The Future is Here: Why Governments Must Support Rejuvenation Therapy Research

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[@PaulSchwarzer-ou9sw]

Investment in Longevity is the most important investment one can make.

[@kajsing]

I would like to point out that, no we dont have long line at the doctor or the emergency rooms. At Least not in most places in EU

[@INTELLIGENCE_Revolution]

I wonder why certain countries aren’t competing for young people ? The working holiday visas and digital nomad visas etc are not that great. I’m surprised countries with advanced economies aren’t basically removing entry barriers.

[@kleyyer]

Prices for insulin are just ridiculous in America. Where I live, insulin is less than $10.

[@christopheraaron2412]

A few years ago, senator Berni Saunders proposed taking seniors on a bus to Canada to buy medicine for cheaper. This needs to happen more often, so we can get more competition in the market place here.

[@squamish4244]

The discoverers of insulin sold their patents to the University of Toronto for $1 each. They wanted it to be affordable for everyone.

[@erkinalp]

@@squamish4244 they should have just let their patents lapse by not paying the renewals

[@sparkofcuriousity]

Where i live, i call the medical center get a recipe walk down the road to the pharmacy and get my insulin. The call cost me nothing. The insulin cost me nothing. Americans have the roughest of deals. 😞☹

[@squamish4244]

@@erkinalpThis was 1922. Insulin was the very first drug that could actually cure anything. I don't think they could have ever imagined what Big Pharma would turn into. I know they would have been sickened. Banting & Best. The idea came to Sir Frederick Banting in a dream. He woke up, wrote it down, went back to bed, and the next morning saw the note he had made - which he had forgotten completely about. That's actually how it started.

[@WGPower_Nonchalant_Cafe]

dey' give you the drug BUT you have to sign a 1000 year indentured servitude contract. ..CAPITALISM BABY!

[@gonzalezm244]

Love these videos!

[@T.efpunkt]

That demand goes up when prices go down is not jevons paradox, not even a paradox at all, just the normal supply and demand mechanism. Jevons paradox is about _efficiency_ and _consumption_ . For example when you switch your sports car that uses 12L/100km for a family car that only needs 6L/100km, you will end up driving more and thus burn through effectivly more fuel than you did with the sports car over the same time period.

[@user-my1gh5ct9p]

when he said in 19:00 on Jevons Paradox: he gave the correct analogy, when you have insulin that costs 20$ per vial, effectively it would be cheaper in the future to 1$ or less, and the efficiency would make it far more available. what's the hard thing to understand in Jevons Paradox?

[@T.efpunkt]

​@@user-my1gh5ct9p First of all, the price of insulin in the US is not tied to production costs but a result of corporate greed. Therefore increased production efficiency would not result in lower prices but higher profit margins. Second, when biden forces big pharma to sell insulin at reasonable prices like he promised, the consumption will not increase. People who have diabetis will not start to inject more than they need and people who do not have diabetis will not suddenly start to inject it just because it's cheaper now. This is not how any of this works. This is not how medicine works and not how "free" markets work.

[@danibitt59]

Unless you keep leaving work for later, cause you know youre gonna live forever babyyyy Those longevity therapies are gonna be many, and expansive, otherwise the economies will break.

[@kathleenmccormick5284]

OMG, the hubris! 60 years of cancer research, and cancer rates have skyrocketed. Life span in the U.S. has gone down, not up, since the mass consumption of industrial food. The trends do not support your optimism.

[@squamish4244]

Cancer rates have skyrocketed because we are living long enough to get it. Age-adjusted cancer rates show that death rates from cancer have dropped drastically except in the oldest people. The mass consumption of industrial food is a terrible thing, but also a relatively easy fix. It's food. Stop eating that sh*t and your health will start improving right away. It's designed to be addictive, but it's also not everything we eat, and can be avoided. The recent drop in life expectancy is mostly an American phenomenon and is mostly due to one major issue - the reckless overprescription of narcotics over the past 40 years. That issue has finally been exposed and action is being taken. The obesity epidemic is a contributing factor, but by comparison not a major one. And I should know, my doctor addicted me to benzodiazepines 16 years ago and destroyed my life. Today, that wouldn't happen, as for the past seven or eight years, you have to go to the pharmacy every week and your use can't be allowed to spiral.

