The Bioluminescent Gaming PC

[@TheHookUp]

I taught AP Biology for 15 years it's sad how much better your animations are than anything teachers get access to with a textbook. This is totally not a dig because I loved the video, but If I was still in the classroom I'd 100% use this video with my students to be able to go over the hand wavy parts and have them find the couple of inaccurate/incomplete sections of the process. Science Linus gets at least a B+.

[@volklii]

kzbin.info/www/bejne/pZbWlHVmg96YoKs

[@StripesOO7]

Exakly my thoughts with a bachelor in Biology (bachelor-thesis in genetic) . Beautiful animations that are 100x better than every old textbook but some parts are either missing or slightly wrong. But nevertheless accurate enough to be understandable and having an educational effekt on the „average“ viewer. 👍

[@majsstenen]

Just make sure to correct it first, that DNA repair animation ain't right :3 // Biotech engineer

[@reyanak9818]

@@StripesOO7 You need a bachelors degree in spelling

[@Kitulous]

@@reyanak9818 don't need to be a douche in the comments. Maybe they're German, that's how they spell "effect" and the languages are pretty similar enough to mix up the words.

[@Julian-og3ps]

That moment where he turned on the pump was legitimetely the coolest thing I've seen in years. Made me feel like a kid going to one of these places that let you do supervised science experiments again.

[@shadowpenguin3482]

12:45 for anyone who wants to rewatch it

[@fantasticparrot602]

@@shadowpenguin3482 a bit later actually for the when he turns on the pump 13:51

[@markj9860]

I much preferred the part where he started pouring the bacteria into the spherical reservoir, that slow blue spill down the sphere is just gorgeous. But yes, this few minute segment is one of the greatest things I've seen in this channel.

[@solarbirdyz]

@@markj9860 YES YES YES that was AMAZING. It literally looked like an SFX shot but was real.

[@FlyingPenguino]

"Oh god" - Alex

[@stephenjeremy5985]

Ive never thought that the day would come where Linus explains DNA translation and PCR to us

[@EhmJB]

Just wait until the "Installing the Intel Cognicyte i59 BioCPU" video he releases in 2063. It's gene splicing all the way down.

[@georgejosifidis]

He just relayed the information like a parrot making noises

[@maciejjabonski833]

Technically, he explained TRANSCRIPTION, not translation (geneticist here). Transcription - DNA -> RNA Translation RNA -> Protein

[@TheIceThorn]

@@maciejjabonski833 it's a quesiton that bohers me since very long... but since dna "evolved" from RNA, now it came to be? An error of transcription? Ther might be some sort of bacteria that has reverse rhybosomes which reverses the reaction and forms new DNA instead of RNA? yeah, i've already tried to find th e answer by myself or I wouldn't be asking, i swear.

[@maciejjabonski833]

​@@TheIceThorn I'm a bit confused. I replied to you hours ago and the comment disappeared. Did youtube remove it? lol Might type it out later again

[@mumble3535]

"Yeah, I have this massive algae bloom in my tank at the moment" "Damn dude, are the fish okay?" "What? Nah dude, my rgb algae has really come into its own and its looking sick" I support this kind of bio engineering

[@spamreciever4208]

I wanna live in the CyberPunk future where I can have a bloom of pet bio-engineered bioluminescent bacteria in my computer full time.

[@AYgameZ]

Fireflies: *look what he has to do to mimic a fraction of our power*

[@kyzinga266]

I grant u my chuckle

[@Nxrreshh_]

😂😂😂

[@Nxrreshh_]

@@kyzinga266 🤣

[@zlano7667]

look what they need*

[@jon4715]

Great comment, and true. I've read this before, where?

[@matiastripaldi406]

Am I actually seeing PCR, recombinant protein expression and bacterial culture in an LTT video? Is this a dream? I study biotech so this is my bread and butter, never thought you guys would venture into it. Amazing work!

[@goldcd]

You are - and I liked it!

[@luxbio]

so glad you liked it! what area of biotech are you studying?

[@FranciscoTC]

As a med student who loves tech, this definitely tickled my pickle

[@matiastripaldi406]

@@luxbio well i'm in 3rd year of university (out of 5). my uni is mostly geared towards research work (which is what I'm interested in) but it also prepares you for if you decide to go into industry (such as producing insuline for diabetes patient en masse with genetically modified E coli). After i graduate i'll probably go into research hopefully in something health or human biology related, there's a bunch of really interesting stuff popping up. Most of my professors are researchers too so they tell you about the work they're doing and it just sounds awesome to work in. But tbh molecular biology in general fascinates me so i'd be happy to work in any lab (with bacteria or eukaryotes) as long as it's not plants haha, plants are incredible but kinda boring

[@luxbio]

@@matiastripaldi406 sounds like such a great school! Have you heard of the Open Insulin project? We love what they are doing - insulin prices are literal evil

[@pranaygohel4630]

"Tech Tip: Don't get E. Coli" Yeah, that would be a good idea.

