Which Molecules are the Most Cringe?

[@shotgunshelz7987]

I've seen this channel come up a few times in my feed, this is the video that's going to make me binge watch every video here.

[@That_Chemist]

Glad to hear it :)

[@fjlkagudpgo4884]

​@@That_Chemist my field of work is just as removed from chemistry as one could imagine, but i bingewatch your videos nonetheless. idk, there's something in your narrative flow that gets me every time, even when i don't understand the topic. you're like "the jdodkfjsoic acid is very good for asdfging the 2,3,5-onium-qwertyade" and i'm like HELL YEAH BROTHER GIMME MORE OF THAT that's talent. you're talented. with all the hard work you're putting in, the content is extremely good. it deserves way more subs than you have now, and i'm so glad i found you early!! lots of love ^^

[@mcawesomestudio]

@@fjlkagudpgo4884 I just told That Chemist this same thing the other day!!😅 I regularly fall asleep with a chemical terminology stream of consciousness running through my mind. And after hearing all the chempolation stories, if I ever work at a university (or even a high school, for that matter) I have been thoroughly scared off from having a classroom or office ANYWHERE NEAR the lab 😂😬 👨‍🔬👩‍🔬⚗️⚛️💥

[@pauline_f328]

​@@mcawesomestudio I'll be motivated to be more serious about PPE if I'm ever in a chem lab again, even high school ones, for sure. I'd like to not go blind or lose feeling in my hand, 5hank you 😅😂

[@pauline_f328]

​@@fjlkagudpgo4884 Yess omg sometimes I have no idea what he's talking about but I'm so hyped anyway lol

[@andrewkelley9405]

As a man who forgets most of his chemistry from school; looking at this is how a Lovecraft protagonist must have felt laying eyes on the elder gods and their servants.

[@That_Chemist]

Haha

[@scritoph3368]

Or how a Lovecraft protagonist felt when looking at a black person, knowing Lovecraft.

[@sauceman5337]

Bro 😂😂

[@TS-jm7jm]

@@scritoph3368 im in agreement with lovecraft there

[@michaelwerkov3438]

@@TS-jm7jm so... youre... racist trash? Are you either misunderstanding the joke, or just saying the quiet part out loud?

[@yaysimonsays151]

Imagine spending years of your life devoted to studying advanced chemistry, to then say fuck it and invent a whole new molecule purely because it looks like a stick man. Legends

[@Costa_Conn]

Saddest paper I have ever read, next to Tour's nanocar. Shame he never managed to get nanoguy into nanocar.

[@josephwilliams5292]

It’s funny because this was also Tour. I just graduated from Rice and he taught me orgo freshman year, he’s super proud of the Nanoguys (actually called nanoputians to reference Gullivers Travels) and still talks about them at the end of his lectures

[@Flesh_Wizard]

Absolute Gigachad

[@GigaTele]

@@Flesh_Wizard cringe.imagine not wanting to make deadly nerve agents for a living

[@BCQM_BCQM]

Those molecules that can't drawn clearly in 2D are so cringe that I don't even know which atom connects to which at the first glance.

[@That_Chemist]

Yeah

[@goda743]

"This can go into B tier" *puts it into A tier* "You don't ever want to see carbon with more than two oxygens." Carbonate wants to know your location

[@ke9tv]

I've been known to disinfect things with Na2H3CO6 (sorry, can't find the subscripts on my smartassphone) - a more or less shelf stable source of high concentration H2O2. The way all those oxygens are bound in the crystal lattice looks kind of cursed.

[@mrreg]

bicarbonate ion has 3 oxygens on a carbon.

[@Mikemk_]

Or carboxylic acid, cornerstone group of life itself.

[@MCDreng]

​​@@Mikemk_arboxylic acid is -COOH that's 2 oxygen's

[@Zwelious087]

Love him or hate him, nanokid is getting bismuth, technetium, helium, and sulfur. Side note, my favorite application of gen x is poisoning large rivers in a certain east coast US state.

