This is your brain on ketamine

[@BeersAndBeatsPDX]

I've never heard anyone ever call it "super acid."

[@JoeyKlu]

You have now, lol.

[@ryanreedgibson]

Never seen it snorted or smoked in a crack pipe.

[@BeersAndBeatsPDX]

@@ryanreedgibson Really? I've only ever seen it snorted

[@Mutantcy1992]

Yeah no one calls it that smh

[@daphne4983]

Apparently also called KitKat 😆

[@KimberlyJose-si2sv]

LSD, DMT and psilocybin containing mushroom are just amazing. I could remember several years ago, i was diagnosed with cptsd. Also suffered severe depression and mental disorder. Not until a friend recommended me to psilocybin mushrooms treatment. Psilocybin treatment saved my life honestly. 8 years totally clean. This is something that really need to be use globally to help people with related health challenges.

[@Morrisbraga-jm9lc]

I love hearing great life changing stories like this. I want to become a mycologist because honestly mushrooms are the best form of medicine (most especially the psychedelic ones) There are so many people today used magic mushrooms to ween off of SSRI medication- its amazing! Years back i wrote an entire essay about psychedelics. they saved you from death buddy, lets be honest here.

[@Paul_doherty-t6h]

Hey mates! Can you help with the source? 😢

[@HxuxjXixid]

Yes sure of Pedroshrooms

[@DonnDenisse]

I'm so very happy for you mate, Psilocybin is absolutely amazing, the way it shows you things, the way it teaches you things. I can not believe our world and our people shows less interest about it's helpfulness to humanity. It's love. The mushrooms heals people by showing the truth, it would be so beneficial for so many people, especially politicians and the rich who have lost their way and every other persons out there.

[@smith23652]

Where do I reach this dude? If possible can I find him on Google

[@alixstaines6725]

Trying to extract only the part of ketamine that helps with depression while trying to remove the psychedelic aspects of it doesn't quite hit for me. I feel like the psychedelic aspects is what helps with the depression

[@LollyMarie1]

The euphoria is not mind-numbing as much as it is expanding. I got a real sense of perspective and it dispelled fears I hadn’t even realized were underlying beliefs & behaviors.

[@jimycrackcorn408]

Absolutely 100%!!!!!

[@ivocanevo]

I've had this thought too, though I have no real basis for it. I guess it just "feels" like the trip is part of the improvement. All the effort to try to remove the psychedelic aspects does seem silly.

[@ivocanevo]

​@@LollyMarie1oh yeah, this isn't talked about often enough: this element of self-therapy. Various psychedelic substances (according to a friend, of course) seem to help you "see through and beyond" your own mental barriers, false assumptions or defense mechanisms, and that can happen quite consciously, where you truly experience how, and why, you are getting in your own way, and can clearly see yourself dispensing with that mental construct. It's like a defense comes down, and you dream a more useful version of yourself. I'm no psychologist, but that sounds to me like how you defeat some types of depression at their core. So: it's not just a molecule that resets something in the brain plumbing. It supports a sort of spontaneous self awareness therapy.

[@ivocanevo]

One friend in particular, remarkably overcame a deep seated trauma during her first recreational k experience. She had been choked as a child. Asking for assistance, while staying in control, over the course of 45 min she systematically challenged and guided herself to permanently overcome the trauma. She intuited the process; no one had told her this was something that one could even do.

[@spookygreg]

I work in rheumatology and see a lot of chronic pain patients get amazing relief with k infusions. Meeting patients, it’s clear how life saving this is. Quality of life is so much better for them now ❤

[@synthwav_]

i'm a minor with chronic pain (probably fibromyalgia, but i am not entirely sure), i do not remember what it feels like to not be in pain. i would love to try these things, and i am hoping that i will be allowed to once i get the specific thing that's causing chronic pain diagnosed. it definitely sounds like an amazing lifesaving thing for me

[@wmdkitty]

@@synthwav_ Best of luck, mate!

[@OvercookedSpacegetti]

​@synthwav_ have you tried researching on getting ket online/the onions/dnm or on the sreet?

[@kitefan1]

I'm so glad that this has come up as a treatment for chronic pain. Long, long ago I took oxycodone for two of my orthopedic incidents. The last orthopedic incident (a broken femur) they were much more stingy with meds and required me to pick them up from the pharmacy in person the first time. So, I don't get why they won't give people with chronic pain things like morphine. Especially if someone is elderly, doesn't have decades left and so on, why are you worrying about addiction?

[@johnrhodes3350]

​@@synthwav_have a personal theory that fibromyalgia is an undiagnosed thyroid disorder, like Hashimoto's and or connected to insulin resistance mitochondrial dysfunction. It's late here and in tired. Forgive me if I'm not clear

[@SirSpenace]

As someone with treatment resistant CPTSD, this is super exciting news. I've suffered for years with my symptoms - and we lost my older brother in 2023 to his. I've been trying to get into an MDMA study for years. Hearing that it's slated for review in barely over a month makes me want to cry happy tears.

[@juliana.x0x0]

Same! My GP has strongly recommended me getting ketamine infusions! It's not covered by insurance (yet), but I've heard that there's a week long one that can be covered if signed off on by a psychiatrist! There are also things like mindblook (the box they advertise where they send it to your home), but there's less advertised ones that seem to be way cheaper and more highly rated and recommended. My friend works in the medical field and got access to infusions when they were first approved. I've even thought about microdosing on psilocybin as I've heard that can be helpful for treatment resistant depression and help with ptsd and cptsd. As much as it sucks to deal with the symptoms of complex ptsd, I am grateful we are in a time where these drugs are being looked at as options for addressing mental health. 70 years ago we might have just been lobotomized! Hope you find healing and happiness ❤ Edit: I am currently trying to see if I can get approved, if not for the week long ketamine treatment, to get my therapist to be allowed to be my "trip sitter" to help guide me through a mail-order treatment process. Dunno if it will go through or be approved, but there's so many possibilities! Stay hopeful!

[@neurotransmissions]

It's a huge deal. I don't want to rain on anybody's parade, BUT it's still pretty questionable whether MDMA will end up receiving approval. Just a month ago, the FDA committee evaluating MDMA as a PTSD treatment voted against it and there have been concerns about the validity of the research used to support its approval. The committee's vote doesn't directly decide whether the treatment gets approved, but it can impact the FDA's decision. They have certainly approved certain treatments, even when the committee votes against it. Guess we'll find out August 11th...

