The science of super longevity | Dr. Morgan Levine

Science can’t stop aging, but it may be able to slow our epigenetic clocks.
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What if we could slow down the hands of our biological clocks? This question underpins much of the research of Morgan Levine, who leads a research team at the life science company Altos Labs.
Levine investigates the fascinating intricacies of aging, recognizing that it doesn't happen at a uniform pace for everyone. Central to her exploration is the concept of epigenetics - the factors that influence gene activity without changing the DNA sequence. Levine focuses on DNA methylation, a significant epigenetic change that occurs with aging, and the development of models called "epigenetic clocks" that can be used to predict biological age.
While she acknowledges that it might be possible to reverse aging at a cellular level, Levine clarifies that the ultimate goal is not to "cure" aging or death, but to delay disease onset and improve healthspan.
0:00 Fast agers & slow agers
1:25 The hallmarks of aging
1:59 What is the epigenetic clock?
3:05 Can we ‘Benjamin Button’ aging?
5:22 The holy grail for scientists
Read the video transcript ► bigthink.com/series/explain-i...
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About Morgan Levine:
Morgan Levine was previously a tenure-track Assistant Professor in the department of Pathology at Yale University where she ran the Laboratory for Aging in Living Systems. In 2022, she was recruited to join Altos Labs as a Founding Principal Investigator at the San Diego Institute of Science. She currently leads a research group at Altos Labs working at the intersection of bioinformatics, cellular biology, complex systems, and biostatistics with the overall goal of understanding the molecular trajectories aging cells, tissues, and organisms take through time.
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Read more of our stories on aging:
Aging gratefully: Will you be happier in old age?
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Blood test can calculate your true biological age
► bigthink.com/health/calculate...
The brain undergoes a great “rewiring” after age 40
► bigthink.com/neuropsych/great...
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[@grilledcheesephd]

And the A.I thumbnail award goes to…

[@djayjp]

Actually I don't think it was AI designed.

[@erickgomez7775]

The Machine Learning honorable mention goes to...

[@thescoobymike]

@@djayjp it 100% is

[@djayjp]

@@thescoobymike They changed it.

[@ripdeth]

Master Roshi

[@redmoondesignbeth9119]

I'm 71 and look and move like I'm at least 20 years younger. I was raised by a Christian Science Healer so was taught that my MIND CREATES my REALITY. Except for brain damage as a toddler, all I use is aspirin. NOTHING else. I've finally recovered from an extremely stressful period. There were murders and I was almost one. My experiment now is to see how far I can push this mental healing. More exercise and basic healthy cooking. I walk a mile a couple times a week to get groceries. This is my latest "trick". I listen to music from the 60s from when I was in HS. I use it as a meditation and let my body "remember" what it felt like to be 16. I mentally "greet and love" the cells of my body as if I was a kid. Amazing results.

[@jonhall2274]

Lmfao, its amazing how well the placebo affect convinces people that their pseudoscience BS is actually useful. 😂😆

[@nicoletrulyyours]

Love this comment and I can relate. I’m in my 40’s and get told all the time how much younger I look. I think genes play a good role, but I also keep my inner child always with me. Like you do, I listen to music I loved as a teen. I still watch my childhood shows and movies. I do cartwheels, I roller skate!!!! I think all of this has help me stay and look and feel younger than my actual age.

[@redmoondesignbeth9119]

@@nicoletrulyyours 😘

[@livephysiology]

As this video accurately describes DNA methylation as it relates to aging, it is also of relevance to point out that exercise training can affect the epigenome as well. Many of the changes induced by exercise training have been linked to an anti-aging affect on the epigenome. There is some evidence that the aging process is at least partially reversed due to the effect exercise training has on DNA.

[@pripple1]

@Repent and believe in Jesus Christ The fuck

[@themasteryocheese8133]

​​@Repent and believe in Jesus Christ D Does this mean I have to eat cow tongues?

[@1IIms]

​@Repent and believe in Jesus Christ hail satan

[@stevenhird1837]

@Repent and believe in Jesus Christ help me funky Jesus iam ageing.

[@aarongottfried5595]

all of this is just keeping weak people with bad genes alive longer as we already are

[@SearchOfSelf]

Rather than chasing individual diseases, targeting the aging process itself could be the key to tackling multiple age-related conditions. A holistic approach for healthier aging! 💟

[@str8gigachad124]

Or the opposite, bryan johnson targets the individual mechanisms because there may be a low chance there's some kind of longevity genetic

[@SearchOfSelf]

@@str8gigachad124 Agreed! Even though targeting the aging process itself could offer a holistic approach, targeting individual mechanisms can be incredibly beneficial in finding solutions and treatments as well. I think both approaches are important.

[@asdfghjklo]

Sounds like blabla

[@himanshugurjar9002]

Nah, not profitable enough. Although a good idea for elites.

[@caiden3396]

I think we should look at how indigenous peoples view aging.