[@libalj]

Grimace is a giant anthropomorphic taste bud who is constantly hugging children (squishing them onto his taste receptors.) That's pretty cringe.

[@That_Chemist]

Grimace is the Joe Biden of maccers lmao

[@lexinwonderland5741]

@@That_Chemist i have NO idea if that's supposed to be a compliment or an insult

[@themrjoe8288]

@@That_Chemist Based

[@willk7508]

Grimace is another synonym for cringe. Maccy’s knows what they’re doing

[@nighthawk043]

@@That_Chemist you and E&F decided on a running gag when you collab'd?

[@cn8229]

Looking forward to the "which molecules are the most based" tier list

[@That_Chemist]

“Which bases are based?” Already exists!

[@chirone_]

@@That_Chemist diethynylbenzene dianion

[@vitriolicAmaranth]

"It turns out it's actually used in sunscreen. It's good at reflecting UV light, and it's also good at absorbing both UV-A and UV-B. So in my opinion this one is super duper cringe." based skin cancer enjoyer

[@That_Chemist]

Isobenzotriazoles are cringe AF

[@lithiumferrate6960]

That chemist should do a sulflower total synthesis. From methane and sulfur obviously.

[@EmyrDerfel]

This sounds like very yellow chemistry, and it's making me nervous.

[@GuyWithAnAmazingHat]

As a non chemist I've been binge watching all these tier lists and have no idea why they are cursed or cringe, and seeing how cursed and cringe seems interchangeable in this list makes me even more confused lol

[@Marco-kd7jk]

Which molecules are the most metal? Edit: Grimace is the most metal.

[@hollowone777]

🟣🤘

[@cmyk8964]

If molecules could talk, Dodecaphenyltetracene would definitely say “BE NOT AFRAID”

[@samuellima6193]

This kinda is "most cursed molecules tierlist 2.0" Tbh, I don't know that much about chemistry, but I find these videos pretty chill and cool to watch

[@That_Chemist]

That is exactly what this video started out as

[@petevenuti7355]

Bibrockathol? For eye infection? Looks like some madman was trying to make super tear gas old school style.. I use capsaicin cream for muscle ache and itchyness , it often gets in my eyes... I can laugh that off. I remember the old-school pepper spray & tear gas that had bromine in it's formula, and WOW that stuff made a habanero to the eye feel like a warm hug by comparison. If I saw that formula on a bottle of something a doctor wanted to put in my eyes, I'd say "Are you trying to cure my eye infection by encouraging me to rip my own eyes out Saw style?" Are you sure that's for use en vivo? Not for transplants of something. I so got to look it up now!

[@jenda386]

Funny story about that. A colleague wanted to use phenacyl-bromide (alpha-bromoacetophenone) for synthesis. Before purchase he had to affirm that he was not going to use it as a chemical weapon. During use a small quantity of it must have got aerosolized, making it extremely difficult to keep eyes open in the lab. Wikipedia states that it is a powerful lachrymator and I can attest to that.

[@CossZt6]

This video has convinced me the line between cringe, cursed and intriguing is rather fine

[@flaplaya]

Nice shout out to Mirex. One of the "Dirty Dozen" persistent organochloride insecticides. Nasty amounts of chloride. The Diels Alder Endosulfans are really wicked too. Used to all be perfectly legal OTC.

[@eltonjolteon]

PFAS are also hellish to work with from an experimental standpoint. They're so good at being non-stick that they'll often drip right out of our pipettes while we're trying to test them. I think a PFAS video as a whole would be super interesting. If you need any perspective from someone who is doing research on their effects, I'd love to share what I can.

[@BecciOnion]

you have my dream job, i want to go into organofluoro chemistry when i graduate! i think theyre so fascinating.

[@lancemakesthemdance8977]

Tom would also agree that Grimace is F, because he loves grimace too.