[@BrianTeague00]

Bioengineer here: The strain used in the lab is quite different from the one that makes you sick! You could drink a culture of it, and it might give you a belly-ache, but not much else.

[@furkell]

Not exactly tech, but a good tip nonetheless

[@rwhite9994]

E. Coli is natural in nature and most all of us have it somewhere at any given time. The kind that makes us sick, or takes over is different. That e coli is as safe.

[@Giangero21]

what the ..... i don't think this is a coincidence

[@emilie6466]

@@DemeDemetreEscherichia Coli

[@ajmatt]

As a molecular biologist I can die peacefully now listening to Linus's voice explaining cloning and bacterial transformation.

[@TheBatracho]

Dude, same here, molecular biologist here and PC fan who never expected hearing Linus talk about His tags lol

[@farhannajme7542]

Samee as a marine microbiologist Linus gave a pretty good lecture there.

[@showjjumper]

But cut the part where he drops the eppendorf pipette 😭😭😭

[@johnkaba2593]

@@showjjumper This is where I died inside

[@Winter_huntsman]

About to graduate with a microbiology degree in a few weeks and completely agree. It’s so neat hearing him talk about lab techniques that I learned in classes and performed in labs so much.

[@damustermann]

Linus DNA tips - really cool that you guys go into a lot of detail about the background of this.

[@_yuri]

amd RDNA

[@MrSerella]

@@_yuri RDNAvidia

[@jonathanmoelester448]

@@MrSerella GeForce RX 3090 XT

[@PetePeteRepeat]

Linus, get your team to do some research and create an LTT Lab Coat, with elastic sleeve cuffs, and quick-release snap buttons... as a Chemist, I would 100% buy one

[@hellowill]

Reminds me of his older videos, around 2013, when he would wear a lab coat for PC builds

[@Aviyara]

Quick-release snap buttons, three pockets (with the pen subdivision on the chest pocket) and in-garment "cable management" loops for threading wired earphones. Forget buy them, I'd preorder them and pay up front.

[@volklii]

kzbin.info/www/bejne/pZbWlHVmg96YoKs

[@Jeffmylife]

As not a chemist, I also would 100 percent buy one

[@ron200088]

Now that they have the technology, they could also create their own brand of bioluminescent "RGB" coolant. ;)

[@ThisIsTechToday]

If only science class was this exciting when I was in grade school, lol

[@doggoonus1414]

kzbin.info/www/bejne/fl6lpouZZp2Zh6s

[@desmanbotts4244]

Thats crazy because I learn about rna and dna last school year.

[@dadsfriendlyrobotcompany]

@@desmanbotts4244 it gets even crazier. I got my degree in genetics and genomics

[@experimental0000]

Little show called Bill Nye the Science Guy

[@markscheuerman7962]

What grade school is going to be able to afford pcr equipment?

[@pedroguincho6580]

Easiest like of my whole life, It’s amazing seeing Linus combining my two most loved subjects, biochemistry professionally and Tech as an hobby. What impressed me the most was how clear Linus’s explanation was of such a complex topic. Well done guys, you really outdone yourselves with this one!

[@MoChuang343]

What kind of biochemistry do you do?

[@thethoughtemporium]

Nyoka's stuff is so cool. I've seen their stuff go by a lot in the various bio groups. It's a neat idea for sure, though hard to say if they'll be successful. Don't get me wrong, the idea is clever, but scaling biotech is really really hard. Take it from someone literally trying to scale up a lab scale biotech project to industrial scale. It's very much non-trivial, even if the idea is very simple. Also the claim you can drink it is mega sus. And they will need a huge amount of certification that there is no contamination of the live genetically modified organisms in the liquid or it would be a felony to dump it down the sink. The EPA would be furious. And if it's just a lysed ecoli suspension it'll always smell awful. So ya, they've got some stuff to address. Also, I really hope those were "stunt" pipettes, cause those are expensive and dropping them like that will wreck them. Edit: They replied and clarified that they've already addressed all this, and this was just the demo version, so nvm I guess. Glad they're further along than I realized! Never gonna complain about more cool biotech companies doing cool stuff.

[@timfallonphd3085]

Yep, I totally agree on the difficulty of implementation of bioluminescence! Biology is a whole different ballgame from tech, as you well know! And yeah, dropping the pipettes not ideal but in my experience not too bad. Every biologist should know how to calibrate / validate their pipettes & do it whenever they have a suspicious fall like this.

[@DiggityDawgDiggity]

My fav biotech youtuber in linus comments? Is this a crossover episode

[@thethoughtemporium]

After what I just spent on pipettes, there's no way I'd throw them around like that. But that's just me. I do have a cheap chinese set though that are specifically for shots like that where you want to joke around. But I film bio stuff all the time. I assume for them the publicity of this video outweighs concerns about pipette calibration though, so w.e. To each their own.

