This Protein Hugs Ice Crystals to Death

[@thegoodlydragon7452]

"Kill it to death." lol

[@hingsunhome]

The floor is made of floor

[@Manzz2]

The box is full of the insides of the box

[@sriramramesh5318]

It's weird thinking of how the hydrophobic side of these proteins are probably making the proteins spin around nonstop whenever the temperature is anywhere above freezing

[@Clockworkbio]

It could be that they aren't made until an organism hits a certain temperature too. Lots of factors here the research is still figuring out!

[@zlodevil426]

There could be quintillions of molecules in your body right now that just spin and don’t do anything else

[@guidedorphas10]

​@@zlodevil426 reletable

[@casualbird7671]

​@@zlodevil426 Like the compliment system~

[@Antleredangelbun]

My brain's reward system lol​@@zlodevil426

[@kalmanchrister1027]

Another interesting protein is kind of the reverse of this one: ice nucleating proteins. They seem to help form ice crystals by providing a kind of optimal scaffolding for water molecules, so that they will bind together. They may have a role in ice nucleation in clouds, and by extension, formation of rain and global water cycles!

[@Clockworkbio]

Welp. I didn't have a _lot_ of time for a research hole--but here we are!

[@bladdnun3016]

How do the nucleating proteins get into a cloud? And why would an organism want ice to form? To use the enthalpy of fusion to keep warm?

[@Avanfalls]

Your video is good​@@Clockworkbio

[@john-ic5pz]

@bladdnun3016 ikr. I call b.s. on this. atmospheric dust isn't an effective nucleation site?

[@MrSaliVader]

@@john-ic5pz It is, but ice nucleating proteins are even better

[@IncidentallyHuman]

Hopefully this channel blows up in popularity. It deserves it.

[@petervansan1054]

shame it died :(

[@taoafro1740]

I agree. ✌🏾❤️

[@1337bitcoin]

2024 finally getting the recognition this channel deserves

[@mmcharchuta]

Your graphics are amazing and your loose style makes the learning process all the more fun. I feel like i'm listening to a friend :D

[@bioZone101]

getting hugged to death ain't sounding half bad anymore

[@Clockworkbio]

I mean, of all the ways to go, right?

[@cassidyhawk420]

Marine biology student here, great video!

[@CanOSpamX]

Great video! I've seen tons of videos here on KZbin talking about how "fish have antifreeze in their blood" but as far as I know no one has actually talked about how that really works and boy is it fascinating. This channel makes we wish I took more bioscience courses. :)

[@arrowinmygluteusmaximus]

but wouldn't this just delay ice forming not lower the temperature required to freeze? as long as there is liquid water below the freezing point a new nucleation point can start right? or do these structures also slowly melt the ice they surround?

[@Lacksi12]

Came here to ask exactly this aswell. If anyone knows the answer Im interested to hear it!

[@AaronQuitta]

Maybe its the temperature foe an entire body of water to freeze?

[@silverharloe]

they delay ice forming, as you say. and then water starts to crystalize somewhere else and gets delayed... and after a few iterations of that, you're delaying it so much that it's not freezing. but if you go colder, then the crystallization goes faster than the delays -- that colder point is the new(lower) freezing temperature. freezing is an average - you take a quintillion water molecules which are all jiggling around and slow a bunch of them down and that's what colder water means - less jiggling overall, but the jiggling hasn't stopped. keep slowing a bunch down (i.e. lower the temperature) and eventually some are so slow they start to hang together more than they jiggle apart. but they are still being jostled by nearby jiggling molecules, pushing them apart as they try to hang together. bits of ice are forming and breaking constantly as the temperature lowers - delaying the formation of crystals is the same as lowering the freezing point, because you need the crystals to start forming faster than they are being broken by nearby jiggling water molecules -- which is to say you need to slow down the nearby water molecules (also known as lowering the temperature) so they are more likely to join in the crystal than to knock it apart. I need some of this guy's animation skills, but hopefully you get the idea anyway.