[@Maquis1943]

@@neurotransmissions I was in a MAPS phase 2 clinical trial for MDMA-Assisted Psycotherapy for PTSD. The validity of the data is incredibly strong, much stronger than the data for SSRIs, for instance. The effect size is huge with over 68% of clinical trial participants *no longer meeting criteria for PTSD*, with the effect size only growing over time. There has been a concerted and deeply dishonest campaign by a small disgruntled group of former psychedelic proponents who are using fear tactics to undermine the study. Fear gets eyeballs on twitter, propagates an "us vs them" mentality, and in an age of vaccine denial, science skepticism, and Q-Anon-like conspiracism, poisons the well. The FDA Advisory Committee vote, while purported to be based solely on science, was affected by this negative social media campaign. In addition, their concerns were fully addressed in the sponsoring agency, Lykos's, proposal, including things like the difficulty in blinding. It's important to understand that the FDA has worked *literally hand-in-hand* with the sponsoring organization to construct the clinical trial, addressing all of the points that the advisory committee raised. Pharmaceutical companies have gone into these meeting with *drastically* less data supporting their drug application and have gotten through. Lastly, note that this is an Advisory Committee-not the actual FDA-and that one out of three applications that have been approved by the FDA have NOT been approved by the advisory committee, so there is 33% chance that MDMA-assisted psychotherapy could still be approved in August. For those concerned, and waiting for this potentially revolutionary treatment modality to be made available, even if the FDA does not approve in August, all the data is there, save for some physical data not taken during the clinical trials. This means that there may need to be an additional study done on physcial effects of MDMA dosing *more than* the three dosings done in phase 3 trials. This modality will not be stopped. The data is very strong. The disgruntled group of naysayers cannot change what we 420-odd participants in the clinical trials know to be true: that this treatment DOES have an effect on PTSD. With guardrails that satisfy the medical community, this modality WILL be approved.

[@Maquis1943]

@@neurotransmissions Hmmm. Why was do my comments *keep* getting removed? It's pretty disconcerting. I think being an MDMA-assisted psychotherapy for PTSD clinical trial participant with direct knowledge of the FDA approval process and the Advisory Committee meeting, my experience might offer useful information to your viewers (especially the ones who are struggling with PTSD and are concerned about the possibility of recieving treatment.)

[@Maquis1943]

Don't give up hope. I am a Phase 2 MDMA-Assisted Psychotherapy for PTSD clinical trial participant. The data from the sponsoring organization, Lykos is incredibly strong. A small group of disgruntled and slighted former true believers have poisoned the well with conspiracy theories, manipulation of information, hearsay, and a deep misunderstanding of the research, clinical trial, and FDA-approval process. None of them are clinicians or scientists and have a political axe to grind. The FDA has worked hand in hand with Lykos over the past five years to ensure that the clinical trial was done to the FDAs high standards. The Advisory Committed meeting's decision, as stated in the comment below, is not binding. 1/3 of all new drug applicants are rejected and still get approved by the FDA. And even if there is more data that needs to be collected (e.g. physical data like heart rate, EEGs, liver and kidney function tests, etc), this is easily done with a likely limited clinical trial. This treatment can't be stopped-the 425 or so clinical trial participants who either *no longer meet criteria* for PTSD or whose PTSD symptoms are markedly reduced, are here, surviving, and will not allow a small group of naysayers to manipulate our experiences to advance their careers or further create division. See you on the other side!

[@alexbrown6620]

I've was stuck in depression without any motivation to work or find any sort of relationship for 4 years, smoking weed to help, eat some magic mushrooms a few times and taking prescribed anti depressants, none of this worked. I tried ketamine for a week or so and following that week was a strive to find work and a girlfriend and both are going amazingly. I've not touched it since and only look back on this substance in thanks for helping me

[@LouisPetek]

I have taken a small amount of Ketamin every weekend for about 3 years. In small amounts it can give you unmatched gratitude, perspective and empathy for others. It can show you what you need to see within yourself and in the world around you

[@Roy.Laguna2988]

Everybody is struggling with mental health and could benefit from careful therapeutic use of substances like these. Wanna try, but keep being told I can't do it alone for the first time.

[@JohnD.Brinich]

Since I tired psychedelics for the first time, I’ve been trying to describe the experience to others so there can try it as well, but i couldn’t find the right words to describe it.

[@Felipe.Oliveira5665]

I find it funny if there's any psychedelic therapy there online

[@ADDAxyz710]

Yoo , do you live on a farm? How do you come across a steady stream?

[@craigwilliams7496]

Define small amounts, please!

[@jeanettemarkley7299]

It's so refreshing to hear someone from your class who believe in bodily autonomy. I believe people should be able to whatever they want with their body. It's so weird that people can't. Like people are children or something.

[@jen7662]

People can do what they want with their bodies, it doesn't mean there aren't consequence's.

[@superioropinion7116]

@@jen7662 there are consequences for anything you do so it's useless to point it out unless you have something else in mind

[@Melvin420x12]

That's because, even though we really want to believe otherwise, we're not exactly great with will-power or overseeing consequences. There are also real consequences to society especially with harder drugs. Drugs, also and especially Ketamine, are very addictive. So sure, bodily autonomy, but there are consequences to society and some people need to be protected from themselves. It's not as black and white as your comment makes it seem.

[@daphne4983]

Who would you feel has to pay for hospitalizations caused by Special K?

[@jen7662]

@@superioropinion7116 consequences is super important when referring to drugs (both legal and illegal). Take a virtual stroll down Kensington ave sometime.

[@janeharry790]

Psychedelics are just an exceptional mental health breakthrough. It's quite fascinating how effective they are against depression and anxiety. Saved my life.

[@MarshallBowen-do4pi]

/lsd is my favorite, only done shrooms one time and that shit was extremely overwhelming, never again. Beautiful experience tho

[@us249]

love this whole thread full of bots

[@mailam8846]

​@@raja-hg6hfyou.... Can't do that on KZbin.

[@cabense]

My first shroom trip was definitely crazy. I took way too much (8g’s), but I was surrounded by friends and it is the ONLY thing that gave me over 6 months of relief from my treatment resistant ptsd.

[@joshuacampbell17]

ketamine is not a psychedelic

[@Joe-bh7pf]

I've done ketamine a couple times but shrooms on the other hand showed me everything i needed!

[@chaemchoiaromdee2229]

The insights I've gained from ket and magic mushrooms have been invaluable. They've helped me understand myself and the world in a new way.

[@muu1589]

The effects of magic mushrooms are like a reset button for my mind. They help me clear my thoughts and feel refreshed.

[@RrDis-q6o]

After my trip yesterday, I did understand why mushrooms are praised... you can have some beautiful experiences on them..

[@Toddler-x4q]

I've seen lots of positive reviews on mushies I'm really looking at trying them.. any idea?

