The Anti-Aging Effect of Removing Zombie Cells [7 Studies]

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References (Cope & Paste in Search)
[1] doi:10.1172/JCI95148
[2] doi:10.1016/j.smim.2019.04.003
[3] doi:10.1093/gerona/glab002
[4] doi:10.1111/acel.13767
[5] doi:10.1007/s11357-023-00830-5
[6] doi:10.2340/actadv.v103.4475
[7] doi:10.1016/j.ebiom.2018.09.015
First Video in this Series: • Is forever food restri...
Economist Video: • Longevity: can ageing ...
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#antiaging #senescence #agingbackwards

[@Physionic]

1 AMENDMENT POSTED BELOW First video in this series: kzbin.info/www/bejne/bHWugqOcprR3e8k AMENDMENT: @4:15 - it should read 'SASP', not 'SAPs'

[@xntumrfo9ivrnwf]

Man, if you think of cells as individual people, biology becomes this epic adventure worthy of Tolkien

[@ThelmaThais1]

Cells are alive...they are not people, when he say zombies he means they are half alive in the process to die apoptosis this happens all the time...

[@ishheredia9626]

It's called Osmosis Jones

[@mowthpeece1]

Yes, it really would be. Fascinating stuff.

[@marknasia5293]

My colon was like “you shall not pass”

[@laurensargent9471]

Would be an excellent way to teach biology at the HS level.

[@Spartnick]

I very rarely write comments, but man your content is great and way more people should watch it Keep it up!

[@Physionic]

I appreciate that!

[@mag4926]

A subjective opinion.

[@lauragee3365]

​@@Physionic question would autography with intermittent fasting work to remove zombie cells?

[@dlg5485]

Wouldn't routine fasting achieve the same result by way of natural atophagy? I get it, most of us aren't so good at abstaining from food, but it does seem to have amazing life extension benefits if done on a regular basis.

[@kb030303]

Attia had an interesting perspective about balancing benefits of fasting against potential loss of muscle. Might be worth checking out.

[@dlg5485]

@@kb030303 Not a fan of Attia. Watching him in interviews is so annoying because he never answers a question directly. He sounds like a politician. I've been doing 18:6 IF for 4 years and a 48 hr fast each month. I've actually added muscle in that time. Muscle loss is not an issue unless you are doing extended fasts and your diet isn't right. I don't go beyond 48 hours, which is more than long enough to trigger autophagy, and I eat a very nutrient dense meal before a 2 day fast.

[@richardbreeze7898]

Use exercise instead does the same thing baby.

[@dlg5485]

@@richardbreeze7898 Exercise alone is not as effective as fasting alone, but doing both together is obviously going to be most effective, ideally exercise toward the end of your daily fast. That's what I do and I am in the best health of my entire 55 yrs.

[@richardbreeze7898]

@dlg5485 it's overrated baby.

[@atabetuatara]

Hi Nic. Left me aching for more! Great video!

[@InsolentVillager]

An NLM article I'd like your thoughts on. "The flavonoid quercetin inhibits thyroid-restricted genes expression ..." "In a previous report, we showed that quercetin inhibits thyroid-cell growth and iodide uptake. The latter effect was associated with down-regulation of sodium/iodide symporter gene expression."

[@michaelcalibri3620]

Thanks for that. I definitely needed to know that on someone else's behalf.

[@vladislavroytapel2830]

yep..i noteced low iodide

[@spakchitown]

If all college professors presented like you, how much more would we all get out of advanced education? A lot more. Compelling, succinct yet thorough. Usually my eyes glaze over at these levels of detail but not with the way you communicate. Thanks for also not being snarky.

[@evebaker4740]

Really enjoying these videos! Ty so much

[@abc_cba]

Next topic : How to keep skin youthful and wrinkle-free, please! 😢

[@incognitotorpedo42]

sunscreen every day.

[@watttylerthesecond7056]

Hyaluronic acid,Astaxanthin,collagen.

[@bill2292]

Water only fasting seems to naturally clear out unusable cellular products, so does fasting eliminate zombies?

[@kiko7723]

Yes

[@kiko7723]

Good video, good explanation not too difficult to understand. Also trustworthy sources. thx

[@Physionic]

Thanks, Kiko. I put a lot of work into it. I appreciate it.