[@defenestrated23]

I like when you resize and expand the molecules first. I'm often on mobile and this makes them much easier to read and see the structure.

[@revenevan11]

Agreed!!

[@That_Chemist]

A user suggested it and I started implementing it - thanks :)

[@DanielWillems1995]

Tom from E&F will need a private moment with Grimace being in the video caption. Missed opportunity defiling it and giving it a yellow tan for Tom

[@That_Chemist]

HOW DARE YOU - GRIMACE IS THE FURTHEST THING FROM TRASH TIER YELLOW CHEM

[@rcteg]

@@That_Chemist i was hoping he'd make grimace explosive but that would require defiling grimace and we all fuckin love grimace

[@123unknownsoldier126]

I’m p sure I’ve read somewhere that TEMPOL was being researched as a treatment for covid. Eating a radical is ultra cringe

[@00muinamir]

Oh WOW. I had to go look this up and yeah, they're doing human trials. If I ever get a bad case of 'rona again and end up taking this, my jimmies will be substantially rustled.

[@metiscus]

Grimace E&F fan eh?

[@That_Chemist]

I have Tom in a mini discord with some other chemtubers 🤙

[@alextaunton3099]

@@That_Chemist yall should do a video on yellow chemistry

[@jeffstaples347]

Omg two of my favorite chemists sharing Grimace memes across the world. Are we getting another Explosions and Fire crossover?

[@fgaucoffee744]

I refuse to believe the Grimace resurgence has nothing to do with Explosions and Fire's latest video... xD

[@That_Chemist]

Oh it does

[@That_Chemist]

But it has even more to do with how great grimace is

[@MrCreeper1O2]

Ah Grimace, fukin' love him

[@koukouzee2923]

Grimace is love grimace is life

[@davidglaser3462]

man, I fucking love Grimace

[@JackFrawley101]

Only Australians understand

[@MrHubert1710]

@@JackFrawley101 Well i'm Polish but still chuckled because of Explosions&Fire. I have absolutely no idea what Grimace is.

[@emmahird2795]

Chuck him on the grimace pile on the dashboard

[@adiaphoros6842]

Ah chemistry, the discipline where structures with a lot of circles in hexagons make me giggle. Also, what do you call the carbon allotrope that’s like graphene, but all of the carbon bonds are double?

[@adiaphoros6842]

You’ve heard of NanoPutians, now get ready for the nanocar!

[@lunascapes]

Grallene?

[@oitthegroit1297]

@@adiaphoros6842 When they're made in Russia, they're called nanoputins.

[@Sebastian-ru3ed]

@@adiaphoros6842 WW

[@NoLongerBreathedIn]

Jawsamycin is named after the movie. The cyclopropyls look like shark teeth.

[@hunterheath_keen8840]

Waiting on a chemist to synthesise Grimace and world peace will be restored

[@callumrosenberg9032]

As someone who does a lot of EPR, I take gripe with your ascertion that unpaired electrons are cringe😤

[@MrTheSmoon]

I thougth you said ERP and was very confused

[@holydiver588]

12:52 >"we probably should put it in the B tier" >puts it into A tier instead

[@chrisb3585]

Once again nature proving to be the superior chemist when it can create molecules that would have most of us just go 'NO' when looking at them let alone trying to synthesise them.

[@That_Chemist]

Exactly

[@justsayin...1158]

Well, nature has a few million more years of experience in the field. Give us some slack here.

[@foxyfoxington2651]

TIL: Keeping rings from being happy is cringe. EDIT: If there's anything that raises more red flags than five nitrogens bonded to one another, it's five oxygens bonded to one another. None of those look like they want to exist.

[@gcewing]

Looks like someone is trying to make a new rocket fuel!

