The Drug Trial That Went Horribly Wrong

[@kaylajohns1020]

I can’t imagine being the person who received the fake medicine, and having to sit there, listening to all this wondering if you are next.

[@scoobty4449]

Wait I don't get this where do they say that they were given the fake drug?

[@kaylajohns1020]

two people recieve something completely else while the others recieve the drugs. But no one knows who got what but the doctor/nurse. i believe its explained in the beginning of the video.

[@baljeep_gay]

neither the docs nor the nurses knew, only the one who packaged them.

[@neontv15]

at 8:03

[@kaylajohns1020]

ah thats right, thanks.

[@burns1921]

I have been receiving a type of monoclonal antibody infusion every 4 weeks for the last 10 years to treat an autoimmune disease. This medication saved my life and allows me to continue surviving. The people who are willing to submit themselves to clinical trials like this are part of the reason I’m still alive, and I have so much respect for them.

[@loveisreal7766]

True but 😅😅😅😅

[@sondragraf7609]

My son has a number of symptoms that are autoimmune in nature rendering him at 35 unable to work and using a cane but some days unable to leave the bed. He has been given possible bur never firm diagnosis for everything from MS to Parkinsons to Meneirs to heavy metal intoxication as he shows signs of all. One of the neurologists who seemed most hopeful finding neuropathy and all the signs of his own immune system attacking his digestive and nervous systoms suggested a drug to him which was described as a chemo drug originally for cancer patients but has shown to aid patients such as he. God i wish we coyld speak to you to somehow find out if you have a similar set of issues. If so much comfort it would be while making this very important and heart wrenching decision

[@StrangerInMorocco2023]

I also have an autoimmune disease. I am taking Telfast and Montelukast daily. If I stop, my throat gets tight and itches all over the body. I live with misery and doctors couldn't help me.

[@lady4191]

There probably not so happy

[@yuliaschannel6288]

Maybe try prolonged water only fast around 10 days? Prolonged fast is the only thing that treats and cure autoimmune diseases. And then carnivore diet.

[@ravenryder6241]

For those of you making fun of the doctor for asking if they're okay, it's actually a very good practice. First of all, he's making sure they're still responsive. Second of all, he's trying to keep them calm. If you saw someone crack their skull open, you wouldn't start shouting "OMG ARE YOU OKAY!? OH MY GOD HE'S GONNA DIE THAT'S A LOT OF BLOOD" no, you'd say "It's going to be okay, you'll be fine." Just so you know

[@toddhoward5749]

lmao some doctor (well, nurse) screamed "OH MY GOD THAT'S A LOT OF BLOOD!!!" when I threw it up once, thought I was gonna die

[@ravenryder6241]

Index III is OUT my point exactly

[@Caperhere]

Raven Ryder I don’t know why Parexel claimed to have no knowledge of their responses, but the pharma doctor read in the literature supplied by Parexel that their reactions were thought to happen rarely.

[@Wiplash12345]

*aRe YoU oKaY*

[@jsesheadphonesset6963]

(OMG YOUR DEAD i mean) its fine ur gonna be okay:)

[@india1422]

I'm being treated for ovarian cancer. I cannot express my gratitude to the people who have risked their life to try to save mine

[@sarahjean3670]

@@india1422 me too and I’m so thankful to the people and animals that helped keep me going. My very best wishes to you.

[@Lala_LilyV]

@@india1422 my thoughts and prayers🙏🏼🩷

[@susanferguson8001]

Be careful those drugs have severe side effects effects that allow doctors,to get away killing off whistleblowers later in off that k ow they were forced into fling along or being blamed for o get away with committing atrocities against ,minorities to suffer the same cover up by I forced treatment t and th. Blaming them and for them to to get away with to b blamed and killing them by and forcing me to do Nyerere I to palletive care to cover it up

[@susanferguson8001]

Please help me thy are blaming me for to cover up their crimes and allow the government to,ent to blame these please people to comply and now I know they are killing off these to people and blame them for instead of rich people,to get away to comply and are know and forcing me into end of life care

[@SciDOCMBC]

My best wishes to you both, and to all cancer patients. Please don't give up.

[@AugustBreak]

It’s truly strange watching British documentaries as an American. American documentaries are so loud with constant motion and nonstop drama. I appreciate watching something that takes its time to tell the story without the need for embellishment.

[@therealgamingderps9608]

I mean this was quite intense too.

[@unknownartist6898]

August Break Same

[@livelaughForte]

It isn't that it's British. They just didn't really need to be flashy because of the content... People fighting for their lives... pretty hardcore as is

[@AugustBreak]

L L there’s a balance that a lot of documentaries and reality shows strike. This one hits right on the mark.

[@elisesatter1473]

August Break omg ikr!

[@mb4692]

I still remember how my 6th year biology teacher warned us to never volunteer to be a guinea pig. Thank you sir.

[@Olivia-W]

See, I'm thankful I study chemistry, not biology or medicine. I can watch them do trials from another building, thanks.

[@yudelleanlisatajirikenyana4519]

Honey Bee 😂😂😂 that's a great teacher

[@jasonsage1417]

I had a science teacher start our origins, universe life etc with: don’t believe everything they tell you, remember many think a supreme being, god, caused creation, others do not... in any case we don’t know how or why the universe came into being let alone having physics perfect for star formation, nuclear reactions, time, matter, all of it. That said... shall we begin.... first there was nothing, then there was a universe... any questions? Right... ok.. and we opened our books to chapter one. The Big Bang. Haha and the lesson commenced. I thought he was clever and wise and he was a great teacher. He also gave us real experiments, not cheesy ones. More dangerous chemicals and dissection, less baking soda and vinegar. Haha... break out the scalpels and Bunson burners baby.. whoops. Bang. Teacher my test tube is no more! You ok? Yeah. Had your eye wear on? Yeah. Ok... do it again but this time don’t skip step three in the directions... sorry Mr. Moss. Haha he was cool.

[@renees1021]

The FDA also recommends not being the first to take new drugs; I'd suspect only people desperate for money (poor/poverty) would/will volunteer.

[@darianbarber3763]

@@renees1021 I don't think they normally end this badly due to prior testing on animals but yea this is also a very plausible outcome.

[@StrawberryNinjaNibbles]

Get this casting director a raise. All these actors look so much like the real people while also being able to actually act

[@lennysmileyface]

I swear some of them are the actual people. Number 2 was definitely the same guy.

[@Thetabringer]

It’s epic bro Best I’ve seen

[@StrawberryNinjaNibbles]

Robert Gardea im aware what a re-enactment is... hence why I said props to casting director

[@nicoleyandle9978]

StrawberryNinja Nibbles #mansplaining at its worst-🙄🙄

[@nicoleyandle9978]

StrawberryNinja Nibbles omg you’re right. Without thinking about it, I unconsciously found myself thinking, how did they have video of these people when it was happening Lolol duh

[@joe1071]

As a healthcare professional that works in a hospital, this is an absolute nightmare all the way around. Everyone lost in this one

[@gizzyguzzi]

and how do you feel about the covid vaccines? That experiment was forced on the world, this was volunteer

[@intothemystic5223]

I've got to stop reading comments while watching documentaries. The amount of times I have to rewind is absurd.

[@ethank5681]

into the mystic comment section is better than the vid

[@overthehedge7591]

@@ethank5681 there would be no comments without the video

[@EdderzX1]

Keep doing the same lmao

[@reggie6871]

thanks for the reminder, i wouldve gone 10 minutes deeper without this comment

[@AdriCr4ft]

I was thinking the same... lol

[@matt391]

Everyone else: *screaming in pain* That one dude: *mom come pick me up im scared*

[@tonypasma1707]

mmm

[@duck3819]

That guy would be me

[@MsT-xm8xz]

@Saint Beelzebub 😭😭😭

[@whipchick90]

「 Cinderblock 」 😂

[@michaelsmith7328]

Hahahahs

[@ROA1988]

It makes me mad to think that the medication was administered 10 mins apart, rather than 90 mins apart. This could have only been one.

[@birthdayplant]

'Berto O. A. you never know if another person will react the same way to the medication if only one person got the trial. that’s why there’s usually more than one person getting tested

[@StanslaMichael]

They just wanted to know who got the placebo.

[@janeyd5280]

@@birthdayplant it was never appropriately thought out and therefore that was negligence in a big way.

