An introduction to the cerebellum and an overview of the main models of cerebellar function.
Пікірлер: 68
@jpark76363 жыл бұрын
This guy just went through all of my week7 lectures in 10 min. Well actually 6mins bc last my uni did not cover last 4 mins
@xiaoxiaoxiao6863 жыл бұрын
This is the field I want to study. I was thinking about going for neurology or studying electrical engineering. This is a wonderfully tasting cocktail of the two!
@RoadkillbunnyUK5 жыл бұрын
This was so useful, I have just had changes to my cerebellum found in MRI and this has helped me understand how those problems link into my physical symptoms.
@thedeadman83617 жыл бұрын
Great channel! Has really helped me revise for my Biological Psychology exam
@ammerrstf8386 жыл бұрын
A 2nd yr med student from Karolinska Institute thanks you
@cupofkoa7 жыл бұрын
Excellent videos! Looking forward to the next one!
@prajuxo_14054 жыл бұрын
This topic was so confusing before. Thanks to this video. Explained very well. 😌👍
@jphb952 жыл бұрын
comprehensive and brilliant review. Thanks!!
@ayeshaabbasi42206 жыл бұрын
This the best i could find so far.Really helpful.great job ✅ done
@ladymusiclover6 жыл бұрын
BEST VIDEO ON THIS!! THANK YOU!!
@supertramp68333 жыл бұрын
EXCELLENT AND BETTER THEN ALL THE TEXTBOOKS ! THANK YOU
@robinhoman85943 жыл бұрын
Beautiful video. Im excited to see if you will make a similar video discussing output of the vestibular system.
@oscarsolaresdelaguila87115 жыл бұрын
Thank you so much, clarified it very well.
@Brainisnotacomputer3 жыл бұрын
Excellent concise lecture!
@rnbbexyjlobt7 жыл бұрын
Great video! I love your clear drawings and concise narration. Can I suggest you leave the each drawing up in silence for like 1 additional second before transitioning, so we have more time to process what you just said? In addition, if you ever feel like upping your production quality, you might want to look into transitions between drawings to put the each drawing into context with the next (moving to a different part of the brain and in which direction vs zooming out/in, etc). The conclusions are great and have the same effect, but then we are a bit confused for longer until it is put into perspective at the end of the section. Great work though, keep it up! :)
@Nordic_Scandinavia4 жыл бұрын
Spot on!
@niemand79383 жыл бұрын
this is such a good video, thank you!
@hamzaafridihuzaifa91156 жыл бұрын
this is the best channel and deserves a sub :)............... you earned a subscribe
@maxcuzak28057 ай бұрын
thanks for making such a great video 😀
@XwitterEye2 жыл бұрын
Why was this such a fantastic explanation?
@dr.jageth93063 жыл бұрын
Its just awesome dude🔥
@KellenVu3 жыл бұрын
amazing video !!
@rsharma4496 жыл бұрын
please add more videos explaning other portions of CNS...very useful.!!!!!!
@omnesomnibus28454 жыл бұрын
Fantastic!
@charlotte97774 жыл бұрын
this video is the best!!
@NguyenTastic4 жыл бұрын
very interesting, thank you
@bonnieprobably Жыл бұрын
Thank you! 🙏🏽
@dr.ranjusreemandal25125 жыл бұрын
thankuuù so so much🙏 life saving video
@kshitijb.36823 жыл бұрын
Thank you !
@AliceInGymLand7 жыл бұрын
Hi, such a helpful video! One question - if the purkinjie cells are the only output from the cortex to the deep nuclei, what does the direct input from the mossy fibre to the nuclei do?
@BrainsExplained7 жыл бұрын
That's a great question! The mossy fibres provide excitatory input to deep cerebellar nuclei, this connection has been much less studied that the purkinje cell synapse, but there is some evidence that synaptic plasticity (LTD) at the mossy fibre - deep nuclei synapse is also involved in motor learning. As I mentioned in the previous comment, after the inhibition of the deep nuclei by the purkinje cells, there is rebound excitation where the cells of the deep nuclei increasing their firing rate In order for the synaptic plasticity to take place at the mossy fibre - deep nuclei synapse, the mossy fibres have to stimulate the deep nuclei at the same time as this rebound excitation. To sum up: If the mossy fibres excite the deep nuclei, just after they have been inhibited by the purkinje cells, synaptic plasticity occurs in the deep nuclei, which also stores information necessary for motor learning.
@AliceInGymLand7 жыл бұрын
Ahh right, thanks for the explanation! Your videos have saved a couple of 3rd year undergrads' lives btw!
@chinyamakazombo1925 ай бұрын
A really splendid explanation. Thank you very much. On 5:12 , how does the body know that it has made a motor error?
@sharedivinelove4 жыл бұрын
Very precise and well explained.
