Drugs, dopamine and drosophila -- A fly model for ADHD? | David Anderson | TEDxCaltech

[@sandytherry8647]

Bravo. As a 61 year old lady with adhd, I pray you can help future generations of adhd suffferers with your research. ADHD has made my life a very difficult one. I wouldn’t wish it upon anyone. May God bless your work. If you ever need a human for your trials, I gladly volunteer.

[@May-xt9pv]

Same with me…

[@lynnhaak8449]

Same

[@carmenaponte362]

Ditto! I just turned down the best job offer of my life because I know I won’t be able to handle the multitasking required…and I’ll be miserable and anxious trying to stay afloat while treading water in the deep end! It’s so tough…

[@swapnilpolkar7711]

Thank you so much dear

[@ioio7470]

In a few decades , adhders will thrive due to the accumulated research findings

[@gmchessplay9043]

I believe people with ADHD have a problem with doing, not necessarily with understanding or learning. While someone may take time to learn something and consistently do the work to demonstrate to others and themselves that they know, someone with ADHD may learn but not do for an extended period of time, and then do only when they deem it very necessary. I think it has something to do with our short term working memory vs long term "retention" memory in conjunction with an involuntary survival mechanism (we do not want to expend unnecessary energy - because most tasks done in modern society are not actually necessary for survival)

[@AmandaSbarros]

Yesss I learn super fast, but it takes me FOREVER to start and finish something?????????

[@madrooky1398]

People with ADHD, like me, can do very well. But only if there is a real motivation. And this is nothing we can control. The dopamine that is used to control motivation and focus in a brain is not well managed. A normal person can produce dopamine for any kind of task, someone with ADHD just cant control it. So people with ADHD are partiluary good, often much better, in fields they have a real motivation in compared to normal people. Also called hyper focus. If you have a job where you can use that hyper focus you learn faster and can work longer than the average person. In that state even the short term memory is working perfectly fine. The memory issue is more a side effect, the consequence of being distracted. And its not like the information is not saved, the mind just cant access it because of distraction. It happens that you cant remember something when needed, but later it jumps right to your head. Very frustrating. All this has nothing to do with IQ or other abilities. The problem is that ADHD causes a number of social problems and this makes life in general a challange, especially if you and your social environment are not aware of your "special" traits with ADHD. I think most commonly it leads to self doubt and depression, and people around you often dont understand what is going on and trat you badly because they think you are just lazy or something.. Social isolation is the consequnce. And no skill helps you when you are alone and full of self doubt and have no idea what is wrong with you.

[@vincentpham8605]

I've done research on ADHD. A good portion of the problem has to do with dopamine levels and dopamine signaling

[@jonjenkins3868]

I might agree with that but i just say i have "in one ear out the other" syndrome....tell me something and i forget almost instantly ...forget to try to remember also..... And the last thing i always try to remember is always rh first thing i forget to bring with me......"ok got my jacket on shoes......ready to go just need my phone" 5 mins later...."dont forget to take the phone its right by the door".....another 5 mins later im out the door without my phone....or keys or wallet....whatever im trying to remember

[@MsJazbren]

@@jonjenkins3868 I headed to a wreckers to sell my car, and left the registration papers at home. Thankfully, since I was selling it as a wreck, all I needed was the VIN, but it's not like that was why I'd left my papers at home.

[@skaterdude14b]

[my attention span has left the chat]

[@sappysissy7]

Thats funny!

[@shanejohn-lewis3715]

Wait you have a attention span 💀

[@MinionInc]

This is a span tag!

[@emad9202]

Span ...spanny...span McSpannertony

[@nativeb.9718]

Lol

[@MilesAndHeights]

RIP to all ADHD brains during this talk.

[@nameless1483]

Hahahahahahahah, my 4th attempt to watch it

[@nameless1483]

@@VAlienIsaiah- is it fun watching it while being medicated? It is not fun for us atm lmao

[@nameless1483]

@@VAlienIsaiah- just trying to figure out how it feels. Interesting and informative topics could be fun for someone who likes learning. And yeah, I watch Interesting ted talks for fun.

[@nameless1483]

@@VAlienIsaiah- you didn't get offended right? I've been dealing with ADHD as well and asked you how it feels, meant no harm. Peace ✌

[@1985is]

Not all, some of us actually find these types of conversations interesting which keep us engaged… I can fall asleep at movies like star wars and fast and furious but this conversation keeps me engaged 😂😂. Some ADHD brains get stimulated by science and research findings 🤷🏻‍♀️

[@energizme100]

I was diagnosed with ADHD at age 33. The 1st time I took the stimulant medicine it was like having the correct prescription in my proverbial eye glasses for the 1st time. Learning deficit? NO. Ability to concentrate and think clearly? YES!! Stimulant medicine makes me take a nap for 30 min, then, brain---GO!!

[@mateuszkruk2699]

How long have you been taking your stimulant medicine?

[@energizme100]

@@mateuszkruk2699 I've been taking Vyvanse since 2007. I have been taking the same amount from the beginning.

[@mateuszkruk2699]

@@energizme100 Thank you for your answer! Additionally, I would like to ask you in which country do you live? I'm asking you about this because in my country it's not possible to get a lisdexamfetamine in the pharmacy, so instead I have to use methylphenidate on daily basis. As a matter of fact, methylphenidate works quite good in my case, but I know that there are other substances that works even better and could bring me the best possible experience in ADHD treatment.

[@energizme100]

@@mateuszkruk2699 I live in Breckenridge Colorado

[@jaromsmiss]

@@energizme100 im so late here to the reply but have you had to up the dosages at all? your tolerance remained the same?

[@SLKnoxx]

The concept that ADHD is a dopamine problem, either the lack of or the inability of the neurotransmitters to adequately deliver it to the proper part's of the brain makes absolute sence. It explains the symptoms including drug addiction, depression and disorganization. It also covers the higher rate of nicotine addiction and obesity amount those with ADHD.