[@caseywinchester7639]

niyah and yet they all reacted the same way

[@charliebrazier2863]

niyah yeah and If it went that bad on one person then they wouldn’t do it on another however if one person was fine

[@kris2455]

They knew about the headache and pain and still injected the last patients. It's hard to comprehend.

[@MaryDeanDotCom]

@@kris2455 Yeah, you would think they would test one person, and see how they reacted, before continuing.

[@YuckFoutube-e1z]

@@MaryDeanDotCom SAFE AND EFFECTIVE. I mean it's only killed millions....

[@nanofivee]

@@jennifermarlow. this wasnt in 2024

[@Emsev100]

@@nanofivee I think they mean that we have lived through how the world reacted to co.v.id. Nothing will suprise me anylonger when it comes to butched up medical treatment after that.

[@Verycoolguy1337]

its very easy to believe, shareholders,pressure, company might go bust if its a failure etc.

[@amtf7251]

Everybody’s screaming in pain and the other dude’s just sitting there

[@michellemuskeyn329]

He’s soooo lucky 🍀!

[@lorenzolatino7023]

@@Timeless80 Haha, I was about to say that.

[@dangerousbuterax6891]

i would’ve hated to be him. imagine everyone around you screaming in pain... terrifying

[@LF-lv4ov]

@@dangerousbuterax6891 i'd rather be him than the ones that actually took the drug

[@dangerousbuterax6891]

L Frosty me too but would’ve still been scary

[@HP-cn4sd]

Omg. Kid was 19 and saving up for driving lessons and now he has no fingers

[@dylanp7817]

Gavin Haase 47:09

[@shyshy8788]

He lost all his toes and parts of fingers. The tips

[@nickhiggins1091]

He can still drive. My mother had crippling arthritis, and could not hold the steering wheel, just guide it with her palms, and turned with her elbows. He only lost the tips. Not the whole fingers. Yes, it is a tragedy he suffered. So did my mother. She still made do. Reiterate, he CAN still drive.

[@ninjasneaks1472]

I mean he could still drive? But they didnt specifically say what exactly happen to ryan..

[@shyshy8788]

@@nickhiggins1091 doesn't sound safe at all. That's why in your driving test you have two hands on the wheel. Not your elbows

[@nicoleslaughter7983]

I noticed they never talked about the eighth man, I looked him up and he’s wheel chair bound and had his fingertips fall off too. How unfortunate for all of them.

[@sarahmai5902]

Wow

[@joyful_tanya]

Thank you for looking that up for us all!

[@janekeller3791]

what did you look up to find it?

[@flowerfaerie8931]

Nicole Slaughter ...It mentions what happens to him right there in the video.

[@wiktoriagwozdowska5484]

any link or name of the man so i could search it pls :) its very scary docu really if i could i would wish for this to never happen :(

[@patsysolatzzo2962]

While nobody deserves the outcome of this particular medical trial, it’s an incredibly brave and selfless act to anyone who needs medicine and even to the lives that are forced into trials like animals. It’s scary but to think of all of the lives and families this event has saved. I’m so sorry to everyone involved but the gratitude I have for such people is incredible.

[@niamphdollieofficial]

I'm sure they instantly regretted it lol

[@cbaker8332]

They risked their lives for a few $$$…. Desperation is more like it - not bravery.

[@NFSHeld]

To those who are interested, the reason was finally found. Fair warning: I'm neither a chemist nor a physician, so I cannot guarantee I summed it up correctly. Also, before you jump to any conclusion or think "It sounds obvious that it was bound to go wrong", I suggest looking into the reports on your own, to understand the complexity of in vivo chemistry. TGN1412 was designed to bind to the CD28 antigen of T lymphocyte cells. Those T lymphocyte come in two sub-types: "Regulatory T cells", and "Memory T cells". TGN1412 was designed/intended to stimulate the Regulatory T cells, which are the same in humans as in the monkeys. However, the Memory T cells have that CD28 antigen as well for humans, but not in the monkeys. And those cells started to emit a high amount of cytokines when activated by TGN1412. This widespread sudden and overpaced emission of cytokines is what is called cytokine storm, and the cytokines attack and kill cells. This is what is called and happens in an inflammation. In a normal functioning immune system, this should happen in direct proximity of an infected cell to kill that cell (and only a few others as collateral damage, which are easily replaced in a healthy person). But here it happened in the whole body at once, basically attacking all cells everywhere at the same time.

[@lentilneeds]

THANK YOU SO MUCH, it makes perfect sense to me now. Your comment is the only one in here that had the science behind what happened.

[@boogiesparr]

Wow a overlook that had devestating result,altho making a new drug is never easy so small things are bound to be missed from time to time

[@tcaldwell1782]

And isn't it ironic that the covid virus that's going around now does the same exact thing in some people, causes a cytokine storm? The monocolona antibodies since then has been perfected and is currently being used in people with covid-19 successfully. The drug is known as regeneron.

[@tcaldwell1782]

Now they use 0.1% less of the drug at 40 times slower rate of infusion then they did in that trial. So basically it was a bad calculation on their part.

[@Matetas-gv8lj]

Can we call it a Drug induced sepsis

[@bonniera3819]

They all must have some form of PTSD from going through that

[@ava-tb3cw]

With a phobia of medication, needles and that i suppose

[@bonniera3819]

Well they nearly died that's pretty traumatic in itself

[@robertbunton6394]

Yea thats for sure

[@taunjabrockway6760]

Well then, they now should be advocates for banning all animal testing since they know the horrors.. but they had it WAAAY better than the animals that are still being tortured

[@cailumwolf1616]

Taunja Brockway but if animal testing had happend it would be different

[@user-ui8sp5th4g]

Imagine being one of the ones that got the medicine and being right behind the guy showing the first symptoms. That would be terrifying. He starts screaming and you have to wait until it happens to you. Talk about a horror movie.

[@MsT-xm8xz]

😩

[@ryanblack3285]

I'd rip the IV out b4 it was my turn. Not worth 2k.

[@ThatFuckinGame]

@@ryanblack3285 apart of the 2k, you would get in a lot of legal trouble, you signed a contract. also by the time the first severe symtphoms showed up, the drug was already administered on everybody.

[@patricknein9062]

If this would have happened in America, they would have been stuck with the medical bill as well.

[@AlucardRawks]

@@Tyler-zw4kq just because a law suit is won doesn't mean they ever see the money

[@hellaSwankkyToo]

big facts. good ole american health“care.”

[@samsamthetrashcan]

Lol accurate

[@patricknein9062]

@AL Cats They absolutely would have. It's the American way. Oh and when you write a sentence calling people stupid, make sure it isn't two sentences crammed into one.

[@susanjoynes6395]

@AL Cats I don't know . you tell us. How do you.

[@julianbell9161]

The worst part was how quickly they dosed everyone. They first guy is in a cold sweat and writhing in pain, and while this is going on they are dosing the guys in the other room.

[@kristie-leecorney7388]

Julian Bell Mark R what was this drug trial for ? what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure , So do you think , is it really a cure they were looking for or is it a way to make people sick to cut down the population , the government plan ?

[@bageda3109]

They should have waited way longer for each person getting injected and they should have given a way smaller dose to check how they reacted to it

[@pepsimax48820]

@@kristie-leecorney7388 lol

[@Jellybellyirish]

@@kristie-leecorney7388 can see that you didn't watch the documentary, so you'll come up with ingenious conspiracy theories. Get out.

[@saras.7928]

Kristie-lee Corney This isn’t a conspiracy video. If the government wanted to cut down on the population they wouldn’t have tested the drug, they would have given it to the patient so they could die.

[@adamdadds4566]

Patient “am I going to die?” Doctor “the real question is am I going to prison?”

[@obelisk5358]

@Kimber 10MM wtf are you talking about

[@itz_bk]

@Kimber 10MM don't you understand it's just a joke , if you don't understand, Okey let me tell you it's a human thing & you need to settle up in a zoo

[@diallogazali7538]

That’s funny

[@johnimusic12]

😆

[@0906blue]

It's an experimental drug, he volunteered.

[@BrochieCohen-q3x]

Shame on drug company. One guys fingers and toes fell off. They infused 8 x faster than on monkeys. These people deserve big compensation and massive apology

[@mariacidaliapereiragaidola5405]

Greed usually does it,the hurry to make $$$$$$$$

[@bradenharris8718]

They got compensation and literally told you that if you had bothered to watch the documentary all the way through

[@Exotic6792]

@@bradenharris8718 an undisclosed amount. could've been chump change for all we know.

