Harvard Professor REVEALS How To SLOW & REVERSE AGING | Dr. David Sinclair

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Harvard professor David Sinclair believes that not only can we slow aging down, we can actually reverse it. On this episode of Health Theory with Tom Bilyeu, David Sinclair explains the three levels of aging, and what can be done on each level. He describes the lifestyle changes that slow aging down, the drug treatments that begin to stop aging, and experimental new procedures that may actually reverse aging once they are fully developed.
SHOW NOTES:
David explains the information theory of aging [0:59]
David explains the difference between genes and the epigenome [2:17]
David describes the way that cell stress causes aging [5:20]
David explains what proteins are and how they work [6:40]
David recommends lifestyle changes to slow down or reverse aging [9:14]
David recommends stressing the system by consistent fasting [10:52]
David explains why we don’t live as long as whales [15:01]
David describes resetting the biological clock [16:16]
David explains how to tell when someone is going to die [18:47]
David explains why people are taking metformin [20:03]
David shares his regimen of exercise and metformin [24:18]
David advocates cold exposure [25:28]
David explains work he’s done to try to reset the aging clock [29:01]
David explains why you don’t want to turn the cellular clock back too far [31:37]
David describes the actual process of reversing aging in masses of cells [33:20]
David talks about some results with mice that appear to reverse aging [36:40]
David shares his father’s story of metformin and NMN use [38:10]
David explains the effects of resveratrol [39:07]
David describes the kinds of testing he advocates [43:13]
David shares the impact he wants to have on the world [45:44]
FOLLOW DAVID:
WEBSITE: www.lifespanbook.com
INSTAGRAM: bit.ly/2kPvLjF
FACEBOOK: bit.ly/2mcAPiq
IMPACT THEORY MERCHANDISE: Check out Impact Theory's Merch Shop: bit.ly/ImpactTheoryShop

[Seymor BUTTS]

My great grandma passed at 107. She slept often, always had a beer or glass of red wine at dinner. She ate home cooked meals and survived the great depression by begging for bread on the street with her sisters. She also drank lots of water and occasionally had orange juice. She stayed sharp speaking two languages and listening to classical music. She passed away a week after being in a nursing home. My family took better care of her until they just couldn't. They all wish they hadn't sent her. R.i.p. great grandma.

[Stephen 777]

@TOP !0 A broken fart is a terrible thing! lol

[TOP !0]

She died of a broken heart

[Crouching Tiger Hidden Dragon]

I've also heard that the more you sleep the slower you age because sleeping pauses aging or slows it down so getting more hours of sleep slows down the aging process. Getting between 9 hours and 10 hours of sleep per night would slow down your aging.

[What sàpp†⓵⓻⓺⓪⓼⓹⓼⓪⓪⓹⓶]

🚀 🚀 🚀 🚀

[What sàpp†⓵⓻⓺⓪⓼⓹⓼⓪⓪⓹⓶]

⬆️Hey mate Thanks for watching have something to share with you hit me up

[nurhan toguc]

Love scientists like Dr. Sinclair who contributes to public health, despite big pharma preventions. Hope we have more of scientists like yourself. Proud of you

[Mykytagnosis]

@Adam Klase that's like world works. It still helps though.

[Adam Klase]

@Mykytagnosis Sure but is it optimized for health over revenue? Nah.

[Mykytagnosis]

Didn't human live span increase quite substantially due to pharma?

[Mary Jamieson]

Excellent questions by Tom! Unlike many interviewers, he has the talent to actually fully listen to his guest, so we get to hear everything the guest intends to say. THANK YOU!!!!!

[johnpearcey]

Tom seems to ask exactly the right questions to aid our understanding of a very complex subject. Excellent interview.

[J M]

Just stumbled across this video - this guy is a fantastic interviewer. To the point, and clear! He asks every question you'd want to ask as a viewer and asks it immediately. This video is 45 minutes long and it was a breeze to get through wasting no time as everyone is concise and articulate!

[Ham N]

Tom is passionate and well read about health and this subject.

[Gym Tuppernation]

It’s always a good sign when the anti aging expert looks over 10 years younger than his actual age!

[ScholaroftheWorld — Alternate History]

Not really. There is often no correlation between external appearance and your actual health inside the body

[durawins]

@Mikey Aurelius H he means he looks 15 years younger than his age. The starter of the conversation said the guy looks 10 years younger than his age. No one would think he looks 15 years old

[Ham N]

Haha yes not overweight, white haired and old!

[Niece]

@Lil Eddy agree

[June03]

@Tomorrow2 I'm 54 years old but I'm looks like 44 years without botox .

[naightengale101]

Tom asks great questions. They really took this discussion to a deeper level.

[interestingvideos4me]

really impressive job by the interviewer. He is a fast and creative thinker, making connections between complex information and articulating them all in his questions - and does it all super fast. Does he have any specific training in this subject? Does anyone know about it?

[Matthew Lillistone]

It's because it's scripted

[ainsley chuck]

K

[Mitchell Buzzard]

Tom Bilyeu is a scholar, and life hacker ....like Dave Asprey. Also an entrepreneur so critical thinking is habitual, then repetition by doing these interviews with potential and proven "geniuses" of their respective fields.

[The Bachinater]

It's called educating yourself about the content beforehand & coming up with questions that pertain to said content. Ya know, being prepared.