[@agaragar21]

yep

[@TroyHill442]

Cool video. As someone with ADHD and siblings with the disorder as well, medication can be a total game changer. However, ADHD does seem to offer some selected advantage to some, if they can find jobs and lifestyles that work for them. I can confidently say that pretty much all of the successful entrepreneurs I know have pretty much all of the symptoms of ADHD. Restless, impulsive, risk taking, lack of or poor sleep, etc.. But the difference between success and failure seems to be that some people have found ways to work with their STRENGTHS rather than to get involved in things that expose their weaknesses. Meds can help in this regard... But ADHD is pretty interesting. It's definitely a real thing, but I think people are affected in different ways. Great video.

[@shenova]

i am adhd and dyslexic. i can’t wait for them to figure out how to do this for humans. it makes so much since.

[@mrrit]

Hey me too!! Great stuff!! Jokes on me, as for both they discovered it late. 😂 Look at me being super smart and hiding my dyslexia and ADHD for adults. ADHD diagnosed three years ago, and dyslexia in my third year of highschool (we have 5 years). So yeah, one teacher picked me out. Called my parents and said, this kid is smart but with writing and learning English she's so behind. Well, she thought me English in one year and went after the dyslexia test for the school. Forever grateful.

[@dianaarmstrong8820]

My son has dyslexia, Adhd and anxiety disorder. As a result of some traumatic events he now also has Complex ptsd. These are invisible disabilities, and as such people don’t understand his limits and reactions, and finding acceptance and understand from the general public is difficult and exacerbates his problems. He listened to this talk, and his response was, “I wish I was a fruit fly so they could cure me.” 😏

[@Yuvraj.]

@@dianaarmstrong8820 tell him there are so so many smart women and men out there working hard every day in every country in the world to create a world where we can make that happen for humans as well. I remember once being that little boy like your son wondering if things get better. It does. Much love ❤

[@TrueSoreThumb]

Wow, really grateful for this discovery and talk!

[@zivotshonzou]

+TrueSoreThumb Guy, you are not sufferer. ADHD is the gift. You just need to embrace it and harness its power. It s just difference in cognition. If you want to get more control of your mind, try mindfulness. Avoid medication. I wish you good luck on your blessed way

[@HOOFBEATTT01]

👍👍

[@medflix9993]

Honza Řehák tak teda chci vědět jak ti brd’o

[@Dancestar1981]

@@zivotshonzou what sort of mindfulness techniques do you use meditation, yoga or tai chi or other methods

[@zivotshonzou]

@@Dancestar1981 it depends what you like. My "gateway" was a mindfulness in motion, when i was walking. I realize that my steps are in "now". Now i m living my everyday life in mindfulness....you can use literally everything in presence

[@joycependleton4117]

Fascinating talk! The analogy of the oil on the car engine fits many medical approaches! I have a major concern with your talk automatically connecting learning disabilities with ADHD. While concentration is certainly a factor for us, the two do not always go hand in hand! I'm now 64. I was diagnosed with ADHD in the late 90s. I graduated in the top 10 of my class, and my daughter, now 41, was a presidential scholar, who rated in the top 3% of the nation. Our biggest challenges are being over-stimulated, especially her. She learns equally well in all styles. Neither of us needed tutoring for lack of ability, we needed support in how to manage how our active brains work. Stimulant meds help, and still, what we truly need is for society and people in positions like you to shed the notion that our cognitive abilities are lacking. She didn't get the accommodations she needed in high school because they erroneously thought that "Because she tested out of first year French" she didn't really have ADHD, because students with that have problems with language". She is now a professional writer. Your work is indeed promising, but please learn more about us as a spectrum of people, and don't limit us in your teaching to others. I highly recommend Jessica McCabe and her Ted Talk. She also has a You tube channel called "How To ADHD". Perhaps it will give you more insight into our worlds.

[@DanitaWaltonhere]

You should read the book “smart but stuck”. I’d say adhd is a learning disability no matter how smart you are because of the challenges we have organizing our thoughts to execute certain academic tasks. I needed a lot of support to learn how to get unstimulating tasks done.

[@tracyreiner6524]

Not always a disability but if that makes you cozy… like short and tall dancers we require less stretching and practice than others but more choreography.

[@orbik_fin]

It should be noted that a label like ADHD or autism really describes just visible behavior rather than its neurological origins, and many quite different types of "disorders" may be (wrongly) grouped under one name. Essentially, what the speaker describes is just one type of neurological difference which produces ADHD-like symptoms, and the results of this research should be applied to humans with caution.

[@MrShark-no3bq]

Exactly

[@agaragar21]

Exactly !

[@mixerD1-]

Why?

[@rach41484]

Agreed

[@JohannaPlants]

@@mixerD1- because ADHD and Autism spectrum disorder are both spectrums in a larger spectrum. Everyone presents differently.

[@whit2642]

I LOVED THAT THIS TOUCHED ON THE EMOTION ASPECT! I no longer have to worry if I am the only human who contemplates the relative importance of emotion by and for, to and from everything experienced in life.

[@andreeaistrate2222]

The more videos I watch about ADHD the more grateful I become about it

[@anonemouse1470]

What about this video makes you grateful out of curiosity? To learn about possible underlying mechanisms is interesting, but as someone who suffers from ADD myself the takeaway I got from this is that ADD and ADHD are likely caused by damaged dopamine systems.

[@anonemouse1470]

i.e. we have brain damage.

[@terminalglimmer]

I agree with the need for more efficient targeting. As far as disorders go, I always tell people that medication always goes so far and the heavy lifting is the cognitive side of things. Because of the relative inefficiency of broader acting drugs, the most you get is more headroom to be able to make conscious decisions. As a psych graduate with both ADHD and Major Depression, I'm looking forward to greater strides in medicine.

[@Nota769]

Makes sooo much sense. It’s evoking images of people over treated just to possibly affect one or two symptoms while the rest of the person is barely awake type of thing

[@GarenPhillips]

Click the little gear icon to set the video speed to 1.5x If you already do this you have ADHD

[@robg5654]

this helped so much haha

[@anneekellogg]

Merlin’s beard, I didn’t know you could do this 🤯 thanks!

