CRISPR's Next Advance Is Bigger Than You Think | Jennifer Doudna | TED

You've probably heard of CRISPR, the revolutionary technology that allows us to edit the DNA in living organisms. Biochemist and 2023 Audacious Project grantee Jennifer Doudna earned the Nobel Prize for her groundbreaking work in this field -- and now she's here to tell us about its next world-changing advancement. She explains how her team at the Innovative Genomics Institute is pioneering a brand new field of science -- precision microbiome editing -- that uses CRISPR in an effort to solve seemingly insurmountable problems like asthma, Alzheimer's and climate change.
This ambitious idea is part of the Audacious Project, TED's initiative to inspire and fund global change.
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• CRISPR's Next Advance ...
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[@elleaubry3772]

This is so wonderful sounding, and yet at least a million things can go wrong in the hands of those who are not so interested in helping humanity.

[@Magic-mushrooms113]

So true…

[@carlosr192]

The world need this but changing the cow's gut...you will need change the cow's DNA. Here in Brazil to help the 0 emissions of meat production the amazon forest needs help to reduce in half the cow's gut emissions .

[@WeylandLabs]

Absolutely, it's natural to approach new technologies, especially something as transformative as CRISPR, with caution. We've seen in history that advancements can be used for both positive and negative outcomes. However, progress in the field of science and technology is inevitable. As a society, our goal should be to foster open dialogue, robust ethical frameworks, and transparent regulations that ensure the responsible use of these technologies. Fearing potential misuse can inhibit beneficial innovations, but being vigilant and proactive in our approach can maximize the benefits while minimizing risks. As with any tool, it's not about the tool itself but how we choose to use it.

[@linzeng6523]

She talked about the complexity of the microbiome being the problem, yet without first solving that, she’s going to carpet bomb them with a mutagenesis weapon known for mistargeting issues and call it precision microbiome editing. See how easily she dismissed the other approach: probiotics, prebiotics, fecal transplant? Calling this questionable is an understatement.

[@rahultiwari.95]

its already not in the hands of favor humanity

[@elainemunro4621]

She won the Nobel prize along with her female colleague! My hometown gal!

[@Danuxsy]

why are you bringing up gender into this? that only perpetuate the idea of man vs woman, etc...

[@itskittyme]

But the fact you are pointing at it, perpetuates the idea of the idea of man vs woman etc...@@Danuxsy

[@LukeFG]

@@itskittymedoes acknowledging reality contribute to its consequences?

[@itskittyme]

How can you acknowledge reality if what you think is reality doesn't seem to exist in that way?@@LukeFG

[@ToneyCrimson]

@@Danuxsy Stop being cringe....

[@figureofteach3672]

Whenever I hear, "Now we can do A without doing/getting/needing B...", I know that at some point in the future we'll be saying "... but we didn't know that we were going to cause C through Z".

[@SamSard]

Unfortunately you can't learn without doing it. As long as we're not omniscient we'll learn by iteration

[@Picasso_Picante92]

Yes. That’s science. The same science that created cures and treatments for cancers and the phone you’re using. Everything comes at a cost.

[@Magic-mushrooms113]

@@SamSard like the researchers who decided to play with batshit and caused a pandemic…

[@johanneslaue5934]

Exactly. When we create new genetic code as of we were God, who knows what wiki happen? May I present the Covid “vaccine “ as Exhibit A.

[@Oompa_Output]

Yep in the 90s they called most of the genome 'junk' dna... not now...

[@davidcantu2665]

I’m a college student and I had the Opportunity to Met Her a week ago at a seminar she gave in San Diego. She was so genuine, and stupendously kind and sweet with everyone, specially with all the young students that wanted to take pictures with her.

[@joeh212]

Same, but in Seattle.

[@illygah]

what is she a celebrity to you? get a life.

[@28th_St_Air]

@@illygahPeople with a life admire and learn from others who have made great discoveries grounded in data and facts that will help humanity. Meanwhile, people like you want mylar balloons captured on drone footage to be proof of alien spacecraft. It’s perplexing that you reject others for admiring someone like Doudna.

[@arankinogon2059]

Thats how they got you , wait for chimeras now

[@jessematchey4802]

She is naive to how horrifically wrong things can/will go when this is in the wrong hands…

[@JakeRichardsong]

I wish she and her scientists peers got far more attention than pro athletes and entertainers and models.

[@93455Driver]

Or loud mouth politicians, social media influencers, and zany business leaders :/

[@walterroux291]

Humans crave entertainment so it will always be a high value job at the top level. Not suggesting every job in entertainment is high value, but certainly for those that are valued within the space, the Hollywood celebs, top footballers etc. And this won't change. Advertisers can't throw a bunch of money at scientists because it'd be an awful return on investment, and that's just how the cookie crumbles in capitalism I guess.