[Cami Snyder]

I am a believer in the exercise to keep you young. I see 60+ year old men and women that workout at my ymca that look so young and physically fit!! You don’t use it, you lose it. Thank you for the actual scientific break down of the enzymes and how they impact our cells. Very interesting!!

[Salsa to Salchow]

Someone once said "figure skating is the fountain of youth" -- what this guy is saying actually explains a lot. Experiencing stress (fear or fret) that is real but not life threatening, minimal eating, exercise, exposed to a cold environment and not bundling up

[SevenFromTheSins]

@Watkin Sells let us know

[Watkin Sells]

My grandmother is 105 I'll talk to her today she's doing well

[topspeed250k]

No, he didn't say fear or fret as a stress. He said PHYSICAL stress, as in exercising getting out of breath. That's way different If you follow him up for more information, in other videos he actually lists mental or emotional stress as something to be avoided. Fear & fret play no part in achieving longevity. Completely wrong

[HELLEN SINGOEY]

Tom's interviews have really changed my life. I started exercises, I now eat healthy and so much more. I now do things differently. From his other interviews, I tapped the knowledge of fasting. Today is my 2nd day of fasting with water only. I'm actually loving how I feel on my 2nd day. I really thank him for this, that he's impacted so many lives in a positive way. God bless 🙏

[Bogdan G.]

In my opinion, it depends if someone was, for example, overweight

[LorenzoRM85]

2 days is too much, he was talking about half day

[René Simon Pfisterer]

Guaranteed Agestopper: 1. Eliminate Stress 2. No processed food 3. No industrial refined sugar. Only fruit sugar or natural unprocessed cane sugar or honey in moderate dosis 4. Regular meditation 5. Regular sports 6. Connect with nature without electronic devices regularly 7. Keep your inner child alive 8. Laugh a lot and take life not so serious 9. Connect and hug with the most important people Your welcome ;)

[Tony Qwabe]

Thanks for summary

[Tina T]

You forgot “eliminate toxic people from your life”

[Ham N]

Dr Berg is the man for diet 1/2 1/4 1/4 plate -low carb vege- good fats- protein and intermittent fasting.

[Tony Davies]

Honey spikes insulin more than refined sugar so your wrong bad advice .

[B]

Man, sugar is too good

[Indian Rose]

Perhaps one of the best videos I have seen on the tube. David and Tom both are incredible. A good Interview is also extracted when we have an intelligent person on the other side. Tom is smart and David Sinclair is mind blowing. Love the way he explains the stuff, phenomenal research and cannot imagine the impact this will have on us a few years on. Must also say that in the Asian Indian Hindu traditions for thousands of years there has been emphasis on fasting to for a healthy body and mind which would lead to a higher level being. Science here collides with a dimension that actually determines human evolution both on physical and non-physical planes. Totally agree that it's important for the body to feel cold, feel a bit of physical adversity, move away from the comfort zone. Excellent interview. Phenomenal science and wonderful tips

[katsan88]

The experiments with the eye regeneration is extremely exiting and can't wait for the future of medicine. Hopefully, these discoveries are made available for all and not just for a select few.

[Akshara Yadav]

Well said.

[johnny maakana]

Is the eye regeneration therapy available or are we talking future interventions?

[Matt Buckley]

Utterly mesmerising interview from start to finish. Such a fine science and ultimately the greatest challenge. Imagine a world where bright minds can continue with their research instead of the reset having to pass it on to a younger generation who may not have the same focus. Of course new ideas are always important, but nothing worse than a genius running out of time.

[𝗪𝗵𝗮𝘁𝘀𝗔𝗽𝗽+𝟭𝟰𝟭𝟮𝟮𝟱𝟰𝟯𝟱𝟮𝟮]

🚀🚀🚀🚀

[lila itzkovitz]

I am at ore at this amazing interview. So grateful for the amazing work you both are doing! 🙏🙏🙏

[J.P Leonardo]

Powerful topic. A lot of things I can take in for sure. Ice cold showers are so beneficial, which I love the fact it's a part of this topic. Making yourself slightly hungry makes sense. Taking care of yourself is the key, mentally and physically. Meditation is such a solid key and always remember this. Age is nothing but a number, but growth and maturation are eternal. Exercise and cook your food. Let's go #Thingsofthatnature

[Jonas TY.]

Lol It’s not just a number. It’s the most stupid thing people tell those days

[T N T]

Boom

[Noxxie]

Tom is such a good listener. I love how he is always eager to learn like a student, his learning mode is always on.,👏👏

[Kabhi Sharma]

Well observed

[mr cat]

@Mr WLF i always noticed a gap in Tom’s lips. i always get an urge to put my pinkie through it 😣. does anybody else notice this?

[Mr WLF]

Luna EB i wanted to make a dumb joke about the ears =))))))))))))))))))))that's why he got them...but i love the guy..he changed my life for sure.

[Jagath Pathirane]

Just happened to watch this though not too late! I totally agree with the extreme temperatures and cold baths to trigger healing! I am 60 year old male and live in the tropics so no question of warm baths instead a daily cold water shower at around 6.30am ! I very rarely suffer from colds leave others …. 🤞! The most important aspect is about the mind game which is not touched here! It’s all in “the mind” for me! My 45 minute daily meditation 🧘 session heals everything and during my meditation I scan my body top to toe through my minds eye and give my inner soul or the subconscious messages and tasks to heal and rebuild and rejuvenate everything that is aged and replaced with new healthy and strong cells! Also I have turned the clock back 20 years in my subconscious 🤪…. I think this has helped me in every way for good health and success that I have achieved thus far! Of course I eat healthy and exercise and most importantly take the “ middle path” which is moderation in everything you do according to Buddhist way of life being one!