[@EricRiosFerman]

I didn't know you could do that! Now he's talking at a normal speed. :P Thank you!

[@chelseasmith4753]

DUUUDE Thank you!!!

[@bobthompson7504]

Where is the gear icon ??? I dint see it

[@soulfoodvisnu]

The only problem with being schizophrenic is that people don't accept you, you don't have a legitimized role, and you can't be comfortable about yourself. It's a social problem. Acceptance and compassion turn suffering into just a difficult moment. It's about recognizing the value of human diversity, and the talents and pitfalls of all personalities and behaviors.

[@BaddWolff42]

I applaud you for sharing your struggle and your thoughtful outlook. When a person's mental illness overrides their natural character, it gets difficult and messy. While this is true for anyone negatively affected by someone else's mental health state, that truth is indescribably painful, isolating, terrifying and confusing for that "someone else". I say this from my observations, understanding, and experiences. I myself struggle with Panic Disorder and Major Depressive Disorder. A few things other people have demonstrated that help ease that mental pain are connection, understanding, presence and kindness.

[@josephp.6353]

"the only problem" is a stretch... it might be your biggest problem, but it is FAR from the only problem. Inability to control your own thoughts and actions would be pretty high on the list of problems for me. Being a danger to yourself and others would also be up there. Perhaps the "problem" you described is simply a symptom of the real problems with schizophrenia, and you looking from the inside out cant see that. There is no value in disorders, so your last sentence concerns me. As someone who suffers from mental disorders, I can say I hope no one values me for my disorder. Also, mental disorder doesn't magically get better with acceptance. Perhaps you are reaching for acceptance thinking IT is the final thing you need to feel normal, when you can never feel normal. Perhaps, others acceptance should be the last thing you search for, and acceptance of yourself should be your real priority. But what do I know.

[@kimstrickland2761]

Well said!!

[@jwvandegronden]

Now that wás interesting!! And entertaining without losing complex content or derail into condescension! Loved it.

[@missyjenn]

Amazing talk filled with great analogies on how our current psychiatric drugs is essentially akin to pouring oil all over the engine and hitting the target

[@frugalfrugal1307]

OMG, this is seriously fascinating and needs more research. Two thumbs up!

[@justjess986]

Great talk, and absolutely brilliant study! Wowww!!! Thank you for your work and dedication to this very important but often overlooked topic!!! I pray you are successful in getting us some REAL and much needed help to get our conditions in check...they are literally destroying our lives, our Relationships, our careers, our families etc...etc...

[@RelaxingPouringRain]

Hope you have had a nice week so far and I hopefully you all achieve your dreams

[@Captain_MonsterFart]

I have to achieve my dreams this week? That's a bit of pressure, ain't it?

[@clanso7887]

Quick note on side effects, what I'm currently taking surpresses my feeling of hunger almost completely and what I took before that changed my personality towards the apathetic and basically drained me of most of my energy levels. Soooooo...he's absolutely right about that

[@Dancestar1981]

Personally I’d rather self medicate on caffeine or energy drinks

[@patrickbateman9314]

As someone with ADHD (ring of fire) it’s amazing what a difference there is in the brain without meds and with meds. And than combine meds with a true desire to learn and focus (not a forced notion like you get in school but something you really want to do instead) and you can end up being hyper focused for hours. But the minute the meds wear off for me, I instantly fall of the train and become distracted by the smallest things and can end up forgetting everything. Bad enough that I can be doing task A, get up and quickly do task B for 2 min and forget what It was doing originally. And that’s the start of the issues with ADHD for me. To detail It deeper would require a few more paragraphs and some parts are hard to explain since I still don’t understand It. (Been diagnosed with ADHD ring of fire since I was about 10 years old)

[@emmanueloshaddai3259]

Thanks for sharing. I’m not diagnosed but I want to know whether it’s a good idea to go with medical treatment for someone who has adhd. Are the side effects worth it?

[@patrickbateman9314]

@@emmanueloshaddai3259 never had side effects from meds. Usually what I’m told is some meds impact your hunger (suppressed usually). Not sure what other side effects there are as I’ve had none. Been on almost every ADHD med since for 20 years now. I take the biggest dose of Dexadrine ER currently without issues. So I can’t say for you if It’s worth It or not. But if you don’t have ADHD I don’t see why you’d want the meds. I’m not a doctor, so I’d ask a doctor before listening to people on social media for advice.

[@emmanueloshaddai3259]

​@@patrickbateman9314 Thanks. Would you say that it's been effective in helping you focus and be productive? Don't worry, I wouldn't seek out the meds without a diagnosis, but I want to know whether it's worth getting a diagnosis based on the effectiveness of existing treatment.

[@patrickbateman9314]

@@emmanueloshaddai3259 it’s about the only way I can slow down to focus. I’m like a jack rabbit all day and the meds let me mentally slow down to focus. Without the meds I’m mentally operating too fast as if I’m on drugs like speed or crack normally.

[@emmanueloshaddai3259]

@@patrickbateman9314 This gives me hope. I do have great difficulty studying. It's been something I've struggled with for the longest time. It's only today that I stumbled on and considered ADHD. It's still not confirmed though, so I won't get too excited.

[@LA-cm9uo]

Lots of Ted talks about ADHD. This is by far the best one.

[@FunnieBunnieD]

I have a BA in biology as well as ADHD. So, videos like this are perfect for me! 😍 It is so cool to look at it from both sides of it. Being able to understand and see it through my experience as a scientist; as well as, my experience as a person with ADHD is just fascinating to me!

[@amarip2007]

How did you manage your ADHD to not impact your studies, education, society. Plz share

[@amarip2007]

@@ASM_Minds I appreciate your feedback. I am asking it for my 5.6 years old son. It is getting tougher for him to focus. Although, he is brilliant with the ideas and creative but, he is not able to materialise them. We are preparing a plan and trying hard to stick to it so he understands the time and discipline.

