Thalassemia, Causes, Signs and Symptoms, Diagnosis and Treatment.

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Chapters
0:00 Introduction
0:51 Causes of Thalassemia
1:37 Signs and Symptoms of Thalassemia
2:43 Treatment of Thalassemia
Thalassemias are inherited blood disorders characterized by decreased hemoglobin production.[7] Symptoms depend on the type and can vary from none to severe.[1] Often there is mild to severe anemia (low red blood cells or hemoglobin).[1] Anemia can result in feeling tired and pale skin.[1] There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine.[1] Slow growth may occur in children.[1]
Thalassemias are genetic disorders inherited from a person's parents.[2] There are two main types, alpha thalassemia and beta thalassemia.[7] The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin are missing.[2] Diagnosis is typically by blood tests including a complete blood count, special hemoglobin tests, and genetic tests.[3] Diagnosis may occur before birth through prenatal testing.[8]
Treatment depends on the type and severity.[4] Treatment for those with more severe disease often includes regular blood transfusions, iron chelation, and folic acid.[4] Iron chelation may be done with deferoxamine, deferasirox or deferiprone.[4][9] Occasionally, a bone marrow transplant may be an option.[4] Complications may include iron overload from the transfusions with resulting heart or liver disease, infections, and osteoporosis.[1] If the spleen becomes overly enlarged, surgical removal may be required.[1] Thalassemia patients who do not respond well to blood transfusions can take hydroxyurea or thalidomide, and sometimes a combination of both.[10] Hydroxyurea is the only FDA approved drug for thalassemia. Patients who took 10 mg/kg of hydroxyurea everyday for a year had significantly higher hemoglobin levels and it was a well-tolerated treatment for patients who did not respond well to blood transfusions.[11] Another hemoglobin-inducer includes thalidomide, although it has not been tested in a clinical setting. The combination of thalidomide and hydroxyurea resulted in hemoglobin levels increasing significantly in transfusion-dependent and non-transfusion dependent patients [12]

[@zenia2084]

Terima kasihh untuk ilmu.. cg saya srh tengok video ni

[@ceran5563]

My son was diagnosed with thalassemia today, He is a very energetic 8 yr old boy and his appetite is very good as well. I can say that imI did not observed all the symptoms you mentioned about having thalassemia except that his nose is bleeding almost 3 times a month.

[@entertainmentuniverse1580]

All future doctorss..should like here😍

[@entertainmentuniverse1580]

Yeaaahh....thanks😁 I got a ♥ from you😂

[@struggler3883]

One day ☝🏽

[@ninajoe5367]

Thank you doctor❤️🙏

[@ibrahimsoofe5921]

Thanks you Doctor

[@mananvaghela]

Watching from India

[@Notyouraveragejoe762]

This isn't so bad as we age we look younger because less oxygen stunts the age process 😊 that's why at 60 everyone says I look way younger .

[@erzas556]

This is really interesting to know!

[@massimo187]

I don't think this is correct 😂

[@docsanti8971]

As allways very well explained. Thank you.

[@sakshibansal4433]

Thank u sir

[@parmoh8500]

Would you please make the video CC and accessible so I can use it in my classes? Thanks!

[@Itsjettondon05]

I’m almost 18 and have beta thalassemia and aside from a really rough childhood where I almost died from illness multiple times and being diagnosed as iron deficient every time I get blood drawn I’m pretty normal. I did have that delayed puberty thing but for some reason I started growing before I hit puberty and kept growing throughout puberty now I’m 6’2 and my parents are only 5’9 and 5’3. I don’t know if that’s normal but I think it’s pretty interesting

[@MedicalCentric]

Wishing You The Best

[@sayanch96]

That's so cool man I wish I also grow to be atleast normal for a 30 old looking guy! I look so like a kid duhh! Can you give some tips or ways that helped you grow ?

[@susmiatikardi9415]

I'm also Thassemia i'm 55 years old now

[@mariocesarbenitez5552]

Thansk

[@debbie1966]

How much folic acid?

[@nolby1758]

I as well was born with thalassemia,currently dealing with light headedness,dizziness,loss of appetite,headache. I'm wondering if the side effect from low iron is causing all these?

[@mary-ks4pz]

Are you on blood transfusion ??

[@saimanognamadha4775]

@@mary-ks4pz are you?

[@saimanognamadha4775]

@@mary-ks4pz if yes which hospital

[@Diya_craft_creation]

Thelasimia k patient kis age tak zinda reh sakty ?

[@paultimson6674]

my blood type is O pos C- , does this mean i've got anemia?

[@zunairaaziz]

thanx

[@MedicalCentric]

You're welcome!

[@kimlabrie7472]

I have thalassemia with enlarged spleen and liver. I need to know what tests to get to find out what kind I have.

[@saimanognamadha4775]

Omg really where are you from?

[@saimanognamadha4775]

If possible go to Hyderabad society in shivarampally the doctors will do all test ok don't neglect I think you need to get medicines. God bless you 🙏🙏

[@tom-ehill2713]

Have beta myself- early onset osteoarthritis..😣

[@roroharris6729]

I have that right now😢

[@midori7148]

i was diagnosed with thalassemia on the age of 2 but i just found out now which i am 12 now HAHA

[@saimanognamadha4775]

😄😄

[@atiyabegum2274]

Hlo!My child is 2years old and he is having thalassemia and he is having blood only 3.8% and he had blood transfusion once the level of blood is increased to 6% now. And he doesn’t eat anything doctor told that he has very less iron so he is suffering from thalassemia. Could u pls tell what should I do. And is there any serious prblm and any risk??And he should be taken blood transfusion lifelong???pls tell

[@saimanognamadha4775]

Which hospital you went?

[@saimanognamadha4775]

If he is thalassemia major then he had to get life long blood transfusions continuously every month where are you from?

[@saimanognamadha4775]

One solution it is bone marrow transplant in early age then he may cure so you should consult right doctor.

[@allknight7905]

I have intermediate it’s a minute by minute ordeal ..If anyone could experience what it’s like, they would immediately run to the ER .

[@MedicalCentric]

"I understand that dealing with intermediate pain can be incredibly challenging and if someone else experienced it, they would likely seek immediate medical attention."

[@betsyi]

What about Hämoglobin E?

[@ujalakumari18]

It carries oxygen to the organs of our body

[@saimanognamadha4775]

If it is less we will get tired for small work als

[@tomu7396]

You said severe Alpha or Beta Thalassaemia and than mild anemia, wouldn't it should be a severe anemia

[@samofficial15]

Doctor if a female has thalassemia and if female will sex with male. is that any possibility that man will affected in thalassemia ?

[@getthefuckaoutmyway]

It's not a virus it can't be contagious

[@user-gk7dn3ts1q]

no, this is not an infectious disease it is an inherited disease

[@QueenASMR2019]

No but is she get pregnant, the child may have it.

[@GolamFoody]

Kya bhai tum log bhi 😞

[@srirampatnaik9164]

Bruh did you watch the video?

[@karthi4144]

Eren Yeager

[@allisonc6064]

Like a baka