett4421]

I love seeing people talk about something their passionate about and it’s amazing that this series allows people to gain exposure to certain topics they otherwise wouldn’t come across

[@BadassRaiden]

I did a report on CRISPR in college for an ecology class and how it could be used, along with eliminating or at the very least be used to design substantial treatment of human diseases, it can be used to do the same in wildlife diseases that unfortunately ravage different species. The specific examples I used is the facial tumor disease which is a cancer disease that affects Tasmanian Devils.

[@N-cubed]

I think I heard something about them making genetically sterile mosquitoes to release and kill all the disease carrying wild ones. Super cool stuff!

[@nzomy3056]

i have one question, will CRISPR be cheaper with time? does anything indicate that it will be cheaper? asking for treating Genetic diseases purposes* Not the weird stuff

[@krisray9]

🤗

[@BadassRaiden]

@@nzomy3056 the answer to whether CRISPR will be cheaper with time is contingent on capitalism. There has always been the idea that the easier something is to produce, both in cost and time, its price goes down. Unfortunately we know for a fact this is not true. There are thousands and thousands of products that have we have perfected making, reducing both cost and time to do so, and they actually cost more than they used to. Take cars for example. Almost the whole process is automated. The process of mining the materials is performed by essentially slave labor where little to no money is lost to pay for that labor. Yet, a knew car still runs you $30k when a new car 60 years ago in the 60s wasn't even close to that. In fact, it was more than a factor of 10 less. $2600 was the average for a new car in 1960, and it's $30k today. The only thing that determines whether or not something is cheaper is the capitalist themselves, if they are willing to sell something for cheaper or not. Since most only begin to sell something for cheaper when they are about to unveil something new they can sell for more, and there really isn't any foreseen system beyond CRISPR that could be sold for more - my guess is the CRISPR system will remain the same in its cost.

[@TAKIZAWAYAMASHITA]

My question about crispr is why don't we see or hear about it's use more? We hear it can do all these amazing things but we don't see the results, why aren't certain diseases already eliminated? How come gene editing is not a standard commercial etc like your average aspirin etc commercial we see. How come I'm not seeing hey i went to the hospital for cancer and no longer have it and immune to it 5 minutes later? Why are we still using chemo etc. Why are soo many genetic diseases and disorders still around if you can unleash some magic fix me button like you can with a corrupt software on a computer.

[@lundi44]

As someone who hasn't studies genetics and molecular/cell biology for a number of years, this brought back memories. Glad to hear about how Dr Sanjana's lab is using CRISPR to create more effective cancer-fighting T-cells. What's more, Dr Sanjana is an outstanding science communicator - one of the best I've ever come across. Also loved his clarity and ethical approach to answering questions about using CRISPR in a 'eugenics'/'creating better humans' context.

[@MultiWeb23]

Here we go again, having to convert degrees Fahrenheit to Celsius: - DNA breaks at temperatures above 204°C - cremation happens around 815°C - 1093°C You're welcome, world (I didn't convert the unities of distance because he gives examples of that distance and it is less important) :P (Really cool video though, you guys are AMAZING ♡♡)

[@erikaveron9738]

Thanks

[@Greystorm1619]

This man reminds me of a real-life Spock, he has an almost flat affect but you can clearly see his excitement in describing scientific advencements in genetics, and even delivers a couple little quips that almost slip by unless you're paying attention. People like this are some of the best teachers I've ever had.

[@wizardsuth]

It's possible he's mildly autistic and genetics is one of his special interests.

[@jillcrowe2626]

Wow. This is the best speaker I've ever heard to explain this material. I worked in science for 30 years.

[@judechristianfrancisco8180]

Bravo Dr. Neville! I wish I had a professor like you when I were in college.

[@justayoutuber1906]

A good use of KZbin - conveying real knowledge.

[@gubbleguard9342]

He reminds me of why I was interested in genetics in the first place. Unfortunately, I was terrible in the class. But this was awesome and well explained!

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@kellylyons1038]

​@@lipstick318because you're a bot

[@anonymouspenguin9118]

​@lipstick318 as he said, they're more focused on treating diseases than enhancing humans

[@TweSunshine]

I can tell by your profile picture that you're very interesting in genetics.