[@jeffrailey]

Thank you Dr. Morgan Levine and Big Think KZbin channel. I’m 51 years young, and a veteran boxer. At my age, I’m able to out box and out perform younger boxers because I tell them to take care of your bodies. Eat smart, get rest, and train like a beast yet train smart. God bless you and thank you for this knowledge. 😎🔥🥇 🥊🥊🙏🏾🙏🏾🙏🏾🙏🏾🙏🏾🙏🏾💖✝️

[@michaelbishop9157]

wish that it was this simple

[@rene-rv6pp]

Be carefull. Strong traing is not exactly a formula for longevity. Rather for a short lifespan

[@Kaledrone]

@@rene-rv6pp which is why healthspan is FAR and I can't stress this enough, FAAAAAAAR more important than lifespan ever will be. What is the point of living long if you are frail and decrepit by the end like these centenarians living past their expiration date? I would much rather "train hard" and maintain a very physical and vigorous body and then die at like 70, which quite a bit lower than the average life expectancy where I live. People who want to live a long life for the sake of living a long life literally have no purpose and meaning to their existence. It is a miserable outlook that I would not wish on my worst enemy. And don't tell me it's because you want to "see your grandkids grow up", if you did things properly you should have been able to do that by the time you are 70-75. There is no reason to live to 100, unless you want to see your "great grandkids" which I would argue is an incredibly stupid goal itself. You want your great grandkids to remember you as a frail, ineffective little old man? Makes zero sense. I had one of my great grandmothers alive until I was about 12, and I TRULY wish she wasn't, may sound harsh but she should have died at least 2 decades before she did. Nobody should be living like she did. You go ahead and enjoy your "long lifespan", I would much rather die at 70 while still maintaining a robust and muscular physique. You may argue that I will change my mind once I get close to 70, and to that I will say there is only one way to find out.

[@DavidHernandez-cw5ly]

​@@Kaledrone The thing is that, Being in that shape plus good diet Will mostly lead to a longer life than most As this girl in the video said "good health equals longevity" So keep at it

[@user-mu6jh3jh2m]

One of the secret of imortality is the vitamin B12. The vegan stay healty and young thanks to that and plants . Thanks God and the resistance.

[@bagster8660]

Firstly, very few people live past 100 and that may not change anytime soon. The important thing is living healthy into advanced old age rather than just surviving in poor health for a decade or more. I’m 62 and have done resistance training since I was 18 and have kept aerobically fit through various sports since I was 5 years old. I also eat little to no processed foods, eat in moderation and maintain a healthy amount of body fat. I do drink alcohol, almost exclusively red wine, but very little hard spirits or beer. My goal is to be able to live an active and healthy life for as long as I am able.

[@33Crazydude]

You could indeed be correct, yet there's also the possibility of being quite mistaken. These are extraordinary times we find ourselves in, and there's no doubt that artificial intelligence is poised to significantly reshape various aspects of human existence.

[@Casualclips17]

Keep going sir, sounds like you have everything in place to do just that

[@lauren_faulkner]

@@33CrazydudeI fully believe we will break every record and every precedent on aging in the next 20-30 years

[@Chris-pt6hh]

Rule of thumb... when a headline is written as a question, the answer is no.

[@brianw1620]

Fun fact: I had this in my Watch Later, and they changed the title.

[@user-mu6jh3jh2m]

The secret of imortality is the vitamin B12, I am a hacker. Vegan stay young for instance thanks to this vitamin. You should try. Thanks God and the resistance.

[@drummer265]

"A lot of people are very concerned about the aging process because of what it does to our appearance" lol oh, here I am just worrying about it because of the whole closer to death thing, but okay

[@amandasunshine2]

I mean.. women are told we're no longer valuable.

[@memecathar1263]

“A lot of worthless people are very concerned about the aging process due to how it affects their appearance”

[@Livinginpeace1]

Watching it happen make you think about it more.. don’t act shocked that’s the reason people try to look better

[@Livinginpeace1]

@@memecathar1263 you you must be one of the “worthless” people

[@rkr-420]

I'm just trying to outrun death and I am only 25yr. I suffer from schizophrenic auditory hallucinations sometimes the voices can say some things that I do not like. I just wish I can live and cure every medical issue I have

[@hwway4488]

I like that she said we are concerned about it because of what it does to our parents, that is generally the closest emotional way that ageing affects us.

[@fisicogamer1902]

It affects us strongly too. For example, If you are an old man that had a child, you don't want to age, not just because you don't want to die, but also because you want to interact with your kid and help its development. You don't need a child by blood: A much younger person than yourself that you want to help causes the same effect.

[@dsnk3777]

she didn't say parents, she said appearance. what it does to our appearance

[@heinousanus9352]

She said APPEARANCE & no, I'm concerned about what it does to me. Most of us are concerned about ourselves before parents. The fact of the obsession over what it does to appearance is proof that we generally care about aging's effect on ourselves before we could fly a single fuck about anyone else.