[@Sajuuk]

It's in government's (and everyone's) best interests to defeat ageing and develop rejuvenation because a healthy, young, happy, skilled and increasingly knowledgeable immortal citizen is more productive and of increasing value to society than an unhealthy or dead citizen. Population control and resources are easy with increased technology, colonization and terraformingof other planets within a post scarcity society.

[@MichaelDeeringMHC]

Book: "How Not to Die" by Dr. Michael Greger.

[@mnrvaprjct]

No need to worry about population because we’ll start expanding into Sol !

[@RadicalAlignment]

Yeah eventually we'll be like "only 8 billion people?? We almost went extinct!"

[@mnrvaprjct]

@@RadicalAlignment hahaha, to think that one day people might look back at our days on earth similarly to how we look at that population bottleneck that happened a few 10s of thousands of years ago is inspiring, humbling & somewhat intimidating all at the same time!

[@Alexander-ry3dx]

In a post aging world, who would invent aging as a way to combat authoritarianism? There are better ways and aging affects everyone INCLUDING the one’s subjected to tyranny.

[@rewindcat7927]

Another idea: as people get older they get wiser. What would this mean to society?

[@RadicalAlignment]

Yes.

[@DerekAndersonMedia]

also if we can target say neurons for more advanced deaging whos to say the society wouldnt be able to keep a "child like" neuro-placiticy.

[@rewindcat7927]

@@DerekAndersonMedia sign me up for that 👍

[@TheMajesticSeaPancake]

Some quick thoughts on if it ends up being in the more expensive camp for 10+ years or more. Your figure towards the end of 100,000$ for 50 years is relatively attainable for the average person, I can imagine it wouldn't have to be all up front, and it would come out to 2,000 a year. Ignoring AI job replacement or UBI, or even if they happen which I find overwhelmingly likely, that's putting aside 2,000 a year which if you still are working those 50 years isn't much of an issue. My initial thoughts earlier before you threw out those numbers was that the economic benefit of having skilled knowledge around longer would pay for itself.

[@fontende]

Ubi or food stamps never will be allowed to collect or esp getting interest from them. By design it's always proclaimed as temporary self burning financial instruments with the main argument supplied as preventive measure against insulation even in theory. It will be only digital from the start, because such easy to remove or delete unused Ubi. All the century old history of food stamps, such also always was temporary. Current incredible inflation are basically from stimulus provided with real money to most population, very generous, in all other world most Earth population in lockdowns spent their savings. In some form it's fair now that western societies pay more. There were better examples like Britain which instead provided huge tax cuts, unfortunately today taxation there are raised more than even pre-2020. Huge mess.

[@dekathema]

Hey David, great video as always. I'd like to ask if you have any views regarding religious extremism. It may be my own current environment but I have bumped into quite a few people who think that artificially expanding lifespan beyong a certain natural threshold (basically, to them, how long people currently live) is sort of like a violation of the natural or "God" laws and therefore should not be tolerated. Some have even suggested revolt as a response. Do you think there exists a serious concern for a certain margin of society to reject this king of advancement and lobby against it or even rise up because of ideological/spiritual reasons? Do you have any thoughts as to how to combat these tipe of arguments when they come up in debate? Thanks as always!

[@Concepts_Space]

don't engage.

[@realitywins9020]

I'm a Christian and I can't stand people like that. That attitude says more about them than it does about God. They're the same type who hate LGBT people because 'God says so'. For all we know, conquering aging may be God's will

[@paultoensing3126]

@@Wanderer2035Deeply flawed assumption based premise.

[@paultoensing3126]

They should be encouraged and aided in every way possible to get to “heaven” as fast as possible. It’s a huge promotion for them and it helps to clear out militant irrationality for the rest of us.

[@javiergimenezmoya86]

But if that medicine is expensive it cannot be expensive for many years because of the great automation and AGI robotics work in the near future. Patents will have to be much more fair because of AGI automatization.