[@ambition112]

0:21: 🧬 Geneticist explains diverse traits, DNA testing, and gene mutations. 3:09: 🧬 Mutations can have both positive and negative effects on our health, including stronger bones, protection against diseases, and the development of cancer. 6:26: 🧬 CRISPR technology uses the Cas9 protein to edit DNA and has the potential to treat genetic diseases. 9:21: 🧬 Genome engineering focuses on genetic diseases, DNA replication, and alcoholism. 12:14: 🧬 The epigenome and genome are constantly changing, and CRISPR is being used to develop better cancer therapies. Recap by Tammy AI with useful time stamps =)

[@ZorinZato]

Man you guys do such a great job of finding these specific experts. They are always so in love with their field and it’s contagious

[@RossAlexanderSmith]

That final question and answer is so unbelievably important for human development. Far more than chasing everlasting beauty, youth or "improvements"

[@veramae4098]

Author James Blish wrote a whole series of short stories about settling planets in a space going future. The decision was made it was unethical to "terraform" planets. Instead, humans were genetically engineered to fit into a planet's existing ecosystem. Something to think about.

[@PeteQuad]

​@@veramae4098ugh what a horrible thought. The greatest creation in the history of the universe, consciousness, consigned to die out on a single planet.

[@ZeroEscape2074]

this guy is absolutely incredible at explaining things simply, I understood almost everything he said here, what an incredible talent to have

[@spongebombepicpants1073]

kzbin.info/www/bejne/boe8Z4uPaLeeqck

[@semoremo9548]

I'm glad he touched on the moral and ethical side of what could be done with CRSPR. Some people don't seem to realize that, specially given how new these technologies are, there are some things as a society that we may be should be aware of. Not everything is fair-game.

[@stelladonaconfredobutler9459]

Dr. Neville is wonderful. charming and informative. thanks for these shows 🤩

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@varoonnone7159]

@@Tsug2803 Unfortunately, his parents thought it wise to name him Neville

[@varoonnone7159]

It's Dr Sanjana

[@ineskowal9240]

​@@varoonnone7159why? I like the name Neville.. maybe his of mixed heritage?

[@junosbitch]

@@lipstick318it’s either not that easy or not safe (ethically or otherwise)

[@Seven35888]

CRISPR is so promising. Would we need to understand the genetic basis for diseases like fibro, muscular dystrophy, etc first before being able to effectively cure/prevent them? As in, knowing how they’re written in the genome in the first place? Many genes, so much identifying 🤯

[@gardenofart62]

experts that can clearly explain complex concepts are my favorite! i could listen all day

[@joannescott3461]

I truly appreciated the last answer. I feel many people have been worried about using this science in that way & his answer was much more ethical.

[@jopo7996]

I still don't understand why our jeans are so important to this guy.

[@sword_fight]

Aye waste fellow, go wear formal pants then

[@RipRLeeErmey]

I don't think he was talking about denim jeans 💀

[@EBSammy0]

honestly jeans are pretty important. depending on how well made some of them are they'll probably last longer in the archaeological record than me lmao

[@TheSuperSangan]

Fashion sense can run in the family

[@mkseed9188]

I believe this might be one of those skadoosh moments.

[@deemosisland3340]

Is it just me or these people teach better than my teachers

[@LENTXT]

they have phds or masters probably

[@-Ricky_Spanish-]

They make way more than them too.

[@Roll587]

Hard to say. These videos are surface level, compared to a college class that require lecturing on the less engaging details.

[@Roll587]

​@@LENTXT Professors must have a PhD.

[@Roll587]

​@@-Ricky_Spanish- What? This guy is a professor at NYU.

[@dinohlabisa2349]

Watching this while doing my genetics assignment. what a coincidence

[@vminhope3040]

They’re watching you

[@bulloozer5552]

Don't let money control this tech please. We are already freaked out about AI. A world consensus based on ethics is absolutely necessary for such practices.

[@KO_______]

Idk if it’s is possible to form a world consensus but I like the spirit lol

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@tinaaa_]

This reminds me of an interesting article that I read last semester pertaining to the ethics of human genome editing. If you have access to it, read "Global Governance of Human Genome Editing: What Are the Rules?" by Gary E. Marchant (2021). While there seems to be somewhat of a worldwide "consensus" for the time being, it will be extremely hard to regulate if proper mechanisms aren't put in place.

[@demodema5192]

​@@lipstick318because it's not easy to do so... without proper scientific training it's not possible to do it. and with proper scientific training the person knows that it is not possible to do it in such a straightforward manner. Hope that helps!

[@IDislikeMacaroni]

They threw some dude in jail bc he made designer babies so I think geneticists are kinda on the same page.