[Matthew Griffith]

Thank you both for this powerful information I am so grateful for you both for having such a positive impact on my life.

[Mike Tapta]

Got to give credits to some ancient traditions found in Africa and Asia who early on understood the importance of fasting and using the elements found in nature to heal themselves despite living in harsh conditions and having limited resources. They have been practicing for centuries what science is explaining and backing nowadays.

[Two Party Illusion]

My mom is 84, works full time, has naturally brown hair, lots of really young friends, stays active, and her doctor treats her as he treats a 60 year old. My dad, same age; retired at 65, he's sick and can barely walk direct correlation.

[skye_bby]

Retirement = old mindset to most people. There's people who are wealthy and retire in their 40s but stay active, travel and live like the young people they are. Anyone sitting on a couch eating all day will age faster.

[MR B]

Smokers?

[Darren Mcdermott]

i truly believe you don't use it you will lose it. so when someone sets their mind on retireing that means they will lose all their power and their body will decline ,because their cells will will know and the cells in the body can hear and thier is a intelligence that keep us going so stay postive and active

[AriaGeige]

@peace love I guess it's genetics - my grandmother also had naturally brown hair until she was around 90 and even now she still has a only a bit of grey!

[Anti-aging withAF]

Wow

[pstubeing]

You have the BEST guests! And you are an excellent interviewer and your obvious knowledge on this topic is impressive. Thanks and keep it up!

[Costas Costas]

13:20 I trust this guy only because of what he said: "nobody knows what is the perfect diet, all I can tell you is for rodents" "what we discovered... what my colleagues discovered..." he knows the limitations of his research and he gives credit where it is due, which means that if he says something I am happy he believes in it and does not hype it up. Trustworthy!

[Lakshmi Patrícia]

@D. Blank please Could you tell me how / with who you came to know that skipping breakfast can lead to dementia? It's really important to me. Thank you so much!

[X 7]

He understands that NOBODY has complete understanding. He's comfortable with acknowledging he doesn't know what he doesn't know. That nothing is certain so yeah he's honest at the very least here to an extent.

[Professor Dumbledore]

A research oriented person always presents the conclusions of his studies this way.....

[Suzie]

researchers always talk like that. nothing is a fact and nothing is finite.

[Rants Of A Grumpy Old Lady]

This is absolutely fascinating! I'm in my mid 60s but I hope that I can still benefit from making some of these changes

[Ali Cassidy]

Of course you can... Good luck

[Paul Cesare]

Cutting edge, outstanding information and guidance!!!! Thank you and keep researching David Sinclair!!!!

[John Milner]

My Mother is 92 and is on zero medication. My Dad Died at 90 but would have lived longer if he wasn’t nagged by my Mother which stressed him out. He should have devoured at 50. I’m 69 and feel like I did in College. I workout 3x’s/wk, eat well, ski in the winter, road bike in the summer, do yard work on a 1 acre lot and play with cars and I don’t look my age.😊

[G Z]

This was great. The supplements do make your quality of life better. I don't think they reverse aging though, I feel like that can be done only in a lab through direct injection of a very specific area. But I think I know why whales live long and we don't. They live in a cleaner invironment, have no wars, eat good, relax, hang out, have no bills, no insane amount of unhealthy stress really, no vaccinations. Also, it looks like our ancestors knew a way to live up to almost thousand years, but those ways were lost to the regular people.

[rlg222]

This is an interesting subject. Some of us will never see these advances successfully but I'm glad they find the ability to work on it and never stop. My first thought is how individuals called out in the bible lived so much long to just to reproduce. Its is investing how my instincts tend to be smarter than my brain's ability to solve a problem within myself. Like how good I feel when I don't eat most fo the day. I would hear people tell me I'm damaging my internal body. I use to be this way naturally in my early to mid 20's. Its funny after all these years I hear about how beneficial it is to restrict your intake or just not eat for some period of time. It's been my understanding that things are always determined by factors and there is no spiritual reason for any of it.

[Amit Agarwal]

Incredible! One thing to take away from this interview is that fasting does wonders to your body and longevity and to my surprise this has been advocated in Indian lifestyle for 1000's of years. My mom has been doing fasting for whole day once a week for 30 years and touch wood she is doing excellent. Wow this has been I think the most useful video I have ever watched. Thanks a lot tom for airing this. God bless you.

[Olga Karpova]

Nowadays western science is slowly approaching things the ancient rishis knew and outlined in Ayurved ages ago

[David Karpik]

You're touching your wood when you talk about your mother?

[Softreck Softreck]

why? you have the best person at home, your mother was able proving the fasting method and you still was not able to understand, but one jew is talking about fasting and now you understood? hey! what wrong with you? give some flowers for your mother!