[@hwway4488]

@@dsnk3777 really? Oh my bad, I guess I just hear how my issues are echoed in these clips

[@evropaheart]

@@hwway4488 glad you're worried about them though :)

[@SilverFan21k]

Hey Big Think this is awesome! Someone shared me this video... its so cool to see you guys covering Longevity and Life Extension! 🧬🔬

[@asdfghjklo]

Its like a cat talking about reading books.

[@bigthink]

Cheers, glad you liked it!

[@pbeasl1]

@@asdfghjklot 2:53

[@asdfghjklo]

@@pbeasl1 2.53 am or pm?

[@user-mu6jh3jh2m]

Try vitamin B12, vegan stay healty and young thanks to this vitamin. Thanks God and the resistance.

[@Aetherius88]

I don't understand why she says at the end that she doesn't think we can prevent aging / death. Her whole talk was about how we have already unlocked some promising methods of potentially reversing aging. Look, the point isn't just to delay death a little bit. Let's aim for curing aging completely.

[@jgarma]

Nicely done, Morgan, particularly how you explain epigenetics as the operating system for the cell. Thanks for taking the time to do the video!

[@loveisthething]

​@Repent and believe in Jesus Christ come again?

[@user-mu6jh3jh2m]

You should try vitamin B12 to cure aging. Vegan still young thanks for this molecule insted of plants. Biohacker btw. And thanks God and the resistance.

[@The_Cyber_System]

An interesting presentation on their study into epigenetics for sure. And a nice rational non-sensational conclusion as well. Bit clickbait in the title and thumbnail but that's the algo's fault. I enjoyed this one.

[@ForAnAngel]

Think about this: There are already many people alive today who will live to see the year 2100. Someone born today will only be 76 when they ring in the new year. With the way technology is advancing I wouldn't be surprised it the first person who will eventually live to be 1000 years old is already living as well.

[@gardeniabrune2125]

That would be great, but at this rate humanity will be out by 1000 years 😂

[@JakeRichardsong]

Human lifespans are going to 10x in the next 100 years? Doesn't seem likely.

[@RoguePC4U]

@@JakeRichardsong Famed author Ray Kurzweil suggests humanity is already very close to escape velocity. Meaning that there will soon be scientific ways to extend life. Short at first, but then more ... and more as time goes on. So someone could theoretically adopt these findings as they go. Thus he believes 1000 yrs will be entirely doable.

[@SPQR748]

There’s two aspects of aging to consider. One is appearance and the other is health. I am seventy years old and I am often told that I look much younger. I usually counter by saying that I may look young but I feel seventy. Regardless as to how you may look or even feel, humans rarely live to 100 years on average. This proves that we are NOT close to figuring out aging. As one man who was 108 said when asked about the secret to his longevity, “There’s no secret. I have lived this long because God wanted me to live this long.” I know that those who believe in evolution will say that can’t be the answer. Soooo wait on science 🧬 and let us see.

[@antonrossouw8015]

Abba Father our Creator will decides how long you will live. You can improve quality of life thru diet and just being active.

[@SPQR748]

@@Chaotic_Order Yeah but I think that if they found a cure for aging they would keep it for the elites because that’s how they are plus it conflicts with their overpopulation narrative

[@neilnewinger3059]

More important than longevity is the overall health. I do not care to live to 100 years and more, if my health is miserable, I can not walk, exercise and enjoy life. I would rather be healthy till I am 80 and then die quickly.

[@Spartan21blue]

@@antonrossouw8015 sorry in this instance , Good has nothing to do with it

[@AK47HEAVYMETAL83]

I just want to live long enough to see how my children turn out to be as adults…that would be nice…or I might have to smack some sense back into them before I turn over into the ground. Lol

[@marketnewsclub5644]

We should cure death. Life is beautiful and we should have the right to live forever if we choose.

[@ryanwellington7493]

I've always said health span is much more important that life span, life is only worth living when you can do things and not be limited by health problems. Doctors really need to start focusing more on prevention if they want to improve longevity and we can only do this by encouraging a healthier lifestyle and educating people better on how the body works.

[@joshuarodriguez8922]

But they wont it will go against the program. If everyone is healthy big pharma wont make nay money. Only you can prevent aging

[@billyhughes9776]

Great stuff - Should always be about the quality of the life you potentially have left to live. Slowing or postponing disease means people may have more good years as they age.

[@johnnycomelately6341]

A clear and quality talk. Thank you

[@robertdragusin5302]

Previous thumbnail had more impact. It actually left an impression.

[@sapphyrus]

There are certain species that can reverse aging and not die due to age so it should be very possible once we solve this. Death due to age is prevalent among organisms but it's not a foregone conclusion. We need to decouple ourselves from dogma that death is inevitable while we explore this.