[@rc0va]

Worth noticing that he was so compelling and didactic during the AMA but at the very end. It would be interesting to know how exposed to and/or involved Dr. Neville's been with DNA editing for human enhancement.

[@laurawoodall33]

Mad props to Dr. Neville for answering all those questions seriously and succinctly... including the asinine questions.

[@joshuamirabal3617]

It’s amazing that no matter how much we know there’s always more stuff to learn.

[@SinisterMD]

The fact that this guy has a chromosome lapel pin makes this video all the more fun to watch. Very well done.

[@GrumpyGills-u2s]

Had to zoom in for that one 🤣😂 Well spotted 👌🤣

[@nimraareej5175]

We NEED an evolutionary biologist here. The number of times people have misunderstood how evolution works is really crazy....survival of the fittest gang need to calm down

[@catzback7]

After my husband was told to put his affairs in order with no cause of his imminent death. We did it 23 in me. The 23 and me, diagnosed my husband's Alpha One Anticipation Disorder. His mutated gene came alive after exposure to burn pits in the war. Currently, he's waiting for two lungs and a liver transplant destroyed by a mutated protein. Until that happens every week he takes an infusion of plasma of other people's non-mutated genes (proteins).

[@YurinanAcquiline]

Did you mean Alpha-1 antitrypsin deficiency?

[@FreddyRaphael-d5q]

How smoothly the man explained the complex concepts. Commendable.. Dr. Neville is wonderful. charming and informative. thanks for these shows .

[@terpman]

He carefully shot down eugenics without specifically calling it eugenics. You could tell he was trying to tread very carefully and spoke very deliberately when that kind of thing came up. It really is a fine line there.

[@A2dy]

The ease this guy explained sequencing is honestly what all of us microbiologists should strive for.

[@ronnianabalos4627]

I love these videos very entertaining thank you for producing this type of content❤😊🎉

[@lipstick318]

Why isn't somebody using Crispr to splice Telomeres for Longer quality of life???

[@morganbrickwall7902]

Just learned something. When I eat cilantro by itself it tastes exactly like soap, something I have noticed for a long time. If I eat cilantro as topping on street tacos the soap flavor for the most part blends away.

[@Xphinity]

Well refined, super well delivered, A's around the board for Dr. Sanjana!

[@jefroukos]

Props to WIRED for bringing education to the desolate rabbit hole that social media can be.

[@angierox6964]

Whoa! You were able to clearly answer many questions in an interesting and easy way to understand! Thank you! Looking forward to another one on DNA and Genetics! 🧬

[@12benzenediol4]

Please make a part two with Dr. Neville! Awesome video

[@AG-iu9lv]

Thank you for even mentioning beta thalassemia! Most of my docs have never even heard of it and I wind up explaining it to them, including having to wave away the harmful and needless retests they try to force on me, I'm going to save this video and let this gentleman explain it for me. It gives me hope that it is being seen and is a candidate for CRISPR.

[@marianaballerina1]

It's a good sign to see this video because I'm going into school for human genetics in a couple months!

[@JaniyaMccall-e5n]

Dr. Neville is wonderful. charming and informative. thanks for these shows . How smoothly the man explained the complex concepts. Commendable..

[@1Skorpia]

Experts in their fields dont get the credit they deserve. Id rather hear about this than another celebrity . If they have a social- can we have it please? Im fascinated 😊

[@Pelusteriano]

Question he didn't actually answer: Q: Why do genes mutate at all? A: The process that copies DNA isn't 100% reliable, sometimes it has errors and that's why there's mutations at all.

[@ryla22]

To compare it to computing: It's like they're compressing everything before copying it for more efficient file transfer rather than perfect file transfer. Compression always has some loss.

[@jasonsmall5602]

Compression does not always have loss. Image and audio compression typically does, because we take human perception into account, but it doesn't have to. Generic files are always compressed with lossless compression.

[@omp199]

@@ryla22 The copying of DNA has nothing to do with lossy compression of files. You have no idea what you are talking about, so please just keep quiet. This is how misinformation spreads on the Internet.

[@ryla22]

@@omp199 I was merely pointing out similarities. I was not saying they're the same thing.

[@omp199]

@@ryla22 You didn't point out any similarity.

[@anhthipham8430]

bro im doing bio and its just so exciting to point out all the stuff that ive learnt in this video like "omg i learnt about insulin production and genetical modifications before" it's somehow very affirming

[@annamarusarz7628]

genes were always the most interesting part of biology

[@Manarinni]

I love that he took every question seriously

[@sumanrodrigues9807]

When the Lenny Kravitz question was asked i genuinely thought he'll talk at length about methylation😂

[@iaimtoplease6046]

This guy is beyond amazing. A real genius moved by endless passion.