[50kT]

The part at around 23:25 about "poisoning the mitochondria" so that you end up with more mitochondria reminds me of gardening. You can keep a flower blooming by snipping he flower before the mature fully, causing the plant to "stay young" longer and continue producing flowers. Also it's like pruning a tree to stimulate more growth so it ends up with even more branches and a fuller canopy

[Sara Perez]

Almost like we have answers around us. Great observation!

[Evon Colon]

CORRECT and it also explains why their are synthetic drugs. It's easy for one to CREATE ANY thing as long as one uses a piece of the original organism. That Part

[Topaze Rox]

Thanks! You've just told me what to do about my tomato plants!

[rlg222]

Good point about the flower's..

[Pelagia Komni]

Every time I watch an episode from Impact Theory, I feel I become a bit smarter. Thank you very much, Tom, for all these interviews full of knowledge!

[Dhiraj Sai]

every time means ???? every 50min ??? How Many 50min ???

[Anti-aging withAF]

🖒

[Dana Pietruszynski]

Stay safe Doc! There are plenty who will not want you to be successful for helping everyone but instead only helping them. GOD speed to you for what you're trying to accomplish

[ThisAccøuntHasBeenCłøned]

Some aging research info: - Lengthening telomeres - NAD+ & Resveratrol supplements - Gene splicing - Calorie restriction - Exercise - Avoid stress - FOXO gene ( If you have 2 copies, you’ll likely live longer and in better health). Skin tips: - Sunscreen (wear sunscreen everyday you go out) - Sleep on your back - Collagen supplements - Moisturize daily - Creams with? Hyaluronic acid, vitamin c, retinol… - Exfoliate (but not too often, once a week is likely enough) - Avoid overdoing facial expressions (e.g., raising your eyebrows). - Don’t smoke (kind of a no brainer, both inside and out, it’s terrible for you). - Cut down on sugar - Get enough sleep - Red light therapy - Skin laser treatments Foods: Dark chocolate Olive oil Blueberries Avocados Salmon Tomatoes Green Tea Bonus = Look up the Eternal Jellyfish, Dr David Sinclair and Aubrey de Grey. Also for inspiration Chuando Tan, Mario Lopez and Cher Any other tips on reversing/slowing aging?

[devotee]

Garlic is very useful as well.

[Jessica Rodriguez @insta shivalingajr]

As a Hindu I definitely don't want to live forever in this form I'm excited to see where I go after this and I also love seeing where I've been before this but it's wonderful to stop your aging right in its course

[Lady Dee]

Short summary: 1. Intermitent fasting - basically being hungry some periods of time - maybe the most important factor! 2. HIIT - high intensity interval training, shocking organism with high pulse rates 3. Low carb diet - no sugar 4. NMN - Nicotinamide mononucleotide 5. Metformin - keeping the blood sugar levels steady by controlling the insuline levels - BUT taking it only on days you are not exercising 6. Exercising - combination of weight lifting, cardio and stretching 7. Shocking body with rapid temperature change - for about an hour - sauna, steam room, hot tube, cold shower - cold exposure builds up brown fat that revs up our metabolism and helps us to stay lean 8. Metabolic winter hypothesis - in our lifestyles we are always warm, wearing jackets, we turn up the heat, we never get exposed to cold unless we don't want to - partly responsible for diabetic problems we have. If you are cold at night, you are gonna turn on your brown fat, burn a lot more energy keeping you warm, and keeping you lean. 9. NAD + booster molecule (nicotinamide adenine dinucleotide) - NR (Nicotinamide Riboside) , NMN 10. Resveratrol - as a supplement - 1 gram a day

[ScholaroftheWorld — Alternate History]

Didn't the guy literally say the genes tell you have long you will live? What is this BS you are providing in comment

[Monner Manush - Supriya Chakrabirty]

Can you please explain No. 4 little mor. Pls. Thanks

[sad flame princess]

Thank you for taking the notes.

[Ijeoma Ogochukwu]

Thank you

[J W]

@Gregorie I'm a fellow, Canadian and yes when I'm shivering in the snow to get to my car I am definitely burning more calories than someone in Thailand. Or when I'm in Vancouver in the rain is pouring on me and I need to run to get to wherever I'm going outside yes I am burning more calories than someone in Thailand. You just don't realize it because you're always in Canada. We walk FAST too!

[Chris Penney]

Tom is an absolute master of the interview. None better!

[Ken Carey]

I have heard many interviews with David. You asked incredibly good questions

[Deborah Duthie]

I love the ease at the explanations, all totally logical and understandable. Brilliant chat guys🧬✅🇦🇺

[Brancaalice]

When i see how diligent the body organs work every single hours, every day it something beyond amazing. Just how the heart pump blood, oxigening the blood, taking waste delivering it to the right organs responsible to make it clean and give back. If there is a system in nature that work in perfect synchronicity, it is the body.

[Coo Coo Kay]

❤❤❤

[Kevin Anderson]

I agree with Jonathan. If your life is totally dedicated to make as much money as possible, this will lead to stress, poor quality of life and a shorter life. However, you do need a decent job or you will be worrying about having enough money to pay the bills and keep a roof over your head. It's pretty tough to find a job that pays well, isn't stressful and allows you to have enough money to enjoy yourself. We all want to win the powerball so we never have to worry about money again and enjoy every minute of our lives.

[Julian De Villiers]

WOW! The amount of knowledge David has accumulated is extraordinary and we thank you for your life work and continuous contributions David! Great show Tom, one of my favs for sure.