@cherry-ks9yb7 ай бұрын
Saving me before my exam 🙏🙏🙏
@Lola_Wilson647382 жыл бұрын
thanks very much very helpful
@ivakamie35683 жыл бұрын
amazing..
@pavarinodu4 жыл бұрын
OMG! Thanks for explaining this subject! Medical students praise you haha
@joeyransdell1336 жыл бұрын
Nice video! I do take issue with the notion that parallel fibers excitatory input is what is responsible for Purkinje neuron firing. This is not true. In the absence of synaptic drive Purkinje neurons continue to fire repetitively and at high rates. Instead, it seems parallel fiber input modulate Purkinje neuron firing rates and may also modulate the degree of synchrony across adjacent Purkinje neurons which has implications for the pauses in firing in DCN neurons caused by Purkinje neuron inhibition. The capacity of Purkinje neurons to fire in the absence of synaptic drive was well-understood even in the 1960's
@walidaouiz96084 жыл бұрын
thx
@jeyananthannavaratnam70552 жыл бұрын
Very speedy explanation
@krautbonbon3 жыл бұрын
life saver
@danielschefte29877 жыл бұрын
Thank you for this video, really high quality in this one. I do have a question tho: What does stimulation of purkinje cells when fine tuning a movement actually lead to? Because it is an inhibitory neuron it should lead to less activity of the deep cerebellar nuclei which leads to less motor activity? How does this make sense?
@BrainsExplained7 жыл бұрын
Thanks! and well noticed, If things were just as simple as shown in the video you would be right, however this doesn't happen because of something I did not have time include known as "rebound excitation". Essentially when the deep cerebellar nuclei are inhibited by Purkinje cells, after the initial inhibition they can actually show an increase in firing rate, which is known as rebound excitation. This isn't fully understood but it's thought that the inhibition probably activates specific calcium channels which allows positive charge to flow into the deep cerebellar neurones, allowing them to depolarise.
@danielschefte29877 жыл бұрын
Thank you so much! I've watched all your videos and it has really helped me alot. You deserve so many more subscribers :)
@vsavchik5 жыл бұрын
In case of most clear spinocerebellum dcn just inhibits red nucleus (the only input to motoneurons, except motocortex) and hence stops cortex command to motoneurons, therefore cerebellum as a whole weakens irrelevant activity or stops irrelevant automatic movements. More interesting that red nucleus projects to flexors while vestibular nucleus and reticular nuclei to extensors. It means that cerebellum makes proper balance between flexors and extensors/
@vsavchik5 жыл бұрын
Maybe if mention spinocerebellum, cerebrocerebellum and vestibulocerebellum and consider their circuits separately, it would be more simple to explain what happens, in contrast to attempt to explain combined circuit. You will surprisingly find that all parts have the same climbing input - from IO, i.e. from muscle proprioception, but mossy fibers go from layers of execution cortex hierarchy. Btw, one serious mistake - thalamus does not project to spinal cord.
@giorgosgranitsiotis3 жыл бұрын
thank you so much sir
@giorgosgranitsiotis3 жыл бұрын
and im not indian
@thatzinged93054 жыл бұрын
Good one
@monilvalia94252 ай бұрын
thankyou saviour
@rgudduu Жыл бұрын
Need revisits to understand
@freckletonj5 жыл бұрын
At kzbin.info/www/bejne/h4bOqKR3lrili8k, doesn't motor cortex project directly down the spine (and never the thalamus)? I assume it's a typo. (amazing amazing videos btw, thank you)
@walidaouiz96084 жыл бұрын
kzbin.info/www/bejne/sHykaZyXrct4rdk just watch this and you'll get it , it is more complex
@walidaouiz96084 жыл бұрын
yes you are right
@queennix89473 жыл бұрын
Here to learn what's happening to my partner who has cerebellum ataxia
@nadagamal56152 жыл бұрын
subhanallah .. thank you for this illustartion
@Jasim_Basheer2 жыл бұрын
Woah bro I got mind fucked
@SumitSharma-cs3gu4 жыл бұрын
Sexy content... Keep it up
@mmse62516 жыл бұрын
nice video, but you are talking way too fast..
@Hudamk994 жыл бұрын
You are so fast,
@marwa58345 жыл бұрын
this is soo fast
@walidaouiz96084 жыл бұрын
this video does not explain well the function of cerebullum , go to ninja nerd science video of cerebeullum if you want to get it
@pamelaramona39256 жыл бұрын
please create a better video where you speak slow and coherently. I just cant catch up to the speed. Thanks!
@soumyasami4 жыл бұрын
reduce the speed to .75x
@anandsingh40716 жыл бұрын
Too fast man
@SilvaMorasten6 жыл бұрын
PLEEAAASE can you pronounce Purkinje cells as PURKINIE instead of PURKINJEE!!!! your video is excellent and it is very helpful for me, but the pronunciation of the czech name is really disturbing
@swetasinha94933 жыл бұрын
It is purkinjee as written in all the books I studied so far