[@danielepp3113]

Sorry for Your loss.

[@arishemthejudge6780]

Cmon now first of all scientists dont do it for fame, they have a passion for what they do. We all crave entertainment, so it’s impossible to not have, at the very least, sports. Imagine a world where everyone just hopped onto their computers to watch the latest scientific innovations, such a world wouldn’t work. Every industry is extremely crucial to this world except P*rn

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@patientzero5685]

If only the good people who invented these technologies controlled how they were used.

[@Hammadaziz03]

Which has never been the case

[@IMJwhoRU]

Well said. I was just thinking something similar but couldn’t think of a concise statement.

[@sanja7744]

that's why it's important we all vote, no matter where in world. solutions exist, many brilliant people invent technologies that can solve all our problems and many of them are already in existence. we just need to put people who will listen to the scientits in positions of power. In every country there is more us (citizens) then them (small amount of individuals who control). the power is all yours.

[@Defirence]

As citizens we always forget sciences are the foundation of our entire existence, scientists who want to do better cannot be overridden by governments, this is a lesson we still learn and will keep learning and improving on to better humanity forward. We also forget as citizens we outnumber governments and bad actors in all forms 1000000:1 and have the power to arrest all forms of state organs via citizen arrest if they don't act in favour of our species or our fellow kin, the rights and power to boycott, overthrow and rehabilitate everyone to be better although there still needs to be a balance and not everyone acts in the betterment of our species sadly... We cannot live in a complete dystopia, nor a complete utopia otherwise we would go extinct very quickly, along with Nature, our Earth and all other species of life... We can always look at the bad and negative side to things easily, but it's just as difficult but even easier to seek out the good things and positive change too. :)

[@jayceh]

It's not an invention, it's a discovery. Once you make a discovery, anyone can make it work.

[@Scriabinfan593]

Dr. Doudna is one of my heroes. Her work has the potential to do lots of good in the world if politicians don't let corporations screw it up.

[@Dave_of_Mordor]

What would corporate do to screw it up? They're just going to use it to help us edit the genes we want to keep or removed. I think the people will start requesting weird gene editing and because the corporations want money, they'll just do what the people say. I don't see how they will be the one to ruin it. It seems more like the people will be the one to ruin it.

[@TheBann90]

Like the infamous quote, 'where is the money in people getting rid of disease'?

[@alechiggins6515]

​@@TheBann90tons of money in it. If someone patented a cure for cancer they would become a billionaire almost over night and would go down in history books as one of the most notable people in mankind.

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@NFT_Artist]

Let’s hope politicians themselves don’t screw it up either. I’m surprised Crispr has been allowed to survive this long, not getting squelched by big pharma. My understanding is that big pharma kills off “cures” so they can continue making $$ to treat symptoms.

[@robnolte2547]

Biggest take away here is metagenomics. If we can better understand the links between our health and and micro biome we could change our diets and environments to address these issues in the first place. Then small number of cases where that doesn’t work or time is too pressing due to life threatening illness we can use a tool like CRIsPR

[@JafarChou]

I agree. Reducing cow farts is just a series of stepping-stones to what CRISPR can do in the future, like editing our own microbiomes. Metagenomics is key in understanding that, and doing so without wreaking havoc.

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@AR-ec9cw]

Going to guess the makers of Inhalers do not want this Asthma treamtment getting out. GSK Wouldn't like that.

[@mattyrjackson4261]

The best comment on here

[@-astrangerontheinternet6687]

4:52 “and show that they are safe and effective” Hear the voice change there.

[@mariod.4809]

The obvious incentive to profit rather than actually solve problems are made very clear with this presentation. Rather than looking at environment and other external conditions that cause disease/disorders (asthma) they are instead selling a product designed to change the organism at the very core. The tech is nonetheless impressive and has insane implications for the future if used correctly but we are not close to societal maturity to have such tech at our disposal.

[@Gruso57]

Profiting and not solving problems are not mutually exclusive. In fact, it's unrealistic to think you can make large leaps in advancements without the need for major funding for R&D. I wish we could get over the "money equals bad" view because it's inevitable. Your idea of social maturity sounds like a naive utopia

[@lilhighway]

I wouldn't blame the researchers, these people are geniuses that basically live in labs, but they're more or less forced to commercialize technologies or else most, if not all of their funding disappears. I wish we could live in a time where billionaires and governments and everyone else invested heavily in the natural sciences without an expectation of financial returns.