[@jessicalynn6576]

10x

[@Litepaw]

Big pharma doing big pharma things, and hiding behind obscure legal loopholes and endless legal battles to do whatever tf they want. It's a way too big of a business, in the hands of way too few people. They're artificially creating a lack of ADHD medication so they can jack up the prices. They claimed oxycodone is barely addictive and can be prescribed for even minor pain and injuries. They said Xanax and Lyrica are perfect risk-free options for generalized anxiety disorder. They constantly make vitally important things like epipens and insulin more expensive. They also try to invent medicine for the symptoms rather than cures. And isn't it also kinda convenient how often you need to take booster shots for this new kind of vaccine? I know it's basically a business and they need to profit, but they're building their empire on human suffering and dead bodies. The amount of greed is just overwhelming.

[@floofytown]

This reenactment is SO WELL DONE. Holy crap.

[@lalala-vk7ex]

Ikr!! I had to go back to the beginning of the video to find where it said it was reenactment I was like damnn

[@susanfoley8360]

They found actors who look incredibly like the real people involved.

[@alexanderplatzberlin3940]

Yes. I totally forgot that it wasn´t real while watching … :D

[@sleepyidiot2010]

Susan Foley are all of them actors? I straight up thought one of them (the placebo guy watching everything go down) was the actual person

[@xposed11]

You believe this? They gave clinical trial medication, as a test...to humans with nothing to actually cure.. it was meant to cure leukemia....which these random people did not have

[@gugumasango1802]

Doctor: How we doing David? David: Screams with agony and discomfort

[@WitheredHound]

Me when my mom wakes me up for school

[@old-yd2kp]

flamingwolfgaming 101 disrspectful but true

[@Insomniyuh]

Ikr

[@WitheredHound]

@@old-yd2kp My bad

[@sqwertt8605]

Doctor : seams ok to me

[@muffinman5741]

"No one's gonna die right?" "Well, we'll see" well at least he was honest

[@TheMausymaus]

That part made me laugh so hard

[@YoutubeCensorsYou]

"We'll see... Well... I'mean I will see. In case you, ... you know."

[@katerickard2804]

followed by evil cartoon villain cackle lol

[@O7ghostX]

yeah doctors cannot affirm things they don't know or they might be charged with lies

[@tracy1394]

I was in labor with my first baby and the pain was absolutely horrible. My husband said that I tried to get out of bed and leave. I truly believed that if I could just leave the room that I would be pain free.

[@Strawberrymerit]

Wording is a bit off

[@skylarstarr3973]

I tried this too. 😂 Funny now but at the time I was in so much pain and I was so scared. I told my husband I just needed to get out of the room and out of the hospital then I'd be ok. He was compassionate but also amused and said something like "but what about the baby? If you leave you still have to give birth." 😂 I don't know, man.

[@smileyone1612]

Should of stood up to deliver baby.

[@anoukkroolvink1397]

They talk about how a lot of the man got back to “normal” but still one guy lost just fingers and a foot and his life was never the same

[@desolationangel5136]

You should also watch the thalidomide documentary on youtube. kzbin.info/www/bejne/bKbMq6mpnsZ7r9k

[@spvillano]

Not a one of them went back to normal, their immune systems are fouled up to this day.

[@thedopeexperiment]

Yeah I wanna know more about Ryan.

[@BS-dq1kz]

And his penis. So there’s that. Pretty significant if you ask me.

[@thedopeexperiment]

@@BS-dq1kz is that true?what a shame & he was the youngest of the group, not that it would suck any less happening to any of the others.

[@michaelwhite7288]

This is the second time I watched this video, what a horrific trial these wonderful men went through, my daughter was diagnosed with leukemia at age 10 with other complications. Without brave people like these, my daughter would not be a alive today. This Was back in 2001. My sarah is doing well today. My only child. I owe it to brave people like the ones in this document. Thank you so very much from the bottom of my heart. Thank you. Mike, from Richmond, Virginia

[@lorinagosso]

That's great. But everyone that I know that had leukemia and was treated for it , died. They spent years of their life receiving agonizing treatment that was meant to save them, costing thousands. They would be in remission, like they were cured, then it returned, only to kill them quickly, since their immune system was gone. RIP: Aunt Marty, Steele, Carmen.

[@finlandjourney6065]

@@lorinagosso While that is the norm, there are a few exceptions. Perhaps her young age aided her recovery. Then again they say 25% of cancers get cured all by itself (not sure if it applies to leukemia though), but I guess most don't wanna play with those odds and go for the chemo route, despite it perhaps only buying them more time and only making their early death even more likely.

[@KhadaJhin04]

@@lorinagosso leukemia in a certain group age and the type of leukemia the person has determines the rates of their survival. Simply put the older you are the deadlier it gets, children have higher survival rates and longer remission. Sorry for your loss though, seeing a loved one succumb to illness makes you feel hopeless and it's a wound that never heals even after they pass.

[@hanasarver3837]

I’m so happy for you and Sarah. I hope she loves a long successful life!

[@rachelvillarim3279]

Hi Michael the world also won a precious gift then : Sarah. Please send her a hug all the way from Brasil !! She isa brave and inspiring girl ❤️🙏🏻

[@AppleYou]

Part 1: company brings patients to trial. Part 2: patients bring company to trial.

[@FreeAmerica4Ever]

If only it was that easy

[@lhaviland8602]

And loose!

[@underestimatedsmilin2429]

AppleYou Brilliant comment!

[@johnimusic12]

I'm sure the patients signed away any probability of liability

[@saganord9859]

Uno reverse card

[@Poorsha88]

I watched this when it first came out 6 yrs ago and let me tell you that i have never forgotten about it. It's truly haunting to think about what they went through.

[@Cafeallday222]

@@Poorsha88 and maybe still are…

[@rehennac5977]

Same and here we are, watching it again

[@possiblyelle]

His fingertips fell off!! They weren't even amputated! Imagine just laying there watching your fingertips FALL OFF!!! I feel so bad for those men...

[@possiblyelle]

@jorge rodi Ohhhhh I'm dumbbbb I got so freaked out!!

[@logicss2893]

Bruh

[@kells8241]

@jorge rodi please use your inside voice

[@jonnyb.animationstutorials7119]

Necrosis is the term for Dying tissue. This is why I think this was blood poisoning. Necrosis can occur when the blood isn't healthy enough to provide the flesh nutrition, and the cells in the tissue die.

[@miriamllamas224]

@jorge rodi Capital letters means you're shouting. So low your voice 🤗 and be caring.

[@m3m3d_]

That one guy just sitting there on the bed was horrified. I feel terrible knowing the mass pain they were going through.

[@scarlettellison3090]

m3m3d_ I felt real sorry for him . He was just siting there and every one else was reacting to it. He was probably thinking that he was going to get it soon

[@mariekekito3998]

I would feel guilty for Being tho One Who got the placebo

[@tryblight]

crumch

[@soiboi1564]

Are you him (Looking at your profile pic even though I know it's just Arin

[@jeaniejbutler4911]

the 2 (one in each room) who got the placebo will definately have long term mental issues from what they saw and heard..I hope they both got some great counseling...crap like that can mess your head up for life.

[@miepmaster25]

an hour long, slow-pace documentary, totally for free on youtube! this makes me very happy

[@ellenorbjornsdottir1166]

Yus

[@Neishianadiaaa]

ᴴᵃᶰˢ ᴮˡᵃᵃᵘʷ me tooo

[@jamie-leighgibson2338]

There is hundreds of them on here they r amazing

[@Grimy_Aaronarr]

What KZbin was really made for

[@Courtneyemily91]

I’d be freaking out as soon as the first guy started to have some severe effects. Omg…

[@tbjorn7374]

My first Chemo infusion took over 13 hours to complete. These men were given a full infusion in 10 minutes...That is crazy!

[@FacelessMan777]

How are you doing? I hope you are doing well. I sincerely mean that.

[@gg-sc6gy]

@@sabitrakhadka8397 wtf is wrong with you

[@kungfreddie]

@@gg-sc6gy 1st time internetting?

[@gg-sc6gy]

@@kungfreddie yeah i made it 29 years and never once did I discover it until today

[@kungfreddie]

@@sabitrakhadka8397 swedish

[@email2336]

In the U.S the hospital would of have tried to charge you for your stay

[@dr224]

Facts.