[@timfallonphd3085]

​@@thethoughtemporium Not to worry, I'm sure Linus is working on a follow up video about calibration of that dropped pipette right now! Right Linus?? Linus? Haha but more seriously: people get all up in arms about mistreating instruments - either pipettes, or things several orders of magnitude more expensive like LC-MS instruments. IMO, minor mistreatment and yes occasionally breaking them is part of the natural learning process, so my philosophy is scientists should be comfortable with pushing the envelope, potentially breaking things, & evaluating when they need to be fixed & how to fix things, and not be afraid if they did break something to ask for help. I can understand in self supported research that changes the equation a bit as each dollar available is more precious due to the limited funding sources, but at least in science education I lean towards the response being "that's okay, let's see what happened". Or at least that is what I tell myself to feel better about when I accidentally drop my pipettes :)

[@matiastripaldi406]

@@thethoughtemporium i thought the same, was really surprised to see the team handling expensive lab equipment. But i guess they're within budget

[@lecuyermarcandre]

As an immuno and microbiologist, this is by far the best content ltt could have produced. Great vulgarisation of the scientific principle behind it as well. I would like twice if I could.

[@dkofkloveeqisgreat6123]

virologist and molecular biologist here, this might help some begin to understand how mRNA vaccines work as well. Tip of an iceberg but a start. other than that is there a version of these products that has both molecules stable before and after binding that can reveresed by say the application of heat. so in the cool part of the loop they bind and emit light but on the addition of heat dissacociate ( pass through heat block over chip), rinse repeat. i guess it depends on how stable the protein or capable of refolding after the techicaly heat denaturing. awesome work either way and shows molecular biology/ bio chemistry off well, in way lots can see and understand. ahh beer and now i cant stop thinking grr

[@argon552]

As a microbiologist that specializes in bioinformatics, this was one of the best colabs and video that LTT ever produced. Well done guys

[@StripesOO7]

Nice to see someone else doing the same thing. I am still studying but switched after my bachelor thesis in molecular biology/genetics to bioinformatics as my master 😅👋

[@argon552]

@@StripesOO7 in that case cheers 🤘

[@MiddleofKnowhere]

Please keep spotlighting initiatives like this with sustainable and environmentally friendly products. The tech industry is probably one of the most wasteful from materials for the actual product to the packaging (all that plastic!). It's something that ought to change and some companies have been doing better I've noticed.

[@okabehakaze6416]

As a molecular biologist that builds computers as a hobby, I just wanna say this build looks awesome

[@ninjashuriken]

fkn mad scientists

[@pauliewalnuts2527]

Why don't you do something similar?

[@marcosmedia7463]

Linus: We make PC that glow War Thunder: This is worth a sponsor

[@tomasalmeida2940]

Nah but is a minor detail

[@xanthosjason9530]

Bioluminescent bacteria: *exist* Linus: "slap that sh*t in a computer!"

[@hojiry490]

@Sahara Gurun no.

[@leonardtao4457]

Next step: RGB bacteria

[@sullychow4123]

Never expected LTT to go all Thought Emporium but love it. More of this whenever you guys can please.

[@DerekMorrelli]

Having a bachelors in biology and a masters in chemistry, this is possibly my favorite video I've seen from LMG. Great job at explaining the scientific process, pretty much as simplified as you can get and still describing the process accurately. You've just made RGB obsolete!

[@YeahRightMCD]

A whole video on environmentalism-meets-technology? Keep em coming, big guy.

[@pdabrowski4831]

Linus already has more going on in the environmentalism space than most tech reviewers/creators, there's been a good amount of highlighting sustainable packaging in their unboxings and his recent serious investment in the right-to-repair campaign with Framework Laptops shows a commitment to the future.

[@YeahRightMCD]

@@pdabrowski4831 You're not kidding. Most tech content creators realistically don't do enough to push the efficiency side of progress, as much as the *RAW POWER* side of the coin. P.s. A+ power move investment on framework. Right to repair, and Wu Tang, are for the children. P.p.s. #$_& a full landfill *throws up fake gang sign thing, or whatever*

[@volklii]

kzbin.info/www/bejne/pZbWlHVmg96YoKs

[@ln1721]

this is just upgraded RGB and i love it

[@gliderman9302]

Ikr? But it adds style points tho

[@basil127]

eco friendly rgb

[@brodyenli]

More like upgraded B

[@subboytris8946]

RGB 2.0 HAS BEEN RELEASED

[@paulgray1318]

We're just getting used to 4 wire RGB controller's and now they want to add DNA controllers - in the 60's you made your own colours :).

[@SnifferSock]

2 things: This is sick. The mixing effect is good enough to replace CGI.

[@EclipsaMyrtenaster]

"Haha. I made you guys watch a Science lecture disguised as a computer video." That ticks off two things on my list.

[@NathansWargames]

Linus, we need a legit LTT Lab Coat for when we're doing computer "science" like this.