[@sharonlima8913]

and we have many movies and series about that, aye anyone still watching - `the boys`

[@slvshy666]

@@Gruso57 yeah but he's not wrong. This tech is being pushed like it will be used to make the world better. In reality it's not curing the cause of disease, it's just a way more expensive, unnatural, and infinitely more complex bandaid.. Like pushing a vaccine for a flu-like disease instead of exercise and general health.

[@timsumner6178]

gainoffunction

[@NathanHarrison7]

What is incredible time in mankind’s history we are privileged to live in.

[@limonadovi]

Unfortunately the climate change brings changes no one ever has seen before. Mankind advances technology, but apparently can't give up its comfort or the power one thinks to own.

[@jessekendall4658]

​@@limonadovi Climate change has been happening for billions of years. Greenhouse gasses are what's creating all the problems for us now.

[@carlrodalegrado4104]

@@limonadovi I do hope climate change will just become a "Malthusian trap" and technology will just solve things you can stop the march of progress

[@michaelgleissner6929]

🤢

[@musikSkool]

Never before have so many promised so much to so few who still believe them.

[@phlogistonstudio8261]

Raise your hand if you can see a future bioweapon in this particular application of the crispr technology. 🖐️ I’m a bioinformatician, and I’m rooting for crispr all day. I hope really big brains are evaluating and creating solutions against what seem like inevitable use cases.

[@krystalgardiner5591]

It was already used, what do you think the past few years was about. People are just walking over the cliff willingly.

[@kashutosh9132]

​@@krystalgardiner5591covid?

[@user-mx5ee7hk6u]

“CRISPR” IS EVOLUTIONARY!!!! Jennifer Doudna & Emmanuelle Charpentier gave it to us. Both internationally recognized in only 10 years! WOW . . . Thank you both!

[@Ashish-nd3xj]

Any hope for psychological disorders and depression

[@stevenvargas6863]

@@Ashish-nd3xjwith this, yes but it would take so much longer because these disorders are super complex since it pertains to the mind

[@SabaDhutt]

This amazing woman should be a household name like Steve Jobs and Elon Musk. Even her name ends in DNA. Jennifer was born to do this.

[@higgsboson9380]

Steve Jobs should not be a household name.

[@kalla103]

nor should elon musk, literally two of the greatest hustlers of our time

[@Ninja-iq2xt]

nice finding, DNA...cool!

[@ChrisBeaman]

@@higgsboson9380 @kalla103 Too bad, they already are. Humanity is better for the companies and leadership of Steve Jobs and Elon Musk.

[@Tauncerador]

"Steve Jobs"… 😅 "Elon Musk"… 🤣 Sorry, but no.

[@Godios119]

I have a relative who has always had a problem with their gut, specifically it’s a bacterial imbalance that causes him a lot of pain when he eats the wrong foods. I wonder if this is something that could be used to help him on the next couple years. There’s currently no cure for him, only staying away from 99% of foods keeps him from pain

[@rubyrue6997]

Look Ivermectin and Bendezalo parisigt end dewormer . Herd red it might cure a lot of probloms .

[@bijanshahidi3933]

Amazing scientist. I sent this to my kids to learn from her. So proud to know of her work.

[@illygah]

she said it came to her in a dream. It's the dream who really deserves credit.

[@ismailnyeyusof3520]

@@illygahit was her dream, not someone else, especially not yours.

[@Magic-mushrooms113]

@@ismailnyeyusof3520 some of my dreams are batshit crazy!

[@michael-vl1mn]

Just some.@@Magic-mushrooms113

[@Jsternshow]

Jennifer Doudna will be remembered for 1000s of years. Her work on crispr will change how we treat diseases also cure diseases and extend human life. This is still decades away, but CRISPR is a game changer for humanity if used for good.

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@robivan9263]

SHE WILL BE REMEMBERED AS A CONFUSED GEEK WHO PUSHED COMPLEX NONSENSE WHICH MADE NO SENSE

[@Jsternshow]

​@robivan9263 How long have you been a bot?

[@Hopefullyhelping5050]

Thank you for your efforts

[@RavarsenBlogspot]

I’m eternally grateful to scientists like you that makes our world a better place

[@thephilosopher7173]

Wait until this science has it’s Oppenheimer moment…

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@freebird7369]

Hope you like eating bugs.

[@hahtos]

Isn't this how the zombie apocalypse begins....

[@tutubeos]

Thank you Jennifer from the heart ❤

[@Praisethesunson]

Jen the dude doudna has the title of most impactful scientist this century. It'll be amazing to see what comes from her tech.