[@RrDis-q6o]

doc.kain

[@LollyMarie1]

At home ketamine treatment saved my life. I was seriously pursuing ECT therapy because my depression had become so bad and a couple different changes to antidepressants wasn’t working. I went through a 6-session program and felt a big shift; but started slipping back into a negative thought loop again about 2 months later. I signed up for a series of 3 -6 session programs and in less than a year unpacked a lifetime of avoidant adaptations. I’ve maintained remission for almost 6 months now since my last K treatment and still feeling transformed. I’ve never seen the recreational allure, but rather as a process, almost ritual, that required respect.

[@avlally]

I thought I could self medicate my own depression but very quickly found myself addicted to it, fast forward a few years and I was injecting 3.5 grams of it daily for months. When I finally stopped the withdrawal was worse than anything I've ever been through, including kicking heroin and fentanyl. I actually used alcohol to help taper as alcohol also has (admittedly mild) nmda antagonism too. A lot of the WD I experienced from k seemed to mimic the symptoms of alcohol induced DTs too, including psychosis and hallucinations (in addition to absolutely insane levels of pain. Which makes sense when you realize that is a funky opiate in addition to everything else it affects.)

[@dcisaak]

Ketamine infusion therapy greatly helped me in recovering from cPTSD but you have to do the work yourself to truly heal!

[@fanxxai]

How did it go?

[@dcisaak]

@@fanxxai it was very spiritual. I felt oneness with G-d and knew that my problems were fixable. I became more religiously observant afterwards, changed my diet, and started exercising. Ket finally lifted the suicidal ideation I’d been carrying for years from an abusive childhood, which in turn gave me the ability to build a mental foundation for myself. Now I am emotionally regulated and much more in touch with my body. I have the ability to just process emotions and move on, as well as outright reject a negative mindset or maladaptive behaviors. Putting my full faith in HaShem was in part facilitated by my experiences with iv ket.

[@zezezep]

I'm beginning to think the earth/the body/the brain wants us to put in some work to earn the reward

[@tw8461]

@@zezezepYou are Absolutely Amazing!!!!🙏🏾Thank you!!!!🕊️

[@PJS_-xh8mp]

I have CPTSD. Tried 10 infusions of ketamine. It was interesting but didn't move the needle. I was with a therapist and she's did say there integration work is where the heading happens but I didn't seem to get any relief. Granted my therapist was pretty passive/listening so I'm not sure what too do to do the "work". I even got with an MDMA therapist, did two sessions and the medicine had no effect. Thrust is their have a psychological block to letting the medicine work that is neutralizing the MDMA. Didn't even knows that was possible but I was given pretty large dose of MDMA/Psilocybin in second session and I felt nothing, no high. Pretty disappointing. I'm trying IFS therapy for the last few months and not sure it's helping either.

[@juliana.x0x0]

GOD FORBID someone who doesn't experience happiness....experiences fleeting happiness! We can't have that in America, the people might wake up and be harder to control!

[@walkerfeet8729]

You want fleeting happiness? buy something. that's the only accepted happiness for lowly consumers

[@bobjary9382]

Its a bit crazy that any sign of feeling happy as the result of treatment is so frowned on , this is America where the pursuit of happiness is mandated in the constitution ?

[@Nick-wd3he]

There are additional side effects to misuse of Ketamine. Just like there are additional side effects to the misuse of opiates.

[@jtism6021]

Find God bro ull be happy having an addiction isn’t gone make u happy

[@juliana.x0x0]

@@jtism6021 agreed that addiction doesn't make happiness, but life is more complex than that. I also agree that finding spirituality can bring meaning, but not everyone finds meaning in a church.

[@isabellabihy8631]

I did get Ketamine right before my hip joint replacement procedure, at least I stopped screaming with pain. It felt like I was in a discotheque in the late 1970s. Flashing pink lights like stroboscopes. A very weird experience. When they wheeled me into the operting theatre, I was out. The procedure went very well and I couldn't remember anything. In the case of knocking out a patient before a surgical procedure, nice way to go with Ketamine. I wouldn't want to use it in any other way.

[@hoosierbaddy3052]

Wow Isabella. I had a hip replacement too. I asked for and got spinal AND general anesthesia. Ketamine wasn’t an option. If I have to do the left one, I won’t be doing the spinal one again. I’d rather wake up in pain than have it slowly come on. You wake up thinking that you’re paralyzed. And they had me strapped to a triangular foam wedge. That procedure was thee most painful thing I’ve ever experienced. I’d never known bone pain until then. Cuz there’s a difference in pain types. Nerve, muscular and bone all bring their special brand of ouch.

[@NdellaTall]

i had the exact same experience when i was a kid 😮

[@bobjary9382]

Here in the uk ketamine was often used as a pre med anaesthetic before the real deal which was ofter iv propofol, I had it a couple of times and it wasnt unpleasant. I think its not used so much now being considered surplus to requirement

[@Whobidia]

I’ve got it for dental extractions

[@creature2479]

​@@bobjary9382Yeah a lot of the time it was being used it was being stolen and sold by NHS staff lmao

[@bgrune1]

I have been doing at home ketamine therapy via telemedicine for anxiety and depression. It seemed to work wonders at first. I felt energized and unburdened. Though I was progressively increasing the dosage I felt like I was getting less benefit as time progressed. It never caused any problems I could detect either so it has not been a negative. If nothing else I completely lost my urge to drink. I was not drinking a lot but I am a health and fitness nut and drinking alcohol never sat right with me. I am grateful that ketamine helped me quit without feeling like I am missing out on anything. I have a couple doses left but I have been going a long time between doses and I don't plan to continue ketamine therapy. I feel like my anxiety and depression are very situational and that is probably why I can't seem to shake them. Maybe if my life circumstances change I will get relief.

[@dnunyabidnesses2519]

I’ve taken long breaks between treatments and I think I’ve experienced a similar plateau of benefit before. What I realized was that I wasn’t putting as much effort into the sessions as they became almost mundane instead of something that could change my world view. Since refocusing I’ve found them helpful again but I do think for me it’s just a piece of the puzzle of treatment. None of this is to say you’re doing anything wrong just my own experience. I applaud and thank you for sharing.

[@tammymiller9773]

I think you will. Glad K helped. Proud of you for using it wisely.💙 hugs from a stranger who's ridden that horse.

[@tsawy6]

The only cure i know for depression is a fundamental change in your life circumstances, but, easier said than done. I reckon all any medication can hope to achieve is sufficient alleviation of symptoms to help you get out of the hole.