[@simplybloxxed]

the amount of ads here though

[@HattertheThird]

This PC lures in gamers with its pretty lights to prey on their free time

[@thekraken8him]

This has got to be the most interesting PC build I've ever seen. What a creative idea, and great execution. The Techquickie style explanation of the DNA reactions was an excellent touch. Also, 9:47 should be the thumbnail for this video.

[@thanhvinhle2893]

Linus holding biology chemicals. Everyone: nervous sweating

[@kemalardaayar]

conspiracy theorists: oh shit L virus is coming!

[@clydemasterson1129]

Next week: Can Linus power a gaming PC with a Tesla Coil???

[@cyber_hacker]

@@kemalardaayar are you talking about that L-vid-2021 (aka. Linus video 2021)

[@kemalardaayar]

@@cyber_hacker oh

[@zerumsum1640]

even though i knew it'd be lab bacteria that are (relatively) harmless, I still cringed when he said it was e-coli. We get examples all the time of why Linus is a bad guy to pass dangerous/fragile things.

[@fireaza]

It was very brave of the staff to hand Linus their expensive scientific equipment to hold, knowing what might happen.

[@ikonikian475]

How is it brave? He's rich. He breaks it he buys it lol

[@zatoichi188]

PCR machine ain't that expensive, and once you have the actual engineered organism you can you usually produce buckets of it for pennies. The expensive bit is the actual engineering.

[@highping5137]

@@ikonikian475 do you know how much money it takes to make a business he probably only has 50% more money than the averege person so he would be broke if he broke one

[@Jawad.1]

Nothing 'might have happened'. Linus knows what he does. He's one of the most intelligent and responsible people I've ever seen.

[@joetownsend6325]

@@highping5137 he has a business and assets, to say he would be broke because he loses the money in his pockets is patently false. It simply means he can't buy a new car until next week.

[@mullokakkarin]

I actually really appreciate as ex Lab worker, that once in a while you make science videos. We actually need more people to get people interested in the science topic and also influencers to put more emphasis on importance of science... I believe that even those 'once in a while videos' can cause some changes for better in that field. (Believe me or not but scientists are in many cases underpaid, and they do not want to invest more than 10-15 years of gaining knowledge to not earn enough to live like a human)

[@TheKeKApex]

imagine if we put the ability to regrow limbs in humans, how many amputee's we can help alone. along with other things that can be cured with designer viruses. it's wild it's even a debate to keep pushing on this.

[@volklii]

kzbin.info/www/bejne/pZbWlHVmg96YoKs

[@wobblysauce]

While YT is good and all, more people in Science is not a bad thing.

[@kristycyw]

That was an impressive summary of DNA transcription, translation, RNA transcriptomics, PCR and genetic engineering

[@joosts4085]

These videos are such an amazing lesson in disguise. The amount of people that now know about this that otherwise wouldn't hear about this for months or years is amazing and will hopefully boost this kind of research.

[@timfallonphd3085]

I totally agree. The type of reach this video has is incredible! Millions of people learning about bioluminescence! So great!

[@Haskellerz]

LTT in 2030, we are gaming on the latest Ryzen 90000 bacteria processor attached to 1000 TB permanent DNA storage

[@TheBackyardChemist]

@@Haskellerz DNA tape drive. Retains data integrity for 10 000 years at -80 °C.

[@optillian4182]

Linus really woke up one day and said "hmm yes I'm gonna put glowing germs in a computer".

[@optillian4182]

@CHIYOKO Begone, bot.

[@yknx4]

He is running out of new things to put into computers

[@Ulandos]

7:12, Linus deciding whether or not he's holding a condom or E.Coli

[@trailfork7815]

I'm still bothered that it looked like a used condom

[@pepkin88]

linus sex tips

[@randomblock1_]

4:52

[@adityadivine]

Me who never got a chance to use it. Ahh life sucks

[@106640guy]

COOOOM

[@MoChuang343]

This is a long comment/suggestion. But I hope you read the whole thing. Using luciferase, luciferin, ATP, and O2 to catalyze an enzymatic luminescence reaction inherently runs into the problem of running out of substrate which then requires refilling the loop with more substrate as you mentioned. The glow stick company needs to use the luciferase system since no additional ingredients are required other than the ones already provided in the stick. But for a PC, you can take advantage of one key ingredient that is already present in any self-respecting gaming PC, RGB light. I would suggest using fluorescent proteins which can absorb specific colors of light and then emit a longer wavelength color light. The most famous is probably green fluorescent protein (GFP). If you filled your loop with GFP, it would look like a dull yellow-green fluid. But once you turn on the blue RGB in your PC, that blue light will get absorbed and then be emitted as a visibly green glow. This glow would be recharged every time the GFP solution encounters blue light from the various RGB lights in your PC along the loop. I have no idea exactly how this would look, but you could play with the proximity of RGB sources to the GFP loop to see if that affects the intensity of the glow. And you could use different RGB effects like strobing to see how that changes the glow of the GFP as it absorbs light unevenly and flows through the loop. You might be able to make a pulsating wave pattern. Or the least exciting would be that the blue RGB in the case simply bleeds all over the place and the entire loop lights up uniformly regardless of what RGB effects you try. EDIT!!! I just thought of another ingredient a PC has...heat! You could tag the GFP to a liquid-liquid phase separating protein. These proteins form droplets like oil under certain conditions, one of which is temperature. Thus you could have this glowing green liquid that mixes well at high temperatures but demixes into droplets at cooler temperatures. So you could observe the relative temperature of your coolant in the loop...or an 80C CPU block will just denature everything it touches...