[@Thinkingisallowed]

You are right, and they would have charged 3,000 a night.

[@duck3819]

You just nearly died because of us... Give us $30,000

[@justjadethings9630]

@@duck3819 That is very accurate. My quack of an orthopedist gave me an unnecessary MRI, over my ankle being swollen and having pronation. It found bone bruising, JUST BONE BRUISING. It was a waste of 2hrs and $900

[@aprilminder6851]

donte ray damn right they would have

[@soapz.]

everyone: throwing up, screaming that one dude sitting: alright ima head out

[@soapz.]

Megan Khadka it’s like... i didn’t know that

[@anncommanda2060]

He was a control/ placebo

[@lulumce6281]

When was that? Just so I can skip a sis is scared of sick

[@zhipeizhou5582]

B lasagna

[@counter_cris6371]

anna commanda what does that mean?

[@mambutuomalley2260]

"I was really down... the worst down" - That's such a chilling phrase.

[@punkyshrewster2736]

The saddest patient death I've ever dealt with was a man who had an unexpected allergic reaction to a psoriasis medication we were testing. He was a healthy guy in his early 50s. No one had any reason to believe he wouldn't be going home to his family the next day with some Christmas shopping money in his pocket. It was really a huge shock to everyone, especially his wife and kids.

[@rubi_4]

I wish I wouldn't have read this.. Now I'm sad....I could only imagine how the wife and kids felt..

[@Plaksa2004]

That is something you should understand taking any drug, isn't it? Let alone the one that was never tested on humans, no one knows whether it is safe and that's exactly the risk they are paid for.. If it was safe (and none of the drugs are just cause of the personal reactions anyway) there wouldn't be a need in testing it..

[@TheRight-handedStranger]

The people are lured by money like the 50 years old man that sadly lost his life. When you are 50 YO with family of your own, it’s not advised to take a trial test. Unfortunately he probably needed the money.

[@hezekiawhite8207]

This is the devils medicine now learn natural medicine.

[@trafficjon400]

Just him? its a lot worse than you think be hind closed doors .

[@eddstudd]

This should be a Netflix documentary

[@Lilvynom]

It should be that would be amazing

[@rph_redacted]

This could be on House MD or the good doctor

[@9852323]

It’s better on KZbin.

[@makarti2158]

Nah, KZbin's where it's at.

[@missy_vicky469]

There is a indie style horror movie made based on this, wouldn’t recommend it.

[@preciousj6931]

Those 2 men won a LOTTERY called PLACEBO

[@tatendamurena3498]

precious lol

[@orchdork775]

@@sunandmoon139 That's not actually what it is. It's when a person experiences a decrease in symptom severity, because they believe they are receiving medication. The placebo effect does not cure illnesses, it just helps to relieve symptoms.

[@orchdork775]

@@sunandmoon139 It has to do with believing that you are receiving a treatment that will make you feel better. I reccomend that you look up some examples and/or articles about it on google, as it's actually quite fascinating. There is also the nocebo effect, which is when a person believes a treatment will have negative side effects, so they end up experiencing those side effects simply because they expected to experience them. There have been trials done where one group of people is give sugar pills (though the trial participants were told it was real medication) and were not warned of any potential side effects, while the second group received the same placebo pills, but were told a list of potential side effects they might experience. The people in the second group reported experiencing those side effects at a much higher rate than people in the first group. By believing they might feel unwell, the trial participants actually caused themselves to feel sick. It really goes to show how much your mindset can effect you. This even manifests psychologically as well. For example, if you believe that you won't ever succeed, chances are you will have a lessened ability to perform tasks, low motivation, and little dedication. One of the biggest effects would be that you stop trying, and that you never actually put 100% into something. I mean, why bother putting your all into something if you are sure you will fail?? Alternatively, if you believe that you could be very successful, you would likely take way more opportunities, work harder and put more effort into things, have high motivation, and be very dedicated. These changes in behaivor have a serious effect on your life, and could actually cause someone to fail at things simply because they are convinced they aren't capable of succeeding. This is called fortune telling in psychology, if I remember correctly. I'm very guilty of doing this myself, actually. It's harder than it sounds to let go of all the negative beliefs one has about themselves and start believing in themselves all of the sudden. It's really hard, and at this point I actually fortune tell about fortune telling. I know that I do it a lot, so I end up doing it even more simply because I expect myself to. It's maddening 😂😭

[@zangetsuu]

@@sunandmoon139 it has nothing to do with religion if that's what you're asking, although those words can be used in a spiritual context. if that's not what you meant ignore me haha

[@filmmade6214]

Comment war

[@kimmead3683]

This is why I don't do trials. I did one and I had the symptoms of malaria. Never again.

[@Emsev100]

Well, the entire world went trough a massive trial three-four years ago.

[@SpoonsInDaHouse]

Did you get the vax? I hate to tell you but, you did it again 🤦🏼‍♂️

[@mariacidaliapereiragaidola5405]

Lesson learned😢

[@mariacidaliapereiragaidola5405]

​@@Emsev100👍👍👍👍👍

[@janie7195]

You took the vaccination for Covid, right? That probably saved your life

[@Noodles03]

I cant imagine being one of the people with the placebo... just watching and listening to everythung around you, always wondering if youre next and when its going to happen. It sounds so terrifying...

[@trinitylivingston1286]

Yeah and he was so young at the time so it really pulls at your heart for the poor boy.

[@onistgaming5177]

American roulette

[@alex73217]

@Addicted 2This but also guilty though. Survivors guilt

[@etherraichu]

Nah. after they were the onlyone in the room it didn't happen to, Im guessing they figured out they had the placebo. But the first hour or so would've been rough, yea.

[@edelleaa]

I would feel so very guilty honestly

[@sarahvela4354]

Who else watched this, and immediately decided to never participate in a clinical trial? 🤯🧐

[@richardblackhound1246]

I heard about this at the time it happened and then decided the same. Your life and health isn't worth playing Russian roulette with. Even if nothing like this happens to you, you don't know what unknown long term effects might be caused.

[@Ashley-on4ln]

Sarah Vela I have participated In one! Nothing happened to me thank goodness lol

[@Jaxon0098]

Where did you participate in your study at ?

[@Jaxon0098]

@Poppy Mystique I'm in a study right now in the states at a place called PRA Health Sciences in Lenexa, Kansas City, Kansas My study right now is 5 days for $3,000 us

[@sarahvela4354]

I had considered cosmetic trials, but after this there is no amount of money in the world that could make me want to participate. Just to risky for me.

[@jojoshaw5349]

me: oh man my knees hurt again *watches documentary * never mind i’m good

[@johnnybhoff226]

Joji Jo I love it 😂

[@Superautismchan]

Same

[@becky2322]

legit me

[@taffymatt6870]

@@becky2322DM me, you look stunning :)

[@zZmiLLi]

LMAO

[@ShihoOttomo]

I have a huge respect and appreciation for the people who raise their hand up for the clinical trial. I hope they stay healthy.

[@jaydensmith920]

This is like watching a horror movie but every detail actually happened

[@LiterallyEly]

Ikr, it makes it WAYYY scarier... obviously

[@SolarBlyze]

@@LiterallyEly honestly this scared me more than any horror movie ever has

[@Vanereall]

It's crazy to think that they didn't have an emergency protocol in place. That doctor was scrambling to find any other doctor.

[@seanshields86]

That dr was probably just a pawn on a larger chess board.

[@billmartins5545]

You can't plan for unexpected reactions

[@donaldprice9230]

Very poorly administered trial for sure. Why inject them all at once??? Pathetic!!!

[@Abdi-libaax]

@@nasramohamed no he called for the other doctors because he didn't know what to do.

[@geemanbmw]

@@Abdi-libaax read the comment before replying the obvious jeez

[@markhurter8668]

If you don't want ads, skip to the end and replay it will make the ads go away. You can thank me later.

[@sarina2364]

YOU ARE A GOD

[@NathanVdV]

@@sarina2364 or install an addblocker, no adds anywhere!

[@sarina2364]

You right, I gotta get on that. Thanks!

[@davidmyles9967]

thanks.

[@moonshiner3223]

A prophet like you comes along every 200 years or so. Thank you for this gift. The gift of this knowledge.