[dihuscientistdj]

wow he's incredible at talking complex science in a way that can be understood

[Anti-aging withAF]

🖒

[brio last]

Extraordinary presentation. Consistent and complementary to other researchers' work. Amazing and passionate questions by super smart host. Buying his book *NOW*

[Gameswithajump]

Longevity really runs in my family and we all have similar habits. Like every uncle, aunt, grandparent etc. are living 90+ years easily on both sides of my family. Everyone exercising multiple times a week. Everyone. We do not eat really any refined sugars, like zero desserts/sodas/creamers/ice cream etc. None of us are obese, obesity will kill you. All of our meals are home cooked, I actually once went an entire year without going to a restaurant once. Also, we all take care of our skin. Even the men use moisturizers and cleansers and creams etc. I think the biggest thing though is that we are all happy. We don't stress, we sleep well, we relax, we laugh, we smile.

[athulya kallu]

Please tell me you are which country

[Amber Rico]

Please tell us what kind of food yall eat and is there any single men in your family over 25 years old ? 😅

[Tatyana Kaucic]

Adopt me? 😳😅🙌

[MP]

May I know your family food menu please🙏 ??? Refined Wheat flour is there?Milk?Meat?

[Oshun Sigler]

That last question revealed a true Gem! 💎 We honestly don’t have to eat, there’s people that’ve decided to fast for months & are completely healthy. We literally can survive off of water intake & vitamins. I’ll soon have my own plot of land with a greenhouse where I could grow my own healthy fruits & veggies for times when I choose to eat. ✨

[Wháts ápp +⓵⓹⓸⓵⓽⓷⓷⓪⓼⓷⓼]

⬆️⬆️⬆️⬆️

[Wháts ápp +⓵⓹⓸⓵⓽⓷⓷⓪⓼⓷⓼]

Let's Chat ⬆️⬆️..........

[Shayan]

I was married into a family that averaged 90 years plus. They ate very little to no red meat, small portion sizes, no processed foods and took little stress because being the aggressive type As they are, stressed those around them into depression, stress and many other ailments.

[Damon M]

Love how Tom really takes the time with his guests to listen and he is right into the interview like focused asf he really proper cares what his guests are saying. He does his research and loves what hes doing

[athos1669]

What a great interviewer you are! It´s clear that you prepare exhaustively for your interviews. Respect!

[Gameswithajump]

I like how he mentioned CT scans and X-rays. Having a few randomly throughout your life poses very little risk and wont really do anything to you. But if you have a lot, then you start increasing your chances drastically of some true cellular damage and possibly cancer. Having one CT Scan gives you a 1 in 2,500 chance of developing cancer from the radiation, so risk of a one time exposure is very small, about 0.09% chance of irreversible cellular damage. But having 5 jumps that up to about 1 in 500.

[Patty]

Most people can’t avoid CTs and X-rays. I mean, we’re all pretty much screwed.

[Patty]

@Lifeonwheels lol

[Lifeonwheels]

Oh shit, I’m doomed then. I had several ct scans when I needed reconstruction on my face. Bye cruel world.

[Nobody]

My grandfather died at 98, i never saw him making exercise, ate avery type of food and spent most of the day resting in his business. What i can tell is that he had a very relaxed life.

[Nobody]

@Patty he did and i do, what i meant is that stress was no really part of most of his life, contrary to us.

[Patty]

Yeah, I really don’t want to make exercise either lol

[The Spotlight Kid]

I'd like to hear this professor explain the developing evolution of the Gnome (defining all our bodies working aspects) in terms of genetic's irreducible complexity, when millions of things have to be in place for the genetic process to work. The known workings of evolution states that: "One tiny change at a time caused by random mutation is only retained for the next generation if it proves beneficial to the biological system" I'd like to hear anyone explain this "irreducible complexity" our genomes have when mutations are by their very nature "Random" so how did these mutations get past one generation at the very beginning of life on earth, & how did these random events align to one common goal??????? . I'm not holding my breath for a valid answer! There isn't one

[Worship Library]

To all beautiful souls listening to this message GOD will solve that problem that has been giving you sleepless nights. Help is on the way!🕊🕊🕊

[Emily Irizarry]

This is probably my favorite interview with Dr Sinclair. He is so articulate and explains things very well. Thanks you sir!!

[hph081000]

Chris Barnard (The guy that did the first human heart transplant) said something to the extend of he has found a gene that activate at a certain time which triggered ageing. He wanted to know what triggered it, and how to stop it from being activated. Chris died years ago in car accident unfortunately.

[Robert Hutchins]

I like his questions and I like how he's answering with great answers!!! I'm learning so much

[Z' Lauriault]

Well, now I have an explanation for why I feel better in cold weather, and feel better being a little chilly indoors, and only really warm at night with blankets only - not turning the heat up. He talks a lot about methylation, and If love to know the strategy for people with methylation disorders (symptoms are many named health issues) and related disorders such as MTHFR which is a lifelong debilitating issue that doesn't wait for aging.

[Sharon Campbell]

Tom you are one of the most knowledgeable and intelligent interviews I've heard. Ty

[Anti-aging withAF]

❤

[Farnaz Ganjeizadeh]

Very informative and simple to follow. Thanks.