[@zezezep]

thanks for sharing that. I think a lot of the big issues are related to the situations we find ourselves in

[@Show_Love_Serina]

Same🫂

[@brookeshane2210]

I have been diagnosed with treatment resistant depression and horrible anxiety ive been dealing with for over 20 years. Ive had Spravato treatments 2x per week for the last month. I have definitely felt a change in my mood. My depression and anxiety have definitely lessened as well.I was also able to get off Klonopin after first dose of Spravato. I cant wait to continue to see even more improvement. Even my family has.seen a difference this month.This video was very informative. Thank you.

[@elgusto8874]

How are you doing these days

[@NancyMcGrath-og4mm]

Were you able to try IV Ketamine? I am doing it now, and wow oh wow, definitely life-changing. I can see how it can be addicting.

[@Psychx_]

8:30 it's not so much about glutamate system dysfunction, but rather that glutamate signalling influences BDNF release. Blockage of NMDA ligand gated ion channels via Ketamine leads to rapid BDNF realease. This is turn promotes the formation of new synaptic connections (neuroplasticity and ability to adapt/learn/change thought patterns) and has anti-inflammatory and anti-apoptotic effects. Other things proven to improve depression, such as TCAs, SSRI and SNRI also lead to increased BDNF levels (with TCAs being the most potent), as do psychotherapy, doing sports, environmental enrichment and serotoninergic psychedelics (i.e. psilocybin, LSD - interestingly enough they also bind to 5-HT2A-mGlur2 and 5-HT2A-D2 receptor heteromers. many other receptors can fuse with one another aswell. This opens up a whole new field of study and implicates a vast amount of yet unknown interactions and mechanisms). Anyhow, BDNF is where most of the different depression models converge, since marks the point of intersection between them.

[@mem7806]

indeed esketamine is more potent as an NMDA antagonist but it's inferior to racemic

[@alphaoscillator]

so 50ml cerebrolysin ED could do the same job?

[@shannonperez9408]

If you get on an SSRI, my goodness you can’t even get off of them. You’ll start having brain shocks and trimmers or if you get on a benzine and you stop you’ll have seizures and die and we’re over here fussing about ketamine. Or we fuss about mushrooms that grow naturally on the freaking ground.. cannabis that grows naturally I don’t know how ketamine is made so therefore I can’t say it’s natural but when I’m saying this is that there’s so many things that they say not so they need to kick back

[@alphaoscillator]

@@shannonperez9408 you can with methylen blue

[@alisonderrick1067]

slow and low titration of SSRI’s and benzodiazepines please 🙏… this point is SO Important!!

[@Jeje-rb1vu]

I personally can say that the ketamine treatments I did saved my life. I did 8 sessions and I went from daily panic attacks, insomnia and deep depression to finally be hopeful. Insomnia and panic attacks gone ( it's been 2 years ). I do 1-2 session a year now.

[@ourgypsysoles1096]

I am going through a treatment program. I have had two treatments at 28 mg. Its early in my treatment but i am working to overcome severe trauma. I believe this medication will change my life. I am having childhood memories come back to me. They arent good or bad memories, it just feels as if my brain has needed a tune-up for years and its starting to fire on all cylinders. Im so hopeful.

[@numinous2506]

It's not super acid, it's acid without the anxiety and existential crisis.

[@bobjary9382]

No , thats ALAD

[@Scotty-vs4lf]

ketamine can definitely give you anxiety and existential crises

[@SerratedPVP]

Don't be such a baby

[@brandonbe5351]

Souns super in that regard to me😂

[@JordanRike]

Psychedelics are just an amazing discovery. It's quite fascinating how effective they are for depression and stress..saved my life.

[@Heisenberg-35]

Psychedelics definitely have potential to deal with health issues like anxiety and depression, I would like to try them but it's just hard to source out here.

[@JoelMathew-qk1qh]

I'm feeling the same way too. I put so much on my plate and it definitelv affects mv stress and anxietv levels

[@UffePTV]

Did 0,5g ketamine + 250ug lsd last year in february. I was completely washed of egoic stains that had covered my psyche. Changed my whole life up and I felt stable for about 8 months, never remember being so mentally healthy for that amount of time. Then life situations sent me into a generalized anxiety disorder, did ketamine + lsd again about 1 year after the first time and it helped. It wasn't like the first experience but I definitively had a good time and worked through some mental stuff :) Edit: ‼This is not a small dose and should definitely not be concidered if you aren't very familiar with psychedelics/dissociatives! xD‼

[@Blueoceandog]

0.5 grams ketamine is approaching induction doses so all I would say is make sure your airway is protected in case you regurg by sitting upright and have someone with you.

[@bleepbloop404]

Ye i read .5 & was like god damnnn! Lmfao but the acid should keep them awake

[@UffePTV]

@@Blueoceandog Yes I made a royal bedding for myself the second time so I wouldn't fall over, first time I had someone with me. We went into the forest above my place high as gnomes looking at big ass rocks, deer and butterflies. I'm so happy no one saw us out there

[@UffePTV]

@@bleepbloop404 It very much did, It's was a hella wonky trip

[@captinbunt]

@@UffePTV sounds fun

[@oda513]

“prisoner volunteers” lol my ass

[@alexklonowski9301]

hell if im stuck in prison and someone offers me ketamine i mean…

[@DesertBirdie]

Ketamine therapy saved me. I was so depressed and barely making it. It got me through until I learned why I was extra depressed. I had severely low iron. I have anemia and had waited too long for Iron Infusions. Three months of Spravato treatment got me through, but I still feel the benefits nine months later. I started therapy during Ketamine treatment and got a much-needed iron infusion. I would do it again if my depression and anxiety increases.

[@lolaab0702]

20:50 - 24:30 What’s that song? There is so much trippy background music under this video that (perhaps intentionally) reminds me of the music the clinic plays during my ketamine treatments

[@xorn69]

I grew up using psychedelics with no real established or clinical frameworks. I had to figure out how to use them safely myself using a mixture of self learning and sampling archaic cultural practices. I’m jealous of young people today because they’re more likely going to have these powerful treatments available to them in safer ways. Also it shouldn’t be illegal to have fun.

[@johnymcredbeard977]

I felt like it systematically went through my brain and hard reset all the different areas. Like a flicking off/on every breaker in the breaker panel. It left me with a sense of clarity and peace.

[@vtop1c]

I was a "recreational user" of ketamine, it definitely helped me a lot. Stopped when I felt like it was becoming an addiction, my tolerance was incredibly high, and my use started interfering with regular life. But under medical supervision I can see ketamine and also MDMA can do wonders for mental health.

[@jimycrackcorn408]

Not to mention, MDMA could be very good use for marriage/ relationship counseling ! I believe that's what it was originally used for in the 60s

[@ivocanevo]

​@@jimycrackcorn408yup, I own a book by two therapists who used it that way. Described many case studies with dosage details etc. I think it was closer to the 1980s.