[@cheryl-lynnmehring8606]

I think we need a Part 2! 👏👏👏👏

[@TomoyoYumemi]

He is super good at explaining, but his super seriousness gets me

[@MissDaisyUeda]

I'm one of those people of Asian descent that feel sick with alcohol ingestion. It is impossible for me to become an alcoholic because my body can't get used to it.

[@veramae4098]

Alcoholism runs in my family, my father's side. Doctor's have explained it as a "predisposition" to become addicted, but not a certainty. Much depends on behavior. I limit myself to 3 -5 drinks a year, birthdays, New Year's, etc.

[@Hetsu..]

@@veramae4098 good on you!

[@rg1283]

Thank you for clarifying that the geneticist in question, indeed, is human.

[@VexMage]

While I kind of wish I did like cilantro, I think it's a bad idea to "fix" these genetic changes. They arose due to some form of evolutionary pressure. To assume this change is "broken" in the first place is a fundamental mistake in the logic. Basically, as mentioned in the beginning of the video, we don't want to homogenize our genome because it opens us up to the reemergence of the original pressure that caused this genetic quirk. For example, the current theory on this cilantro aversion is that there is a parasitic insect that lived/lives in our bedding. The people who developed the cilantro aversion gene picked it up because this parasitic bug emits a chemical that's unfortunately shared within the flavour/aroma profile of cilantro as well. The interesting thing about the quirk too is that the people who like cilantro cannot detect the smell, and by that I mean, they're incapable of smelling or tasting the component. The people who you want to "fix" have the ability to detect the chemical. If anything perhaps the solution is to "fix" the cilantro to remove the component that "normal" cilantro loving people can't even tell is there? Of course now we have a paradox, do we risk humanity for the sake of cilantro of risk cilantro for the sake of humanity? If a choice had to be made between the two, I'd think perhaps we would risk cilantro for the sake of humanity because we likely could maintain two branches of the cilantro species in one of several capacities without genetically putting cilantro at risk as we would continue to cultivate and protect it.

[@Helga-fe5xl]

Interesting theory! I think cilantro tastes like the smell of stink bugs

[@g2k222]

To clarify: There are many types of bananas, but the banana he referenced was the most popular commercially produced one for the US back in the day. For instance, there were some bananas in Asia that were different , and did not die out due to susceptibility to disease

[@joels5150]

Gattaca is a great film about the consequences and potential problems with genetic editing to weed out ‘undesirable’ genetic traits in favor of ‘enhancing’ humanity.

[@hwway4488]

Best practical genetics lecture on KZbin

[@tashokukisune]

I wanted someone to ask about the implications of this and eugenics vs ethics in gene therapy.

[@TegraZero]

The Name's Bond... Genes Bond.

[@anilachar323]

"Pour me the usual - 3 ounces Amylase · 1 ounce Lipase · 1/2 ounce dry Protease · Bile, for garnish ... Shaken, not stirred."

[@eoinokeeffe7014]

I'm glad they got a human geneticist to do this.

[@User_1976_Dodge]

Easy to understand and quite informative. Thanks.

[@adorablegodzilla5628]

There are a lot of alcoholics in SE Asian countries. Just because they can't metabolize it, doesn't mean they don't battle with alcoholism.

[@corynardin]

I love the last answer. Not just can we do something, but should we.

[@TheSuperSangan]

I wonder what mutations were missed out on because that person did not reproduce Edit: 23&me will also replace expired kits. I had a kit that expired in 2020 and got it replaced a few months ago. It was lost during a move but found after another. Pretty good service

[@feynstein1004]

That's kind of the thing. If the mutation was helpful/good, it would've been passed on. It's kind of like asking how many geniuses have dropped out of college. Well, if they were geniuses, they wouldn't have dropped out now, would they? 😉

[@TheSuperSangan]

@@feynstein1004 do most geniuses go to college?

[@potmeetkettle]

@@feynstein1004 Or the person decided not to have children and it has nothing with how helpful/good their mutation was

[@jeffreyjohnson7359]

Almost all mutations die out, whether good or bad. It's pretty random which ones survive, because even if they give a slight advantage, the odds are still way against them.

