Nervous System Development Part 1: Neurulation

[@peterdorfmann4043]

Wow! What a great resource, thank you Dr. Moore for making it available for free. Due to connectivity issues when following online lectures I was confused on some integral parts of neural development and your lectures have helped greatly to put everything into perspective. Thank you again and hope you are doing well.

[@thehistologywizard5783]

Hi Peter, I'm so glad it was helpful for you. KM

[@dr.m.umairmajeed9675]

Splendid... Kindly make some videos on GIT embryology too...

[@thehistologywizard5783]

Thank you! Digestive embryo videos are coming this fall

[@TheYaddail]

Hi, do you have an article regarding BMP4-binding molecules and neural cells being the default ectodermal cells?

[@thehistologywizard5783]

Let me see what I can find for you.

[@TheYaddail]

@@thehistologywizard5783 sorry and thanks.

[@reninroy5435]

i have a doubt regarding the neural plate formation .. where you said it forms from the non involuting ectoderm(surface ectoderm) from my understanding if i am wrong please correct me .. i cant understand it good . if u have time please can u explain .. the neural plate is forming on the involuting ectoderm right ....how its forming from the non involuting as the non involuting ectoderm is producing BMP to block the formation of the neural plate .

[@thehistologywizard5783]

Hi- It's complicated but to try and simplify, you can think of the ectoderm in sort of 3 "areas", cells in each area receive different levels of signaling. And the level determines the fate of the cells, meaning they will turn on genetic pathways to differentiate toward different adult fates. Cells in the area that receives the highest levels of BMP signaling are inhibited from becoming neuronal cells or neural crest, these will take on ectodermal fates. Those cells in the area with the lowest levels of BMP signaling (because of signals from the notochord that inhibit BMP locally), these undergo neural induction and will take on neuroectodermal fates. Cells in the border areas, receive "intermediate" levels of signaling and those cells will take on neural crest fates. They undergo epithelial to mesenchymal transition, which allows them to detach from their neighbors, change shape and move, migrating to multiple areas of the body.