[@user-cv3ph9bh9r]

I think you could even get a work around to the GFP being thermally stable when it touch a cpu blocl. According to a study by Ishii et al., "Study of the thermal stability of GFP in glucose parental formulations" in 2007, you should be able to have GFP fluroesce even up to 100C in the right conditions. so it could not denature, or denature more slowly as it lights up!

[@occasionalglory5261]

Linus: "Traditional glow sticks are full of toxic material." Me: *Starts having flashbacks to cutting open glow sticks and smearing it on my face as a kid*

[@willy.c]

I remember well biting into one and having the liquid shit in my mouth to scare my friends...p

[@aarontimm]

bruh WHAT

[@hpsmash77]

tf!!!

[@Soosss]

i used to bite into them like an idiot

[@t_y8274]

One part carcinogen, one part high concentration peroxide. Yum!

[@DrNarf]

LTT, you're laying the groundwork for producing better, higher quality, educational videos than McGraw-Hill when it comes to Biochemistry. If you need someone with an MS in Biochem, lmk because, yeah. Awesome work. We need more content like this. I already enjoy your "tech longer". Go full send. Keep at it, bro.

[@20quid]

I love how he's holding a model of a tardigrade when he's explaining how they get the genetics from a crustacean and put it in a bacteria, neither of which are tardigrades.

[@Kuli24000]

Nervous laugh.... yeah that.

[@la24dogg21]

Lmao I knew I would learn form someone here

[@paigewhitehead2157]

yeah we didn’t have a model of those on hand! We brought our tardigrade in the hopes it would make it on screen - it was hand made by someone on our team 😆

[@benezzy]

I was waiting to see when the tardigrade Linus was holding was gonna be talked and it just never happened lol😂

[@tomrl6674]

@@paigewhitehead2157 tardigrades are pretty cute

[@Cobyc5150]

I want more science lectures from linus, he's surprisingly really good at explaining everything. He uses some very easy to understand examples.

[@bigboij3027]

The magic of writers

[@Benzene2997]

As a researcher in a microbiology lab, I am so happy LTT made this video. He did a pretty good job of explaining pcr in lamens terms. I didnt expect to see the wonders of microbiology shared by a tech channel but I am very glad they did.

[@volklii]

kzbin.info/www/bejne/pZbWlHVmg96YoKs

[@mindgame112]

As someone wo used to work in Molecular Biology: Linus dropping the pipet: SHIT now you need to recalibrate it...

[@mayanksoni2399]

forget recalibration, my lab ones would just shatter and break

[@MitgliedT5]

If we broke a pipette in the lab, we had to go to the professor and pay for a new one ourselves, depending on the situation.

[@arksy8703]

@BIG ASS you will never be a real woman, 48% yourself

[@Spork0]

@@arksy8703 its a robot btw. not a real person

[@ilodabomb]

Dropped so many pipettes in my life... recalibated a whopping number of 0 pipettes 😄

[@DVMJon]

I LoL'd literally. When I realized Linus was giving an actual lecture in polymerase chain reaction (PCR) 😂

[@Grocel512]

Linus next week: "Let's overclock and water cool a PCR machine." **shows live Covid-19 samples** "This will be our benchmark!"

[@CsTvInc]

truthfully, I love it when they head out and meet up with companies with cool ideas and goals. these are some of the best type of videos

[@Slinder14]

We did a bioluminescence experiment in my bio lab a few years ago. To me it’s one of the coolest things in nature, and bringing it to a pc is amazing. Awesome video

[@doggoonus1414]

cool r6 clip ---> kzbin.info/www/bejne/fl6lpouZZp2Zh6s

[@luxbio]

we so agree. what kind of experiment did you use bioluminescence for?

[@jordanm2984]

As a biology undergraduate and a PC enthusiast, this is one of the coolest videos you guys have released!

[@Aepus]

That pipette technique tho

[@floofthefops]

Am I the only one that absolutely loves when Linus goes to explore what other companies are doing? These videos are always very cool and usually talk about stuff I would never hear about otherwise. The episode about quantum computing was absolutely fascinating to me.

[@Swordsmanjan]

As a biochemist working in enzymology I truly enjoyed this episode. Great job everyone, both for the entertaining content and the high degree of scientific accuracy. Seeing educational content like this is great!

[@devinou-programmationtechn9979]

Linus : "Minor details like our sponsor : war thunder ..." War Thunder : "Am I a joke to you ?"