[@amarip2007]

@@ASM_Minds Thank You for your detailed feedback. Will definitely try these points. Thank you once again.

[@joycependleton4117]

@@amarip2007 I understand, my daughter,, now 41, has ADHD, as do I. Please understand it is much, much more complex than discipline. The challenge is to meet his needs while modeling for him that completing assignments is important. What those of us with ADHD need is support & understanding that no matter what you do, our minds work differently than most. For many of us it isn't a deficit of attention, it's a surplus, because we don't have the same built in filters that mitigate the input. In short we are often over-stimulated, which can be frustrating on many levels. I highly encourage a counselor who specializes in this area. Seek out as many books as you can about parenting a bright child with ADHD. A great you-tube channel is "How to ADHD" by Jessica McCabe. She also has a very insightful Ted Talk. Best wishes!

[@amarip2007]

@@joycependleton4117 Thank you. God bless you. I will try to do the points mentioned

[@miglena2s]

Love this lecture. Outstanding information and presentation. Persistence (Time) + Intensity + Valence. Exactly!

[@epistrophynunez4342]

Definitions on learning are a little worrying, but this is an incredible piece of research.

[@timbird4023]

Agreed. My expereince of ADHD is that I can know what I should do, but watch myself doing somethng else instead. That something else being something more stimulating. Being in my body can feel like being a passenger in a car that someone else is driving. There is a possible risk in equating learning with action, especialy in relation to ADHD - although I understand the use of it in the case of flies!

[@gauracappelletti3893]

What does he mean by learning deficit? Everything else I've seen about adhd says it doesn't have anything to do with intelligence, and that a lot of people with it are successful if they can get help being motivated to focus on work

[@gauracappelletti3893]

@@verkanntoderverwunschen Right, like I never fell behind academically until highschool, but when I realized at 19 I probably have adhd I realized there were always issues. They just were more abstract issues than the term deficiency would imply. That's why I don't really like this guys premise - it's like his thought process is "adhd can be associated with a 'learning deficiency' -> 'learning deficiency' in my head sounds like an inability to learn -> if some of these flies can't gain conditioned behaviours, a form of learning, they must have adhd"

[@krackzthegamer7751]

@@gauracappelletti3893 I think to a certain point, when the complexity goes up. The ADHD brain tends to not like it anymore, because it takes hours upon hours to learn a certain thing. Where as back in the day when u were a kid. Everything was simple, there was hardly any complexity in the study/thing you wanted to learn.

[@gauracappelletti3893]

@@krackzthegamer7751 i don't think it's even the complexity, because it also involves hyperfixation that can lead to really specific and weird knowledge and skills. It's more that if it's boring, or not immediately gratifying, it's harder to stick with it

[@krackzthegamer7751]

@@gauracappelletti3893 I mean, yeah. But that's also a point to take in. Boring tasks can lead to not doing anything, or procrastinating. But how is it that you could grow to 19, and not have so many issues with studying etc?

[@gauracappelletti3893]

@@krackzthegamer7751 but I did have issues, that's the thing. It has never really been about how hard a thing is. I always had issues even with things I liked or things I understood easily, because if I was thinking about something else or was bored of a subject at the moment it was impossible to pay attention. I just didn't fall behind until later in high school because that's when my teachers stopped forgiving me, and when tests were hard enough that I couldn't pass without studying like I had before. Before that point it was enough to just remember stuff from class or wait until I was interested enough to teach myself. And that's why I don't like the video's premise, it's way more complicated than just not being able to learn things.

[@Mr.E503]

My attention was fleeting till I saw the comment about the 1.5x speed really helps lol

[@zzzzzz6073]

We do not live in an ADHD friendly world.

[@ChristopherCraven]

How can they tell the difference between an emotional reaction and an instinctual survival reaction?

[@B3nkeii]

I like how you think. Im proud

[@mauronarf]

Loved the presentation and how cleverly the experiments were carried out Amazing! Great work!

[@djtuskan]

His final thoughts seemed to trigger thoughts back to what the studies of psilocybin have been showing, that they effect specific neurones and receptors... perhaps there is merit to these studies after all - so refreshing to hear this approach to brain science and mental health

[@nathanashley2693]

how could someone not like this talk?! there are always some. amazing research

[@thatguy-uy8if]

...I caught about half of that.

[@Shark1103]

Brilliant! ADHD is definitely an illness, I can't focus, I cannot understand half of what I read! I want to be cured!

[@brettneuberger6466]

Madolite This isn’t necessarily true. Someone with adhd can read every word on a page, chapter or even a whole book and not learn or remember a thing. It’s much like driving home on a familiar road; it’s so automatic that we often get home and not even remember what we saw or how we got there. Our subconscious mind takes over while our active mind thinks about anything else we focus on. It’s the exact same thing when reading, especially when we’re not interested or engaged. Thus, Sweet Potato is far more correct in his/her assessment than you are in yours. While it’s true, we can get distracted and not actually read or finish reading something, inadequate focus is very much a consequence of adhd. Go get tested Sweet Potato and good luck to you!!

[@SanoKei]

@Madolite that's not true. Did we watch the same video? He literally just explained how the two have no correlation to each other and can be cured separately.

[@dars861]

@Trunks 23 you probably dont have ADHD then and just dont have motivation to do anything

[@nicksteven5521]

I have adhd and i struggle with a lot of things on a daily (and hourly) basis but i still wouldn’t want a “cure” even if i could.

[@hayleyferguson5284]

I was diagnosed with ADD and I understand lots of what I read 🤷‍♀️. I might have to stop and think for a moment before moving on but don’t most people.