[@amandasunshine2]

I like your username and you're absolutely right. Did you hear about the mice we've already reversed aging in?

[@sapphyrus]

@@amandasunshine2 Yes, ultimately this will be tried on humans. Let’s hope we will survive till then.

[@amandasunshine2]

@@sapphyrus I think we will. It's progressing on a similar timeline as other treatments, my guess is it will be ready for human trials in 10-15 years. Things happen obviously, but the chances are in our favor I'd say. Unless you're significantly older than me lol

[@sapphyrus]

@@amandasunshine2 I hope to be around another 30-40 years but am also aware how sluggish medicine experiment phases tend to be. Maybe just in time!

[@quantumfx2677]

This lady is only going on what she knows and I will tell you that there are some out there that are way ahead of her understanding what she knows and keep information in a small group of what they discover. The truth is we are not alone, they already know how to extend life and there are technologies that we have learned to build from very intelligent beings that isn't made public. We have some not so nice people that need to be removed before anything will be known. Nothing is going to be front page news about extending life span into the hundreds of years and healing all diseases when the goal is just the opposite. Disease and population reduction has been on the list and it would be suicide if you were to share anything that would promote the opposite. Anything we hear without digging will just be surface news. I 100 percent believe by 2028,29 everything is going to change and somethings are going to shock the world, we just need to stay alive and get there.

[@MiguelTonetJr]

Excelent video!

[@fryingraijin]

For some reason, my body has known, how to balance my unhealthy behavior for half my life. If there were signals of thirst, fatigue or being agitated, I would cut out sugar, drink only water or go for periods of exercise, to counteract whatever damage I had done. When I saw Dr. Levine the first time, talking about age, I knew, she had to be over 30. Just like her, I have been stuck looking around 20. It’s not all genetics, but what you fuel your body with, and how you expell/utilise said fuel.

[@Holycryptonite47]

I would like to ask a few questions here based on my little to no understanding of cells and their science. 1) Dont all cells in our body get replaced every 7 years so if the focus is reverseing ageing how does it affect the possibility of new cell formation or does it just shortens their life cycle or it just simple like reminding a clock 2) Also can cells learn? If you make a cells revers itself in age most of the time, when it becomes cancerous does it like not die becuase thats like the number 1 defence against cancer isn't it. Would live to hear some more on this.

[@crukih7527]

It's somewhat of a misconception that every cell gets replaced every 7 years, although 7 is the average if you will. Skin cells get replaced roughly every 35 days, whilst red blood cells get replaced every 120 days. Muscle and nervous cells can take up to 15 years to get replaced. It used to be believed (and still is in some circles), that cells have a limited number of cell divides. This is known as the Hayflick limit. Every time a cell divides, it loses some of it's information, as described by Leonard Hayflick. In essence, your body ages because it keeps making a copy, of a copy, of a copy. Think of it like taking a polaroid picture, of a previous polaroid picture. Most of the information is kept there, but maybe there is a 1% decrease in acuity each time. That builds up over time. It was thought that this loss was through loss of the genomic information, but the recent information theory of aging states that it is because of epigenetic loss instead. David Sinclair and his team recently found that the body contained a 'backup' of sorts. Think of it as if your about to take a picture of the 50th version of that photograph, and someone walks in and states they have found the original. You can now start the process again from photograph 1. Cancer cells are a little different. Cancer cells are human cells that divide uncontrollably. Because we have trillions of cells in our body, cells need to communicate with each other to make sure they are doing what they should be doing. It's like being in a crowd, at a rally or demonstration or something. You can't see or know what's going on. if you want to figure out which way to the burger stand, you need to talk to people around you. Our cells communicate like this, sending signals to each other through paracrine signalling. Cancer cells usually have DNA mutations which make them start to divide uncontrollably. Normally when a cell starts doing this, it will commit not alive through apoptosis. These occurs through proto-oncogenes. However if the mutation affects these proto-oncogenes, they become oncogenes (hence oncologist). The cell now will not destroy itself. Other cells around it will see this happening, and start to release chemical signals via paracrine signalling to say 'yo buddy, cut that out'. But with those mutations the cell no longer responds to these signals. The cells will divide uncontrollably, and without checks and balances by our body, will grow into tumours. In theory, because epigenetic resetting restores the cell to a younger version, it would actually decrease the chance of that cell line becoming cancerous again in the future. Of course a lot of this stuff is still in it's infancy. I know Aubrey de grey fears epigenetic resetting could increase the risk of cancer. Only time, more experiments and clinical studies will tell.

[@RoguePC4U]

Author Ray Kurzweil figures human escape velocity is closer than we think. Scientific data on aging is only going to accelerate after all. Even David Sinclair (Professor of Genetics at Harvard.. and author himself) has made recent discoveries with mice - extending their lives, curing blindness and making old grey mice young again... it's incredibly exciting.