[@moniqueengleman873]

Same here. My tolerance went straight up. Now once a month.

[@moniqueengleman873]

​@jimycrackcorn408 I used to make the best MDMA in college in the 70s. I literally put myself through college and grad school with MDMA. I am a Scientist. So I study myself now with Katamine

[@SanjeebKumar-wh2ty]

You use oral or injection

[@jeremiahrellis1]

Thanks!

[@contentconsumer487]

I appreciate my Dr. for trying this to treat my treatment resistant depression. Tried a full course of EMS first and it just left me hopeless. Started ketamine microdosing troches. Dissociated for 3 weeks I was either asleep or feeling like I was coming out of general anesthesia. It was NOT pleasant and I cannot imagine people enjoying this. All that being said, everyone is different and if you aren’t responding to other treatment you should give it a try. A lot of people are improving. Let you family and friends know because you may not realize you are zoning out. Take care everyone.

[@ILLUMINATED-1]

Disassociating is pretty fun and i think a big aspect of why its so effective, though. I think of it sort of like a sliding scale. The more you take the further away from yourself and your worldly issues you go. A little bit will make you analyze your issues in a more objective and less biased (by mental struggles) light which helps you contextualize your problems properly. Take a lot and you end up in the shadow realm thinking you are thinking like god does. You know the usual

[@Aaaa-iy1sb]

​@@ILLUMINATED-1the shadow realm huh elaborate? Seems like the person's vessel gets taken over by another spiritual entity from my observing experience! The space dust spirit 😂 like alcohol spirits, you lose your sense of your sober higher self.

[@ILLUMINATED-1]

@@Aaaa-iy1sb eh, theres definitely nobody taking over when im on it. If anything your body just feels kinda hard to control. It doesnt move how you want it to move and you cant talk as fast as youd like to talk. But your brain can move pretty quickly. While your body and whatnot has had its performance nerfed your brain moves faster, and can analogize better. You make connections you never would have made sober. Its an interesting thing, I take it for depression and its helped a lot. Not in the “i feel high all the time” way but its depression relieving effects can last 1-2 weeks

[@thelasthop3035]

Oh my god! I found my new favorite channel. This is packed with so much great info it makes my brain go brrr. Thank you very much, this is what's been missing for the last 50 years, I'm going to have to watch all of your videos.

[@yayinternets]

I was in a band called Cicada In My Pants years ago, but now it’s dormant.

[@Take-the-Ticket]

Probably still popular under ground.

[@tomislavzivkovic3978]

Finally. Person with real knowledge explains all views in the way that I can understand without bias. She is not saying take it or not. She just presents benifits and dangers. Excellent.

[@lmullen9478]

You are a phenomenal educator om the science of the brain! WOW...nice work and you're a little bit sassy too,! I was totally engaged the entire time. Thank you!

[@beyondthemedicine-LYTmarketing]

Thank you for NOT mentioning the former friends star. Ketamine is a wonderful support to offer an alternative experience to your day to day habits. I have used it recreationally and therapeutically. What people consider a k-hole is, in a calm and supported environment a beautiful way to sit beside a challenging behavior or emotion and find alternatives. Thanks for the informative video!

[@erindabney2758]

It’s interesting to me that scientists keep searching for a purely biological root cause of depression that isn’t provoked by external stimuli. Maybe the cruelty of others or the pain of unwanted social isolation are the actual catalysts for the biological changes that cause some cases of depression.

[@EliShh-n2n]

Jackpot!!!

[@Tyler-mz2sm]

Props for the intro song, its a slapper!

[@dnunyabidnesses2519]

I’ve been doing mindbloom for about 15 months. I would say that it is the most beneficial medication I’ve ever taken. I’ve been on a dozen different antidepressants throughout my life. I think it requires a lot of time dedicated to the integration and benefits greatly with additional individual therapy. Is it a cure? Not quite. But it was the missing piece of the treatment puzzle that took me from regular sue eh cidal ideation to none. Something I’ve never experienced regularly since I was 12(37 now).

[@evolvetodeath]

the way it changed my partner’s ideation. I saw the immediate benefits in her mood, her departure from heavy use of marijuana, her general overall happiness and less crippling depression. she said it created new neural pathways in her brain and cleared a lot of “cobwebs”. I believe it’s a very beneficial treatment to anyone who battles clinical depression and/or chronic pain and they should try infusions if they’re able to.

[@dnunyabidnesses2519]

@@evolvetodeath I'm so happy it helped your partner. I do think it lets us escape the ruts and try new pathways.

[@StephenPhantom]

And lets not forget that great NMDA receptor drug Dextromethorphan ( DXM ) also hits NET ( norepinephrine ), and Kappa Opiod receptors ( not too much so dont worry on that point ) i take a gummy every day ( each one has only 10mgs of DXM ) but does the trick for me. I stop every few days to build stop tolerance build up, but otherwise its a easily available anti-depressant that you can get at nearly every drug store. Saved my life too.

[@nuclear_chook]

Used in higher doses it gives a crazy good high, the antidepressant effects of lower dozes definitely can't be understated though

[@nieczerwony]

Well it is also SSRI.

[@StephenPhantom]

@@nieczerwony best not to mix with SSRi's as that could be serotonin syndrome city visit

[@dianaonaespinel6649]

And as it was mentioned just the wealthy have access to the treatments. But the thing is that the non wealthy people are the most affected by depression and major depression episodes leaving the society sick.

[@rez.ghiyasi]

this is the most complete video on ketamine, literally everything about ketamine is explained in the best possible way, thank you

[@LadyPantera57]

I always find it interesting that they want two other types of antidepressants to fail first before trying the one that works when those ones don't. Those ones can lead to suicidal thoughts, Spravato can relieve suicidal thoughts. Hmmm... Let's try the one that causes suicidal thoughts first... twice. I know someone who was heavily depressed about 11 years ago. Zoloft had done nothing in the past, cymbalta gave them daytime hallucinations, and then Wellbutrin almost led to them ending their life. I didn't find out that they we're having suicidal thoughts until a year later. Maybe start with the safer one first (I know it's not without risk) and if that one doesn't work, then try the one that can cause suicidal thoughts.

[@eray9934]

I think just about everything can potentially cause suicidal thoughts, my guess is ketamine can too.

[@LadyPantera57]

@@eray9934I don't think it works in the same way that certain antidepressants do. I know someone who had never had suicidal thoughts, no matter how depressed they had been in the past, and then they took an antidepressant to try to get better and all of a sudden they started planning to end their life. Considering what Dr Tracy Marks said in the video, the way that ketamine works seems to be completely different from to traditional antidepressants and therefore might not have the ability to trigger suicidal thoughts in the way that traditional antidepressants can. There may be some people however who don't see a reduction in their suicidal ideation, there isn't much in this world that works for absolutely everyone. I just hope that this medication becomes more accessible for those who really need it.