[@carolcsantos1]

Her book "The Code Breaker" is fantastic! Thank you for your work ❤️

[@relax_chiguire]

It’s not her book

[@relax_chiguire]

It’s about her.

[@illygah]

it's not a good title. People don't like when things get broken. She shouldn't break things. She's a doctor, she should have called it "the code healer" or "the code doctor" or "the code decoder". The way she's titled the thing is suspicious and revealing. I don't think she respects nature or believes in the almighty.

[@kreek22]

@@illygah She's not a doctor.

[@ClarkPotter]

​@@illygahIntelligent ppl don't believe in deities.

[@samcoding]

This sort of discovery gives me hope.

[@Magic-mushrooms113]

Thanks for sharing… I’ve given up and moved on to despairing for the planet and the human race. But by all means let’s go to Mars instead of building houses with solar panels and water collectors and give the homeless some human dignity… keep hoping for me though I appreciate it!

[@rexplorer.official]

They said the same thing with the “fusion energy” news a few months ago too.

[@abduazirhi2678]

Fascinating ! thanks for sharing

[@BestFitSquareChannel]

Astounding! Thank you. Carry on… Best wishes, health, joy, wellbeing… 🖖🏼

[@benjamindover5355]

Can we have crispr get to work on male pattern baldness? I had a great head of hair in my 20’s! Looking forward to a midlife crisis muscle car and renewed head of hair. So if you guys could get right on that it would be great thanks!

[@cha0s1999]

Try finasteride and minox this stuff is far to cure mpb they will cure serious illnesses first

[@tanbui7869]

Amazing scientist in Dr. Doudna. Startalk opened my curiosity in crispr!

[@Torrle]

Great to see more good uses for CRISPR!

[@minibobber]

Living genius Jennifer Doudna and her colleagues

[@FayeFaye-]

Im glad to hear good news about CRISPR research

[@user-kk6pi8lm9x]

2621 이하영 I didn't know that technology like CRISPR and metagenomics can change our human society, identifying characteristics of a specific microbiome and precisely editing the DNA. It was a surprise for me to know that these tools can handle climate change and also prevent human diseases. I wish this brand new field of science could develop more so that we can make the world a better place.

[@dinkohrvat344]

This is an exceptional period in Science.Such exciting times . This woman will go down in history !!!!

[@carpepoulet4943]

A fan of development, progress, understanding... but this one also came with an aftertaste of dystopian horror. When i heard those words, "...safe and effective..." i got chills.

[@mitchellsteindler]

It's because you've let fear mongering get to you

[@sophialong640]

i hope you know that we are using crispr to work towards a cure of cancer. not saying this technology doesn't have ethical concerns. minimizing suffering for the humankind is always our priority, but whether that technology gets compromised by malicious people or used to contribute to a "dystopian society", is a question you should ask those in power rather than those who are merely doing research for the greater good.

[@Danfloww]

@@sophialong640 whether or not its for the greater good we will see in the end. And if you're considering yourself to not be apart of those who are in power while in the forefront of this technology then I don't know what power is. Concerns would probably be better served welcomed rather than immediately shedding the weight and responsiblity to those in power.

[@sophialong640]

​@@Danfloww not sure if you've noticed, but our societies are not controlled by scientists but rather politicians and the rich. an example for elementary school kids: if scientists have been in power, then they won't be ignored for decades in the issue of climate change. by the way, the "concerns" that I'm talking about regard to "the misuse of technology" and the resulting dystopian future. i suggest you re-read my comment. do you think it's the scientists' intentions for tech to create a worse future for humanity? if not, then i suggest you to rewatch oppenheimer and see how the game of politics is played, and how this game does NOT give scientists say over their own tech once the military or whatever government body takes over this tech. yes concerns should be raised but it's no use if raised to those without power.

[@richeby6436]

How anyone of intelligence could possibly think something horrific isn't going to be created by accident or design is beyond my comprehension.

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@malcolmrose4694]

I believe that Precision Microbiome editing is great but the example she gave with the reduced methane production in animals is promoting factory farming. In turn it will promote animal cruelty, deforestation, monocultures, soil degradation and a lot more. The other examples sounded great to me and i hope that it will be focused on problems like these so that it will not only help to build a more resilient future for us as humans, but for the whole planet, with all of its inhabitants.

[@sidstovell2177]

I remember driving down Hwy 5 in California, past the gigantic, famous feed lot. The stink went on for what seemed like miles.

[@Debkah]

I need 🍖.

[@bobsterbeat216]

I had a similar thought 🙂

[@kyletabor636]

Same. She’s focusing on those problems because they get more funding !!!