[@dlcfredericks]

Amazing research, I’m very intrigued and hope ADHD medications go in this direction. The dunce cap fly image was offensive to me. Having ADHD and struggling to keep up with my peers was difficult, and caused me to have poor feelings about my intelligence. So this guy pointing and laughing is insulting. ADHD may cause poor grades in school but it doesn’t necessarily cause a low intelligence. A dunce cap was used for public shaming and the fact that he uses this shows how little he actually understands about the people that have ADHD. He may know the condition... but he cannot truly understand the symptoms if he buys into the dunce cap analogy. He was likely just doing it to get a laugh.. very professional of him.

[@attheranch873]

daniel fredericks maybe he will read this and change it.

[@jorgefuentes5237]

Honestly at first I thought the dunce cap was more of a visual representation of how the world sees people with ADHD. But going back in the video it does look like he's using it as a lazy way of defining learning disorders as well as giving the presentation a 'comical' spin, sense he didn't provide much context for the dunce cap. Well, at least he's passionate about cracking the code :/

[@subjectively-observered]

Fantastic. As somebody with mental illness and as a former neuroscience researcher, I've long been telling people that we don't know jack about how the human brain functions or doesn't function. We are in the infancy of understanding and treating mental health conditions. I love to see research looking at this from a fresh angle. Great talk.

[@purplepixi18]

Thank you! Thank you! Thank you! Thank you! Thank you! Thank you! Thank you! Thank you! Thank you! Thank you! Thank you! Thank you! I need this research ASAP! I'm so tired of the current state of ADHD drugs. I'm in the latter camp where I'm very hyper, but I learn exceptionally well. But being hyper and lacking the ability to focus keeps me from being able to get things done. It's very frustrating! I hope this research helps the next generation to be able to avoid this kind of inadequacy.

[@ChristopherCraven]

I believe perspective shifts are the equivilent of a "rebalancing chemical soup". You can't just add the chemical that's low, you need to fix the emotional/psychological issue, and with that you will see better balancing of the chemical dance in our brain.

[@joshuatelem8796]

This man speaks the truth. To bad most family doctors aren't as smart!

[@phaeb]

His tone and manner of speaking are incredibly pleasant

[@ilovemyfriends3804]

This is actually really cool! I came here because I need to review it for my bio class, but I surprisingly want to know more

[@laveases]

[edit: i got diagnosed with adhd yesterday lol] clicked on this video hoping to learn about my potential adhd, only to realise 13 minutes in ive been on my phone the entire time not paying attention whatsoever

[@jacqueline755]

Find a BETTER source of info...

[@laveases]

@@jacqueline755 ???

[@UNUSuniversitas]

I found the use of a “dunce cap” icon in this presentation to be utterly distasteful.

[@anondananda6705]

I saw insights into PTSD in the PUFF-O-MAT data (and the variant of complex-PTSD in the graded data)

[@ndrm_chooky]

ADHD like me can learn really fast.. but we cant control what we learn..

[@hanskraut2018]

More talks like this adhd spesific and up to date models of adhd please!

[@mattr4886]

I see this as being dated the beginning of the year 2013. We've (you've) identified the problem, but what advances have been made in therapies and treatments in the past 8 1/2 years?

[@brendatomlinson]

I made it through 5 minutes. I’m very proud of myself.

[@SianaGearz]

The main problem with schizophrenia sufferers is that while they are social just like the rest are, and they love and want to be loved like we all do, due to their issue, they end up hurting the people they love, and by that hurting themselves in turn. There is no social role which can accommodate that and keep the schizophrenic happy, none can exist.

[@reginabreder997]

DOPAMINE, Me , i rather prefer to remain in excitement ,elevated moods without any swings.Stable mentality actions ,understood by those who knows the level of message - communication at the reason time for truth with acceptance in their ranges.Amen .From NAMIBIAN ,R.B.

[@sq42na]

Lovely. With due caution, I think there's a good chance the separability of two observed problems (hyperactivity and learning deficit) also applies in humans. Also, the possibility of treating specific parts of the brain, not just the 'engine', seems interesting - I'd like to hear more on that.

[@powerhour4602]

So is ADHD a superpower or not? What is TEDx trying to say?

[@hayleyferguson5284]

TEDX is just a platform. But I love your point 😉

[@derrickagonzales]

I'm in the mood for a run! Move the body change the mindset

[@Zupecki27]

If you close your eyes, he's literally Ted Danson.

[@Plethorality]

He is literally not. Maybe he sounds a bit like him? Yes, even his timing... Well observed.

[@show_me_your_kitties]

No

[@hanskraut2018]

Amazing talk i hope they get a lot of funding this kind of research seems promissing and very economical for the hole world if those disorders can be treated!!

[@MrXtenzion]

2.01 The slide is wrong, the dopamine and norepinephrine should be on the opposite side.

[@aniksamiurrahman6365]

Wow! This is a milestone talk. I never thought like this b4.

[@sav2swagg]

I have ADHD, Dyslexia, General anxiety disorder, and panic attack disorder.

[@energizme100]

Can research be done using mRNA for vaccines for covid be used to reprogram ADHD receptors? Hopefully eliminating need for stimulant medicine. Or would research never be done because pharma profits too much from ADHD medicine?

[@gamezswinger]

Superb talk from a critical thinking mind.

[@JamesBailey13]

So cocaine is good for ADHD....I knew it....I'm just sayin'

[@plebiansociety]

+James Bailey nah, I have adhd and coke just makes me a douche. LSD on the other hand, especially at low doses, that just takes the cap off my brain. It's like all those trains of thoughts that conflict with each other suddenly work together, like being able to juggle while playing soccer while reading a book while playing a harmonica while listening 15 audiobooks all at the same time. That is, until the dosage gets too high and and I end up having a conversation with the snake on my wall about how unfair a game of tug-o-war would be with an alligator. F'in alligators, always winning at tug-o-war...