[Angelo]

My father lived to 92. Was healthy till the end. He ate little his whole life. Remained active. Read allot and limited the drama in his life. He was also very stubborn so I think his mind refused to die. 😆

[Paula Poche]

Lol

[MP]

@Peggy De Weerdt It's also the gene which don't have much genetical disorders

[MP]

@Chris Erics Then how did in olden days people lived 900 years????

[MP]

@peter carrick Then how in olden days people lived 900 years??????

[Michael Hernandez]

I like how he said is not what you eat is when you eat... If you're not hungry do you really have to sit with the family during dinner time and force feed yourself?

[Georgiy Potulov]

I’m 35 and look younger, the secret to staying young is not mental stress but more of physical stress such as surfing, surfing has some of the best benefits to what Tom is talking about. Because every time you charge after a wave you get what Tom is talking about not to mention you arc your back (especially on a short board) and this gives you good posture, keeps you flexible and very relaxed yet gives your muscle good tone, I used to swim in the middle of winter with 43 degree water in my spring suit and this helped me dramatically, not to only get in shape but it helped me out with my singing. ( I am a classically trained singer)

[Ian Dalton]

I've always been super healthy ,fit.dark hair until I was 33. I'm 35 now with very white hair on my face like a wizard. Its like age slapt me in the face from stress. My faith changed aswell after looking at all religion as a whole. Once you see the truth,it's like opening pandoras box and can't be unlearned. To be blind is to have faith. I've always believed the mitochondria is what gives us our lifespan. The powerhouse. Our lifespan is only based on what we get from the mother if that's the case. Male uses his mitochondria to swim to egg and is lost in conception. What if we use the male mitochondria instead of female during conception.or combine the energy. Thoughts?

[Ed .Z]

I have back pain issues a lot and 28 years and im getting older because of this hard sharp pain😢

[shake speare]

My granddad lived 102 years. I am 42 and feel like 65. The difference is that my granddad lived all his life very close to the nature. He grew his own food, had his own cattle, worked really hard, gave his fullest to his family and friends and led a very simple life. On the other hand I have been in a very well paid but very stressful 9-5 job for years, eat supermarket food and ready meals, spend hours of my eyes on computer TV and Phones, spend time on useless electronic media, always feel uncertain and fearful about future etc., I am sure you have figured it all out you all my wise fellows

[HOMKiNG H7K]

It’s still everything in your hands bro, try to break your limits everyday!. After one year u will difference..

[Elliott Rubenstein]

Always informative.

[Thus Changed]

Thank you both, so much, for pushing this convo fwd into the public!

[AnswersFromGod dot Com]

It is amazing to listen to this guy. He clearly recognizes that DNA is a digital language, and language (information) must come from a mind per information theory (which is based upon the entropy laws). Then he goes on to conclude that our bodies somehow evolved. Hummm... No cognitive dissonance there...

[Liz P]

This is fascinating and makes sense. I'm glad I watched this video. I'm going to try everything he's doing.

[forestfox66]

I have unintentionally fasted daily my whole life 18:6 as my body does not like breakfast, I eat when I am only hungry and stop when I am full, I eat healthily, I sleep in a cold bedroom, I hike mountains every day even in winter, and it makes me feel great, and I live in cold Norway. I have also lived 5 years in the tropics. My body can easily adapt to extreme cold and heat, and I am never sick. At 50 kgs, I am lean and mean. I am 40, look 30 and have a 20-year-old figure. All this new science is very interesting, but listening to your body and what instinctively makes you feel good is equally informative! I am a zoologist, we are animals, but sometimes we just think way too much ;-)

[Annie Ezekiel]

Love yr comments. So much.

[M K]

@HuskyTheDog No drugs or alcohol *ever* ? No vaccines as a child? No cold meds? Never even tried alcohol? Where do you live and how were you raised?

[Kishan Chali]

@HuskyTheDog Do you avoid any meal, like lunch or dinner?

[Rx P]

I battle with food addiction, sugar. I was raised with parents from Italy with the mindset - We Live to Eat as opposed to eating to live. Hard to get away from now that I’m close to 50. I’m trying though.

[Eddie Tan]

Question: Does the act of fasting or the sensation of being hungry reduce aging? Because I have been intermediate fasting and I rarely get hungry

[bw sa]

He was talking about hunger in a metabolic sense.

[Leanna Bond]

About 6 months ago I decided I was going to start getting younger...I now see how powerful our minds are as I actually look and feel younger and have lost about 30lbs now without any scheduled exercise but rather doing isometrix type exercises at every moment of my waking hours.

[Anti-aging withAF]

❤

[Ancient Chart Music and Art]

I've been doing one meal a day for several months, making sure that what I do eat is nutritionally dense. I also think I was lucky in my family's genepool, because of my facial characteristics. I looked younger than most when I was 18 - and when I was 23, this one guy wouldn't even sell me liquor. He was adamant that "You're NOT 21." (It still pisses me off when I remember it LOL). Now than I'm in my 50's, my round face is working to my advantage - people are genuinely surprised that I'm as old as I am. It happens often enough that it's not a coincidence. I feel so fortunate that way, and I also gave up alcohol and smoking years ago (almost killed myself with alcohol). So, it's a few different factors that play into it, and I am happy to learn that fasting is also conducive to anti-aging. Honestly, my skeleton is small enough that I don't really carry extra weight very well - but I'm also not terribly skinny. Thanks for the informative videos - Love your show!!