[@silverharloe]

Now I'm envisioning a dance club full of people all bumping into each other as they dance - and some people try to slow dance, but with all the bumping they keep getting bumped apart. some people get tired and start dancing slower, but there's not a DJ that tells everyone to stop and find a partner all at the same time. because the DJ isn't there to tell everyone to be cold all at once, it takes a long time for everyone to get tired enough that more and more slow dances can come together without being bumped apart. in addition to what I said about freezing being an average - the other important thing is that freezing is the default state. the water doesn't GET slowed down, it's slowing down all on it own. "making it colder" is a process of "adding less and less heat" and letting the heat it bleed off. but absolute zero is very difficult to achieve - so you're never really adding zero heat, just less heat. you can add so little that you aren't making up for heat that is going away - we call that the freezing point, but you still need some time to let all the heat drain out for it to actually finish freezing. I'm trying here, but even "freezing water" is complicated stuff. Sorry if I'm not properly explaining it.

[@person8064]

​@@silverharloe So, basically, at tiny scales ice likes to spontaneously decompose, and by delaying its rate of formation you keep the ice decomposing faster than it can form.

[@rudihoffman2817]

As a fully signed and funded Cryonicists for 30 years, following this emerging tech and science, Imfound this fascinating! Bravo!

[@noel.gonsalves]

This legitimately blew my mind. I did not see that coming.

[@Clockworkbio]

Biochem is so nuts, right?

[@noel.gonsalves]

@@Clockworkbio indeed it is

[@brianrubin2069]

"kill it to death" the most scientific of terms. Great video! Hope more people start watching you soon! Also did your website go down where you had the more in-depth explanations?

[@Clockworkbio]

Yea I had to shutter the in-depth explanations for now! When you're a small youtuber--the budget is real tight. I decided to crowdsource the details/ disucssion on my twitter (@this_clockwork) and use the website budget to fact check my bigger scripts for now. This one didn't make the cut for fact checking since I needed that whole budget to make sure I nail the facts for my March video. There are some really interesting wrinkles in what make these proteins work tho!

[@brianrubin2069]

@@Clockworkbio Makes sense! Good luck with production!

[@somethingsafoot]

biocord represent great video

[@arrowinmygluteusmaximus]

any tips for a fellow creator? you seem to be able to crank these videos out at an incredible pace, even though they are so heavily edited and high quality while simultaneously being so small (in number of subscribers) that I'm assuming you don't do this full time.

[@Unraveled]

He's awesome like that

[@AntonWongVideo]

I'm guessing planning and scheduling helps a lot with that!

[@Valgween]

oh the unexpected connections never would have expected to find you here.

[@arofhoof]

Such an incredibly high quality channel, it should have millions subscribers! Fantastic!

[@mf1ve]

Bah, KZbin, why did you not show me (and a bajillion other people) this channel four years ago!? Awesome stuff.

[@Unraveled]

Someone stole my "hexagons are the bestagons" comment so now I don't know what to say...

[@Lars_Maassen]

3:09 Hexagon is bestagon

[@Clockworkbio]

It really is! And there're EVERYWHERE in biochem and Organic Chemistry!

[@ItsGray3]

This channel has such amazing videos and deserves way more attention than it currently has!

[@Information_Seeker]

so cryosleep is back on the table?

[@nickcooper8995]

It seem so, with these we could freze only some specific organs

[@justenkem5514]

"Your test results came back aladine" "is that aladine or aladine" "it is aladine" 😅😳🥺😅🥺

[@adityasingh-yz7tr]

Absolutely great video . i hope the algorithm gives you the reach you deserve even if it's 3 year late

[@rosemarychadi7734]

Great video! we really enjoyed it

[@AaronQuitta]

Crazy, amazing, I love this! Thanks for the great video.

[@brahimbest1]

Really, that blows my mind!

[@mininimi2228]

hello! im making a project for my bioinformatics class, your video helped me a lot! Thank you, its really well made

[@AntonWongVideo]

1:16 plankton are VERY important for the food chain...just not for the Krusty Krab Also, I'm digging this "stop motion" mograph animation style! How many times did you use "wiggle" expressions in After Effects?

[@Snecktf2]

How am i not gonna immediately click this video with information as cool as this

[@Alexadria205]

I can see crops being genetically engineered to produce these proteins to create frost resistant crops!

[@sethsoarenson7414]

Texans: WRITE THAT DOWN! WRITE THAT DOWN!

[@xavierestelles9327]

This is FASCINATING

[@hedgehog3180]

You should cover electricity conducting proteins used by sulfur bacteria.