[@uno2326]

Not exactly... Sinclair made a mice age faster, and then made it young again, it's way too different

[@luisgil8614]

We have know this information many millennials ago. Its harder than writing it, however, is done by keeping the body moving, eating right, and fasting.

[@eggbenedict-gt7mw]

Fake news

[@malifestro3319]

One way we already know has helped is the studies of people in the highest concentrations of centennials. It was found that while genetics may have helped, lifestyle and diet made the most impact. The diet was always plant based. That means less meat, not none. Think of meat as a condiment and you'll get the portions and frequency correct. I think of meat as red wine, not bad for you but probably dont have it every day at every meal. Lifestyle - chill the f out. Take walks. Have friendships. All the other good things of a positive relaxed life.

[@VietYork]

summary by Molly.côm 00:00 Aging affects people differently 00:46 Quantifying the aging process at the cellular or molecular level is critical for understanding disease risk and remaining life expectancy. 01:48 Epigenetics plays a crucial role in defining cell characteristics and changes with aging. 02:41 Epigenetic clock measures biological age based on DNA methylation 03:38 Epigenetic changes can lead to dysfunction at the organ and system level 04:38 Epigenetic changes can modify biological age 05:32 Intervening in the aging process can prevent multiple diseases 06:28 Slowing aging could postpone diseases

[@bowilliford7822]

You have a maximum of 120 years, perfect environment, perfect diet, good genetics, which noone, IMO, can achieve nowadays. Enjoy every day as it may be your last

[@virtualdrudgery]

that's depressing. i thought we were close to reversing the aging process 😔

[@empirical77]

😂😂😂

[@amandasunshine2]

They've already reversed aging in mice already. Do you know the average time discoveries go from mice to humans?

[@amandasunshine2]

Also, what about this made you depressed? It's incredibly promising. Living an extra couple hundred years is all I want, anyway. I don't want to live forever.

[@namidawhamida5958]

Stack on an extra 20 years on your life. Sounds good to me

[@gorgzilla1712]

@@amandasunshine2 I mean, will you say that in 200 years tho? The real purpose of this science should be to allow people to age gracefully and lessen suffering

[@dannave7816]

What do you think of Senolytics? I took a couple of courses of Fisetin and Quercetin with Piperine (black pepper). The results were significant, I thought, especially the first time I did it. (at about age 68)

[@laszloszabo556]

Köszönjük!

[@beerman204]

Part of this aging business, I believe, is to reject all the learned attitudes and cultural expectations of "you are now old, act like it!" How many seniors conform to what they believe old age is supposed to be, to look like.

[@RicardoSanchez-zf4km]

Okay, so now we know that we can study aging and benefit from it. Thank you, who would have thought...

[@user-tz5te1ei6m]

It makes a lot of sense for scientists to invest their wisdom and curiosity into the aging process since there is a huge market for not-looking-as-old-as-they-actually-are. Just wondering whether the slowing-down or the reversing technology is affordable for the average public...Otherwise when someone looks much younger than their age in the future, what we can tell is that this person is really rich.

[@eggbenedict-gt7mw]

Useless

[@freeman7738]

Dear, Morgan Levine , today you are young, but over time you will grow old, no matter how you delay this process.

[@buddhaneosiddhananda8499]

Staying happy and eating a PBWF diet as well as meditation... can go a long way to living a long healthy life...🥳🥳

[@mariettestabel275]

Take the reality.. You CAN'T TURN THE 🕛 Live healthy ❤

[@DONMADDENDOESITALL]

It does happen you basically become as needy as you were as a child.... basically history repeats it's self but just in a different form but the finalization of it is the knowledge you've gained and left behind ... balance your shadow and the mirror work along with deep meditation also sometimes pass on the meat and you'll freeze your looks ...if you're gonna eat meat be careful with it ...and don't forget to walk and drink your cold smoothie

[@glennwhitney1494]

Excellent

[@ArichiKulukatoo]

Am I the only one that was hoping to hear more from this video? 😀

[@shakkeebk2298]

Yes, you sre the only one.

[@loveisthething]

You're the only one indeed

[@guardiansfitness]

Yes, yes, Mrs fancy pants, but, I, do not want to die...

[@paull9086]

Don’t drink or drugs, sleep well, eat healthy, fast, exercise high intensity periodically.

[@EG-kx4vp]

Bryan Johnson will be proud

[@dagobertosantosdeoliveira9546]

There's no secret. Healthy food+ physical activity= super longenvity

[@DomFortress]

It's basically cellular apoptosis vs necrosis, either a healthy programmed cell death in multi cells organisms wherein a cell will retire after performing a set number of mytosis, or a very messy process of mutated mitochondria thus forming cancerous cells.

[@ptaytv4775]

HEALTH IS YOUR WEALTH

[@andrewfinlay5160]

Restoring glutathione levels in the elderly.. with high dose glycine powder and NAC..a clinical trial done... Glutathione is the master antioxidant..this two supplements would be part of the strategy.