[Ancient Chart Music and Art]

I also agree with the fact that it's the temporal nature of life which makes it more precious.

[Ivonne Lopez]

I’ve stressed out all my life. I’m 31, people say that I look 18. I’m wondering if there is a correlation between stress, aging, and trauma.

[Silvia Mihailova]

Happy new year, but you dont really look 18.....

[Anti-aging withAF]

❤

[Georgiy Potulov]

I’m 35 and look younger, the secret to staying young is not mental stress but more of physical stress such as surfing, surfing has some of the best benefits to what Tom is talking about. Because every time you charge after a wave you get what Tom is talking about not to mention you arc your back (especially on a short board) and this gives you good posture, keeps you flexible and very relaxed yet gives your muscle good tone, I used to swim in the middle of winter with 43 degree water in my spring suit and this helped me dramatically, not to only get in shape but it helped me out with my singing. ( I am a classically trained singer)

[Alena duplantier]

No offence but you look 40 in your profile iam also 32 by the way

[Genesis Fox]

This guy is a blessing. I'm glad people don't feel like death needs to happen. I'd rather fight aging and go down kicking I think.

[A.I. Video Fun]

Props to you, Tom, for understanding what he is talking about and having an intelligent conversation. Respect!

[Aayu]

This professor is amazing!

[Jenny Liya Paintings]

very interesting topic.. i was in a very bad and unhealthy lifestyle for years..!! i was getting sick day by day.. now i m trying to lead a healthy lifestyle and already i am observing the differences .. Eat healthy, be active and keep your mind stress free that’s it.. live your life.. ❤️

[Nunya]

I’m a firm believer that there are a few factors that ultimately affect aging. 1) diet (obviously). Those who eat a lot of processed foods, carbs, junk, age a lot faster than those that control it or don’t. 2) fitness. Fitter people just in general automatically look atleast 5 years younger. And then always being active provides the same effect. There’s people at the gym who are like 10 years older than I think they are because they love to workout. Dude I was talking to in the sauna today was 53 but I thought he was early-mid 40s. Hes always lifting and at the gym 5x a week. 3) fashion. When you get older you stop caring about what’s hip, or the clothes you wear..guys especially. Big no-no. While you don’t need to be buying the latest trends in fashion like the teenagers are, having a good fashion sense will almost always make you look younger. I know guys in their 40s who rock the sandal/sock/cargo/polo combo and they seem to like it. Good for them but it definitely adds like 5-10 years of what you really are. 4) attitude. Simple, there are people who get angry over everything, stress over everything, complain for the smallest reasons, over-sensitive, quick to attack someone, etc…. Yea those things age you quick too. Look at Johnny Depp in that trial. Dude was just being silly and laughing where it’s supposed to be a serious setting…if I didn’t originally know his age, I would NEVER have thought he was 58. Dude could pass for early 40s. Your mannerisms can age you, and if he behaved what we expect 58yos to behave like, then he may pass for it.

[life simple]

My experiment raw food plant base diet makes me younger and am happy for that 😎❤

[Dick Armstrong]

David Sinclair is brilliant. I hope to see more of him interviewed by someone who doesn't look like they had a rough night at the pub last night and barely made it to work.

[Shells Pink]

Would love to hear more about how Fluoroquinolones work and how they speed up the aging process.

[Emet]

The interviewer is doing his job almost perfectly. Just wanted to say that, good job man!

[Anti-aging withAF]

Agree🖒

[Keto Bodybuilder]

when they zoomed into the sticky out ears though i chuckled

[LaMar]

@Pennie Hutson Totally agree. Ppl often feel the need to use the F word when feeling inferior to someone who is far more intelligent.

[Spiro Angelatos]

100% scripted informercial.

[Pennie Hutson]

@N M one swears when they have not the knowledge to speak better. Sign of ignorance.

[H O]

Wow that’s an amazingly informative interview. Thank you.

[Bea Wesley]

I had multiple health issues. Last year I started fasting. I don’t eat from 18.00 to 12.00 the following day. I have given up sugar, caffeine, gluten, alcohol, dairy and processed foods. My health has improved dramatically. I would also add that drinking a really good quality water makes a big difference as well.

[gd]

Are your health issues gone?

[pstubeing]

Dear Dr. Sinclair, please don’t confuse pharmaceitical companies with society. Thank You, keep up the great work and good luck to you!

[Chris Schey]

What a terrific show. David looks like a mischievous boy despite his 50 years. His research may ensure he will be the same at 100. Thanks both of you for such exciting information.👍🌹🌹

[Limitless Joseph]

I’m so glad Dr. David Sinclair is trying his very best to thrive and change the pattern of humanity a little bit. Likewise, I’m beginning to sense that excessive of our energy being invest in one thinking approach can result in a higher chances of consequences. There are other scientists takes on the same career just like Dr. David Sinclair are Dave Asprey etc. If these types of scientist can cooperate and work together therefore humanity will have a high possibility in achieving age reversal or unlimited life span. Hope it happens very fast and I’m begging you to prevent this disease.

[JaNae]

I love their chemistry lol Professor Sinclair loves to teach and Tom loves to learn. You can genuinely see the glee in the professors face when Tom poses a great question. Love it!!