[@hilariousname6826]

Curious that he took the question of 'why' there is genetic mutation as a kind of 'moral' query - "because genetic mutation gives us adaptability, enables us to survive, etc." I doubt that that's what the questioner was wondering.

[@sydney6268]

I have the gene for brown eyes, but have blue eyes due to the other genes. I'm fascinated to see if my baby will inherit that other gene or not, or if my husband (who also has blue eyes) and I will end up with a brown-eyed baby.

[@codename495]

I have brown eye genes, but green eyes. I also have parents with darker skin and I am pale and sunburn. My kids have blue eyes, bronze skin and light auburn hair. I have dark hair, hubs is blonde. Genetics are insane.

[@katherinepettus5132]

I have blue eyes, both my parents also. My husband has brown eyes, but only his father has brown eyes. All 4 of my kids have brown eyes. I thought 1 would be blue. Nope. Sigh. 😂

[@misteryA555]

My parents both have blue eyes, and all their parents have blue eyes, but 2/3 of their kids have green eyes! Eye color is crazy, man!

[@Furienna]

But I thought that two blue-eyed parents can't have a brown-eyed child?

[@sydney6268]

@@Furienna that's the thing about it that's weird. According to genetic testing, I should have brown eyes. So I only have blue eyes because of some other gene that is blocking the brown eyes. It's not the same gene that causes blue eyes for most people. About 1 or 2% of people with blue eyes have the same situation

[@aylavall9483]

Such a great video! Would love to see him come back to answer more questions, especially as new breakthroughs occur.

[@Undisputed_King]

I wish this guy was my biology teacher

[@NoellaScott]

Wow, thank you, OCA2! And Doctor Sanjana 😅 I appreciate my eyes and the knowledge

[@The_Wailing_Doom]

This was highly informative and very entertaining. Thank you.

[@danielpieterse8264]

The thing with trying to edit genes so we can be “better, faster, stronger” is we first need to know what a gene like that looks like. We might know the letters of this alphabet and know the words that exist (ours and other creatures’ genes) but making a new gene that actually means something positive and have the effect we want, is kind of like trying to find a word in a heap of jumbled letters without knowing what the word looks like.

[@aadams4233]

Can you do a video about gene or DNA involvement about curly hair? My mother has it too (we're Caucasian). But, we both had straight hair until puberty.

[@wyattbooth6372]

"DNA is the the letters that make up genes" Wrong, those are called chemical bases, and when 2 corresponding bases are bonded to each other we call that a base pair. DNA means Deoxyribo-Nucleic Acid, which is the name of the molecule with the 2 helical backbones with base pairs in-between. I'm sure the Geneticist already knows this, but man did he ever incorrectly describe it.

[@nedsantos1415]

This is really exciting. If put in good use, CRISPR can help end so much suffering in this world.

[@gur262]

I want to glow in the dark though

[@emb7854]

Pity he didn't see the humor inherent in some of those questions. Such serious answers!

[@Pressity1]

My mothers father is a complete mystery. All we know is that her “dad,” my grandmothers husband, was NOT her biological father, and grandma would never speak in it any further. My mom unfortunately passed in 2017, so no DNA testing her with anything like 23 and me. Would I be able to be connected to my mystery grandfather via DNA testing like 23 and me and possibly other family members, like mothers possible half siblings, their children (half second cousins?!), maybe even my mom’s paternal great grandparents, if *I* take ones if those DNA tests???

[@YurinanAcquiline]

I think so. I think it does show who you are related to.

[@jefferylarson3218]

Glad to know he's a HUMAN geneticist, not the robot kind.

[@petersage5157]

I've been rewatching _SeaQuest DSV_ recently, and that last question sounded like it came straight out of the Season 2 premiere, which introduced a hominin race of genetically engineered life forms (GELFs) who, due to their engineered genes, could survive and thrive in a low-oxygen environment; due to the destruction of rainforests, the use of machines that capture CO2 to sequester carbon and generate oxygen to keep our air breathable, and a fully implemented SDI system (ask your parents about that last one, kids), this was a crucial plot point. Unfortunately, Spielbergian pseudoscience woo tanked the plot, not just for the premiere, but for the rest of the series.

[@Subliminalsapper]

The coolest thing I've heard of in gene editing this year is the genetic modifying of silk worms to produce spider silk.

[@ratsalad178]

I do wish Americans would specify that when they're talking about all bananas being the same, they're talking about Cavendish bananas - here in Asia there are still hundreds of varieties of bananas

[@fatimamccullough120]

I am so thrilled to hear your video on genetics. Genetics has always been one of my favorite fields of science, but I love all fields of science.