[@LFTRnow]

This is not my specialty but as an engineer, i love these vids. You can just watch the chemistry and mechanical features in action, and in fairly short vids too!

[@Valgween]

0:40 The Dalal Geothermal Field Is the only known body of water found not to harbour life. yes extremophiles exist but these pools of water are extremely salty acidic and hot all at the same time and there's no known extremophiles that can handle all free simultaneously. Source Video: The Only Water on Earth Without LifeSciShow Channel: SciShow

[@jujjuj7676]

Make more please!!! More biochem!!!😊😊😊😊

[@jesusvalencia5520]

Great video!! I have a question. I read that inside the Beta sheets, the Threonine aminoacid was the one binding to the ice crystals. Maybe a different protein in the same family?

[@quantumview8151]

What happens then. Wouldnt enough clumps eventually take over enough area that the cell cant function, or do they expell it or destroy it in some way?

[@noekiyu]

You really sound like Jim Parsons from the Big Bang Theory.

[@cykonot]

i like that your proteins jiggle

[@thesmallcheval]

Holy $hit that is wild to learn. I love this channel!

[@diakritika]

The million dollar question is: can it work in reverse? I.e., turning a solid block of ice back into microsopic ice crystals?

[@ToniMorton]

wait could this protein be used in humans or is it toxic/immune detected? cryonics??

[@beastypie99]

Very cool!

[@Clockworkbio]

thanks so much!

[@DanielAusMV-op9mi]

Hey i really love your channel, its awesome Can you do a video about subjective experience? I think that would be very awesome

[@pimbel8830]

This video isn't part of any playlist so it will be kinda hard to find

[@MrAngelos006]

first video and I'm amazed

[@MrAngelos006]

gonna watch and like all your videos

[@agnosticmuslim6341]

Loveee Biochem when taught like this

[@lauradftba4653]

This is so cool!!!!

[@Clockworkbio]

NO YOU

[@deliyomgam7382]

How to freeze carbon to graphene?

[@realkekz]

Please come back

[@Clockworkbio]

ONE MORE MONTH

[@realkekz]

@@Clockworkbio :) I found this channel at the exact right time!

[@Just-a-Orion-on-the-internet.]

@@Clockworkbio Phew, i thought this was a legendary channel that was never going to come back. Glad to see that i am wrong!!

[@defeatSpace]

Phenomenal videos 😁

[@hoteny]

Time to freeze ourselves then

[@DerMarkus1982]

"* bestagon" easter egg found!

[@Clockworkbio]

three years on and honestly this is still one of my favorite kinds of comment lol

[@SquallHart05]

Proteins are soooo cool 😍

[@zeroTorsion]

love it

[@KitsuAwA]

Dumb instrusive thought,could a human consume this to last longer in cold envs

[@Pigeon_Flipper]

Cool

[@jabu5427]

Water life

[@Clockworkbio]

and a little sunlight and some air and a couple minerals!

[@particleonazock2246]

Meanie protein

[@deliyomgam7382]

Nano bots?

[@vinniepeterss]

❤❤

[@matteomezzetti1]

I love this channel but its dead😢

[@matteomezzetti1]

NEVERMIND SEASON 2 JUNE

[@3glitch9]

Stay squishy my friends...

[@Clockworkbio]

brb stealing this line

[@shy_dodecahedron]

The science is somewhat alright in this video, but I suggest you to use less jargon, and unnecessary words such as "process" in sentences like "the election process was rigged" first off, you come across as snobish, second it doesn't gell at all with you using "casual" slang; thirdly in this circumstance it doesn't enhance the communication _process_ , but cripples it.

[@saddish2816]

jfl

[@sheldondrake8935]

great content, should have a ton more subs...but the vocal fry is unbearable...

[@michaelshea4834]

I’ve always been annoyed by people who ascribe intelligence to an inanimate (evolution) process. It’s an argument for God.

[@kventinho]

who says "al-a-NINE"? It's 'al-a-NEEN'!! It's vaLEEN not vaLINE, it's threoNEEN not threoNINE, it's pronounced glootaMEEN, not gloota-MINE!!!! This annoys me so much! You are a biochem channel, get it right!!!

[@ekbergiw]

2:48 shout-out to @viheart

[@john-ic5pz]

wth...I've never heard alanine pronounced that way is glycine /gly - sine/ too?