[@VerbenaIDK]

As someone that barely knows any chemistry: all of these look like they dont really wanna be there, and all look great to give cancer, especially the iodine one idk why iodine is all that of a good leaving group but it just wants to leave

[@Kyoobur9000]

Iodine is such a good leaving group because of its size. Its bond with carbon is very weak because the bond length is so long, and its anionic form is very stable because of the high volume available to the extra electron.

[@LlamasAtMidnight]

It's nice to hear you talk about pfas, my sister did a lot of her research on it I would definitely watch a video on it

[@mastershooter64]

does a metal technically count as a "molecule" like one huge molecule of course the atoms are covalently bonded they have metallic bonds

[@That_Chemist]

It just works

[@seneca983]

You could also say that e.g. diamonds are huge molecules as well as some polymers.

[@hydrogenbond7303]

Imagine something like "ChemComic" where the most curaed molecules bully the most cringe molecules. And there will be all sorts of different molecules and they would different relationships between them and would be the most nerd comic ever. That would be so awesome. OMFG MÖBIUS CARBON BELT imagine if carbon klein bottle existed

[@That_Chemist]

That would be amazing

[@petevenuti7355]

You would need an extra dimension... Maybe there is a subatomic analog...

[@springtrap8434]

11:20 bruh i accidently read that as "Morbius Carbon Nanobelt" and assumed he was joking loll

[@That_Chemist]

It’s morbin time (I morbed everywhere)

[@springtrap8434]

@@That_Chemist i was so shook when i found out that you had morbed everywhere (The morb was too much to handle) Oh and also Grimace is great

[@muh_v8787]

brb getting an organic chemistry PhD just to do macaroni art with functional groups

[@That_Chemist]

Hahaha

[@That_Chemist]

If I ever have my own group, I will totally include meme compounds in all of my scopes

[@jamesb.6177]

Analytical Chemist here. Another cool application for TEMPO is as a free radical initiator for the sequencing of peptides via mass spectrometry. Basically it allows for the generation of fragments that you wouldn’t otherwise see using traditional collision induced dissociation and therefore can lead to better sequence coverage.

[@fioragaming19]

Morbius was so popular they named a chemical after the movie. What a time to be alive!

[@Kyoobur9000]

Wait until you hear about Molecular ORBitals…

[@lithiumferrate6960]

That chemist should make a compound where all hydrogens in a benzene is replaced with an azide group.

[@IronTeddyBear]

Glad to see a diyne in your list. I used to work in a lab where we polymerized diynes using a Cobalt-60 radiation source.

[@That_Chemist]

Cool!

[@venomzmadz]

When you cover PFAS, you could also inform (at least yourself) about Organoclays, which could potentially remove this shit from water

[@DeathMetalDerf]

GRIMACE FOR LIFE!!!! I don't think I'll ever get tired of these. I absolutely love the tier lists because it inspires me to do more research after learning about something new, and exciting I've never heard of or had the chance to work with. I'm not in school for organic chemistry yet. I'm still working on a cybersecurity masters program at the moment. However, once I'm done with this I'm definitely going back for O-Chem. No. There's absolutely nothing anyone can do or say to change my mind. I want to do something very specific.

[@mutated__donkey5840]

Tom from E&F loves grimace should have invited him again

[@zaquepifer2376]

Grimace gang! Favorite thing to find in my water is a purple guy with a smile :)

[@Mystictiki]

TEMPO analogues are really useful for NMR and EPR spectroscopists for biochemistry. Very useful for Paramagnetic Relaxation Enhancement experiments and for determining the dynamics of proteins.

[@Aquatarkus96]

Bromo-DragonFLY belongs here also, Calicheamicin is probably pronounced closer to ca-lee-che micin, as it was discovered in caliche (a kind of chalky gravel) pits located in Kerrville, Texas, and that's how we say caliche

[@That_Chemist]

it will be in a future one

[@RicoElectrico]

13:44 in Poland triangle pointing down = toilet for men, circle = toilet for women 😅

[@RicoElectrico]

Although standard signs are most commonly used nowadays. Probably due to confused tourists.