[@davidbutler99]

I'm with you. I also wonder about a mistake which really doesn't have to be a mistake to be a mistake. You simply improve a microbe it outperforms the others. Shure what could go wrong

[@vijayrajamanickam6847]

lovely talk. well spent time watching tedtalk.

[@AniruddhJain111]

Classic case of the tail wagging the dog. Do we ever question to keep our unending consumption in check instead of modifying nature to produce more? Do we ever think about the downstream effects of these gene modifications on other aspects of nature? Instead of modifying the animal itself, why aren’t we asking the question of reducing use of these animals in the first place. Animals deserve that basic respect.

[@IronMongoose1]

I hope this doesn't go horribly, horribly wrong.

[@nicktaylor5264]

I hope everything doesn't go horribly horribly wrong

[@davids9522]

Well the odds of this technology being used as a weapon in one form or another is about 100%

[@YoutubeLoves2Cenosor]

It will dont worry

[@HaraprasadMohanta]

Any advancement in science and technology will always be misused unless we fix the animal within us first.

[@MichaelVileleagueofintrigue]

ahhh!! there we go.. found the aLaRmist!!

[@heroclix0rz]

"Look at all these systemic problems we've created for ourselves. We've designed a new system for solving them all. Nothing could possibly go wrong."

[@Everything_Abbie]

She's my hero. Absolutely brilliant!

[@Freiheit1232]

This would be incredible for people with IBS…

[@ssriramsrs]

im sure crispr has great potential. but when someone talks about using gene technology to 'change the world' i get chills up my spine

[@Remingtonmae]

because it's criminal in it's very suggestive nature. Are they going to ask the world for their feelings about it? Their permission to do so? Will they cease moving forward if the whole world speaks out against such a global move that is sure to have many unintended consequences? No, likely not. And, history repeats itself once again. A tiny group of people get funding and power and use it to do things THEY want to do. THEY think is good. They do not consider or respect that ALL of us live on this planet together and have a voice on these issues, because we may not have the same outlook that they do.

[@bhvnraju8493]

Great innovations are happening than ever before,hoping CRISPER may address many issues related to mankind in future both medically and environmentally, interesting discourse 🙏

[@truetech4158]

Great innovations require daily interventions though, to remind our species that fiction isnt fact, and that praying is willful ignorance.

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@BoogieBoogsForever]

How would you edit the child's microbiome? I get that you can edit a dna sequence, but so you give them a food to eat which changes things?

[@MrGriff305]

Please find the reverse aging switch. Thank you!

[@jimstark1810]

Ted talks are awesome. What sucks is they are held in a barbie doll dream world setting. These are people with the best of intentions. The real world is filled will all sorts of people with all manner of intent. Much of that is self interest.

[@sidstovell2177]

Just listen. Don't look. It's a talk.

[@lawrencefrost9063]

Walter Isaacson's book on her is awesome, highly recommend.

[@TheBusinessLife360]

This is really good Science!!!

[@sudipchatterjee]

Fascinating! ❤

[@cccccccharlesssssss]

There’s already a way to perfect one’s microbiome and it’s eating natural, whole foods. Works for all animals, and makes the ones which we consume much healthier for us too. CRISPR editing at this scale will have disastrous results long term.

[@Jamesthegiantpeachlover]

Incredible technology, but hopefully we can put in place code of ethics for this powerful technology. And with its advancement, the inherent wisdom to use this tool wisely across the globe.

[@elmono558]

The code of ethics will be warped by the desire for profit.

[@markwalker3499]

No thank, your "wise" is not necessarily what others would call wise. Just look at splitting the atom, not wise at all, and any benefit it promised never happened, all the dark and evil that could come of it has. I do not need you to tell me what I can do with my body. And no matter anyway because there will be no benefits from CRISPR till they can figure out how to keep it only available to the very wealthy anyway. In 2021 I had a problem that took me to the ER, they did a CT scan and ultrasound. Bloodwork. $16800. In 2022 the same problem happened and had to go to the ER again, $40 thousand. Same everything except cost. The VA paid but the point is if you cannot afford to break an arm or get a blood clot how the F*&^ are you going to afford this technology?

[@eric2394]

But there stock?

[@yoxat1]

Not a chance. CRISPR technology can be mastered by a college student

[@MYKEYCARD]

Thank You For Your Phenomenal ✔ Global ✔ Outreach ✔ Support ✔ Helping ✔ People ✔ To Know Their Worth ✔ And That Authenticity ✔ is Priceless ✔ 🙏💜🌍💜🙏

[@thetruthserum2816]

When Jennifer Doudna "Do-U-DNA" speaks, the world listens!