[@tweekest]

my friend was on traditional anti depressants for 20 years, came off them, killed himself. i believe it shouldn't be a 3rd option.

[@LadyPantera57]

@@tweekest I'm so sorry to hear about your friend. They must have been experiencing something unbearable. The person I know has since been able to get a sublingual ketamine prescription. He was very lucky because his doctor knew that insurance was unlikely to cover Spravato, which as new prescription is of course extremely expensive, but the doctor worked with a compound pharmacy that was very inexpensive if paying out of pocket, and insurance covered it anyway. When he had an appointment with his sleep doctor, the doctor said she noticed that his sleep quality was much better through his CPAP data, so it's making a measurable difference.

[@delsings]

I've been strongly considering ketamine treatment for some years now. Thank you for this resource. My depression and anxiety disorders are ripping my life out of me.

[@Elroy-z6v]

I had ketamine treatments and it brought me out my major depression and I was able to stop drinking alcoholic beverages with 5 treatments taken every other day!

They gave me Ketamine in the hospital following a shoulder dislocation...Holy molly I never felt so good in my life! It's like I left my body and went in a dimension of light, I felt no pain and every breath I took was so satisfying.

[@annabellknajder7518]

Never subscribed to a channel so fast. You had me in 10 seconds with the little song ❤

[@shueibdahir]

Here's the real question: What if the psychedelic effects are a major part of why peoples depression improvements massively?then that would mean reducing then would immediately make the drug less effective

[@amiiSpears-p6i]

Yus

[@buleetu]

I'm on on Ket now. Feel wobblely and happy. It's a nice feeling

[@lnxguit]

I really enjoyed your presentation! Thank you 👍

[@kaymakesthings]

This is a gorgeous discovery. I am so excited and happy that high-quality medically informed educational resources like this channel are gaining traction here, and with the understanding of intersectionality and culturally biased role of the federal scheduling system in banning what are *profoundly* transformative and useful tools in psychiatry. This is hopeful, but I'm not the only one with this optimism. Thank you for being a catalyst for these discussions and doing the hard work of distilling information into easily digestible ways.

[@Lilsydlifts]

Gained new subscriber! I love content like this. So interesting

[@98Zai]

Awesome video as usual! Really appreciate the cozyness and atmosphere of your videos.

[@jeanettemarkley7299]

I'm on medical Marijuana due to being taken off of my much needed depression medication due to kidney disease. It does work, but only really works well when I'm stoned. It's pretty hard doing everyday things and I can't drive or even cook. Maybe I'll try this? nothing else but a drug that came out in the 80s ever worked for my depression.....other than the MJ, but I get pretty bad lows using that also.

[@daphne4983]

No you can't function normally on K.

[@jeanettemarkley7299]

@@daphne4983 No. It doesn't look that way. Thanks.

[@hoosierbaddy3052]

@@jeanettemarkley7299 I use cannabis for my CPTSD. I also take a cocktail of pharmaceuticals for bipolar disorder and depression. But the cannabis is crucial to my overall sanity. I can operate and work while baked. I used to smoke before going to my job as a food server. It helped me deal with the general public and their unique problems. Why can’t we all just get a bong?!

[@Anne_Onymous]

​@@daphne4983 Actually there is something called microdosing so yes you can.

[@LIVEMETRIX187]

@@daphne4983the effects of taking it last a hour, that’s all. the antidepressant effect is a background effect and not impairing.

[@Dmitriikurgin]

7:07 where’s the link??

[@suecordova5264]

Does anybody know how this is dosed? I’m sure they build you up with each visit, but what’s the lowest amount given?

[@LIVEMETRIX187]

you actually can get low dose prescribed daily in troche form which isn’t as strong as infusions or nasal spray but helped my ptsd heavily, but with infusions they start you on a fairly high dose but you raise up a little but it’s still a powerful experience

[@leothecrafter4808]

Very good video indeed, I agree that there is a lot of research with ketamine but not much with LSD or MDMA, this needs to change. (Not to mention other novel psychodelics which may be quite a bit less harmful than MDMA in a long term psychiatric use szenario but are even less researched even). If you ever need any information about LSD or any other substances, feel free to ask, I have quite a bit of knowledge both from reading websites and papers as well as eating papers (It's legal for me ok, don't judge).

[@Codex7777]

What a great channel! Intelligent, informative, balanced and brilliantly presented! So refreshing! Most social media channels are either sensationalist, pushing fads or conspiracy theories, incredibly dumbed down, heavily biased, subjective, trivial, or some combination of the above. As I said, in contrast, this channel is so refreshing. You kept me engaged throughout! Thank you! Subscribed! :)

[@vishva8kumara]

My old ginger cat had to be given Ketamine for a dental procedure - total extraction due to gingivitis. She is a very happy old cat now. I'm more of a Cannabis person, and maybe Salvia once a while. I had recurrent major depression and BPD. Lexapro and Seroquel was very useful. I take synthetic medicine only under strict medical supervision. Cannabis and Salvia should also be taken very carefully - even if they "grow on trees". I don't think I would need Ketamine anymore. I want it to be available for those who need it.

[@VictorInyang-jn1kt]

Breaking through mushroom was the craziest experience I’ve ever had.truly an astonishing moment, I could refer where I order from and ships all sort of psychedelic

[@VictorInyang-jn1kt]

Trip_worlds2.

[@tracyhill5903]

It would be nice if people who are on Medicaid insurance could have it covered! It's a lot cheaper than the costly alternatives.

[@newlife2281]

I'm third week on Ketamin. Sniffing two times a week, 3-5 times small doses per evening, listening meditation music on my own in the room. After first evening till now I feel very very good, much calmer, brains feel very sharp and clear.If that effect of Ketamin then he is amazing thing.

[@tjjohn6310]

Does the spray gives you a euphoric feeling/hallucinations?

[@PatrickFDolan]

And how did you get it outside of a clinical setting?

[@newlife2281]

​@tjjohn6310 yes, and euphoric and mild quite deep exploration inside.

[@newlife2281]

​@@PatrickFDolanI bought from local guy😃👍

[@user-en5vj6vr2u]

That’s not how you use it 💀

[@davidream808]

This is such great information. Thank you

[@marv4895]

after 10 sessions in the k-hole with sleeping mask, i also had a breakthrough moment. I finally cried the tears that have been stuck for two years. I cried for two ous straight. It was a relief without comparison. but it's not a miracle drug. you have to reflect and work with it. and it can be very scary in there, not knowing if you'll ever leave this realm agian, since time does't exist there.