[@blumoogle2901]

Automatically liked for "Hexagons are the bestagons" ++

[@shaunkelly7223]

Looking forwards for the pfas video! nice work!!

[@revenevan11]

Is Grimace in the thumbnail because of Explosions & Fire's McDonald's video recently? I saw your comment on it, too!

[@That_Chemist]

Grimace is just so great

[@michaelcurran4819]

haven’t taken a chemistry class in 3 years. I don’t understand or know why but your videos are extremely interesting and engaging and I’ve been hooked on them.

[@pseudolullus]

5:50 re: josamycin, I just read a couple days ago that they're tweaking a very close molecule to turn it into a high energy-dense biofuel

[@lard0NINja]

This isnt the video, but I recently watched one of your videos and you mentioned how toxic brake cleaner is, and my anxiety started snowballing. The amount of times ive washed my hands with the stuff is actually terrifying. My father is the one one told me it was fine to do so, but Ive never questioned whether or not he was right. Fuck me, was he wrong.

[@That_Chemist]

Yeah a lot of Dad advice is actually pretty bad

[@That_Chemist]

Glad to hear there are fewer people washing their hands with brake cleaner

[@jonored]

Huh; I'd thought (based on the smell of at least one brand) that brake cleaner was mostly acetone with some modifying ingredients. Upside: acetone is, while a bit more toxic than ethanol, relatively normal for your body to deal with (you've got proper metabolic pathways to deal with it and have some endogenous generation of the stuff) _and_ relatively effective at removing grease from hands. It can dry your hands out pretty badly, but so would the brake cleaner.

[@Kyoobur9000]

As a theoretical chemist, I’d like to add that anything involving nickel is ultra mega cringe.

[@tazzyhyena6369]

the Moebius Carbon Nanobelt made my goblin brain go "oooh shiny"

[@not_estains]

6:01 "We also have an alpha beta gamma delta unsaturated amide" me: "a what how who now why what??"

[@not_estains]

reminds me of the oahu honolulu ala moana target

[@That_Chemist]

Ooma ooma nuka nuka Apuwa ah

[@francovlla]

Do a boomer molecule tier list. Housane has to be the s tier boomer molecule…back when it was affordable

[@That_Chemist]

Lmao

[@alzeheimersgaming]

This is one of my favorite channels, because where else can you hear the line: “Grimace? Grimace is based. Show some love for Grimace in the comments. You know what isn’t based? Tetradioxin.”

[@That_Chemist]

:)

[@CyberBinary]

Bisoctrizole looks like two 3rd form Friezas about to dab each other up

[@jplouthelgm5156]

I *LOVE* your justifications for what precisely makes a molecule cringe, as well as to which degree it is cringe relative to the others!! This comment is quite cringe, but idgaf! 🤣👍

[@grn-xx]

Wasn't tetrachlorodioxine used in the Vietnam war as agent orange? They sprayed it on their forests and then the trees lost all their leaves. Also it seems to have been very teratogen

[@That_Chemist]

it was a contaminant in it, yeah

[@grn-xx]

@@That_Chemist ohh okay, thanks

[@Gabiscis]

shots fired at grimace, tom's gonna come for you lmao

[@sauceman5337]

just listening to you say right off the bat "and today were gonna be deciding which molecules are the most CRINGE" Is so funny to me 😂😂

[@WallBush]

Wow, never thought I'd see a biocide I work with for consumer products in a tier list

[@revenevan11]

Carbon hexoxide looks a bit like a round bottom flask? Does anyone else see it?

[@That_Chemist]

Yeah

[@elnombre91]

If anyone wants to learn more about PFAs and a particularly bad scandal involving them, I wholeheartedly recommend the movie Dark Waters.

[@That_Chemist]

It’s a great video for non-experts but there are several issues that have come to light in terms of accurate PFAS detection

[@petevenuti7355]

Nanopution has only 3 fingers..humm... Grimace, a shout-out to Tom(ex&f)? Covered vi-heart too with the bestagons... Makes me wonder what references I missed??