[@ItzBrittKneeBish]

As someone with auto immune disease its heros like this that risk their lives that give me the medicine I need to survive.

[@unapologeticallyauthentic]

@@ItzBrittKneeBish ❤️

[@wendychavez5348]

This is why I'm open to being involved in clinical trials! I have these conditions, and am interested in improving the care that other people with them can obtain. Like Subject #1, I understand that it's important to report anything even slightly out of the ordinary because information is vital! I wish these men hadn't suffered like this, and thank them for their sacrifice.

[@that_dam_baka]

At 57:44, they confirm what most of us guessed. It wasn't the drug itself, but the quantity and time. The reactions of patients were like an overdose. You can't increase the concentration like that! Edit: Actually it's 47:50

[@mateoferretto2175]

@@wesleyp3024 The thing is chemo also kills things it shouldn't kill and is way more invasive and dangerous... In fact, there are still producers of vaccine-like cancer cures.

[@wakingohiomama9110]

Right, I was initially thinking it was actually DECREASED, but I realized that they had increased it by was it 500 times?? I feel horrible that this happened truly. Been quite close a few times to participating in clinical trial research for the money. SO GLAD I WATCHED, NEED AGAIN! Edit: apparently the dose was decreased. Can you imagine if it had been the opposite??? SMH.

[@wakingohiomama9110]

@@wesleyp3024 WOW. These poor chaps.

[@that_dam_baka]

@Fab Elger I meant at the London trial. They used too much, too fast.

[@bannanagaming434]

Wesley P Yeah it's kind of like having a voice give you an instruction, as long as the voice is still there it will still give you that instruction whether weaker or louder

[@kandeejohnson]

ME, thinking I'm going to only watch 5 minutes of this and end up watching the whole thing!

[@kylieskaggs1444]

Sammmme girl

[@dorametasimpson4985]

This really does intrigue me .

[@dorametasimpson4985]

God Is So Merciful .. Amen .

[@dorametasimpson4985]

No amount of $$$$$ ... Is worth playing the , maybe , or , maybe not day !!! Which is a memory of , I'm alive !

[@reyno6826]

Same! 😬

[@zainabxoxox5094]

can we just give these men a round of appaluse for what they have endured that must have been really traumatising especially the guy that lost his fingers and had his foot amputated

[@summerdaisyxx]

!!!

[@williamarmstrong1017]

For their Stupidity for taking a few bucks?

[@cica8427]

@@williamarmstrong1017 I assure you, they would not go if they would be well informed. And what they do now with vaccine is pretty much the same! And they not have to pay for it.

[@williamarmstrong1017]

@@cica8427 For a elegal mrna vaccine?

[@RK-su4hs]

@@cica8427 💯

[@20PINKluvr]

This is probably why clinical trials span a few months rather than a few days

[@imho2278]

Even the placebo dosing is done over a month these days.

[@wendychavez5348]

Most of the medical trials that I've looked into ask for a commitment of 2-3 years, and specify that the patient can withdraw at any point. I've never looked into a First in Man study (now I understand that as a female, I don't generally qualify for that), though I do understand how vital that step is. Now I understand a bit better!

[@soldatheero]

unless you are in a global scamdemic and they are virtually forcing everyone on the planet to partake

[@KreativeKerri]

​@@wendychavez5348actually we can now. I was in a phase 1 trial. Its for a medicine for specific heart disorder. Although I'm healthy now, I've had quite an extensive heart history. Its like being a ticking time bomb with no way of stopping it. This opportunity came about and I was all for it. Its a double blind study. Couldn't get my blood work for my syndrome until 6 months after I was done with the trial. My number actually was decreased. I know I got the drug and it works. Cannot wait until phase 2. Hoping it will be at the same hospital so I can take part.

[@jeanroeder5534]

As a cancer treatment patient I understand the importance of drugs being administered at a slow rate.

[@nealdamkjer192]

I hope you get well and go into remission forever.

[@Masonwhite12796]

Hope you are doing better

[@FamousSnatcher]

It's basically poisonous nuclear waste they're dumping in people's bodies.

[@CygnusStarz]

Cladrabine 7 day IV infusion slow I know it

[@noshadean787]

That's because you don't know the great physician, the lord god almighty.Amen.

[@danavenzor1169]

The 2 receivers of the placebo are in my opinion entitled to damages as well, as are the staff who all were undoubtedly traumatized by witnessing this dreadful horror.

[@SaraWOanH]

You do know they willing signed up for this, knowing that there could potentially be a risk of death right?

[@_dooley]

Nope

[@andreabobbette825]

Agreed.

[@andreabobbette825]

@@SaraWOanH Where does it say in the contract "risk of death"? Do you work in this field?. They would never get people by stating that fact. They Will Say it may cause side effects (like organ failure) but not death. I do see what you are saying but they picked strong healthy young men. Emphasizing death is not a priority. Also... I would never do it. My friend fell fast after being talked into a trial cancer drug by her doctor friend....sad scary and I'm not built for it. My nerves and worry are too bad...😆

[@thebikehub7421]

Sounds like an inside job done by a lone crazy scientist.

[@Stiasteny]

It is glanced over so quickly that Ryan lost his finger tips and got a part of his toes and foot amputated. Wow my heart goes out for him ♥️.

[@JoyfulNerd400]

Considering he has sadly passed, I think this was the least of his problems. This entire trial was absolutely horrifically botched, whether by accident, on purpose, the medication simply didn’t work or otherwise

[@BlackKiryuu]

@@JoyfulNerd400 He died??!! When? As a result of this trial?

[@JoyfulNerd400]

@@BlackKiryuu he did end up passing away, yeah. His organs failed and as far as I’m aware his treatment failed in the end

[@BlackKiryuu]

@@JoyfulNerd400 Oh my God. I feel soo sorry for him! Did his family get any help after his death? Like compensation for damage and what not?

[@Celestephial]

@@JoyfulNerd400 what is the source? My most recent found are articles of 2021, and all of them do not mention a death of Ryan, "just" his amputations and the unforeseen health problems in the future of all participants.

[@bliven8704]

As a mom whose daughter is making progress against pancreatic cancer we were originally told don’t bother with chemo, it won’t work, enjoy your last 7 months, thank you to all who sacrifice in hope to help others.

[@colesmith7509]

The poor nurses. They couldn't have imagined this was possible, and they definitely felt partly responsible.

[@finlandjourney6065]

The old nurses knew. They've seen all sort of things. That's why they tend not last too long in the profession, and thus are all the time replaced by younger better indoctrinated by big pharma teachers ones.

[@eri020]

@@finlandjourney6065 oh the lunacy

[@ross1116]

They were in part responsible. They rushed the injections from how it was explained. The first man was showing bad reactions before the last couple were even injected.

[@colesmith7509]

@@ross1116 I think it was the protocol they were forced to follow. I agree that they definitely should've stopped though

[@meganbretbrunner2344]

It is a nurse's responsibility to advocate for their patient, they can in fact, intercept prescriptions, and refuse orders as long as it's in the best interest of the patient.

[@karenbarnes852]

I found this a very interesting article. My granddaughter had a rare cancer at the age of 2 and ALL of her treatment was through international clinical trials. Part of her treatment was immunotherapy, where one of the risks was a cytokine storm because of the use of monoclonal antibodies. After nearly four years of treatment she is now five years in remission. The harsh treatments she had have left her with a variety of health problems, but she is a happy 10 year old now and very precious to our family. Whilst she has contributed to many clinical trials through her treatments, we are indebted to the children who have gone before her and may have since died of the illness or the treatment. Anyone who contributes to the advance of medicine through participating in clinical trials (of whatever stage) is making a massive contribution to the rest of humanity.

[@pamsam8933]

Amen. I agree. And with any trials, all precautions should be taken, and there should ALWAYS be an ESTABLISHED anecdotal plan in case of known, and especially unknown, side affects.

[@jandoel]

The posh doctor interviews between creepypasta-like reenactment scenes is such a mood

[@sanderson2]

@@pamsam8933 I I IC think ⁹I 99

[@rylandavis2976]

@@pamsam8933 the problem is that you can't know the side effects to 100% certainty in advance. You can inject them into mice and monkeys and test on human cells and determine it "might" be safe. When you are the one taking a drug that no human has taken before, nobody can predict with certainty what is going to happen, it's a big risk and they should (and almost always do) tell you that it is a risk.