[@snafitzer]

+plebiansociety So glad I read the comments, I find the same effect from taking "psychedelic" drugs... I have a continping to think about what im saying. I become motivated - taking action rather than just talking about things. I am much more open to new ideas, and can follow a conversation and reply with intellect rather thauous train of thought without stopn just "yeah" "mmmm" "okay". Stimulant drugs working mostly on high amounts of nor-epinephrine with some dopamine and nearly no serotonin - Tend to give me ADHD like symptoms, I cannot concentrate.. my thoughts loop. While LSD and other psychedelics (in lower doses) that work on serotonin and dopamine with very little nor-epinephrine give me tip top focus and micro dosing is a very effective anti-depressant for me.

[@airbornstone8448]

u got some lol

[@jonelmes4460]

it calms down but is not good for the human body. I was on methylphenidate for years and it turned me into a zombie. The side effects were horrible. My ADHD (and asd) are what made me who i am today and a coming off the medication has enabled me to realise that my difference is what has set me apart, there is no drug that wil cure (which i would not seek)

[@nathanashley2693]

I'm going to discuss this with my psychiatrist ;)

[@ClintonLang]

We're breaking boundries with neuroscience. both with our ability to map these ciruits (connectomes) and with drug specificity (protein-mediated drugs.) Its a new age

[@mistrch]

Having scholarly credentials helps the person who would reverse engineer mental illness. If one speaks from experience, no matter how much merit his personal observations, family and some doctors may argue or ignore attempts to understand one's own malady. . Who best knows what's wrong than the afflicted. Enlightening talk - where do I get my flys~ Covered With Oil

[@kittycat1302]

Does anyone know if this research is still being carried forward? If so have there been any trials or advancements for humans?

[@Givejordr]

Honestly, I was spaced out for most of the time, but still here. I didn't get what he said for my ADHD buuuuuuuuut, his presentation and charisma were awesome.

[@Christalaleah]

Same

[@doczak69]

If his theory is good ie: amphetamine increases dopamine so the learning and hyperactivity in ADHD, then when we give antipsychotics ,which blocks dopamine should worsen ADHD, due to increase in dopamine. I have not seen that in my clinical practice yet. ADHD does get better with Ritalin but may be his dopamine theory is not accurate. Or it could be two different pathways in brain.

[@maxwellnjati1756]

Yes thank you for the clarification

[@leosousa7404]

more receptors imply the opposite of Attention Deficit. The cocaine is desensitizing the receptors, so that is how they are calming down. Take desensitization away or just give them cocaine everyday and they will become even more active due to receptor up-regulation.

[@leosousa7404]

Furthermore, testing flies for learning ability is not conclusive: dopamine implies reward seeking behavior, thus risk taking behavior is increased with more dopamine activity, this fly is more likely to ignore the risk of humans trying to swap it. Now how can you test flies with odor in a closed system? When you open an exit the odor will be equally spread, and you just said that dopamine flies have more activity after a stimulus in a puff-o-matt test, which implies dopamine flies are more likely to travel through the exit to the other chamber, or depending on the type of their activity, they may be less likely simply because they get exhausted hitting the wall and fail due to less overall iterations. Neither of the flies understand what chambers are, no learning can be implied because they have different core decisions to stimuli.

[@leosousa7404]

To explain the two behaviors of the two sites of DopR rescue: one of the functions of dopamine is body movement, and in the human brain this relates to the primitive central brain due to natural selection. Thus the fruit fly's central complex also relates to movement and if you restore it the fly shouldn't move as much, but will still be resilient, risk-taking, thus ignoring smells related to pain, which could be for example, the smell of an animal. And thus the Mushroom body is the more abstract part of its brain, and if you restore it to normal levels of dopamine it won't be able to process many if-then conditions to take the risk of ignoring the smell related to pain. Think like this: you are brain damaged and becomes unable to react to danger that would be normally solved under the previous level of cognition. Then now you have to avoid it, which I believe is what humans would call regular anxiety: low skill and hard problems. A human was hurt outside and now that he never leaves his home, you are saying he has effectively "learned", but the one who still goes out hasn't "learned". And you take a dog and applies Pavlov conditioning, and the smart dogs who don't react when there is no food but only a stimuli are called "stupid". Horrible video.

[@leosousa7404]

EINFACH GELD MACHEN they upregulate and desensitize, meaning that more receptors appear but all receptors become temporarily inactive due to overactivation. >u mean that giving them cocaine everyday would upregulate their receptors ? Yes. >HOW that ? It is the same mechanism for all drugs taken under a disruptive dose. Addiction is clinically defined as tolerance after exposure, so if you are controlling for that, as in, if you are not taking more just because you are temporarily desensitized, and there are more tolerance mechanisms, then just like nicotine and caffeine, cocaine increases catecholamine receptors. Let's go further and take a look at the mechanism of these 3: nicotine is a acetylcholine-like agonist, so it increases and desensitizes the receptors, caffeine is a adenosine-like Antagonist, so it increases its receptors but doesn't desensitize them because there is no activation and reduces acetylcholine reuptake, thus increasing acetylcholine receptors as well; and cocaine, which unlike coffee, Directly disables catecholamine reuptake, of these dopamine reuptake disruption being the most studied, thus increasing DA, and certainly also 5-HA and Epi, receptors.

[@timdevolldable]

Leo Sousa thank you for this

[@Jazmine.star17]

adhd is more a lack of receptors taking in chemicals

[@hayleybourgault4114]

I totally understood him!!!

[@atomspalter2090]

great talk.

[@TheErgunPascu]

Excellent talk.

[@sharontree7272]

oh how i wish My brain could be analyzed.

[@johnstrickland6860]

Is Adderall better than stratrra I think the stimulant works better

[@wmg5939]

What should be doing different after watching this video ?

[@theultimatereductionist7592]

I love the reductionistic specific neuron-targeting. Like he says: this holistic tossing oil everywhere on the engine block approach does not work.

[@josephgermain2003]

So anything happen because of this? It's intriguing to hear and I'm very curious where it's led you to. Any follow up on this almost decade old r&d?

[@themrchimpie]

mosquitos don't have emotions, they're cold and vicious.

[@kennethnewell6829]

pinco palla straight up

[@aremedyproject9569]

pinco palla And they suck.

