Ketamine + Rapamycin: Optimizing Ketamine's Antidepressant Effects

Watch my interview with Dr. John Krystal here: • All Things Ketamine, T... | Brought to you by Athletic Greens all-in-one nutritional supplement athleticgreens...., Helix Sleep premium mattresses helixsleep.com/tim, and Allform premium, modular furniture allform.com/tim
Show notes and resources: tim.blog/2022/...
Dr. John Krystal is the Robert L. McNeil, Jr., Professor of Translational Research; Professor of Psychiatry, Neuroscience, and Psychology; Chair of the Department of Psychiatry at Yale University; and Chief of Psychiatry and Behavioral Health at Yale-New Haven Hospital.
Dr. Krystal is a leading expert in the areas of alcoholism, post-traumatic stress disorder, schizophrenia, and depression. His work links psychopharmacology, neuroimaging, molecular genetics, and computational neuroscience to study the neurobiology and treatment of these disorders. He is best known for leading the discovery of the rapid antidepressant effects of ketamine in depressed patients.
He directs/co-directs the Yale Center for Clinical Investigation (CTSA), NIAAA Center for the Translational Neuroscience of Alcoholism, and Clinical Neuroscience Division of the National Center for PTSD (VA).
Dr. Krystal is a member of the U.S. National Academy of Medicine; co-director of the Neuroscience Forum of the U.S. National Academies of Sciences, Engineering, and Medicine; Fellow of the American Association for the Advancement of Science (AAAS); and editor of Biological Psychiatry, one of the most selective and highly cited journals in the field of psychiatric neuroscience.
He is the co-founder and Chief Scientific Advisor of Freedom Biosciences, a clinical-stage biotechnology platform developing next-generation ketamine and psychedelic therapeutics that recently emerged from stealth in August 2022.
ONE VERY IMPORTANT DISCLAIMER: I’m not a doctor, nor do I play one on the Internet. None of the content in this podcast constitutes medical advice or should be construed as a recommendation to use ketamine or psychedelics. There are psychological, physical, and sometimes legal risks with such usage. Please consult your doctor before considering anything we discuss in this episode.
Please enjoy!
About Tim Ferriss:
Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 800 million downloads and been selected for “Best of Apple Podcasts” three years running.
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[@zoeywinston6826]

LSD and mushrooms completely changed my whole outlook on life. I became a better version of myself This experience gave me a lot of confidence about my self and my body. A bunch of bad thought / behavior patterns were broken. One of these was pretty bad OCD that made me wash my hands a lot. It gave me a lot of hope that things will be fine, this is the one thing that I heard throughout the trip: Everything is alright. The main reason for the trip was my severe depression and it definitely helped me (although it's not gone). Before all I could do was lay in bed. Now I am trying to rebuild my life one step at a time which wasn't possible before."

[@georgewilliams1062]

Psychedelic’s definitely have potential to deal with mental health symptoms like anxiety and depression, I would like to try them again but it’s just so hard to source here

[@sarahh321]

@@georgewilliams1062 [_James_tray] Got psychs

[@georgewilliams1062]

@@sarahh321 Where to search?? Is it IG?

[@sarahh321]

@@georgewilliams1062 Yes

[@georgewilliams1062]

@@sarahh321 Thank you, I will check him out now

[@albert.robles7]

I've heard so many good things about ketamine, Psilocybin mushrooms and their health benefits, I also heard it helps one get through addiction and depression. Am just wondering where or how I can get my hands on them cause I'll love to give it a try, I'm passing through a state of terrible depression lately and it's killing me

[@lopeztwinjason]

Most of my experiences with mushrooms and ket was extremely good...a few bad trips, bad it was my fault...was not in the right 'mood' for it...As a result of taking them my lucid dreaming has intensified over time. Still get occasional flashbacks and don't regret taking them...

[@userconspiracynut]

[hilary_chase11] Sure plug*

[@ugmiles.]

@@userconspiracynut where to search? IG?

[@userconspiracynut]

@@ugmiles. yeah, He has variety of stuffs like mushrooms, LSD, DMT even chocolate bars

[@user-nancyy]

I literally don’t know why but shrooms make me giggle so much like I be cheesin for no goddamn reason

[@sebastianfelipe515]

I can't find a source anywhere for any good psychedelics in my area, I suffer some pretty bad depression and i got a chance to try K and man it was a miracle substance, I felt free,the only high or euphoria was from the relief of my vices being released, that's exactly what it did

[@evelynbecker4916]

Mushroom completely turned my life around and my anxiety and panic attack disappeared and my personality changed into a much more generous loving person

[@lisadavidson1523]

Check (doctor_mckenzie) He's got psych's*

[@odentenzin3129]

I had 3.5 grams dried lemon tek most beautiful experience ever!!

[@lisadavidson1523]

@@fluffypineapples8852 Yeah, he's got magic mushrooms, LSD, dmt etc

[@sebastianfelipe515]

@@lisadavidson1523 alright, I'll reach out to him immediately to get some

[@itzhakbentov6572]

So if mTor is involved….would fasting prior to ketamine help?

[@anewperspective247]

The issue of microglia and low cortisol activation in ptsd subjects is possibly due to early life exposure to depressive/traumatic events that have resulted in lasting hormone adnormalities/compensations.

[@joedavis4150]

.. I would certainly avoid immunosuppressants whenever possible.

[@joedavis4150]

.. same thing with the antidepressant effect of cannabis. As the years go by, you can space out the treatment longer and longer between treatments, and it will still work just great. One learns how to be permanently cheerful and healthy.

[@patrickdezeeuw1594]

My microglia are gobbling new synapses and I wanna know why. I’ve got Neuro plasticity for 72 hours before they start to die. Zambonis of my brain, first responders just same… Oh Micro glia I wanna see ya Dance like Gene Gene the dancing machine Not clean clean like the Zamboni Machine

[@cocobololocoloco]

6mg Rapamycin *before or after* ketamine treatment ...and all in one go in either case ?

[@dmtdreamz7706]

Dreams, as we all know, are very queer things: some parts are presented with appalling vividness, with details worked up with the elaborate finish of jewellery, while others one gallops through, as it were, without noticing them at all, as, for instance, through space and time. Dreams seem to be spurred on not by reason but by desire, not by the head but by the heart, and yet what complicated tricks my reason has played sometimes in dreams, what utterly incomprehensible things happen to it!

[@JuanaLove6931]

Maybe the folks that are already imunocomprimised are the folks that responded better than those that were not imunocomprimised. I'm referring to rapamycine explanation...

[@kattypan3293]

he says 6mg of rapamycin, is it per day or per week?

[@brooksbarbee6433]

I would assume once per week.

[@angeloselarja]

I'm not gonna use a drug that has the word mice in it 🐁

[@bgrobbins]

absolutely fascinating stuff

[@akhiy5384]

I have fear trauma and get visual flashbacks .how can this be effective in suppressing/ersing Trauma fear memory

[@susanhall4063]

Don’t ask how or why. We can over think everything. Just do it, you won’t be disappointed.

[@akhiy5384]

Is it useful for abused victim