[@zUnderscore]

tbh war thunder is a joke

[@Everyone9z9]

"I will not be making any *AHEM* unscheduled visits to the bathroom." - Linus. This implies the existence of SCHEDULED bathroom visits. Hmmmmm

[@sphrcl.]

Bro someone copied this exact comment word for word and they got a lot more likes than you because they have a check mark next to their name

[@Everyone9z9]

@@sphrcl. oh well. As long as I'm the og, I don't care.

[@stefa4013]

I mean on work days I have set times I go to the bathroom so yeah you can totally schedule them

[@cubeventure]

@@Everyone9z9 i respect that you don’t care

[@clared5812]

@@sphrcl. why does it matter, internet points are completely meaningless

[@mohidwaseem7997]

Its amazing when professionals from two different walks come together to do something fun.... Like linus us so excited during the chemistry part and the people there are all serious and want to get it to work, then as soon as the PC comes in Linus goes serious 'lets let it run for the air bubbles' mode and the team there is all excited. Just a wholesome and lovely collab

[@thecomfyshirt]

It SO beautiful!!!! I wish it was practical to actually have on of these. This is why I love LTT. Today I learned about chemistry on a PC building channel. What a great vid!

[@balintmajor5416]

Linus speaks like he knows what is he speaking about, he is a very good actor.

[@DamnCyrus]

That shot of the reservoir lighting up was so fucking good, hope those people get the work done to make the bio-luminescence usable in the future

[@niaomipeck]

Linus, I started watching your videos before I built my first PC just over a year ago. I had no idea how any of this PC building stuff worked, but seeing your informative videos, as well as your huge amounts of passion for what you do have been a great help at teaching me about computers. It's through you and other passionate, knowledgeable enthusiasts that I went from PC illiterate a year ago, to pursuing a degree in computer engineering with over a dozen builds under my belt. On behalf of all the people you've taught and inspired, thanks for staying cool and keep up the good work! P.S. never shave that wonderful beard

[@bkrc123]

Thank you for giving nyoka labs recognition. Will be following their progress.

[@errhka]

This is one of the raddest videos you've ever done. As a former biochem major the explanation was excellent and the chemistry was awesome to see.

[@FranciscoTC]

If you want to do this at home you'll only need: *200 dollar variable volume pipette*

[@timfallonphd3085]

There is always Ebay :) Rather than a variable volume pipette, a standard medicine dropper, releases about 20 to 50 microliters per drop - more than enough accuracy to do this type of experiment at home.

[@zechsta28]

you could use a thin straw as long as you make a good estimate on the volume. a bikewheel as centrifuge, and pots and pans with different temp water in them for the thermalcycler (Its gone take a while though getting your sample from pot to pot 40+ times)

[@timfallonphd3085]

@@zechsta28 Yep! I think there are lots of ways to make this work at home, without the "professional" equipment, just have to get a bit creative. After all, biologists in the 1800 - early 1900s had pretty crude tools but were able to figure out a huge amount of stuff!

[@kehrnal]

Also if you used the centrifuge he showed, you'd be spinning small amounts of that culture all day long... Not 10 min

[@adamengelhart5159]

At least the column is only five cents? Oh, wait. I think I might have that confused with something else. :-/

[@xitup1]

Man, the part when Linus turns it on and the blue spreads through the system.... Gave me chills, watched it like 20 times!

[@mirrorsandstuff]

This is one of the neatest projects the LTT team have come up with recently and I really hope whoever led the project's research is proud of themselves. The organic chemistry was well explained and the level of detail was at the right level whilst still being engaging.

[@anwari3264]

keep it coming, Linus. environment-friend techs, repairable techs, things will eventually get better. hopefully.

[@eisenklad]

Linus should get Solar and possibly Wind power on his home

[@Elwarez1994]

As a Biochemist i loved this episode of LTT, linus it's an excellent host explained hard stuff to the general public and making interesting to keep watching to the end. pure gold

[@TechDove]

My PC glowed once too, when my power supply shorted and caught on fire. Much cooler looking than this, but far more dangerous and expensive 1/10 do not recommend

[@johanesrafael9679]

Wow, power supply AND arc welding machine in 1 package! Now that's the deal of the year 😂

[@TechDove]

@@johanesrafael9679 hell yeah! I got so much done that the fire department came to congratulate me

[@karine3126]

AISURU.TOKYO/mizumi/?[🤤] (◍•ᴗ•◍)✧*。18 year and over KZbin: This is fime Someone: Says "heck" KZbin: Be gone #однако #я #люблю #таких #рыбаков #Интересно #забавно #девушка #смешная #垃圾

[@karine3126]

AISURU.TOKYO/mizumi/?[🤤] (◍•ᴗ•◍)✧*。18 year and over KZbin: This is fime Someone: Says "heck" KZbin: Be gone #однако #я #люблю #таких #рыбаков #Интересно #забавно #девушка #смешная #垃圾

[@Telhias]

My PC glowed too! There was a fault in the power supply and it sent so much current to my graphics card, that it melted glowing red hot. Don't cheap out on power supply guys. The money saved on it was not worth that GPU.