No mention 😮 of Telomeres!!

[@contris1]

well, that was all nice but no concrete action mentioned what to do. Or even what to avoid (what increases the clock speed)

[@thetruthsetsyoufree1492]

Such a very powerful search for the fruitful fountain of eternal youth. So, be at ease . . .

[@dusklvr]

Lots of fresh 🥬🥦🥑🍒🍉🍑🫐🍇🍠🥗🍵🥤🧹🛏️🌄🏞️🌲🌳♥️

[@James-ip7zk]

Lifespan is completely irrelevant without healthspan, and we know quite a bit about how lifestyle choices impact our risk of metabolic diseases, atherosclerosis, neurodegeneration and cancer. Yet still, scientists and pharma want the pill ! Stunning.

[@michaelbishop9157]

because lifestyle choices can't overcome genetic limitations

[@eggbenedict-gt7mw]

​@@michaelbishop9157 yes this is million dollar comment.

[@eggbenedict-gt7mw]

Fool if u crack life span , indirectly u better health span

[@Kaledrone]

​@@michaelbishop9157And it never will. Your issue is simply that you think 75 years is a short amount of time and would rather live for 75 million years. This is purely a psychological issue.

[@Kaledrone]

​@@eggbenedict-gt7mwno it's not, it's the same recycled npc comment left thousands of times before.

[@rzadigi]

Eating unhealthy and not moving is the key to aging. Some do it extremely well and others choose the opposite path. Aging is a given but it’s also a choice❤

[@eSKAone-]

Kids, alcohol, work Drama, tobacco, not enough sleep No physical exercise, bad nutrition, to much eating There you go, that's why your school peers look so old 💟

[@tylercunningham4311]

It's the basic stuff: diet, exercise, smoking, sun, sleep, stress, and genetics.

[@michaelkojocarter4762]

At 6:46...The idea of 'solving' or 'curing' death begins I think with the wrong premise, and as Dr. Levine says, it shouldn't be the goal. It suggests that death is a disease, a malady or problem that can be wrestled with and eventually overcome. Rather than a natural, inevitable stage of an organism's development. I also take some issue with the concept of reversing or slowing aging. A simpler, and more practical approach is to focus on enhancing health, life, and total being performance. Put another way, expanding this moment, every moment...rather than trying to delay the next one. Remaining young as long as possible...!

[@brucegelman5582]

Thank you for the intelligent summation.Solving death should never be the goal.

[@hilariousguy]

..... Unless billionaires fund your research !

[@springteen3743]

To age is a blessing, by itself. 😊

[@marcelrivest5413]

I took measures to live eternally; so far, it works!

[@DavidCNavas]

You don't have to "cure death" but if you advance lifespan faster than time, death is postponed indefinitely. Better to concentrate on quality of life first, of course.

[@PraveenSriram]

Quality is definitely the most important

[@Lildizzle420]

Einstein said that "prolonging life was tasteless" and I just think about how much more progress humanity would make if people like Einstein didn't think that way and lived twice as long as they did.

[@bcataiji]

Tyrants would be living twice as long also.

[@falaicha]

@Brian Allen Then, humanity will get enough time to punish them.

[@bvdek]

You really believe ppl would be MORE productive, knowing that they can live indefinitely longer? I think having a limited (seemingly short) lifespan, along with the knowledge of our inevitable (unpredictable)death actually propels us to do more during that time. Its arguable Einstein may have already given us all he could have, and that any extra time would be superfluous, or worse, detrimental.

[@esparda07]

He would have found a way to silently kill himself. You underestimate how our brains work.

[@prepperfitness7932]

I agree with Einstein. I believe it was Benjamin Franklin who said “we die at 25 and are buried at 75” we should focus on living life because it’s a gift. We should be thankful for what we have and build a better future together

[@craigcrawford6749]

Im 62 and a total specimen, just like all the other posters here. I can outlift people weaker than me, outskate people from barbados, i look 52 years younger than my actual age. I truly have discovered the fountain of ME

[@eggbenedict-gt7mw]

Fake news

[@Hawk2phreak]

If we can reverse the age of a cell and groups of cells, why can we not eventually cure age related death itself? I find that outlook remarkable from a researcher in the field.

[@unascertainable]

I had a good laugh @ 'solve death'. Thanx!!

[@Mark1Mach2]

What's up with the background screen. It's so annoying to make your guests sit on a White Strip and for viewers to look at!

[@rxb364]

Instead of the science of longevity I wanted to see another version of the secret of longevity !

[@chuck5279]

Interesting that after watching this video, Keith Richards started showing up in my feed.

[@francoisvanderwestthuizen6757]

You should get Dr. M Levin next

[@SAMMYJR00777]

i am 50 now and i can still fart like at my 20s and going strong w it.

[@melon9680]

Fundamentally it depends on your lifestyle too. No point slowing aging, when our foods are being riddled with forever chemicals and tons of Sugars as time goes on. Counterproductive i might add.