[@Chaotic313]

I started down the rabbit hole of taking biohacking supplements a little over a year ago, fisetin included. One of the recommended (by a number of KZbin proponents) way to dose was a large amount for several consecutive days once a month. But I also take quercetin daily which can also act as a senolytic - a less slash and burn approach, but continuous. So when I ran out I didn't buy more, opting for the kinder gentler approach, lol. However I am considering taking it again, but on an every few months schedule. The last thing I need is a bunch of zombies messin' with my innards. Thoughts?

[@baneverything5580]

Are any of these in plants I can grow, especially indoors, since I grow my own salad greens, mini tomatoes, mint, watercress, peppers, etc inside in winter? I have gigantic mustard greens in my outdoor garden and a lot of turnip greens and radish plants. I did freeze several bags of wild blackberries from a 100ft long patch bordering my yard but I had to share those with raccoons, squirrels, possums and birds since it`s the only patch around here. I think those contain quercetin.

[@ashleyparker1203]

From what I have read, purple onions are high in quercetin and strawberries are an excellent, growable source of fisetin. Happy gardening!

[@baneverything5580]

I have purple onion seeds. I guess I need to order strawberry plants and try my luck. It looks like they aren`t easy in indoor hydro gardens though. @@ashleyparker1203

[@silkhead44]

Been taking quercetin and nac for decades

[@marknasia5293]

I do the liposomal Fisetin three days high dosage, but do daily liposomal quercetin along with liposomal curcumin and I feel it at the end of the three day, and do it every 28 days

[@189643478]

I've been taking rapamycin for almost a year now with no side effects. I wouldn't experiment with senolytics because my big worry is that we cannot be certain that they don't have off-target cell killing (like some rare stem cell population or some highly specialized immune cells that would not be detected in gross necropsy studies).

[@lolerie]

But stem cells all have activated telomerase they are Immortal just like cancer cells

[@jimwood1062]

How would Methylene Blue impact continued cell division or recovery of senescent cells?

[@bartoszkazibudzki2729]

Great insights. Last time I'm thinking about senescence in relation of integrated stress response. Do you think these topics cover themselves on some point?

[@seranonable]

Will you do a video on the best OTC senolytics?

[@richardbreeze7898]

Nick do a video on Rapamycin and whether its a good idea. The fact its a immunosupressant is a bit worrying.

[@beezowdoodoozoppitybopbopb9488]

Any thoughts on dry fasting supposedly being hyper effective at inducing autophagy?

[@jmc8076]

@8:04 Me and most watching? No. But IMHO these days incr number would. Plug the insiders club. Offering that quality of info and format is needed now. It’s on top of my list after this phase of health challenges. ✌️

[@walkingSherpa]

Hello I would be pleased if you could expand a bit if Spermidine has some , and if yes, what influence on senescent Cells

[@annettestevens2260]

Thanks

[@Physionic]

Merci, Anette!

[@volos_olympus]

You forgot about the clinical trial done by the ITP on fisetin which showed no lifespan extension.

[@MightyRoy]

The senolytic fisetin was not found to extend lifespan in the Interventions Testing Program (ITP), although it could be a dosage issue.

[@MiguePizar]

Thanks for video, by the way, can you do a video about fatty15 ( c15:0)? Supposedly it's also an anti aging supplement and nobody is talking about it, like it was with NMN a few years ago when it was new. Best

[@stephenwillis9571]

A bit of a tease - circumin is another. I do think you should point out the dangers of senoytics - they appear ot be crucial in wound signalling and may be involved in suppressing tumours. There is some reference of one senolytic being withdrawn in the 80s irrc which some cancer patients bled to death. One or two people taking sustained high doses have reported some problems with wound healing.

[@amytucker6142]

I used in cancer therapy no problems

[@george6252]

I've been using Grape Seed Extract a couple times a week for zombie cells.

[@georgiosdaskalakis5263]

brilliant video

[@Joe_C.]

I recall reading several years ago that fisetin should be cycled in some way. I think there was one protocol that said to dose once or two consecutive days a week, and another that said to take everyday for ??two weeks?? like once per quarter 🤔... Also, fisetin by itself is VERY poorly bioavailable. I think the trick was to take with a compound extracted from either fennel or fenugreek. Can't recall which of the two, but it I know it was a 'fen'. And it also has a synergistic effect when taken with quercitin, which also has senolytic properties

[@Battery-kf4vu]

Fat increases the absorption of fisetin and also quercetin IIRC. I mix my fisetin and quercetin with a gram or so of olive oil and eat that every couple hours during the senolytics days.