[@kinngrimm]

How would you prevent stagnation and vegy syndrom, when people hold office for hundreds of years with the same convictions and no change in sight, how prevent people from becoming vegetables by not having to think as that is done by AGI for them? Would we see an age of mass suicides where people who defined themselves formerly by work now are just idling, building up some muscles for no good reason other than to live longer ... for what? Family over time can be a burdon, friendships can go sour, it is at times not about the physical but the mental age that keeps people fit and i would suggest that in that mental fitness is the more important seen over the aeons. What will happen to societies that are not fully embracing that change, but split down the middle, like Amish people on one side and Transhumanists on the other? Will transhumanists become a new species not able to interbreed with homo sapiens anylonger and if so, how to prevent war between the too? If i have to endure someone like Trump for eternity, death may start to look pretty good. What happens if we have immortal sociopaths and psycopaths that wont go the inward way to deal with such, but outward hurting others. Not everywhere is the death sentence still a thing, but even if, would taking immortal lives be worse than an morrtal lives or is there no differance and who decides that? The mortals or immortals? The safing grace of the human race sofar is, that the worst of the worst eventually die of old age. How about population control, should everyone still be able to fuck their brains out and get childreen or as we become immortals so to speak do we constrict births somehow. How do you square this with religious people? How do you control this for influential/powerfull people? Even if we would live for "only" 300 years, most of the issues above stick. I guess we could try to regulate the age up incrementally over time in a way that societies would not just implode, as that is my prediction would happen in extrem cases. So say we limit age to 140 for the first 200 years, but increase the area within that lifespan where we are fit like a 20 or 30 year old till say shortly before death. Even if it turns out then it would be bad in some ways, how could we make sure to go back or into another better direction? Many of the institutional sollutions you mention may not even exist anymore in a society with either AGI or immortality. How do we decide what genetic changes we would allow into the gene pool? One could argue anything that is already in the gene pool is acceptable to spliced into embryos or base for a gen thearpy. Then one may also say, sure sure, but what about genetic defects and illnisses? In both cases, evolutionary advantages and disadvantages play a role that may have helped us at one stage or another in human evolution to survive. Maybe we don't need them anymore and therefor also could avoid the negativ effects. Sure. So we are already better on average in every aspect as we choose the traits that let us think faster, have a better more efficient metabolism, therefor consume less food and still have an excellent body form. What next? We have gone this far, so why not splice in some Salamander for fun? Or some Rhino for thick skinn that might come in handy when going to other planets, if not that maybe some frog or bear stuff to be able to get into a state of hybernation for long distance space flight. At that point, i doubt we still could call us human at definetly it gets into the range of not being able to breed anylonger with the former humans. But why stop there? If you haven't read the culture cycles, it is very fascinating scifi. So why not allow us to change gens on the fly, become other animals for a while and then change back? Thats sounds likefun, not sure how viable this one is hrhr but hell why stop anywhere? To the point of another scifi (SG1 and the race of Thor).. aeons later the first genom of homo sapiens has been lost to time and an old flue virus resurfaces and noone has immunities anylonger and all die. The end. The ultimate enemy is time and only eternity laughs at it. The more roads we take, the less are left to choose from.

[@MichaelDeeringMHC]

How many channels do you have?

[@ryzikx]

any opinions on bryan johnson and david sinclair?

[@RadicalAlignment]

I think Bryan has severe trauma, David seems to be on the right track

[@xGriffy93]

Even at 100k for 50 years it would be cost effective for the state to pay for it, as you get those 100k back in taxes much sooner than those 50 years are up Seeing how so many countries are facing issues with their pension plans alone, paying to keep people in working condition might be one way to go about it.

[@ArekStryjski]

Is AI not changing everything here. We will get much quicker progress in medicine, but also this progress will not be dependent on how many healthy people we have. Who needs healthy old people in post labour economy?

[@blazearmoru]

so you're saying everyone should start living healthy and watch the streets before crossing bc that will determine if you make the cut or not xD

[@thebozbloxbla2020]

i have a question. an important one. you talked about patent trolling, and how big pharma has just been very unethical. why can't it also be true that the "form of the fountain of youth" that is being researched might intrinsically be of the nature of expensive, or be more able to be kept behind closed doors?

[@RadicalAlignment]

That's kind of what I was getting at with the beginning - there *probably* won't be a single rejuvenation therapy

[@leiladasha]

Not as existing system

[@adcaptandumvulgus4252]

Yeah I think Rich billionaires got that covered, they have the means and desire to make it happen for us as plebs don't even have a chance unless we're one of the researchers that comes up with it but that's just my two cent hot take.

