The Impact of Senescent Cells on the Body & Aging

This clip is from an episode of Longevity by Design. Hosts Ashley Reaver and Dr. Gil Blander are joined by Dr. James Kirkland from the Mayo Clinic, one of the world's leading figures in aging research. This episode is a deep dive into aging research, cellular senescence, and senolytics. Dr. Kirkland discusses the impact of cellular aging (senescence) on healthspan and his discovery of the first senolytic agents that remove senescent cells and extend healthspan, illuminating his pioneering work in aging research.
In the full discussion, they cover:
What is geroscience, and what are fundamental aging processes?:
What are the differences between targeting aging vs. the traditional medical system?
What are gerotherapeutics, and what is their relevance for healthspan and lifespan?
What are senescent cells? What is the impact of senescent cells on the body and aging?
What are senolytics? How do senolytics work to target senescent cells to remove them?
How Dr. James Kirkland discovered senolytics such as fisetin, quercetin, and dasatinib? What clinical trials on the effects of senolytics in humans have been done?
Discovering biomarkers for senescent cells
How might senolytics be used clinically in the future if proven safe and effective?
What are the effects of lifestyle, such as diet and exercise, on senescent cells?
What excites Dr. James Kirkland the most about the potential for extending people's healthspan and lifespan with therapies, drugs, or interventions in the coming years?
Full episode: • The Effects of Cellula...
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[@paulburick1506]

Valuable information. Thank you all.

[@bowser2005]

Dr. James Kirkland is looking younger than usual.