[@Tyler11821]

The reason things like this are big stories is because of how rare events like this are. The vast, vast majority of first for human clinical trials have the worst problem of people withdrawing due to side effects. This occurs in both the cohort getting the drug and the cohort getting placebo. Multiple fatalities in a single trial is so unusual as to lead to videos like this. The risk is higher in rare illness, where there just fundamentally isn't as much data in. Even then, like in this case, actual death is exceptionally rare.

[@andreahughes5042]

I know the guys in this trial regret doing it, but I just want to tell them thank you. Because as much as that sucked they saved so many lives. Think of the consequences if this had gone for trials at st judes.

[@thygreek8076]

Which lives are you talking about? There's no cure for leukemia.

[@hevbushnell4013]

ThyGreek they mean the lives of other test subjects I think

[@thygreek8076]

@@hevbushnell4013 Yeah that makes more sense.

[@knuffelbeer193]

ThyGreek yes there is? People are being cured from it every day.

[@mentak2593]

@@thygreek8076 um yeah there are cures for many forms of leukemia. What used to be a certain death sentence is now curable in up to 95% of cases, depending on the type...

[@india1422]

I'm a former nurse and i remember hearing about this at the time. As i remember it they essentially gave all the patients the drug basically ask at once

[@imho2278]

No placebo?

[@laurahall3094]

​​​​​@@imho2278no they mean the preparation was too speedily injected AND to all subjects essentially at the same time. Both are non testing- protocol bonehead moves. Amateur hour. I don't see ice packets on the beds, nor any mention, there weren't enough dialysis machines, no blood work done to rule out infection before providing immunosuppressive drugs, just a festival of silly.

[@defenderofjustice7077]

I actually feel proud of them that they were brave enough to test it but at the same time I feel bad that they had to go through all of that

[@MoneyStrategiesSOULutions]

Juyaaa Gwapaaa : brave? I’d say royally stupid.

[@jacquelinehadid8043]

heck if I was getting paid 2000 quid I'd do it as well. Brave would be doing it for free purely for the purpose of medical advancement

[@ariellucas7755]

Avatar007 Exactly right they couldn't pay me enough to put myself through something like this..

[@whitexchina]

They wanted to make a quick buck.

[@convoy034]

I agree

[@inga5258]

Tbh, it is the drug company responsible, not the doctor... Idk why everyone is blaming him. He had a job, he tried his best... I'm so sorry to the men that you had to experience that

[@latoyanelson69]

Agreed

[@neamhdhlisteanach6720]

Exactly. He was just there to inject them and make sure they were ok. It was completely out of his control

[@vVaader]

I honestly think no one is responsible.they've tested it on mice and the mice did not show any of the probants symptoms. They also warn you and hand you a contract where they warn you that there might be some serious long term complications while testing the drug. Sure I wouldn't hope anyone was in their position and this was a very dangerous situation, however the probants knew that there might be serious complications. So in this case, no one is to blame and those who went running to their lawyer are nothing but morrons from my point of view.

[@phasorthunder1157]

But they injected humans with the drug much more faster then was done on previous testing on animals.

[@Ryan-44]

@@phasorthunder1157 TBH, the speed of the injection likely had little overall change on the drastic effects. The severe reaction in people probably came from the differences in T cells between mice and humans, which was newer knowledge at the time.

[@daddydancer1555]

Poor guys i hope they have managed to deal with the PTSD from this event. This is not something you can get over easily.

[@Whocares158]

Agreed. I don't blame them from being very weary about man made medicine.

[@andybricks576]

100% Correct!

[@pilarlastname8053]

KZbin, I don’t think an add for a drug trial study is the best thing to run during this video. Like seriously, I don’t think people will want to take part in a study after watching this.

[@MsLouisVee]

Pilar Tromacek 😂😂😂😂😂

[@skeeter7932]

2 months later and I got the add too!

[@maibster]

ye THIS TOTALLY HAPPENED...

[@netook8]

Yea KZbin has no humanity or morality left. Google is probably run by Skynet

[@petavirus5558]

XD still gonna, because someone got to be the one to do it

[@Courtneyemily91]

The major issue was the drug being administered to every man within minutes of one another instead of adopting a wait and see approach, which you think would be standard initially in a first in man trial. Side note: David’s family is beautiful! So happy to see that.

[@juditmlnr]

While that's clearly the case, it seems they still have done everything according to protocol, haven't they? At least they say that in the documentary, so it may not have been standard at the time?

[@Courtneyemily91]

@@juditmlnr you would think it’d be common sense though. A drug that’s never been given to humans before and they’re rapidly dosing everyone before any side effects are able to take effect. Live and learn, I guess. I’m just glad it wasn’t at the expense of someone’s life.

[@junk_DNA]

@@juditmlnrI mean technically, yes, they did everything according to protocol - but the protocol is largely determined by the entity running the trial following some standard guidelines and requirements. personally, I think the biggest problem is that this kind of reaction should not have been so unforeseen (they even acknowledged cytokine storm as a possible side effect beforehand) that they didn’t prepare for it to happen in a first-in-human trial.

[@margaretwade]

@@junk_DNA The doctors were not prepared for anything to go wrong. Common sense says you should be prepared for ANYTHING when testing an unknown drug!

[@RPcropland]

@@Courtneyemily91yeah but how longbdoyou wait and see 10 min 10 days you know

[@RubyCoughDrop]

That moment when you realize only three of the eight people are in the documentary ...

[@imjustchilling4477]

Nononoooo

[@imjustchilling4477]

That... no

[@secnytsecnyt2981]

I am fairly sure they all survived, though someone can correct me if I’m wrong. More likely, they couldn’t get in contact with the others, or they weren’t interested.

[@lorinagosso]

Lawsuits, NDA agreements.

[@lovelovelovexo]

Yes very strange. I wonder how the boy is doing who lost his fingertips and a few of his toes

[@pharmacyman6415]

Placebo guy: reading his book Guy next to him: in horrible pain Placebo guy: *chuckles I’m in danger*

[@sgtrexy1479]

Ralph wigam

[@graceaxisa4213]

Totally irrelevant, but the dramatization of this event was first class. As a cancer survivor, I am so grateful to anyone who participates in trials. Including the medical staff who take part. I am sorry that these men went through this horrific experience and I am grateful that, despite the dire consequences, new protocols relating to trials have been adopted. Seeing David with his young family was a huge relief ❤️

[@sylviaking8866]

My twin sister nearly died from Covid. The dramatization in this show is similar to what she went through. People next to her who did not make it were wheeled away. She said it was the worst experience of her life. Thank God she survived.

[@graceaxisa4213]

@@sylviaking8866 oh my goodness, how traumatic for her. I hope she is fully recovered now.

[@billyballsup2685]

There's not enough money to be made giving you a cancer wonder drug. Probably been around hidden for years. Pharmaceutical is a business. It's all about money not your good health.

[@HansonFan7383]

I've watched this so many times-- the reenactments, along with the survivor's stories are so compelling.😢

[@Fluffy65]

I'm a multiple organ transplant recipient, and on roughly a dozen medications, several of which are beyond critical to continued survival. This reminds us just how important clinical trials are, and to appreciate the sacrifice and risks those people took, to pave the way for better health and lives for all mankind. Thank you.

[@TheEclecticEmpath]

I work for a clinical research organization and I always thank our volunteers

[@gemmawatson1879]

Liver transplant recipient here 👋

[@bethhoward4364]

Here here! It's an enormous risk to participate in these trials. I've been tempted to do so for the $$$ but the thought of what *could* go wrong had held me back. You know how commercials list all those crazy side effects like diarrhea and death? That's because someone experienced that.

[@nonamenoname9322]

This was malpractice in testing.

[@emmaleary3767]

@@gemmawatson1879 me too

[@kellymurphy6667]

This is astounding. I'm 24 years in remission from Leukaemia and two years of gruelling chemotherapy treatment I endured from 16 - 18. I imagine at some point each one of the toxins in the specific chemo cocktail I received were one trialled by participants equally as brave as these hero's. And I can say I wouldn't have envied what they put themselves through in doing so either! But I'm beyond grateful they did! Even given the long term ramifications I'll be dealing with from here on in, I wouldn't forsake that for the experience I had knowing what it is to be in love and the pure joy I eventually experienced in giving birth to two gorgeous and extremely precious daughters.

