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In Dresden, a constellation of institutions, including the MPI-PKS and MPI-CBG, collaborate to blur the traditional boundaries between biology and physics. These multidisciplinary efforts drive groundbreaking discoveries. How did this innovative approach begin in Dresden? How does biology benefit from physics, and what new physics can emerge inspired by biological systems? Join us for a fascinating conversation with Tony Hyman, director of MPI-CBG; Frank Jülicher, director of MPI-PKS; Kai Simons, director emeritus of MPI-CBG; and Jonathon Howard, former director of MPI-CBG. This discussion takes you on a journey starting from the very foundation of MPI-CBG. They explore the importance of interdisciplinary science, the challenges of working in such an environment with diverse backgrounds, and how they found their unique path to scientific collaboration.