[@subjectively-observered]

Thank you. Very well organized and articulated.

[@louarmoon8064]

Hello My name is Lou I really like your speech and attitude toward the medication in general .what is the best way to contact you in person and talk about your discovery of these new medications. Thank you.

[@mitchellmooso7658]

Great information and great take from an obviously highly qualified scientist. I appreciate your time making this video. Keep it up. We rarely get knowledgeable professionals talking about this subject

[@pageperson1954]

Please be aware that on the street this substance is frequently contaminated with fentanyl - please learn to use test strips and keep naloxone on hand. Be safe.

[@focusmen]

Posible but not common side effect of S-ketamine™️: feelings of cicadas crawling in your pants

[@shizenkv]

WHAT?

[@focusmen]

@@shizenkv you have to watch the entire video to get it. Lol

[@pum8661]

After I was SAed ketamine managed to make me return to baseline mental health after only 2 years of monthly use. Before using It I basically couldn’t even look anyone in the eyes and would have nervous breakdowns when hearing certain words. Now? I’m basically like before the event and I have 0 problems taking about it openly.

[@numinous2506]

I hate grapes

[@ivocanevo]

I'm sorry about your experience. Are you open to answering a question? I'm curious if part of your healing was things like: conscious new thoughts, looking directly at what you were afraid to, noticing the consequences of mental obstacles and consciously deciding more helpful ones. Do you know what I mean? So feeling empowered, self aware and taking control of what's in your thoughts. I guess a kind of self therapy. As opposed to just taking a drug, and ending up better. I've experienced this, and I wonder if others have too. I feel it's not talked about enough.

[@pum8661]

@@ivocanevo Hard to fully articulate but I'll try to in the least abstract way possible- it was as if, I was slowly chipping away at the traumatized parts of myself and replacing them. The first few months thoughts relating to it were all that went through my head. I was very much still functional, however it was if it was always there. The fear aspect was more so in something like that happening again, - or in the feeling that everyone I met would be capable of doing the same, even though I knew that's not the case, the feeling of it still didn't go away before I had used ketamine. What I feel separates it from normal therapy, was more so in the sense that - I can know certain fears weren't likely- however It wouldn't change that it was what I felt. Whilst on k, It basically let me very slowly reverse engineer negative feelings.

[@deraal86]

I've threaded my own Depression with Ketamine, this was dangerous, but I had enough trust in myself. It helped immensely. One thing that I rarely see discussed that Ketamine helps overcome thoughtpatterns. You can think about a topic in a new way, and after the trip keep the insight... this amazing in dealing with difficult topics where your mind seems stuck, where you're unable to come to different conclusion, or approach a topic from different perspective. Having said this, I also had issues with addiction, where in very stressful weeks it helped me calm down and relax. But also was okay to get out, by not having any at home and relaxing my environment. I would not compare it with Opiods, where you're body is craving for it. Also these habits only developed after 5 years of taking it the first time. It's very unlikely to get hooked on it after a few uses. I actually helps a lot with other addictions. From seeing the good and the bad, I would highly recommend trying it, in a safe environment, and being smart about it.

[@PiXieDesiderata]

Schedule 3 yet its highly addictive and wreaks havoc on your body....never understood that. I've seen it turn decent people into shells of themselves and they frequently wet themselves etc. Destroyed the party scene, I could go on! Really interesting video thank you 😊

[@captainheartspace6583]

I've heard that In Europe, extremely large daily doses are being used in the party scenes ect..for very extended (years) of time. Eventually having bad effects & is easily habit forming .This leading to the in particular bad reputation of K. Not good to consume alcohol with it either, & one should be practicing other healthier habits while using k for best benefits.

[@johnlong1846]

I ordered eight doses of ketamine orally dissolving tablets from better you cost is about $700 and my experience with it was quite positive. It took me probably two months to do those eight doses. The first few doses were a little bit shockingly to effective as far as putting me out in an aesthetic way, I don’t know if I was particularly sensitive or something, but in any case, I am a very strong proponent personally of the in-home ketamine dosing and it worked spectacularly well for me and I intend to take a monthly maintenance dose

[@joncabotxox9389]

How did you order it, on Mindbloom or a company like that where you have to do the counseling and everything ?

[@SaraBoBara5591]

I have a 15 year opioid dependency and needed emergency surgery and there wasn’t time for me to tell them I am schizophrenic and have a very violent PTSD history and I essentially blasted off planet earth for almost 2 weeks til I was finally back in my body enough to tell them I need a sedative and now. I felt like I was just sucked off the planet and locked in a room of all my worst fears. I could just watch my nurse’s but couldn’t speak. I was so glad when I was back in my body that when I told them I’m schizophrenic I can’t take ketamine they immediately gave me a Valium drip and it was so very needed

[@jakeolthof]

My at home treatment is less than 10 dollars a session and more than half that is going to the initial provider consultation. After that it should be less than 5 a treatment. I am lucky my provider is an idealistic crusader for extending these benefits to people that aren't rich.

[@sarahpamula778]

Your presentation is uplifting and why not, medicine as Fun.

[@barrypickford1443]

Just don’t use too frequently and binge or you’ll have gallbladder attacks that will have you in A&E. Be clever people it can be extremely addictive for some.

[@chriscline7905]

I used to cook ketaset in late 90s blue & yellow label. It feels just like PCP to me but at a very shorter time span, do too much and my stereo was hitting the ceiling and then the floor for over 30 min. I was so high we tried to call 911 but couldn't remember the number. My pupils were soooooo tiny I looked like a snake and my legs felt gone at the knees. I drove once in the rain and was going 15 mph on a 55mph highway in the rain, thank God I didn't injure anyone. Blessed to be grown in my 40s and 25years out of that life but both PCP and K are wild and hard to describe but not for novice drug users due to severe dissociation

[@x1uber1x]

But what if the psychedelic experience is part of the healing effect? The headspace it gets me in most of the time helps me see situations from another perspective, helps me processing toughts and much more

[@akwajcurtis]

Ketamine is LIFE CHANGING! I have been on antidepressants and completed 2 rounds of TMS for my resistant depression. After 2 ketamine sessions the changes were noticeable. It is crazy how/that it works, but it worked for me.

[@airasarsoza9342]

Iv or spravato?

[@VDJ4500]

she is so excited talking about drugs

[@phillipstreams]

I have a friend who went to rehab because of a ketamine addiction. He's fine now but he almost lost everything. This is dangerous stuff.

[@robdevine69]

100% agreed, it is very very dangerous.

[@nieczerwony]

Hahaha. I know at least 10 people who losy everything due to alcohol addiction, and 1 of them died in rehab. Yet it's still perfectly legal stuff.