[@Joe_C.]

@@Battery-kf4vu, yes true. Good addition 👍.... How do you cycle your concoction?

[@Battery-kf4vu]

@@Joe_C. I do one 3 day cycle every year at 51 years old. 600mg quercetin+1500mg fisetin+100mg dasatinib. I also add 400mg oleuropein, it's been shown to have a senolytic effect. To tell you the truth I don't know if it is optimal, I don't think anybody really knows what the best dosage and frequency are. So it might be better to err on the side of caution. My 2 cents.

[@sergey9986]

Fisetin is almost identical to Quercetin from chemical standpoint is there a big difference? Many people consume Quercetin already.

[@incognitotorpedo42]

Fisetin is said to be a more effective senolytic. When it comes to biologic response to molecules, a single atom's difference can be a night and day difference in outcome.

[@sergey9986]

@@incognitotorpedo42 Could you please help me finding the proper reference?

[@Battery-kf4vu]

What is the optimal dosage of senolytics? Some people do 2-3 days per months but I fear it is way too much. D, Q, and F don't have very good selectivity so it may kill a lot of good cells, and also killing all the senescent cells may not be the the best thing to do. I do 3 days once per year of D+Q+F but really I have to so say it's a wild guess.

[@CessnaPilot99]

I liked your zombie drawing and animation! Did you draw those yourself?

[@redemptivedialectic6787]

It would be cool and interesting to hear your take on peptides.

[@Physionic]

Which ones?

[@Froddel-xy7wg]

GH secreting peptides

[@redemptivedialectic6787]

@Physionic there's a few like Epithalon, thymalin, and cortagen which supposedly help with anti aging. Some like BPC-157, TB-500 and Vilon which are said to help with healing tissue damage. And quite a few for Fat Loss and muscle gain including but not limited to the growth hormone releasing peptides. I took some AOD9604 and lost 15 pounds and have been able to keep it off with minimal changes to my diet

[@redemptivedialectic6787]

@Physionic there are also a few nootropic peptides like selank and semax which have positive anecdotal reviews.

[@KunstPicker]

​@@Physionic delta-sleep-inducing-peptide seems really cool

[@steve-o7620]

Since cell death is normal, how many "zombie" cells are considered normal and what point would that number be considered abnormal?

[@lluviahirschortega1393]

Great video!! First time i heard of zombie molecules, have you heard of the opposite? The hope molecules, which I am not sure they do exists, but i heard about it all the time, thank you for the video ❤

[@johnallen7230]

I found a KZbin video referring to a Fisetin Flush......I've been practicing the John Hopkins recommended protocol for 3 months......👍👍👍

[@jackbuaer3828]

I am going to guess that neither John Hopkins nor the Mayo Clinic is recommending that you do a supplement program to reduce senescent cells at this point in time.

[@jodyjackson5475]

Maybe so but I very much doubt that Johns Hopkins would

[@JustAnotherYoutubeHandle666]

I watched another video about how fisetin probably won’t work on humans. That mouse study used a bunch of inbred, genetically similar mice and when fisetin was used on genetically diverse mice they saw no positive or harmful effects.

[@Corteum]

It does work ron humans. Do more researrch.

[@JustAnotherYoutubeHandle666]

@@Corteum Look up who paid for the studies. If the study was done by a lab owned by a company that sells fisetin supplements then you're just being fooled. Unbiased, third party labs called, "Intervention Testing Programs" have shown that fisetin did nothing to senescent cells.

[@Roberta-qe7km]

Mr Physionic - What is your health regime?

[@gristlevonraben]

Soursop fruit helps fight cysts and cancers by helping the body recognize bad cells and foreign intruders, through protein markets, I thought. Is soursop fruit, graviola, a silenescent?

[@gdiup9241]

Would HGH help get rid of / push out senescent cells?

[@TJAllcot]

Was that Dr. Cynthia Kenyon towards the beginning of this video?

[@incognitotorpedo42]

Yes.

[@stephenbrickwood1602]

Long term lock or loss ?????? at 3.45

[@MN76.]

Interesting 👍🏻✌🏻

[@free_spirit1]

Those UV damage spots some people have on their skin... are those senescent cells? Is that the reason Bryan Johnsom lasers his skin?

[@MarcMallary]

You mentioned quercitin. It's a lot more natural.

[@JustAnotherYoutubeHandle666]

Anthrax is natural too. Natural doesn’t mean anything.

