The TALISMAN study: prophylactic treatment for talquetamab-related oral toxicity in myeloma

Taste disturbances, known as dysgeusia, are a common side effect of talquetamab treatment and significantly impact the quality of life (QoL) of many patients. Rakesh Popat, MBBS, MRCP, FRCPath, PhD, University College London Hospitals, London, UK, shares insight into the Phase II TALISMAN study (NCT06500884), which will evaluate prophylactic treatments for talquetamab-related oral toxicity in patients with relapsed/refractory (R/R) multiple myeloma (MM). The therapeutic strategies that will be tested are dexamethasone mouthwash, oral pregabalin, and clonazepam orally dissolving tablets. This interview took place at the 21st International Myeloma Society (IMS) Annual Meeting, held in Rio de Janeiro, Brazil.
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