[@daroofisonfire6370]

Doudna is such a brilliant human being

[@armartin0003]

Speaking of microbiomes. I remember having a bad ear infection because my dog (unbeknownst to me) was sleeping on my pillow while I was at work. Antibiotic didn't work, nor did drops. Then I saw a great gob of ear wax in my toddler's ear and I reasoned that it must be full of bacteria. So, knowing about microbiomes and fueled by a healthy dose of desperation, I got a Q-tip and put his earwax in my infected ear canal. Cured me within days.

[@ArlenKundert]

Amazing!

[@francescopatella1772]

The end looks like the begin of "I Am Legend" or other movies about zombie apocalypse

[@richardblock2458]

A genuine genius.

[@volkerbosch9078]

I don't believe we can solve the problems we have today with the same thinking that created them . Despite everything, an impressive step forward

[@ClarkPotter]

No thinking created genetic disease.

[@sounavapandit7888]

haha haha ur so wrong

[@haput160]

Excited about the future but worried too

[@user-gg8we2ot4b]

Super & Thank You!

[@itskittyme]

ur welcome!

[@fractal_gate]

I'm sure nothing will go wrong with this technology that allows us to freely edit the basic code of life.

[@whimpypatrol5503]

To bad crisper won't ever transform the moral nature of evil people who can use it to harm mankind or to profit from un-kosher products it can create that are not environmentally friendly. I know this sounds like something out of the mouth of a goon, or from someone not tightly connected to "the know". But I'll say it anyways. Growing quietly and unseen inside of all of humanity is this thing that looks now like just an innocent weed sprouting from ground. It is called wickedness and has serendipitously infected everyone. When it matures and is harvested humans will destroy each other using high tech, diseases, nukes, famine, robotics, AI deception, chemical, and advanced weapons by the billions. This scenario spelled out in many ancient scriptures once seemed like a fairy-tale but now appears clear on the horizon. The only antidote is to personally recognize it rooted in your life and accept Jesus to redeem you. Humanity cannot redeem itself.

[@MrSmellyBoxer]

Read Jennifer’s book “a crack in creation” read about her dream meeting a pig faced Adolf Hitler

[@wlhgmk]

Fantastic and of course nothing could go wrong with such a powerful technology and it is fortunate that it can't be used for nefarious purposes.

[@user-cu7uz5le3h]

Sounds like something you shouldn’t mess with. We are just fine the way we are now.

[@frankmccann29]

Pretty and brilliant! What a babe. Thank you for explaining CRISOR. Modulating the human biome could allow the telemeres to stay put permanently. Best shot for immortality so far! Wow! 😊

[@TomBrown-ij3jk]

Be very careful to monitor arrogance in your disciplines! This is a phenomenal discovery. Use it wisely ❤️🙏

[@sharonlima8913]

and we have many movies and series about that, aye anyone still watching - `the boys`

[@Praisethesunson]

So what you are saying is we need to weaponize this. Alright. -CIA

[@mgyb8269]

In in one ear, out of the other. They are trying to play God and are opening Pandora's box. The Human species will be separated in 2, natural Humans and genetically modified ones.

[@nerd26373]

Jennifer Doudna sure has exemplary and concise insights to share with audiences. Even the back of my neck I can feel the tips of my hairs rising.

[@Novastar.SaberCombat]

Those are two of some of the strangest sentences I've ever seen paired together.

[@PerspectiveEngineer]

Love that science!

[@PerspectiveEngineer]

@@Novastar.SaberCombatget out more... ❤

[@MrSwider87]

They said they can cure sickle cells... i have a rare blood disorder i've had explained to me as Familial Hemolytic Spherosytosis.. I have had abnormal red blood cells since birth. Does anyone know if they could help me somehow? I always feel so tired...

[@peterryan8591]

I was put off that Dr. Doudna was wearing a shirt with an advertising logo. Then I read the comments of what a genuine person she is. It is a great lecture and hopefully this will help us all. Thanks!

[@David-hi9nz]

The Doudna Lab logo? You're joking, right?

[@Magic-mushrooms113]

On,y if you can make money out of it for some capitalist millionaire

[@GrahamMayer]

What is your rollback plan if there are unexpected consequences to your interventions?

[@neithanm]

This is one 'rollback plan' to the "hey let's just burn these harming fuels" plan. It's simple history, science and technology.

[@MichaelVileleagueofintrigue]

hahaha... well.. the OLD x-tian standard would be to run to the nearest church and start praYiNg really haard.. LoL 🤷‍♀ and pray eVen harder that youre even "praYing" to the "correct" one.. !

[@justayoutuber1906]

What were they in the past for other inventions?