[@MakDemonik]

As a student of Biotechnology I have to say you did a great job of simply yet effectively explaining the whole process of cloning genetic material via the PCR method and how the entire bioluminescence process works. (You could have just mentioned that each cycle gives you orders of magnitude more material - doubling it every time - than just having "more" in general) Loved the video.

[@jackgotgamez]

I bet with a lot of those “glow sticks” and the luminescence you could actually make yourself a diy glow in the dark lightsaber from Star Wars.

[@oMega-sm1eg]

Then it will be pretty heavy since it's filled with water, and not retractable of course. Now some excellent-looking lightsabers already exist using diffusion of a beam of LED light to light up the entire retractable blade.

[@nickthemage2052]

I feel like LEDs, a toggle switch, and a sanded plastic tube (to make it opaque) would be lighter and far cheaper lol

[@oMega-sm1eg]

@@nickthemage2052 Yes, that's what cheap sabers are, a LED strip in the middle and plastic outside. It's not retractable though, thus not a true lightsaber but a fluorescent lamp with color, attached to a handle

[@nickthemage2052]

@@oMega-sm1eg yes I’m aware.

[@DownwithEA1]

Legit one of the coolest things I've seen in a while. I wish Nyoka Design Labs the best of luck on their ventures.

[@luxbio]

Thank you!!

[@kelvinnkat]

"I will not be making any unscheduled visits to the bathroom" Does that mean that he schedules his bathroom visits in advance?

[@CallanElliott]

You'd generally want to take your toilet breaks before a shoot, I'd reckon.

[@kelvinnkat]

@@CallanElliott Timing something is different from scheduling it.

[@Auroric]

This is so rad! Stoked to see Nyoka getting some good exposure, would love to this take off

[@luxbio]

Thanks Auroric! How had you heard of us??

[@bushidobrown9857]

This is one of the coolest videos LTT has made in a long time, and y'all have put out some really cool videos

[@Ash_Lawless]

Y'ALLLLLLLLLLLLLLLLLLLLL doggy YEEHAW

[@rogue3398]

Now THIS is how you make specialized information accessible and entertaining to your demographic! Great job, LTT!

[@randaranatunga7259]

Alternate title: “Tech men fellows potentially harm millions of Bioluminescent bacteria”

[@Nxrreshh_]

😂😂😂

[@ultra_gagayay]

Its not potentially he will harm them.

[@MistrzDemotywacji]

depends of the scale of the culture, but should be much more than milions :P and yes, they're killed (by cell lysis) every single time you need to purify protein that sits inside their cells. there is also a production method where cells secrete protein of the interest outside of their cells - in this way you do NOT want to brake them up, so there's this approach for pacifist scientists :D

[@timfallonphd3085]

E. coli can't do too well outside a human body & your body probably has billions if not more of them! Sadly they probably don't do to well when they end up in the toilet rather than your body.

[@dkursada]

It was such a fun episode, legit props for the explanation w/ great animations! As someone long time PC enthusiast who's just started studying biotechnology, this video is such an eye opener for me, for the bioluminescent gaming PC is such a cool demonstration of what happens when you bring knowledge of two seemingly distinct subjects together with a fun idea or two. What you do doesn't always have to be practical. A PC with glowing water cooling is just plain awesome. It's good getting to know Nyoka Design Labs folk, too. They're doing awesome work with reusable and longer-lifespan material! p.s: Linus Biotech Tips lol, I could get used to this. Would be such a fun channel

[@Cazamalos]

Guests: engineering new bio-molecules to make cool stuff Linus: spilling water all over a $3000 pc Exactly the content you are looking for

[@kyzinga266]

Linus woke and said: “Hell Ya Science”

[@karine3126]

AISURU.TOKYO/mizumi/?[🤤] (◍•ᴗ•◍)✧*。18 year and over KZbin: This is fime Someone: Says "heck" KZbin: Be gone #однако #я #люблю #таких #рыбаков #Интересно #забавно #девушка #смешная #垃圾

[@Dangineering]

I have a degree in molecular biology and I am surprised that I got to watch a LTT video where you explained PCR and column chromatography rather well!

[@FriendBe]

This is pretty amazing ngl. The applications for something like this has me pretty excited for the future.

[@phil_matic]

Probably one of the most literally jaw dropping things I have ever seen when it comes to PC tech. this was phenomenal.

[@supaavtr700]

Do more of this. The showcasing of scientific breakthroughs that would have otherwise gone unnoticed by the general public

[@spongerglory]

The whole Anglerfish bit in the beginning won a “like” from me!

