The Cure Chronicles: HIV with Maria Mejia

[@bladebrown4341]

Hope a cure is discovered within 10yrs. At least once a year treatment would be great.

[@alexsandro5063]

Esquece meu amigo só Jesus Cristo

[@JudeBoi1313]

We are estimated to have a cure by 2030, possibly a little bit earlier than that depending on the progress.

[@ryanb9930]

I'm considering going on the new treatment where you get a shot every 2 months. I want to wait a bit to see how well ppl tolerate it.

[@bladebrown4341]

@@ryanb9930 The FDA approved ARV 6 month injectable Sunlenca aka Lenacapavir

[@ryanb9930]

@@bladebrown4341 True but that is only used for ppl who's hiv is resistant to other treatments and it's used in combination with other drugs as well.

[@mpat100]

Blessings good health and good luck for Maria

[@inexpensivebeauty5046]

Please let your interviewers talk instead of cutting them off, otherwise great content

[@tantodiodiosalmundo5]

Sars really needs to send you to seitan

[@alexsandro5063]

Só em Jesus Cristo há a cura

[@aysesefiloglu747]

Ne zaman gelecek kesin tedavi lütfen 🤲🤲🤲😭😭😭😭

[@alexsandro5063]

Esquece, só Jesus cura

[@jorgevillaran3748]

We don't know, but the world needs a vaccine and a cure right now, the number of people who get this virus had increase and each time that we let time pass, are more probabilities that more and more people get infected

[@harunctrashid9474]

What about trail in an interview he speaks about cure till 2026

[@jorgevillaran3748]

I hope the cure cames this year... The world needs a cure and a preventive vaccine for HIV

[@laishramdilipkumar6104]

May God bless u

[@mamemariemecellou656]

Oui😮😢 oui lui oui 😮😢lol i 😢 li lui il ool yiii ko😮 o😢😢😢 l Loulou il io 😢 oui y lo iii lolou😢ii😢 28:22 i😢 i

[@mamemariemecellou656]

@@jorgevillaran3748 lo

[@Mr.Majestic77]

​@@jorgevillaran3748 Excision BioTherapeutics' EBT-101 or American Gene Technologies' AGT103-T? Which possible HIV "functional" and/or "sterilizing" therapeutic cure will be the first to come out of human clinical trials and FDA approved for safe usage? [1]. Excision BioTherapeutics' *EBT-101* as a potential "sterilizing cure". EBT-101 is currently in human clinical trials and in September 2022, Excision BioTherapeutics dosed their first participant in the EBT-101 Phase 1/2 Trial. EBT-101 is CRISPR-based, single administered therapy, designed to cut and removing HIV DNA out of human cells. This potential gene editing treatment employs an adeno-associated virus to deliver CRISPR-CAS9 nucleases and dual guide RNAs targeting three sites within the HIV genome that tell the enzymes where to cut. The website reference and for additional information on Excision BioTherapeutics and EBT-101, please go to www.excision.bio/ , as well as clinicaltrials.gov/ct2/show/NCT05144386 . [2]. American Gene Technologies' *AGT103-T* as a possible "functional" cure. AGT103-T is currently in human clinical trials and in June 2021, the first patent was treated with potentially curative HIV cell and gene therapy. AGT103-T is a cell product made from an individual's own cells and modified with AGT103 lentiviral vector for HIV resistance. The Phase 1 trial found that AGT103-T was well tolerated in humans and persisted in the body. AGT103-T is designed to restore the Gag-speciffic CD4+ T cell response in persons with chronic HIV who are receiving antiretroviral therapy. The website reference and for additional on American Gene Technologies and AGT103-T, please go to www.americangene.com/pipeline/hiv-aids/ There is also the possibility of stem cell transplants from donors with the *CCR5Δ32 gene mutation* , as "sterilizing" HIV cure. On February 20, 2023, a 53-year old man in Germany, named the "Dusseldorf Patient" (Georgia native, Paul Edmonds, of the United States, that later relocated to San Francisco) has been documented as the *5th person totally cured of HIV* by receiving a stem cell from a doner with a *CCR5Δ32 mutation* , which blocks HIV from infecting the body. The 53-year old patient was diagnosed with HIV in 2008, and after their HIV diagnosis, was placed on antiretroviral therapy (ART) which suppressed the viral load within their system. The patient enrolled in the University Hospital Dusseldorf IciStem program, which explores potential HIV cures requiring stem cell transplants. This 53-year old patient was diagnosed with acute myeloid leukemia about three years after his HIV diagnosis. Remission of the cancer was achieved through initial rounds of chemotherapy, but was followed by a relapse shortly after. During the 53-year old patient's treatment of his cancer, he received a stem cell transplant from a female donor with whom they matched, and the female donor had the CCR5Δ32 mutation. This stem cell transplant occurred about two years after the 53-year old patient's cancer diagnosis and five years after being diagnosed with HIV. This stem cell transplantation, was a person with the CCR5Δ32 mutation is a complicated procedure, normally reserved for cancer patients, and comes with many risks, and is too risky to offer it as a option as an HIV cure for everyone. Some individuals were born with the CCR5Δ32 mutation, which naturally blocks HIV, there were those that are considered LTP (Long-term Progressors), which they will carry HIV for decades before their HIV progress to AIDS (with HIV medications).

[@sJ-ls8pw]

This was 35 years ago. 1989

[@alexsandro5063]

O mundo jas do maligno