[@tiredanddepressed]

It's crazy when you think about the fact that healthy people took chemotherapy drugs first to see if it was safe. Knowingly taking the equivalent of a bomb going off in your system since it'll destroy everything in sight is wild

[@lissakaye610]

Success stories like you are exactly why I work in research. Every single cancer therapy and Alzheimer’s drug trial I hope not so see any observations or toxicity. It is always very sad when something doesn’t work as intended.

[@PhoenIXPhantasies]

Not brave but stupid. Usually people in need of money. Your life is worth so much more than money!

[@nickidaisydandelion4044]

No to pharma.

[@MiVidaBellisima]

Congrats to you, and I hope you live to see 103 😊

[@cathycathy6295]

Hard to believe all infusions were not stopped once first patient demonstrated such severe symptoms.............

[@irrelevantFJS]

I believe they said that by the time the first patient started to writhe in his bed, they were already finishing up the last infusion. So things hadn't gotten bad enough to warrant that, in their minds. They had no idea it was about to cascade and affect everyone. But yeah, now we've changed the rules so hopefully this won't happen again.

[@highlyfavor1905]

I agree

[@janettn]

They still have to test the drugs though..

[@vanessaruiz4705]

also, one of the experts said that the dose was infused 10 times quicker than it was with the animals. Why are they omitting that fact in the final report? It looks to me that such fast infusion could have been the cause, or at least it looks highly negligent and irresponsible.

[@AllThePeppermint]

Mara Ram, yes, it was administered 10 times quicker, BUT it was also a 500x smaller dose.

[@nathanh2917]

I was one of the early people treated with skin grafts. I had 3rd and 2nd degree burns when i was little. Now I have no scars. I appreciate the human test subjects for what they have helped achieve.

[@laurahall3094]

@@nathanh2917 I met a group of children who had received grafts in the 60s. The grafts were done with full thickness host skin so they were very bulky compared to today's grafts. Huge thanks to all the pioneers!

[@katnblu]

The fact that this is real, makes me feel so freaking scared...

[@thevideogamelover99]

Why?

[@MayimHastings]

How is it scary?

[@josephdockemeyer4807]

Right. When he talked about the headache coming in WAVES, building and ebbing. Like birthing pains in the head. That started to make me anxious. I'm at 15:33 and had to pause for a minute.

[@darianbarber3763]

I mean this is why we test drugs before mass distribution and why we test on animals. While yes it may be immoral to test on animals this video's content would become more common without testing on animals. It's good they went through and prevented this drug from hitting the market because it could have done way worse had it not been tested.

[@naiyahnunnthewificat8195]

Im glad i was born in 2007 before 2006

[@starthejar1419]

Everyone: puking, screaming, dying That one guy: okay think imma head out ✌️

[@harssamoanlal2947]

@Jimo National ok boomer

[@rickastleyisnevergonnagive5673]

@Jimo National ok snow roach

[@emip4669]

@Jimo National and this is a problem because...

[@bettyjanemaynard2269]

@@harssamoanlal2947 kip

[@jaydon7819]

@Jimo National apespeak isn’t a real word either 💀 what a mong

[@nisas.5628]

I didn't have this drug, but I had a different monoclonal antibody - rituximab - and it saved my life. I had stage 4 cancer at 17 (actually, lymphoma, like was brought up in this documentary) and thiys documentary just made me feel so thankful to all of these men. Their positivity and outlooks are wonderful, too.

[@hailstorm2244]

i know its been 6 months since you posted it but im a 2 time lymphoma survivor myself but do you remember if you had hodgkins or non-hodkgins lymphoma

[@goha9218]

Wow at such a young age how are you doing now ?

[@hailstorm2244]

@@goha9218 im doing great now i do have higher risk for cancer later in life and i had a few side effect from radiation like lack of hair, stunted growth on my left side, and a few more but im fine for the most part

[@theyracemesohardchair]

Are you dead now?

[@hailstorm2244]

@@theyracemesohardchair i wish

[@erdnuzz8368]

Calling People fighting for their lifes and suffering trough a lot of pain "Elefant Man" shows just how disguting humanity can get.

[@dovermcmanus4595]

This is one of my favourite documentaries. That doctor was pissing his pants no doubt. In the USA they'd be sued to the moon and back no matter what they signed.

[@marneo7514]

They were

[@kriss8499]

Dover McManus you’re right! No matter what you have a patient sign they can still sue!

[@tobiasreaper3650]

@@kriss8499 your execution of responsibilities is always subject to question and judgment...

[@YZER19]

Absolutely not..... that's an very dumb stereotype and also makes no sense considering that the pharma industry obviously have to how tk protect themselves from lawsuits. Since side effects are essential while testing....

[@flower-uw1hm]

Not as much with vaccines.

[@dinosaurplushie9755]

I love these documentaries that get straight to the point unlike American ones... this coming from an American. Very well done.

[@lewiemcneely9143]

@Rally And remember. No matter what it is, we have to get it already worn out by the so-called 'media' and I use the term VERY loosely. Lots of people are finally waking up to the bare fact that EVERYTHING they say is a LIE. But, sadly, some will never see it. And we're ALL lab rats to some extent. Some more than others.

[@lewiemcneely9143]

@Rally You're right.I despise business.

[@cherylangel1714]

I agree! I couldn't keep watching a documentary earlier because they kept going in circles, and taking forever with their pretty cinematography! I'm American too, but seriously! Just get to the point! lol

[@divcrfc]

Wee Brits do everything better

[@lewiemcneely9143]

@@divcrfc My jury is still out on that because I haven't seen 'everything'!!

[@nikkic.8012]

Wow that was so sad and scary to watch... That poor kid just wanted driving lessons and now he has no fingers and no foot. I hope he got millions!!!

[@lowsled1]

Why would any of them deserve compensation beyond the 2k? They all signed waivers, did they not?

[@user-lg4vp4eq7c]

@@lowsled1 because they nearly lost their lives....? it didn’t go to plan and left them in critical condition so why would they only get 2k

[@daddypig6591]

it said the worst that could happen was anaphylactic shock, loss of fingers and feet is much much much worse you wet sock

[@MsGreer01]

Nope he would not get millions as he signed consent to do the trial

[@poppy7210]

@@MsGreer01 he signed consent, with only the knowledge that he would experience side effects such as hives and other less serious damages therefore he has every right to ask for and receive more money, does he not?

[@greenbrain8725]

Can we take a moment and acknowledge how horrible it is that we must subject animals (macaques in this case) routinely to these horrible experiments, and after a life of horrendous isolation and suffering, these animals are simply discarded like garbage.

[@diannbajewicz8952]

So what are they suppose to do to help people then give them a solution then

[@srccde]

Yeah it's horrible but there's no other way.

[@crazyvida2091]

Our lives aren't above animal lives.

[@user-br9br2dk4n]

Look up Dr hadwin / Animal free research charity it is possible

[@samsamcupcakes6476]

All of us could just die then? It's a sacrifice we must live with. Unless we choose to do human trials only, or never advance in terms of medicine...

[@elliearnold8241]

Guys the reason for the doctor saying “okay how are we doing?” In a calm voice is because they need to keep the patients calm, it’s worse for patients to know they are in serious danger and start panicking. They would do what the guy in the beginning was trying to do, escape the hospital.

[@robertflannigan5760]

Ellie Arnold to keep them calm like you said and to test if they can properly respond to the question still

[@dallasgir]

Ellie besides the responsibility of the medical team to react calmly, they ask bcz they need the patient to tell them, in their own words, the symptoms they are experiencing. For example, the machines monitoring their heart rate couldn't tell them that the patient was experiencing an instant migraine, or the level and location of pain they were experiencing. They needed to evaluate ALL symptoms into the diagnosis, and info from the patient is critical with these sudden symptoms.

[@angeldela7633]

That’d work opposite for me

[@tammymoor4061]

I'm so confused as to why cancer drugs would be tested on people who don't have cancer.

[@ferretsnax]

to see if this is what's going to happen

[@cmlvlogs4258]

Me too..

[@tammymoor4061]

@@ferretsnax I kind of get that, but maybe if the drug had something like cancer to fight it wouldn't have acted that way. There are so many variables when it comes to new medications that you can't really expect a drug for sick people to act normally in a healthy person.