[@cobhallagames6997]

Pulling out all the stops with the references! Love it

[@Beargain]

Oh hell yeah, another Grimace.

[@nickt513]

TIL all my doodling with models in Ochem was actually producing nanoputian molecules lol

[@madddd1]

This video nitrates my maccas

[@shengshu3510]

Love the cgp grey reference lmao

[@rcteg]

Which one was that?

[@dandeeteeyem2170]

Nice shout out to Explosions and Fire channel :D

[@That_Chemist]

Check it out - I got him to add grimace to the thumbnail

[@JaxMerrick]

I swear, bisoctrizole looks like a dude trying to look into the 5th dimension.

[@potatortheomnipotentspud]

Some of these look and sound like fantasy creatures

[@That_Chemist]

Hilarious pfp btw

[@potatortheomnipotentspud]

@@That_Chemist thanks

[@Sonicsis]

I love your content, as a chem student this is very helpful for my adhd.

[@That_Chemist]

as someone with ADHD, I completely understand

[@nimmen]

Looks like you missed 3,3-Diethylpentane But it might be more suitable for your age-restriction challenge video instead

[@Jose-wq4zr]

Today a learned that chemistry is chaotic neutral on a good day

[@That_Chemist]

Yes

[@RylTheValstrax]

Not only are superbenzene infusions in carpathite quite pretty, they also fluoresce under UV light. The naturally occurring gamma form glows green/yellow, but the beta form glows orange.

[@PaulSteMarie]

I see Grimace is doing the tour of chemistry channels this week! Where's he headed next? Nile Red?

[@That_Chemist]

Hopefully chemiolis and Thyzoid

[@That_Chemist]

I don’t think advanced tinkering would do it, but we shall see

[@edwardkuenzi5751]

Most polyunsaturated fatty acids found in nature have uncongegated double bonds. That's just the typical structure.

[@That_Chemist]

True

[@daikucoffee5316]

I’m still not sure what your criterium is for a molecule being cringe.

[@KirbzYyY]

Hmmmmm... grimace... reminds me of a certain chaotic evil chemist... hmm...

[@flaplaya]

TCDD shout out too. Organo-Chloride was my lifelong passion of study. Must admit I'm on Fluorides now way more scary. Good stuff sir always A+

[@goryao]

Sulflower? LOL! that's amazing looking; could you possibly link to a paper where its talked about?

[@That_Chemist]

cen.acs.org/articles/95/i7/new-sulflowerbloomed.html

[@Fragmentofbone]

This is nothing, compared to what you can do with "Programmable Atom Equivalents"

[@douro20]

Superbenzene is also known as coronene and its mineral form is apparently very pure. A group of Chinese chemists published a paper in 2015 on the synthesis of graphene using this chemical.

[@alexgreen4131]

This is insanity, and so unbelievably preposterous. You just earned a subscriber.

[@benyahun]

Why am I watching this, I dont know shit about molecules or chemistry

[@That_Chemist]

you are watching this so that you will know shit about molecules and chemistry!

[@D3CD95]

Starting a Grimace cult with E&F

[@vincentd1120]

Disappointed that cycloparaphenylene isn't on this list.

[@actually-god0816]

This man is a shameless Ex&F fan, and there's nothing wrong with that

[@That_Chemist]

“How about a friend”

[@sebastianfischer429]

"Grimmace is awesome"... I feel like a certain specific explosive Australian man would agree 🤔

[@devenhull3677]

GenX is also concerning when it's in high concentrations in your rivers

[@happy24mr]

c is for carbon and cringe meaning all organic molecules are cringe

[@FabiansLab]

why was tungsten dioxide not included?

[@pacificcoastpiper3949]

WOO? Oh boy

[@thomaszedderman]

at this point im pretty sure that all chemists love grimace (as they should)