The Impact of DNA Damage & Lifestyle on Aging & Longevity Medicine with Dr. Morten Scheibye-Knudsen

In this episode of Longevity by Design, host Dr. Gil Blander is joined by Dr. Morten Scheibye-Knudsen, a leading figure in aging research. Dr. Scheibye-Knudsen discusses his groundbreaking research on the role of DNA damage in the aging process and its implications for chronic diseases, aging research, and longevity medicine. The goal of his work is "to discover interventions leading to healthier, happier, and more productive lives."
Dr. Scheibye-Knudsen's work is on understanding normal and premature aging, with a focus on the pivotal role of DNA damage in the aging process and interventions for healthier aging. By combining computational methods with laboratory experiments, his team explores innovative strategies to target DNA and counteract aging processes. This conversation illuminates the intricate relationship between DNA damage, aging, and chronic diseases.
Dr. Scheibye-Knudsen also discusses the impact of lifestyle (diet, exercise, sleep, social factors) on health and aging. He goes on to describe his work using data-driven approaches to better understand aging and developing interventions, including identifying novel targets and drugs, for healthier aging. Additionally, he explains what longevity medicine is and the importance of educating clinicians and politicians on this topic to translate research on aging into healthcare and improve people’s healthspan and lifespan. Dr. Scheibye-Knudsen's dedication to unraveling the mysteries of aging is advancing scientific knowledge, which has tangible benefits for global health and longevity.
Introduction: 00:00-03:04
What led Dr. Morten Scheibye-Knudsen to become a scientist?: 03:05-04:35
Could please give us an overview of the research you are doing?: 04:36-05:52
What is DNA damage, and what causes it?: 05:53-07:52
What do we know about the influence of DNA damage on aging and age-related diseases?: 07:53-09:39
Can DNA damage be repaired? 09:40-14:12
What questions are your research group asking to better understand DNA damage and repair and their effects on aging?: 14:13-16:20
What is NAD, and why is it relevant to aging and age-related diseases?: 16:21-19:54
What are the benefits and risks of NR and NMN supplements in humans?: 19:55-24:48
What is a ketogenic diet? What are the effects of a ketogenic diet or ketones on DNA damage or repair and aging?24:49-31:06
What is the effect of a ketogenic diet on cancer?: 31:07-32:27
What is the Aging Research and Drug Discovery (ARDD) conference and its mission?: 32:28-40:41
What are the most prevalent features of aging?: 40:42-47:52
Are there differences in aging between females and males?: 47:53-50:19
Are there differences in tissue aging trajectories?: 50:20-53:59
Identifying compounds that target aging: 54:00-56:14
Can nuclear morphology predict cellular senescence and cancer?: 56:15-01:04:02
What is longevity medicine, and why it is so important for physicians?: 01:04:03-01:07:23
What pharmaceutical drugs are the most promising for targeting aging to extend human healthspan and lifespan?: 01:07:24-01:11:58
How important are lifestyle factors such as nutrition, physical activity and exercise, sleep, and social engagement and connections for human healthspan and lifespan?: 01:11:59-01:16:37
Dr. Morten Scheibye-Knudsen’s top tip for improving health: 01:16:38-01:18:20
Longevity by Design is produced by InsideTracker, your data-driven wellness guide for optimizing your healthspan. For a limited time, visit hubs.li/Q02vy8lP0 for 20% off any InsideTracker plan.
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[@MrCarstennielsen]

1:08:00

[@MrCarstennielsen]

27:00

[@KJSvitko]

Go vegan for your health, whole food plant based. Go vegan for the animals. Go vegan for the planet. Go vegan and be healthier and happier. A lower risk of heart disease and cancer for you and a better planet for everyone, human and animals. Eating healthy is not a diet it is a healthy life style.

[@KJSvitko]

You are what you eat. Your diet impacts your health. Lower stress, reduce obesity, get enough sleep and more exercise are key to a healthy life. Obesity in children and adults is rising across the world. Fast food and sugary drinks including fruit juices are contributing to the problem of poor health and obesity. Eat a healthy plant based diet and exercise regularly. Reduce or ELIMINATE cows milk, eggs, cheese and meat. Eat more salad greens, beans, fruit and vegetables. Eliminate fast food, snacks like cookies, cakes, chips, and sugary drinks and juices. Every adult and child should own a bicycle and ride it regularly. Regular exercise will help you sleep better. Yoga is a great stress reducer. Obesity is all too common today. Get off the couch. Get off the phone, ipad or video game. A variety of stretching and other exercises help with increased mobility. Ride to work, ride to school, ride for fun. Every city should be a bicycle city. Speak up for bicycles in your community

[@orjanbern4766]

Lol, truely lol.