[@mandeep3.14]

It would’ve been interesting to hear more about eye colours

[@RogerC]

With regards to cilantro, this man knew we could. But he really thought about if we should. Props. "Really, should we do this?" At the end.

[@nvcn86]

the question was "why" genes mutate: because DNA replication isn't perfect, mistakes happen. when the mistake in germ cells isn't lethal, you get a mutation that can be passed on. sometimes even a single nucleotide mutation can change the amino acid which can significantly change the protein. imagine using Fahrenheit to talk about temperature xDDD

[@samwisethesoulless9734]

the one thing that annoyed me a bit, either use centigrade, or man, even kelvin, just... not farenheit

[@loldoctor]

​@@samwisethesoulless9734 Yes, because a popular audience will understand kelvin... Obviously he chose F to make it accessible, although I agree he should have given both. Not everyone is American.

[@samwisethesoulless9734]

@@loldoctor fair enough, I would say C, kelvin was something I decided to say out of spite, as it is "the proper measurement of temperature" but being pedantic for that is pointless. but absolutely, I think it would very much benefit american audiences to experience the metric system more as a whole. just like you said, no need to remove the imperial, just have both to one side

[@lancechua859]

And we have a system to correct the mutation, if ever happens.

[@peterpan408]

CRISPR on a living person can be fatal.. Converting your DNA significantly can cause immune rejection on a massive scale..

[@jamo3976]

Fabulous guest! Plz have him back again!

[@t1sk1jukka]

Could you add units in celsius(, kilograms and such if the subject has these units) in these videos too I don’t know fahrenheit and don’t always want to google whenever I see those units

[@aysa1619]

he explains like he would be the most excellent teacher ever

[@AwfullWaffle]

So, if you have a blue eyed person in your immediate family but you have brown eyes, you are also related to the person with the original mutation? That dude must have been getting busier than Gengis Khan considering I can’t think of a single person I know who doesn’t have someone with blue eyes in their family.

[@thattinawoman5119]

I love this series. I want to see more of the mortician, he's amazing!

[@julittok]

These are the people we should be spending our time listening to, not the moronic plethora of actors, pop singers and the like. We would have a massive cultural overhaul if our idols were people contributing to the betterment of society and the planet.

[@feynstein1004]

While I do agree with your argument, it is in itself quite ironic, because it suggests that everyone should be doing the same thing when just like genetic diversity, we need intellectual diversity too. Everyone shouldn't be interested in the same thing. We need different people doing different things

[@julittok]

@@feynstein1004 My problem is not with people engaging in different activities, it's not a matter of everyone doing the same thing. My point is that society spends too much time, effort and money tracking the everyday life of artists and athletes. We put way to much énfasis on them, when their real contribution to the planet is basically entertainment. I think we can do better than that.

[@tuiteyfruity5010]

I want to correct one thing, 1000$ to sequence a human genome is ridiculously cheap, considering it cost 10X more just a few decades ago.

[@stanleykassim2839]

For every action, there is an opposite and equal reaction. If we engineer the genome to enhance something, it will cause a chain reaction. Let's say we enhance the genome to increase bone density: this should cause the body to give priority to the bones when ingesting phosphorus and calcium, causing other phosphorus- and calcium-dependent parts of the body to be starved of those elements and be underdeveloped. Balance in everytthing.

[@feynstein1004]

Please stop misrepresenting physics. It's why people are losing trust in science. That's not how Newton's third law works 🤦

[@veramae4098]

"For every action ..." is a physics statement, not a medical one. For example, the big old WW II battleships that let fire all guns at once to port or starboard, would rock backward in the opposite direction. Balance is not everything in all fields.

[@alextaylor3850]

Although this is oversimplified there is some truth in it - the overall homeostatic balance has to be shifted to accommodate changes to genes.

[@phillipanselmo8540]

guy is contesting literally the culmination of decades worth of research by numerous biologists lmaooooo

[@ADTillion]

@@phillipanselmo8540. Unfortunately we live in an era of anti-science politics. This person seems to be a follower of known conservatives whom are quick to accuse scientists of hijacking studies in order to hide real evidence and push political agendas. It’s undeniable that scientists today are far more political and profit-driven than they were a century ago, but it does humanity no good for either side of the political spectrum to use science or anti-science purely to get votes.

[@demonschnauzer1555]

As someone with the cilantro tastes like soap gene, I can confirm that you can just learn to get over the aversion to cilantro.