[@whatthefunction9140]

Is it bad that I took quercetin for like 6 months...?

[@totmirmis]

if the zombie cells call the immunesystem, and inflamation does happen, why doesn't the immune cells gobble up the zombie cells?

[@misiukowalski5653]

Hey babe, I’m not that smart but I need get rid of my zombie cells ASAP what do I do!!!!?!?

[@grego4835]

Do you sauna for this effect?

[@_chimera_]

You look like you need to get rest and fluids. The cells will still be there once you recover ❤

[@Dan-dg9pi]

This video might have been better timed for Halloween!

[@Physionic]

Honestly, I really tried to make that happen. The idea came to me about a month before Halloween, but doing all the research, writing the notes, creating the illustrations, paying the editors to edit 5 videos, and then doing the background work post editing wasn't feasible in 4 weeks. I definitely tried, though! :)

[@theshadow8008]

Epigenetic-induce deregulation of longevity genes.

[@user-ik7rk7lz9p]

Omega-3 Fatty Acid And Anti Aging? Butter And Anti Aging? 15 Years Old Ask.

[@rejiequimiguing3739]

Keep the fasting insulin at minimum. That's the best strategy to slow down aging process.

[@Nthompson50000]

seems like messing with this could be a costly double edged sword

[@WattisWatts]

Who (or what) are we trying to make ourselves perpetually young and strong for?

[@louisemorgan3237]

Who do you want to get old and weak for

[@rejiequimiguing3739]

You want to be in wheelchair for 3 years before you die?

[@WattisWatts]

Why are comments assuming I want to be old and sick?

[@ericzimmerman7775]

Review your original question…

[@MyBeautifulHealth]

My children, and potential grandchildren. I want to be here for them as long as possible.

[@markaguilera493]

Does fasting get rid of senescent cells?

[@mowthpeece1]

Yes.

[@user255]

No.

[@incognitotorpedo42]

Maybe, Maybe not.

[@markaguilera493]

@@incognitotorpedo42 🥇

[@petervafeades4095]

the ITP found fisetin ineffective

[@incognitotorpedo42]

Don't they only look at lifespan? Nick mentioned that senolytics seem to improve healthspan more than lifespan.

[@manvsmachine1]

Wasn't there evidence that Metformin could kill these cells?

[@StyleshStorm]

I've heard my granpap talk about this before but I ignored him mostly because he doesn't know any new science. However. Now that he's talking about this topic I now know it's real and worthy of attention. Let's see.

[@todrichards1105]

Oof! Nick! At 15 seconds in, you say, “extremely unique..,” C’mon brother, you’re better than that. :)

[@Physionic]

I don't understand? Something can't be varying levels of unique?

[@todrichards1105]

@@Physionic unique means one of a kind.

[@ZappyOh]

In Danish, Fisetin would mean Farting-metal ... Just sayin'

[@Physionic]

How can it NOT be effective, then? ;-)

[@bytefu]

Good name for a genre of metal. Such a genre may not be "officially" recognized by the metal community, but there are definitely many bands that play it.

[@man_at_the_end_of_time]

How is Aubrey de Grey is doing these days? This topic was his bread and butter.

[@andrewchoi5808]

#DefeatAging #AntiAging

[@marcv2648]

Why do you always say SASPs, but write SAPs?

[@Physionic]

My illustrator, not me. Not sure why. Simple mistake, not a big deal.

[@susymay7831]

Exercise is a senoletic

[@user-ik7rk7lz9p]

"Foxo Gene".

[@LowHangingFruitForest]

But zombies don’t age? Shouldn’t we be multiplying the zombie cells?

[@cedarabbey]

God, you're so cute.

[@jayrawlings8938]

Wear a white shirt or something my man. You need to represent your intelligence with slickness. Great work though!

[@ausmiku]

It's a waste of time designing anti-aging drugs. None of them will ever control all the mechanisms of aging at the same time. Even if senescence is controlled, aging will still occur from all the other triggers. All the anti-aging clickbait is a sick joke.

[@rosaflorpuig3971]

Nick… I thought the Interventions Testing Program concluded that Fisiten had no effect on removing senescent cells. This is very confusing. Please advise.

[@Physionic]

I’ll need to look into it :)

[@rosaflorpuig3971]

@@Physionic Thank you! I love your channnel!

[@sweetness583]

I read an article that explained why senescent cells aren't all bad.

[@Physionic]

They aren’t, it’s true.