[@chrispeers4111]

I get what he’s saying. And I’m all for changing the psychiatric routine that’s placed in doctor/gp practices…there needs to be some massive change and understanding also different treatments. However…for now in this era these meds that are so bad as he says can be are only current hope to live a more normal life. Some of these meds have stopped really unwell individuals to being relatively normal and happy. Don’t be so dismissive to these meds fully. I agree the side effects can be horrendous I know that first hand. But for now alongside better lifestyles and therapy is our only hope. Until the days come for these new treatments come into play we need to keep going as we are. I’m all for being a trialist for new mental health treatments as it can help many more people. -(Undiagnosed mental health problems over here) 😂 potentially ADHD, and OCD

[@deanrouleau8403]

Great presentation

[@schnemley]

Have you heard “there’s no such thing as a bad kid”? What if that were true of teens and adults as well? More specifically, those who commit mass shootings, which is ultimately a one-time behavior. What circuitry is allowing a growing number of people-and mass shooters are indeed people-to carry out this horrendous example of bad behavior?

[@jacqueline755]

He throws "Disorder" and other value judgements around quite freely. I believe we've gotten to the point that ADHD is not a Disorder...but a difference in function. It can be a "Disadvantage" in our Society... for some even life changing. However, it is not by itself Negative.

[@alexanderfriis1]

To me It just sucks. I dont get much done and feel umotivated which gives me anxiety. The medicin makes me more productive and makes me feel motivated and focused and i feel much less anxious

[@Ribcut]

The 3-set Venn diagram at 2:00 got dopamine and norepinephrine completely backwards

[@soulfoodvisnu]

The great thing about humans is they express an amazing range of personality and talent, and their behaviors are full of complex quirks and elusive charms. People who are good at one thing are not good at another. Our species overcame endless hurdles by forming groups, where we took advantage of the range of talents and personas to ensure our survival and to make survival enjoyable. We need entertainers, mechanics, farmers, doctors, caretakers, and we need crazy prophets and visionaries.

[@agaragar21]

except if you have ADHD you shouldn't be President !........it all ends with everybody dying in a nuclear war !

[@GiantPetRat]

Maybe it's due to my own ADD, but I kept getting distracted from this presentation's actual content by this man's apparent fetish for soup.

[@kittyheart1432]

Araxie Rose lmao. soup.

[@debrahughes104]

This comment made me LOL Funny!

[@islaynicklin3964]

Yasss!!! XD

[@sarcasticnotsad5155]

I wasn't paying enough attention to count, be he did say soup a lot.

[@Niran333]

Wonder how the research have progressed for the past 10 years.

[@Mortison77577]

Now that's some striking convergent evolution.

[@WriteSign]

This is why drugs for ADHD just DONT WORK. However I object to calling it a learning disability. Maybe learning handicap is a little bit more accurate though because it can be overcome and managed and just changed up a bit so that learning happens just as well as school learning but in a different and more easily accepted/retained way for the person. Maybe just "intense learning difference" because it doesn't mean you can't learn, just that you learn differently. Maybe a fruit fly "can't" learn but people are more intelligent and complex so we can find ways to teach and learn in a more varied and interesting way so that people with ADD and ADHD can still learn just as quickly and effectively. I have ADD and some days are better than others, but I just translated a talk, many of the words I simply didn't know but was able to get across, when I've only been learning ASL on and off for half a year or so. That is really impressive if you ask me! Why? Because I am a visual learner and the kind that wants/needs to experience a thing to learn it effectively. In other words you can't say to me that because I am ADD I can't learn since I just proved you wrong. I can learn, maybe even faster than you "normal" people, but I learn differently than you. So is being different than the main stream a disability? No, it is a challenge. You know why ADD and ADHD people suffer depression (now there's a disability)? Because we are highly emotional beings and even though it seems we don't notice that we are different, deep down we are acutely aware of our differences and the lack of acceptance because of them. Heck, even we don't accept ourselves as we are... kind of been trained not to (speaking for myself at least) by most every teacher in school and kid on the playground with that look on their face that clearly says "You are weird and stupid. You'll never get this simple thing." Also we don't tend to forget our mistakes and they like to pop up and remind us to shut our mouths so we don't screw up so badly ever again. THAT I'd like a cure for, find a cure for that one and I'm all for it!

[@MsNicolT]

Allura Zynx Neither term is suitable, both suggest the same thing. learning difference is what it is.

[@alhjooj2002]

Allura Zynx my drugs work on me so yeah

[@alhjooj2002]

What I hate the most is when the class understands and moves on quickly without giving a glance to the ones who didn’t they just say read it all over again and you’ll get it ffs

[@stri7015]

I can relate to all of what you wrote down.

[@yugolago]

Now that we know this then what? What's next ??? Do they have solutions and start helping people who 's suffering ???

[@lunatico501]

The problem its.... that we're not there yet.

[@cyberneticwhitehat-student6296]

He is soooo right!!!

[@nickyhurry6262]

I was trying to share my thoughts and you bring up if I want to continue . So I hit the wrong button and lost my text. I thought it was sharing educational and real life experiences. So I'll sum up living on the streets in Boulder a graduate student ask me if I would fill out a form for a psychology program. I said sure. The grad student told me as I was shrinking in the chair across from him. I was told I had low self esteem and I will develop a work ethic that will be excellant. As I try to say when my mother told me at 5 I was not good with my hands. I felt as if bubbles ran up and down my whole blood stream. Took the test at 17 on CU Camps. Now at 58 I live in NYC also a small beach house in Kure N.C. High school I reached the 9th grade. Hyper I always will be. Smoking pot help to read,use math, play music.Plus much more.(nothing follows)

[@nickyhurry6262]