[@robdevine69]

@@nieczerwonyAlcohol is also very dangerous 100% agreed 👍

[@iancook2921]

Ketamine infusions saved my life

[@evolvetodeath]

I’m glad you found it. 🙌🏼

[@thebadhack1049]

Never tried it because I literally get depressed when I take something that makes me feel good (knowing that my experience is determined by a slew of chemicals). Mostly experience with MDMA, and the night terrors that followed days after.

[@JuliaMarieH]

I get those with Molly too, but K doesn’t do that! It’s v nice

[@blemisheddiscgaming6464]

Absolutely amazing work!!!

[@sallyjayne444]

I’m starting to think, when didn’t people use A LOT of drugs… 😂

[@wilhouts6173]

i a friend who has benefited from a clinical program, and is encouraging me. The nasal application is interesting. Can you recommend a place to explore that option.?

[@KadeSuchan]

I receive ketamine infusions for chronic pain. I also happen to have bipolar disorder. I receive ketalar (not going to go into my dosing, but suffice to say it's n mg/kg) for 5 days, every 12 weeks at Cleveland Clinic. I would not want to party with it. I am grateful to the nurses who help me stay safe and reconnect me with this planet as we know it. I am grateful to work for the same entity, so my insurance covers it.

[@XYZ.VISION]

super informative video, thank you! pharmacologically, ket is a salt making it water soluble. that's how it can be as a nasal spray- basically the same as sniffing it really. you also Forgot to mention that the crystals (still present in the nasal spray) serrate blood vessels, then the kidneys where it gets deposited causing great problems for chronic users. i had had 'interesting' responses, feeling like im travelling through some scared astral plane whilst puking. and many other stories ;) Keep up the good work!

[@Dziaji]

esketamine is definitely more psychedelic than arketamine. Arketmine puts you in a more clear headspace, so it is better for thinking clearly and your muscles work better on it too.

[@TylerShacklefordDurden]

When did they stop calling it R and S and switch to ar and es? Is that big pharma marketing naming?

[@pidgepagonis]

Can you say more about the muscles working better? Very interested.

[@Dziaji]

@@pidgepagonis I think I misspoke a bit. I meant your ability to use your muscles, like your coordination and reflexes. With esketamine, or normal racemic ketamine (mix of both arketamine and esketamine, which is most common), you tend to lose coordination and your reflexes are highly delayed, so on medium, or even low, doses, you will find yourself stumbling and tripping on stuff. With arketmine by itself, you remain way more coordinated, and can walk to the bathroom without stumbling, or catch yourself more effectively when you trip. Although, if the dose gets high enough to put you in a k-hole, you still end up immobilized and falling to the floor with arketamine, but before that point, you can basically physically function like a normal human, instead of your coordination being comparable to being drunk like esketamine causes.

[@TourniquetTwin]

P.P.S. This has been an excellent video, you have a new fan.

[@sallyjayne444]

Almost everyone who takes Trazadone take it for sleep. I haven’t heard of anyone being prescribed Trazadone for depression. Funny it’s still considered off label for sleep. But it is… Like you said, “it’s complicated. It doesn’t really have to be tho…

[@toffiklubitoffi8561]

I really like the music in this video, it's simultaneously serene and motivating. Could you share what tracks you used? (I guess some AI might have been involved?) Huge fan of the "There's a social shift happening" section

[@gerryatrix74]

Are you stoned perhaps?

[@NYBrandywineTree]

They gave me ketamine for a procedure because I smoked pot about eight hours before the procedure and they couldn’t give me the regular anesthetic. The doctor told me not to smoke any pot when I woke up because I would have crazy wild vivid dreams. I went home and smoked some pot. He was absolutely 100% correct. I felt like I was in an Alpine slide in Switzerland.

[@geraldmerkowitz4360]

The drug scheduling in the USA has the patent ridiculousness of IT specs written by the sales department

[@Krista-388]

can I please be this skilled at speaking?!?! maybe a script (or tons of practice or editing) is used but if so, it doesn't come across that way. This is a great video and yay for critical thinking - so important and not enough of it happening. I haven't tried. I would consider it but would not consider recreational use due to certain uncontrolled variables.

[@jonarmani8654]

10:45 "You can think of it sort of like a brake pedal..." Video shows someone punching the acceleration pedal

[@neurotransmissions]

Wait…really? Lmao

[@jonarmani8654]

@@neurotransmissions It's thin and the brake pedal is fat, for safety reasons. Also, it's always on the right-hand side of the brake pedal, regardless of which side the steering wheel is on (e.g. right in Japan & UK, left in most other places).

[@statonra]

I like that you keep saying "you can't have any fun." It seems so weird that if there's a drug that makes you feel good then it's automatically bad somehow. But drugs that treat depression need to make you feel good. So it's kind of self-contradictory that depression is treated with drugs. I guess they just picked the worst ones possible for treating depression instead of the ones that actually work.

[@Datflyincat]

One of the first things said was calling ket a psycodelic, its a dissostive anesthetic. Not a psyodelic, ik its said properly later in the video still upseting.

[@nieczerwony]

It is classified as dissociative hallucinogen so she is correct. This is one of the reasons why it is being used recreationally.

[@Datflyincat]

Ketamine’s dissociative effects alone make it a recreational substance, and while it can cause hallucinatory states, they’re not like those from classical psychedelics. For instance, diphenhydramine has hallucinogenic properties, but it’s classified as a deliriant because the effects are different. I think “dissociative anesthetic” is just a more accurate term. I’ve used ketamine and other dissos, and while dissociation can include hallucinations, it’s not the same as the effects of traditional psychedelics. So while I get your point, I still think dissociative anesthetic is the better classification, Plus she literally used the word psychedelic, not hallucinogenic, dissociative properties innately induced hallucinations, but ket vs a real psyc is a huge difference, So it's hard to call it a psychedelic.

[@NourElNahlawy]

I love this video! Unbiased and informative 👌

[@eray9934]

So are you saying that the additional effects on opioid receptors and HCN receptors is due to ketamine directly binding to it also? Or just downstream effects of the NMDA antagonism?

[@mikey100swim]

I wonder if clinically prescribed ketamine has less side effects on the bladder than recreational/street ketamine? I've considered hopping on ketamine therapy, as I loved the antidepressant effects I experienced from recreational K, but I noticed unpleasant effects when urinating after just a handfull of small doses. Maybe sublingual dosing would have a different effect on its processing than through nasal insufflation?

[@LIVEMETRIX187]

unless you take a gram a day you shouldn’t feel bladder issues but some do, is it like hard to urinate for a few hours after or? because that’s normal side effect wise