[Kabhi Sharma]

Exactly

[Miguel Chipps Inteligente]

Tesla referenced human energy 🌬👻jesus christ referenced living waters 💎👩‍🎓👨‍🎓science described water memory 🌊👨‍🎨👩‍🎨existence reflecting psychologically, psalms16:24 k,j proverbs 27:19👻💎👩‍🎓👨‍🎓💖🗽🤍🧮⚖☄🌪🌬

[Alexandre Dumas]

One of the best summary video about aging, David is amazing!

[Guy Noir]

I'm 71 and work as a professional mechanic 40 hours a week . I workout before work and again after work . When I can't do a hundred push-ups in a row and 200 crunches I'll retire . I've stayed extremely active all my life and plan to remain that way as long as possible. I've had over 30 broken bones including back and fractured skull , not at the same time , I have no arthritis , I'm sure genetics plays a part but since my grandparents and parents lived a similar lifestyle as mine I don't know how much .

[Jessica Rodriguez @insta shivalingajr]

I just experienced this literally five days ago I got fired for my toxic job I got forced to go back to my old job the universe have been telling me to go back to and I can't believe my skin it's so clear I've never seen it this clear since 10 years ago my stomach immediately went back to how I like it

[Yayang Tapir]

That's a great detailed information about ageing! Thanks for sharing!

[Anti-aging withAF]

❤

[Agata Hooper]

Good interview but some vital info missing like: 1. What is David's diet 2. What are the side effects of the drugs he is taking that he briefly mentioned (but Tom interrupted him before he explained). 3. What is his intake on meditation and mind attitude for health and longevity? 4. Does he get sick at all? These are all very important for the whole picture. I don't take these drugs but I also look 10 years younger and have not changed shape since my early 20's. I am vegetarian border vegan, do 20 min exercise every morning and intermittent fasting for 16 hours every day. Also, have been taking CBD oil regularly twice per day for the last 3 years and since then have not been sick for one day even with a common cold! CBD is proven to stimulate your body to heal itself, eliminates inflammation and hence, improves your immunity significantly. So it is not all about just taking the pills he is talking about. There is much cheaper solution like CBD to help your body for good health and longevity and with no side effects!

[Gameswithajump]

Resveratrol, which he takes and mentions in this video, does not have any side effects as well. It is a natural antioxidant found in grape skins.

[Kitty Kat]

Thank you this is soo true. I pill can’t do everything

[Kevin M Ruel]

He listed what he was on watch it again towards the end

[Lucy A]

Aside from diet and lifestyle, the key to anti-aging is truly relaxing, laughing and loving what you do despite the hard times. Keep it simple.

[Jing Consengco #Realtor63]

Very true. If you love what you do its effortless to do it and you will enjoy doing as often as you want. Its gives you extreme happiness and its key to stay young both physically and emotionally.

[RAVI VARMA]

You nailed it.. laugh, love and live... Focus on quality of life then quantity is bi product...

[Timmy]

This is such an awesome fact. Not a reason to be lazy, but an incentive to feel healthy in order to be healthy. Because the reason people choose to live healthy is ultimately, to be happy. Such a beautiful cascade effect.

[Sara]

powershel23 Married men actually live longer than non married men. Funnily enough, opposite effect on women though.

[Jameson Keating]

@QuantumBraced What David Sinclair essentially just said in this interview is they are looking into resetting bodies at the cellular level. In a way I guess you could call that genetic intervention, but if you want to be more correct it would be epigenetic intervention.

[Elisa Frye]

Tom, I REALLY appreciate your tactful ability to press your guests politely, but FIRMLY for further details when they might be being a bit vague about providing some of them. 👍❣️

[Ashley G]

Ok. So cells are born knowing what they are and their functions within the human body (relative to this video), but can you imagine if each one of us were born in the same manner??!!! 😩😂 Great video 💯💯💯🔥

[Kev Curtis]

So basically, put yourself in in comfort challenging situations as a normal life , " Be a savage , harden up & do the Warrior life...been living like this since I was 5 yrs old , I'm 53 now & do 1000 exercise challenge monthly, eat simple , and look to do things tht challenge my bravery..Love it !!

[Kim Meakins]

This guy is very informative. My input is with this much design in our bodies, were we designed by a higher power or just slid out of the ocean from a blob and designed ourselves.🤣 our brain was designed for a thousand year input. We through diet and other problems have reduced our lifespan.

[Soul Rarity]

All I can say is wow! I love your questions bc I would have been lost without you!! Great information!!

[Hadas Sasson]

Thank you for this inspiring, healing information! This has been vital. Bless you both for your hard work and dedication for the betterment of humankind!

[Healthy Living With Chris Gault]

Yes, these guys are brilliant!

[CygnusRays]

This is scientific validation of (master faster) Prof. Arnold Ehrets work, ‘Rational Fasting’, ‘The Mucusless Diet Healing System’, his use of Grape Juice fasts etc.. Great introduction to David Sinclair- Thank you!

[Azian Madun]

Interesting stuff. However, we know that our brain is capable to learn new things, so if we put our body in shock consistently, our brain can l learn about it. Therefore we have to consistently upgrade the intensity of the shock, otherwise our brain will not see it as shock. Could you please ask the professor about this when you invite him again in future?

[Professor Jay]

This interview is an add up to what I’ve already studied from Dr Bruce Lipton. Epigenetic is really the new biology.