[@paaabl0.]

Ticket prices for TED Vancouver were absurdly high. One would though they have a noble mission of sharing the knowledge, not just another elite club for super rich.

[@Magic-mushrooms113]

It all comes back to the money doesn’t it… we are all screwed

[@mgyb8269]

Is it gatekeeping or simple economics ie supply and demand? Was it sold out? What type of venue was it in? How many speakers? All these should be taken into account in my opinion

[@teachrare]

10+ years of innovation - we are ready for it to make its way from theory to practice.

[@31samu]

wow, very interesting, but boy was it hard to follow at times. Very interesting indeed though!

[@satorimystic]

All my instincts say ... "proceed with caution."

[@johnballantyne9501]

Sounds wonderful. What could go wrong?

[@thomasstevenrothmbamd2384]

Wow!

[@paultidwell8799]

exciting.

[@MyName-vg8yu]

I love how the essence of being human is no longer literally the essence of existence that is DNA, but problem solving 😂😂😂

[@keng7758]

An incredible scientist and human!

[@tigerdevon]

Good video! I got a bit distracted at the end when I realized she kind of sounds like the judge in the beginning of super mario sunshine

[@oryxchannel]

Just the wording ("...a blueprint...") I was looking for- theorizing with a science-meets-biology-medicine LLM (A.I.). Had a need for a "blueprint" of my friends recent case of pronounced Alzheiemer's. In chats with said A.I....togehter with "persistent memory" (excluded in conventional chatGPTs)...I will theorize on Jennifer Doudna + Co's "precision microbiome editing" here and the new field of "bio *sonolithography* " . We should be able to...non-invasively "suggest" "to" the condition... back into pre-symptomatic states. eg. Robin Williams "Awakenings" but instead with lasting results.

[@lorez6063]

Wonderful stuff. And when will this amazing technology trickle down to the average person, so that we may live more comfortable lives? Or... how much is it going to cost, in a world where dreams only come true for the mega wealthy?

[@Praisethesunson]

Good news! You will be subjected to this tech in your corporate owned food supply.

[@skyhavender]

Is it true that this could be the thing that would allow us to live longer or extend the human lifespan?

[@jkbaseer]

😂

[@jkbaseer]

@@m.a.4500 you nailed it. Way for pfzire to charge higher for premium segment giving the aspiration the people can live longer

[@jhunt5578]

Potentially

[@stu2024]

In terms of average lifespace, yes. Individually, it's just mitigating risks.

[@jhunt5578]

@@samudramanthan8645 For as long as I'd like to keep living

[@mattbba8451]

Excellent.

[@itskittyme]

exactly what i thought

[@kaushikidutta319]

I bow down before her and Emanuelle Ma'am, every time I see them 🙇‍♀️

[@totalfreedom45]

Sophisticated technologies-life extension, nanotechnology, AI (AGI and ASI), information technology, the singularity, CRISPR gene editing, robotics, cryonics, mind uploading-must be in the hands of scientists and ethicists *_first_* and then in the hands of governments through regulation and law enforcement. 💕☮🌎🌌

[@RJZII]

Mind Duplication

[@joannot6706]

@@m.a.4500 Absolutely! We should have the right to maximize our chances of getting infected and infect other people, especially those with an immune system too weak to get medical treatment or medical prevention. Freedom!!! That is the same energy as the one that gets the survivors killed in a zombie movie

[@zakyvids6566]

Absolutely not

[@adedejijubril8048]

Leaving technologies in the hands of government is how it has always ended up being politicized in the first place. The list is endless: space tech, nuclear energy, vaccines

[@axumitedessalegn3549]

Nice set of words you have collected there.

[@hakim6933]

This technology is incredible but can we truly trust humanity to not abuse it

[@vhscopyofseinfeld]

No we cannot. And as gene editing becomes designer-like it’ll only be available for the super rich and the disparity between rich & poor will widen even more.

[@johnyliltoe]

@@vhscopyofseinfeld Pretty sure we're getting close to the tipping point of rebellion. History has shown that wealth disparity will only go so far before the guillotine comes out. While I don't believe the rich are as special as they're made out to be, I do suspect they are by and large well enough informed to try to avoid that tipping point.

[@jimmytimmy3680]

Covid 19 showed we can't trust the military and the capitalists running the world.

[@kalla103]

*the rich who have access to this technology not to abuse it

[@shanekoker7171]

"I had a dream that the meek inherited the Earth. It really shook me" You are humanity brother. Can we trust you?

[@masrizal82]

Looks eerily familiar. Like the opening scene of a movie. Something about Umbrella Corp..