My name Chris Hald I forgot about the head enegeries I experienced as a child the first I was running at night as fast as my five year old legs could propel me. My foot caught the step on my parents back cement steps porch . The front of my head hit first as I crashed on to the porch. I hit so hard that my mother could hear the impact from back of the house as my forehead was the first part of my body that hit the cemented porch entrance.That allowed access to the house from my parents driveway. I Cried like a baby and was scared. I was taken to the hospital than sent home. It was a big inconvenience for my mother. She did not like to drive . The second was a fall from my bike age six. I had a concussion my second. The first from the fall on the porch. Age 8 from a friend of my eighteen year old brothers friend . The friend of my brother and I were playing around I accidentally hit his nose or face. The friend got angry and threw me to the hard wood floor resulting hitting me head. Third concussion and I vomited . The fourth was when I was hit by a car one Sunday in November resulting in a crashed ankle . I Was placed in a cast ,first six months from toe up close to me private parts. Then a walking cast below me knee with a green peg under my foot . The cast was replaced off and on to reduce the odds of infection. The orthopedic surgeon I had head trauma the nine stitches on top of my head if there is a scar my hair would hide it. All told from getting hit by the car nine months Ina cast and a head concussion. Iam gonna stop now. I'll continue if I remember or if I run into your video. I Like or agree with what you say about being hyper. I was always on. Resume later. Takes a lot to type this information. I Will add that I had by the time I was a man and making my way through world at seventeen a dislocated elbow and a compound fracture of me right arm. The measles,mumps,chicken pock,and a kid bit me so bad he must of thought me arm was a turkey leg.the kid tok away a good bit of flesh. I write this because designer drugs don't work for anger or depression. If a person is so depressed one can't get out of bed or angry. Any drug given should make the person feel euphoric. Any addiction is better than hiding in a dark room and can't get out of bed. No drug can make a person normal. Our society doctors included have a Calvinist attitude.Normal person I have not met such an animal.(above text has not been edited for grammar and so forth...)/nothing follows/

[@agaragar21]

@@nickyhurry6262 , nothing follows/.................thats a bit dramatic...........were all just here, nobody chose that it would turn out this way Live your life ...not the dream life

[@naokikojima6045]

I like how this guy negatively stereotyped people with ADHD. At least his brilliance sort of compensates for his insensitivity.

[@agaragar21]

he's a scientist...he's just describing the assholes for what they are !

[@jh1keener]

It is science, explaining new information, not making you feel good.

[@curious_one1156]

Why cant we place good copies of dope receptors in humans ? And also permanently alter the genes responsible for expressing those receptors ?

[@wadeguidry6675]

How much voltage shocks a fly without killing it?

[@paisleesheppard5629]

Have you ever hit a fly with an electric slapper at a bad angle? That much.

[@vishvajeetsinh_solanki]

What other than cellphone, laptop or an addiction distracts you in ADHD? What if we learn to avoid them? is there any other thing which makes it worse other than this 3? also, if we can't resist using any of these 3 things, it is also to do with ADHD or some other issue other than ADHD is involved in that resistance?

[@daleks_exterminate4050]

Literally everything. Is this serious? Haha. As a child I did not have a cell phone, labtop or an addiction. I only watched regular TV on Saturdays and yet I was distracted by everything, constantly day dreaming, wouldn't move on with the class until I was finished with what I was doing, I couldn't sit still, I was always in a book or something else. All of my teachers were frustrated because I was extremely "smart" but could not focus, was too talkative and only followed subjects that I found interesting. If something was boring I could not bring myself to do it. My parents were also very strict disciplinarians and thought that maybe they could force me to focus. Haha. Hahahaha. Yeah no. They we're against medication for adhd also, so I had tutors, and structure, was grounded a lot, etc. Yet when I went off to uni I started ADHD medicine as my own choice and none of these issues happened. Hmmm but sure, it's "technology".

[@rainbowocean5075]

@@daleks_exterminate4050 that was really interesting to learn. That is too similar to my child hood. I always have ideas and thoughts in my mind I was always that kid day dreaming spacing out and always had turned at every sound. It was frustrating. Then I went to a behavioral therapist who helped diagnose me with the term ADD I thought it was kind of funny to say I have "add"-anyway I was then prescribed my first medication Adderall as I entered into the 4th grade and my grades sky rocketed compared to 3rd because I was the slowest in the class and when we did these multiplication drills...I never finished them fast enough so I was stuck in the 0,1, ending at the 2 times table by the end of the year while every other classmate were at the 11,12-and beyond. For the next few years, I had honors! Once I had high honors!-until my medication over time had less effect on me so after we couldnt increase the dosage I tried one called Vivance- yeah...that was a big mistake I became really aggressive and my grades suffered that and the next year as well- my mental state decreased for many reasons...most of it building up from my past with...socially difficult situations with peers...so to say- but every combination made things...more difficult. After switching back to adderall my grades balanced up but once again overtime became less effective so about a year or 2 ago I switched to Mydayus- then back to Adderall. So if you dont mind I am curious about what medication you have seen as effective and yeah having a structure is important especially getting older-time and priority have been my biggest issues... While yes that other person points out it can be from the more daily use of electronic devices its not the devices themselves- but by the contents on it that cause intrigue- for instance getting side tracked with topics or a story- articles with different sciences-or some new creation of any form that catches you with the type of format online. Because in just a click away you can learn ANYTHING. The internet is a blessing and a curse, a blessing where you can access the world in one place, and a curse when you tend to be hyperfocused on one specific topic- and when you put school work on the computer you may start with 1 tab but within the next 30 or so minutes you now have 15 on the screen with several other windows in the background...and then people may look over at your screen and silently judge how many tabs you have completely disorganized. Heh...I didnt intend to write so much. If you read this thank you. I would like to know what solution to the medication or in general because I am accepting that all my original plans and goals would have worked and now I am contonplating about what I should do now.

[@kashphlinktu]

How can you tell if a fly has attention deficit disorder

[@MrApplewine]

Try a ketogenic paleolithic diet (exception including butter if necessary) and you may find that some mental disorders go away. Check the fuel if the engine isn't running right.

[@user-zt4zr7eg6z]

It helps because it increases dopamine. But it doesnt repair it. Intensive excercise nearly heal ADHD.