[@Flushable5000]

Cancer risk grows exponentially as we age: What if cancer cells are cells that think or behave like they're younger than the sorrounding cells. Or that they're just cells that skipped the cellular aging process?

[@wecouldbefree]

Answering as a chemist: cancer cells and benign malignancies are the result of cells that continue to age but that when they reach the point where theyre ratio of 'function performed' to 'efficiency of function' would demand senescence (cell death) theyre unable to comply (multiple reasons) and continue to multiply as part of that functional discongruity; TLDR - cancerous cells arent "young cells" but more like "ignorant zombie cells" Hope that offers some clarity 😊

[@amandasunshine2]

​@@wecouldbefree exactly, it's kinda the opposite. I'm not sure if you know this, but cancer is a concern with using Yamanaka factors, because it can cause out of control growth

[@proffezur]

The issue with cancer isn't just the continued growth, it's the fact that it consumes huge amounts of energy to do nothing BUT grow. It pretty much loses all other function until it takes you over and you ultimately die. Good thought though.

[@pyros4333]

​@@wecouldbefree cancer is a metabolic disease. Cells that have been damaged and lost their ability to do their standard complex tasks including self elimination. They are actually a "young" version. But more accurately they are an devolved one

[@roberthigh7945]

Cancer cells is nothing more than damaged cells caused by eating acidic and processed foods

[@LetsEat973]

Fruits like berries , mangoes& melons reversed my aging on a cellular level ,

[@PraveenSriram]

Thank you for sharing. I will give it a try

[@eggbenedict-gt7mw]

Fake news

[@rene-rv6pp]

Aging start to accelerate markedly after about 60. From then everythings go fast. Not only your body aging. Also the time goes faster and you can feel it

[@kfireven]

So what other mechanism in the body will cause us to age, if we'll be able to "reverse aging"?

[@eggbenedict-gt7mw]

It's fake news

[@user-xy7nj9wo9u]

as someone who is terrified of death, i wish this was the answer to that

[@amandasunshine2]

It.. is. I mean, kinda. You don't actually want to live forever, the inability to die is a curse. But living another couple hundred years, that's very achievable with what she's talking about. They've already reversed aging in mice. It's mainly stability of the treatment we're hammerimg out. Another scientist thinks that in probably less than 20 years, we'll be able to take a pill or two that will make us age backwards, then we'll take another pill that'll stop the process. Because otherwise, we would literally Benjamin Button and turn into fetuses. Imagine an adult sized fetus. Remember to take your pill 😂

[@amandasunshine2]

And that's the "stability" issue I mentioned before. Used in the wrong way, it can really mess you up. So we're fine tuning the cocktail of Yamanaka factors to make them usable. Lemme put it this way, Yamanaka factors were discovered in 2006. They successfully used that research to reverse aging in mice in 2019. Sure, 2020 probably slowed the research down, as it slowed everything down, but we're already well on our way to be able to view aging and death as treatable, much like we view tuberculosis, when not even 100 years ago, it was how most people died.

[@leadeaus1090]

it's ok. try your best not to die soon because you have the gift of life given to you and you want to reap it as much as possible. death is terrying because when we are alive our brains cannot comprehend possibly not existing and being and feeling nothing. but truly, it won't be as scary as you think. live a good life and do good to others and when you die let all the weight of this life be taken off your shoulders. you dont have to exist within the constant balance and dynamic of good and bad anymore, u can simply exist within nothing as apart of the Universal infinite energy. thats truly a blessing

[@jamespowers8826]

Death shouldn't be terrifying at all. We actually live in the past, and after we die, there is no past. Folks oddly are often fearing missing their life, after their death. Once we die, we never existed.

[@user-ni3bj2bi4z]

There are many experts that do believe this is the answer to imminent mortality, death by age, and that it will arrive in time for us to use. In fact, some of these technologies are already here and are accessible. Please read: * Lifespan - Why we age and why we don't have to by David Sinclair * There is another book Lifeforce by Tony Robbins. While it is true that the life extension we have with current technology is currently only till 120 years old... with the rate at which the technology is progressing the next life extension will come out before we hit that 120 year mark... and the next life extension after that will come out even faster before we hit that new limit... The runaway effect of these life extensions will give every one of us the means to break free from death by age if we so choose. Eventually there will be a final extension that will grant eternal youth, providing the answer you seek, a solution to death by age. I am giving my life to get this technology out there faster. It is real, it is coming. We are already in the advent of rapidly developing AI, and as longevity experts themselves are able to keep on living longer (thus preserving the momentum of their research) the speed at which this technology develops will accelerate incredibly.

[@cleander97]

Aging clock gets its rhythm from earth evolutions around the sun (I.e. the passage of years). If you settle on the moon or Mars, you will age at a different rate or won’t age at all!