[@timfallonphd3085]

Fun fact! The type of bioluminescence (in terms of the luciferase and luciferin) is different from both the types linus showed here: Firefly (yellowish green glow) and the Marine copepod Gaussia (blue glow)

[@DrivenKeys]

Perfect reservoir for this, and great camerawork. Absolutely amazing developments. Keep making these videos.

[@93izak]

Yesterday: Let's build a water cooled PC Today: let's build a Bio Luminescent cooled PC Tomorrow: Let's build a small civilization that would work to cool the PC. Special guests the writers of that Rick of Morty car battery episode

[@Frostycrypton]

Day after tomorrow: Urine- cooled pc

[@geatsuneee]

2 Days after Tommorow: Blended Feces-cooled PC

[@justcanaan]

3 days after tomorrow diarrhea and urine crossover cooled pc

[@RyuukoKobayashi]

Absolutely love to see biology, genetics, and tech cross paths.

[@OSSTaz]

As an ophthalmology resident who used to love molecular biochemistry back in med-school and a PC/tech enthusiast (if I may), it is euphoric to see scientific topics I relate to on my favorite tech channel. Somehow I feel rewarded and appreciated for my role in life. I'm totally sure these young scientists are having a blast, too. Science is cool, it only needs more recognition... *cough" and a sprinkle of RGB and 4K footage. By the way, this is also quite the same way the new vaccines work. Only instead of Luciferin code and E. coli, it's Antigen-fragment code and human cells. Don't be afraid guys, it works.

[@captainheat2314]

*ye but i dont wanna glow like those cells*

[@TheBackyardChemist]

@@captainheat2314 why not it sounds rad as fuck

[@OSSTaz]

@@captainheat2314 Unless you want to, you won't. Instead of injecting oneself with the actual virus (old vaccines) you are just ordering your cell protein-builders to build its arms or legs to recognize it once it actually shows up. By the way, this has been happening in your cells every time you caught a cold. Yes, viruses inject code and replicate the same way. Had cold viruses RGB-coding segments, we would have had RGB nasal secretions. Unfortunately?

[@madhazza64]

I really enjoyed this! I love science, Linus delivers things so well and I honestly wasn’t bothered at all that computers were hardly involved. I’d super appreciate more videos of this style thrown into the regular mix more often ☺️☺️

[@powermaker6967]

"Minor details, just like our sponsor" It doesn't make sense but I like it.

[@MiGujack3]

It felt like... small details, like this trash game, let's move on.

[@serdarcam99]

@@MiGujack3 war thunder isnt trash game its trash game u cant stop playing cuz there is literally no other game that has mechanics war thunder has but economy worse than venezuela

[@stevenhess1446]

I love how he's going against the grain opening things and they are like "Don't open it" because he has a track record of causing chaos xD

[@AlessandroDeCicco]

Great coverage! Love that you are exploring new areas, and hope it brings new viewer to the channel

[@jora9655]

I absolutely adore how you give us the background knowledge to understand how bioluminescence works and even how the gene manipulation involved functions. You're a tech channel, but you have such a broad horizon. Love it!

[@tywer1297]

*gets safety glasses last* “safety first, ladies and gentlemen”

[@mattjc]

Proceeds to roll up sleeves and leave labcoat unbottoned, leaving the most likely areas of exposure unprotected

[@pookachu2392]

As a former bench scientist, thanks for doing this and making the work accessible to people! :) Makes me miss going into lab.

[@MiraiKishi]

Linus: "You had one job, Alex." *Proceeds to list off many tasks*

[@BaconDanish]

My thoughts too.. 😂

[@Cheesyxable]

"that's the joke"

[@AllDayBikes]

The moment it flowed through the system was amazing. Although it kind of reminded me of an XP startup haha

[@minhkhoalecong6334]

As a Biotech student I genuinely freaked out when Linus dropped the pipette lol. Not that it was unexpected, but cuz those bad boys are so expensive and prone to break as well as to be wrongly adjusted. A small touch and they could go haywire

[@pimplordcthulhu2369]

Bacteria: "What is my purpose?" Linus: "You cool my pc off so I can run old school Runescape at 4k and 60fps" Bacteria: "Yeeeeeeeesssssss"

[@blackdragonxtra]

"Just keep the screen visible from the loop, bruh, and we cool."

[@galacticviper4453]

This was actually very educational and interesting! Would love to see more things like this, where you explain the science behind it.

[@WendtKyle]

This and the Framework laptop video from a day or two ago are a new and really awesome direction for this channel.

[@slyfoxyandalifesaver]

Bioluminescence is so captivating, natural biological chemistry that occurs but is found practically exclusively to marine life. It's just so enigmatic, I would have watched this video even if it wasn't posted my LTT.

[@maybedonn]

This is cool as hell but my brain can't stop thinking about how this is just "Linus Tech Tip: genetically engineer bacteria to get RGB watercooling"

[@Cha0s009]

This was amazing! I’d love to see more crazy science builds!

[@smurphsFTW]

My brother in christ just explained my entire design project for my engineering degree for a fucking meme build