[@tammymoor4061]

@skxtxn m I see. So it's not just about how the drug will affect the cancer, but also the body to see if the cancer patients could even handle it. But then there leaves the question of knowing if the cancer patients could handle a drug that someone with a healthy immune system can. I understand these things need to be done to save lives, but there's just a lot about it that truly confuses me.

[@reginarhianacharles9034]

Cancer drug???? Giving that drug is like doing an abortion on a woman who wants children all her life. How could they be so STUPID. You are right. Give it to someone with Type 4 Cancer. They are closer to death. They had nothing to loose. Ah! SAD,

[@TheMutantCreeper]

I wish we could have had Ryan in the interview. I completely understand that he wouldn’t want to since he went through so much. I just wish we could understand what his life was afterwards.

[@Monkey-fc9nc]

He probably can't due to settling litigation out of court.

[@kirin1230]

I wouldn't want my life broadcasted online either... but I wish him the best

[@tshs1663]

ryan died actually

[@Invalidchannel-1]

@@tshs1663 according to who?? Simple google search says absolutely nothing about him dying. He nearly died during his 4 months in hospital but he is very much alive after this horrific experience

[@Mangafan47]

@@tshs1663 source? I googled it, but couldn't find anything regarding him dying.

[@ilhaamhartley7468]

All those symptoms seems extreme and scary.Sounds like a nightmare

[@liofotia]

Doctor: How are we doing, David? David: *screams into the 5th dimension*

[@normalhuman78-53]

heiress of stupidity more like weirdly cut moans

[@u.s.n.retired1995]

I was thinking the same thing. The patient is clearly in distress and a great deal of it!!

[@teknacious]

lmfao best comment

[@breonawarren1507]

Valincia Pruitt They ask anyways to make sure you can respond. Yeah you aren’t doing good but are you responsive?

[@teariet.tekken-wolffenn5881]

That's what I thought.

[@csarah7948]

16:07 How the doctor sees the patient squirming in pain and then causally asks, "How are we doing David?"

[@cutebutsadisticable]

The doctors and nurses have to remain calm and clinical. Honestly alot of people react well to that as it shows everything is under control. If a doctor panics I lose all faith in his/her training. It's been proven a doctor who stays calm and collected keeps the nursing staff calm and help the patient stay calm too. They also save more lives that way.

[@kennamartin416]

Lol made me spit out my dasani.

[@shevongibson3496]

Kenna Martin dasani water? We have that in suriname

[@kennamartin416]

shevon gibson. Dasani flavored water. I drink them everyday!

[@muzic4life655]

That’s the doctors’ way of staying calm and keeping the patient calm as well. If they panic or show signs of panic, then the patient panics too. I was in the hospital for 2 months after having my lung removed and from personal experience, I can say that at first it’s a bit annoying but it slowly becomes a bit reassuring.

[@joshnyman218]

These men did indeed end up contributing a great deal to science and should, although very tragic, be very proud.

[@kristie-leecorney7388]

Josh nyman Mark R what was this drug trial for ? what the heck was the drug trial for because all those people were 100% healthy and had nothing to cure , So do you think , is it really a cure they were looking for or is it a way to make people sick to cut down the population , the government plan ?

[@tiggerie345]

you don't do a first in man test on already sick people, simple as that

[@phantom_kitsune7424]

@@kristie-leecorney7388 isnt this a stolen comment? 😏

[@LaPlaztique]

tiggerie345 As an ill person with Cystic Fibrosis which is a genetic terminal illness, I can tell you that all drug trials for CF patients are done by CF patients. And trust me, we are sick and very immune compromised.

[@thewhitefalcon8539]

@@kristie-leecorney7388 if they wanted to kill people they would just use the lethal injection, dingus.

[@emilybarker3240]

I work in clinical trials! When it goes wrong I feel horribly- we do everything we can do to minimize risk. Thank you to all who volunteer- you make the medical breakthroughs possible.

[@hoggarththewisesmeagol8362]

After trial: here’s your two grand. Don’t spend it all at once!

[@energydrink8300]

patients: we are dieing here

[@johnimusic12]

Actually two thousand pounds converts into $2,562.91

[@jamesonly9998]

Definitely deserved a lot more. As in 5,000,000,000 for each person effected by the drug physically

[@OskarP2601]

James Only r u mad? If a person died there they would have to only pay from 100k - 2-3M €

[@Yggdrasilkuru]

James Only that’s why they have u sign all ur rights away before the test :)

[@chuaailing99]

They allowed the guys to suffer 4hrs before getting help from hospital?!

[@stefanManiak262011]

they tought maybe they will recover shortly and wont be needed for other medical intervention,likely no one will find out,but...didn't happend like that!!

[@wiisportsisthebestgame7958]

They thought they could possibly recover in that amount of time and they didn’t want to ruin the trial if they did eventually recover

[@jaelzion]

It's insane. They had no plan in place for severe adverse reactions. At the first sign of distress they should have said "Screw the trial" and focused on stabilizing the volunteers and getting them treatment. To let them suffer for four hours, sustaining massive damage to their bodies over that time was incompetent and highly unethical.

[@squidiz496]

@@jaelzion Before the drugs are tested on humans they are researched immensely. Again such reactions had never been recorded. Its extremely rare. Not justifying it but its so rare the hospital staff probably thought it would pass soon, unfortunately it didn't.

[@jaelzion]

@@squidiz496 The whole point of a clinical trial is to see how the drug works on actual people. There is ALWAYS a risk when testing experimental drugs on humans for the first time. No amount of animal testing is going to tell you how human beings will be affected by a drug. There is zero excuse for (1) not planning for adverse reactions and (2) watching your test subjects suffer for four hours without doing anything. That's why the rules were tightened up after this incident.

[@cosmicmuse2900]

I love how they've made this documentary. It is packed with information and honesty every minute. No overly dramatic scenes and annoying music that gets excessively loud when no one is talking. Gosh, watching this is a lot easier because of these factors.

[@krashd]

Just a regular British documentary.

[@cosmicmuse2900]

@@krashd it's good stuff

[@kirabradley9497]

At the same time it's not a total info dump. It's so well balanced. Agree!

[@nolusizodlalisa5573]

You are absolutely right, I didn't even realise how long it is because it's just packed with information and no dramatisation of the events

[@personincognito3989]

I don't care for the Sensational way that the American Media reports news or documentaries. It's so loud and so fast paced and repeats itself so many times with masses of assumptions. This makes it very hard to watch. This documentary was much more interesting

[@DakodaS246]

I feel so bad for all the patients involved. It had to be terrifying not knowing what is happening to you or possibly going to happen due to the placebo. I hope they all received mental care for their well being. You all are courageous. We salute you for your efforts to help people get healthier. Thank you.

[@UsernamesForDummies]

I see lots of people commenting on the high number of ads. I didn’t have a single one...

[@NetITGeeks]

Maybe the country you are watching the video has no relevant country-specific ads available. Google (which owns KZbin has trageted ads to specific countries). Here in Canada, I got few ads but I don't think it is that bad. KZbin is free to watch so I don't mind.

[@taaurus13]

I'm 39 minutes and haven't gotten even one ad yet.

[@republican4u2nv78]

UsernamesForDummies I had at least 4 but I don't mind them.

[@JavierBonillaC]

If you have youtube red there are no adds... bright

[@kari7403]

UsernamesForDummies Nope. Me neither. But that's cuz I have KZbin Red! Lol. I always forget how many ads there were and how annoying they used to be before Red. It really did ruin some of the content I would have normally enjoyed without all the ads.

[@gracelinenfelser8663]

patients: puking, fainting, screaming in pain doctors: *Don't stop administrating the drug*

[@JacyTheAngel]

Mhm

[@Hazel4love]

😥

[@jasonwishere3121]

doctors: its working its working..infuse more drug

[@simonbarr9476]

Ahhhh, the benefits of knowing more in the name of science

[@whendis.roberts6817]

Ya what's that?

[@gem.8042]

THE ACTORS LOOK SO ALIKE THE ACTUAL GUYS

[@FaithandNova]

They do, even the woman who played his wife

[@colourmycosplay]

That's a first

[@noahz7968]

theREALmurtibing r/iAmVerySmart

[@Ryan.A.Gardiner]

@@FaithandNova r/wooooooosh

[@amirgill3006]

Thought I was the only one that noticed

[@kanemura93]

My mother told me about this when it actually happened and at the time I was too young to understand the whole thing. It sounded terrifying though. I'm happy to get to see this documentary now and find out about what she told me about.