[@eggbenedict-gt7mw]

Where is proof

[@cleander97]

@@eggbenedict-gt7mw My people age much less than me. I’ve been around for a few millenniums since came to the earth.

[@godmisfortunatechild]

I for one think we should try to eliminate death through aging. Especially if we are to become a planetary species

[@jamesprice6875]

Dr Rhonda Patrick talks about a Finish study on Dry Saunas. She says the data shows a 40 percent reduction in All Cause Mortality for people who used a Sauna (dry sauna not infrared) five days a week.

[@eggbenedict-gt7mw]

🤣🤣🤣🤣 fake news

[@pyeitme508]

Maybe

[@user-sx4gw7ys3s]

Yes agree we can slow ageing

[@RICKONORATO]

My ultimate goal in life is to one day be the oldest man on the planet - or die trying.

[@gzfashions]

You can’t reverse aging because that would be traveling back in time. You can nourish and be your best in the current present which will sustain youth at a longer rate of time.

[@PraveenSriram]

I am turning 40 years old this year and people say I look 18/19 but ℹ recently got new glasses which make me look more my age unfortunately. That is a bummer

[@eggbenedict-gt7mw]

The people telling u look 18 need new glasses 🤣🤣🤣🤣

[@janklaas6885]

📍4:44

[@jopwarmy]

She’s the first person to say this that I believe because she looks like she hasn’t aged past high school

[@WILRARN]

Professor Sinclair would beg to differ!

[@quinns3072]

I think regular exercuse, plenty of sleep, and healthy eating are some of the best ways to target overall health which will largely prolong your biological youth and physical appearance. Whenever I would hit finals week throughout college and grad school, my sleeping and eating would suffer along with not having ample time to exerise. I ended up getting covid one year and always deal with getting sick or am very low energy the following weeks. Cutting even one of those three out can hurt your immune system very quickly. People spend so much money on supplements and all these crazy diets to avoid putting in hard work either in the gym or doing whatever excersie they prefer. It doesn't work, there's no way of getting around doing actual exercise to achieve a healthy body and mind. Fortunately I also love weight lifting, and the gym is my favorite hour or two of the day, many people don't enjoy it much, but they should still devote at least half an hour a day on somesort of physical exercise that is at least a litttle challenging. Side note: The woman presenting in this video is absolutely gorgeous. I don't think she would mind if I asked how old she is either lol.

[@Roust7]

If you demethylated a DNA of cells in organisms, would that increase risk of cancer? Demethylated DNA could be expected to lead to uncontrolled cell growth!

[@eggbenedict-gt7mw]

Yes certainly

[@johnkola6475]

Very good info. The constant hand gesturing is very distracting tho.

[@tyaajathailani]

Jean Calment lived to 122 years of age. Did she die of decaying cells or cancer? I have never heard that she died of cancer. I do think I read that she had gone blind before she passed on. And, what about the Chinese gentleman who reputedly lived to 256 years according to Chinese governmental records?

[@eggbenedict-gt7mw]

Fake news

[@markrothery8719]

Im surprised dry fasting wasn't mentioned in this video for slowing the ageing process and curing cancers. But then, the medical profession would never agree with this theory as it is free and natural, two factors they hate. Also, if we slow the mortality rate in a already over-populated world, there won't be enough room to swing a cat around in 50 years..

[@jlvandat69]

We will "solve the death problem" but not with the science we have today. And thanks to an exponential rate of increase in our understanding of cellular biology there's a decent chance we'll see significant healthspan increases for many people fairly soon.

[@crazycat1345]

You are living in a dream world if you think this technology will reach us common folk.

[@jlvandat69]

@@crazycat1345 they said the same thing when computers were invented.

[@warrendirwai4660]

@@jlvandat69 We are talking about the most complex object here in science that is the human body not metallic objects such as computers

[@jlvandat69]

@@warrendirwai4660 understand your point. But with the major improvements in our understanding of cellular biology we are gradually learning exactly how the cells function and how to manipulate their growth and division via genetics. I believe there's enough resources being focused on stopping and reversing aging that we'll soon know how to keep the cellular functioning healthy far beyond today's norms, resulting in an ever-increasing lifespan for humans.

[@hardikb15]

@@warrendirwai4660 AI is one of the most complex things humans have come up with and look how widely accessible it already is to the common public.

[@Marijanus]

I'm much more optimistic about Ending Aging than this madame. I hope we'll get some more videos about longevity!

[@masonarcher]

Me too- it surprised me that she said she didn’t think ending biological aging should be the aim.

[@a_bar8579]

All hallmark of aging must checked before adjusting them !

[@west9785]

Thumbnail looks alot like Logan Roy

[@MooreMoonies]

The content cannot controll

[@JackHughes1212]

Eat less, sleep more and exercise!

[@11froglegs]

Life is living😊

[@rsavage42]

How long is “super” long? I’d just like to be here to play Starfield in September.