[@714acedeck]

while these talks are great, its pretty depressing as a poor person to consider what's most likely going to happen. i'm pretty odd probably, for being so poor, but having followed intellectual discussions on youtube for over 10 years now, including the work of dr. david sinclair, who claimed recently the problem of aging is already solved. and martin ford, who's been discussing UBI for longer than most people have heard of the concept. but i suspect these medical technologies will be cheap to make, but not cheap to obtain, and not even available to "the public" for possibly decades. there's an interview joe rogan did with mel gibson that's already 6 years old where gibson talks about taking his father down to south america or somewhere for some gene therapy treatments. and it already sounds very impressive what could be accomplished 6 years ago. so like always, the wealthy are going to hoard all of the fruits of mankind's struggles, all the blood sweat and tears of countless nameless forgotten people, in the hands of a few, just like always...

[@Borishal]

So the problem is the billionaires. The solution is obvious.

[@BenoitStPierre]

David Shapiro, 2024: "There's always a way to die."

[@RadicalAlignment]

It's just a matter of creativity and willpower lol

[@geometron3646]

It's a very epicurean/materialistic viewpoint to want to live forever. From surveys I've seem there's around 50/50 split in our societies between that and some spiritual/platonic viewpoint. I assume you and most people in the comments have never had a strong spiritual experience or have neglected it if so? Fine, but take into account those who have or feel differently. So say 10billion people, nobody dying, no space to have children. "below replacement level" does not compute, I've been to busy nightclubs, it's one in one out. Some comments are saying "let's let the religious types get to heaven quicker." What if they feel happy with you living forever, as long as you unidirectionally exile yourself from Earth and leave space for their people? Needs to be a lot more grown up, empathetic, and serious conversation here. The likelihood is we all will live together, traditional tribes, thru wireheads, self-cyborgs, through to people transferred onto silicon, so we need to consider what is right and fair, no?

[@baraka99]

When you were discussing longevity and consolidation of power in the hands of few immortal oligarchs you never proposed a solution for that scenario. Plus... when are we gonna hear you play that guitar in the background?

[@rewindcat7927]

+1 guitar

[@rewindcat7927]

Really curious if anybody is into reincarnation here, and what this would mean to them?

[@TaraAnne2024]

I am probably the only one who thinks that a smaller population is optimal if we are going to have AGI doing most of our jobs. I am sure I am missing something, which is why I am probably one of the few who thinks this.

[@KleptomaniacJames]

Sure what you're missing is that a "smaller population" is something like a couple thousand people. AGI is going to be able to do just about everything.

[@helge666]

I think what you might be missing is the ethical aspect. About 100.000 people die *every day* from ageing-related diseases on this planet. In two years, this gives you a heap of bodies the size of world war 2. All these people do not all fall asleep peacfully the day they turn 65; most of them suffer bodily and cognitive decay for 10-20 years before they finally die. If we have the means to develop a set of treatments to prevent that from happening but chose not to do it, we're committing an unspekable crime that dwarves all crimes humans have committed during the course of history. The option "smaller population would be optimal" is off the table with LEV, we need to find more ethical solutions.

[@gdok6088]

Actually you are missing pretty well everything, which is not meant to be dismissive or unkind as I suspect that the majority of the population are not up to speed with all the transformational, disruptive and dramatic advances that are already happening and are about to change our lives. And these are most likely to be very positive changes in all domains of life. We are headed for an era of hyper-abundance of goods and services and dramatic advances in medicine, technology, energy production and more.

[@TaraAnne2024]

@gdok6088 you actually proved my point with your reply. AGI can take over most of the jobs, leaving the working folk without work. This leaves us with free time to garden and hike or do other activities that keep us healthy. We will live longer, so we need to be healthy. Since we won't be working , we will have to lean on the government for income( UBI). Fewer people means less strain on the government. Becoming self-reliant for our food reduces strain on resources.

[@KoroushRP]

Is david sinclair full of it when he says theyre only a few years away from anti aging pills and treatments?

[@danielguyton8976]

I'd say it's not impossible, depending on how things go. Ray Kurzweil thinks nanomedicine will be here by 2030.

[@AkkarisFox]

I mean nano dialectric smartlets augmented by reprogrammable Huygens meta surfaces Is something that's pretty close.

[@christopheraaron2412]

Low birthrates make it a good investment for population stability

[@PrometheanVision]

I don't want the Boomers to benefit from this technology, way too much ignorance in that generation.

[@EskiMoThor]

Most generations seem to think earlier generations were idiots, as far as I can tell, so future generations will probably think your generation was ignorant too. Should they deny you health services if that turns out to be the case?