[@a7xfanben]

Spectacular!

[@1Kent]

Corruption never sleeps and will inevitably control this technology.

[@jurajchobot]

I hoped she would talk not just about CRISPR's applications, but also about its advancements. I heard a couple of years ago, they still had problems with achieving 100% accuracy and it was also really expensive to edit large parts of genome. Therefore it was limited to tiny, precise changes rather than complete bioengineering, that would take a long time with current methods. Also if you can, I would love to hear about those 0.50$ DNA tests, where you just drop a sample into a playing card sized sheet of plastic and a large grid of genes starts coloring based upon the presence and absence of genes. It sounded like a ground breaking invention as you could test for presence of hundreds of genes in humans in very short time and at large scale, possibly allowing us to sequence everyone's genome for possible disease predispositions, intellectual potential as well as genetic strength and endurance of patient's muscles. Sadly I didn't hear about it in years.

[@AQBPlays]

That’s some Theranos level pie in the sky.

[@willgreen8310]

There have been advancements in engineering CRISPR-Cas9 to be more specific. The best examples I can think of are nickases where they catalytically deactivate either the HNH or RucV endonuclease domain (each one cuts a single dna strand leading to coordinated double strand breakage) so that only a single cut is made. You can then dimerise this nickase cas9 and it increases the specificity through a longer reqired recongnition sequence, and any off target single strand breaks being much more readily repaired by the cell. There's also efforts looking into changing the PAM site requirements or base and prime editing where you add an effector deaminase which changes individual bases much more effectively. Prime editing is even cooler as you fuse a reverse transcriptase to Cas9 with a pegRNA (prime editing guide) which has the edited sequence of interest encoded on it for the reverse transcriptase to use. So there is lots of cool stuff going on, but I agree it would have been nice to find out more, as i've not kept fully upto date

[@BearMeat4Dinner]

Dr Doudna is da best ❤!!!

[@TeddyshaCelestine]

I would love to go one on one with Chris per and it's inventor

[@sweetsounds9674]

This, like all our tech we create, will be for rich folks only. Stem Cell, Lasik, invisalign, hormone therapy, advanced pharmaceuticals, and many other procedures are so far out of reach for most of us. Lasik is the cheapest of this tech and is still over $3000.00. That means 97% of humanity cannot have this, and it's been around for over 30 years. Greed always wins with the medical community, not helping folks.

[@Youtuberkt]

Medical tourism. Lasik is far cheaper in india, mexico etc

[@MrShikaga]

You have a great point, but I think that perhaps you are thinking backwards. The problem isn’t that LASIK or any other medical treatment is too expensive, it is that many people are too poor to afford it. I think it would be more effective to focus on ensuring the poorer amongst us get more wealth, than to try and find further ways to cut the cost of shining powerful lasers into our eyes. In my opinion, it is worth spending the money and making sure medical treatment is done right. But more importantly, I think perhaps you don’t quite appreciate how much cheaper most medical technology is these days, especially in genetics. The price for DNA sequencing has come down in price over a million times in the last 30 years, as have many others, so I think you many be overly pessimistic when you say “all tech” will be for rich folks only. Another example would be flying, which was extremely expensive 60 years ago, something only the rich could afford, but can now be afforded by most people on earth. But do let me know if you don’t agree, I would love to discuss this further!

[@The1stDukeDroklar]

Good speech. Pretty basic but good for those who are new to it. In time it will allow humans to live on inhospitable planets while terraforming is in progress. It will also allow for much longer lifespans and many other things. In time, the definition of what it means to be human will have to be reevaluated.

[@kreek22]

Humans won't be around for that reevaluation.

[@HarpreetSingh-xg2zm]

@@kreek22you don’t know that

[@iluminado.3491]

We are one of the last groups of humans who lived a short time on earth, 70 80 years. Our grandchildren will be born with luck.

[@kreek22]

@@HarpreetSingh-xg2zm True, but odds run against it.

[@marks8052]

can it be used to reverse myeloproliferative diseases?

[@Val-zx7ro]

I told my p.i about the asthma research and how it was connected to the microbiome. He didn't beleive me. Now here is a nobel laureate who has clearly also read this research, saying the same thing. O_O

[@geokon3]

Thank you for your amazing work professor 🙏. If this can be used to cure intenstinal diseases like UC and Chron's it will lift immesurable suffering from the world 🙏🙏

[@joelface]

That was what my mind first jumped to as well. Curing Crohn's Disease, or at least better controlling the symptoms would be so huge!

[@sidstovell2177]

A friend of mine died two months ago of her intestinal/bowel disease at age 44. She left an 18 year old son. RIP Clara.