Why and where do senescent cells form?

[@TheSheekeyScienceShow]

Now I like p16, but then I also like p21....but which one is better? There's only one way to find out...

[@lennihe]

There can only be one.... Worlds Coolest Protein!

[@r.guerreiro140]

Hello Sheekey What about a report on the current status of senolytics? :)

[@liquis5]

Naturally I'm looking forward to studies that selectively kill both P16 and P21 identified senolytic cells to see if there's an additional benefit!

[@stevenh109]

🤣 A reference which might be lost on your overseas viewers

[@toresagen7346]

When you say high fat diet is it a high fat, high/moderate carb diet or a healthy keto diet?

[@KenOtwell]

wow.... at 4:33 I literally jumped out of my seat to see what what going on outside! lol.

[@mingxu9431]

Thank you for discussing our paper. I believe both p16 and p21 are important to study senescence.

[@marilialevacov2939]

Your graphiics do help to understand the subject. Well done!

[@Anjanya1948]

I'm certain there is an intricate and complex relationship between hair growth and senescent cells. Getting rid if them may cause hair loss?? I just wish you could address this. I'm a senior citizen wanting to grow very very long hair. Why don't you do a whole segment on hair growth and any research with that?

[@littlevoice_11]

I wonder if lifestyle and dietary measures that specifically target the areas were these cells build up wild help? Perhaps a future video topic?

[@_StevenB]

I think the greatest strength of your channel Eleanor is also your greatest weakness - it's very informative and not speculative at all, almost every second is about what's happening right now. If you ever want to try speculation though, it would be interesting to see where you think the field is heading!

[@Krunch2020]

There are plenty of channels that will satisfy your need. Isn’t it obvious where the field is heading? We have Rejuvant alpha-ketoglutarate on the market now. Let’s concentrate on facts and current knowledge. I’m anxiously waiting for James Kirkland’s Fisetin study results. Let’s not speculate and be wrong.

[@iblisthemage]

any study of inflamation in women taking Tamoxifen? And does hs-crp correlate with p21 or p16?

[@christopherellis2663]

I find this to be completely whelming 😷🙏

[@johnhemming]

Thank you for this video. I think what happens is that an increase in inflammation causes a reduction in NF-κb which causes a reduction in SLC25A1 which reduces the number of citrate carriers which causes the differentiation of stem cells to fail more often and those turn in to senescent cells which then increases inflammation. Obvoiusly those would not be all senescent cells, but I think it would be a substantial proportion. Noting that the Naked Mole Rats don't really have that many it is consistent.

[@johnhemming]

Oddly enough I think it is the anti-inflammatory Interleukin-10 in SASP that drives this.

[@shresthashreya5418]

love this xx

[@sebek12345]

Love your channel! Thank you so much!!

[@RK-eb9vf]

Can someone please write the steps. I cant seem to figure them out, thank you!

[@michael-qp9xd]

Hello - thanks for update with very latest on senolytics. I know Mayo is studying fisetin and the D&Q Combi for removal. Do you have any ideas on best natural senolytics besides fisetin and timing when might have some indication for partial benefits for humans?

[@Earwaxfire909]

53 = 21 + 2 x 16

[@danno1800]

Very clever!

[@Earwaxfire909]

@@danno1800 I only wish it suggested something useful.

[@sarvleenkaur3375]

How much difference is there in cell( type) population in p16 rich senecent cells and p21? Are there like more senecent or less senecent cells?

[@avidey7050]

Wow ! I am focusing on "Zombie Cells" at Hypothalamus (Human), where administration of "aging" is located as identified already. To "Slow Aging" before "age related chronic conditions" can set in, I want to identify either a consistent "Synolytic conjugate" or a "Exosome" that can be delivered via a "pill" taken daily as a "dream solution". How ? What clinical "success story" so far in 2024+ Going forward ? Talk OK ?

[@weisberd]

I'm a native English speaker and I have no idea what she said.

[@selfcensorship1]

"high fat diet" is way too broad a term.

[@Hansulf]

Yeah... They should always point to the percentage of calories in the diet that comes from fat. We need a standar asap

[@sherrybulsa8742]

Internal scar tissue cells

[@wigglywrigglydoo]

Interested too. How do they target / program the P21 and P16 anyway?

[@sherrybulsa8742]

@@wigglywrigglydoo only the CEO of Beam therapics knows

[@joelmccoy9969]

Audio quality and pronunciation is horrible. The `P´s are popping. Your audience is not just regional.

[@optimisticnihlist9705]

I'm disliking onlybecause it's 2:28 and you almost gave me a freaking heart attack and I stg I think my roommates heard me gasp and just woke up

[@Hansulf]

You mean 4:30 right? 😂😂