Tissue identity and rejuvenation - going skin deep with Luis Garza!

[@TheSheekeyScienceShow]

the paper: www.science.org/doi/10.1126/science.adi1650

[@rhyothemisprinceps1617]

Thanks for the article link, but it leads to a paywalled version. There is a free version available on PubMed Central.

[@alexz1104]

FASCINATING interview. It is criminal that this video doesn't even have 500 likes! Learning about how cell identity changes after changing places on the body due to bidirectional communication opens so many interesting questions. Sheekey Science Show always delivers absolute masterclasses in education and inquiry. Would gladly donate via Bitcoin lightning if you put an address in your video descriptions sometime. Keep up the great work!

[@jefftee7354]

This was a fun one. You could could see Dr. Luis getting more engaged and excited as you moved through your questions!

[@audreybennati2618]

What an intriguing chat! Love that so many variables can come together to do this exciting research. Thank you to the scientists, test subjects and funding. 👍🦋

[@peterz53]

@42 min the comments on ECM and MMPs reminds me of the plasma exchange work done by the Conboy lab several years ago. They showed that removal of old plasma (replaced by saline) altered DNA expression of many genes towards a younger phenotype. They also observed improvements in the 3 tissue types and lower senescent cell burden. Would be great if this work could be extended, maybe to mimic older human plasma donation, and assess what changes occur over time by repeated long term removal of portions of the plasma. As I understand it, blood plasma migrates throughout the interstitial spaces in the body so over time, lower negative factors should manifest in positive ways.

[@faze-ys6tn]

And ive read about experiments on removing free fatty acids from blood , that rejuvenates tissue and activate younger fenotypes

[@faze-ys6tn]

Can you please recommend books, research, scientists, etc everything that you've found interesting? I'm very interested in expanding my research. I'm a newbie biomedical researcher .

[@peterz53]

Thank you for going into details and allowing guests to elaborate.

[@Joe_C.]

Growing up on the lower east side in the 60's is how I got thick skin

[@Seanonyoutube]

Can anyone provide a bottom line actionable insight? I don’t have an hour to watch…

[@GeorginaJett]

Kinda rude, but I know what you mean...

[@manmoth4]

Nanomachines, son

[@ToddHoff]

This interview with Dr. Lis Garza, an associate professor of dermatology at John Hopkins School of Medicine, explores the fascinating world of skin regeneration and the potential of fibroblast therapy to address skin injuries, particularly in amputees. Dr. Garza discusses his innovative research, which includes a clinical trial using fibroblasts from a patient's foot to thicken the epidermis in their thigh, demonstrating the potential for cell-based therapies to modify skin structure. He also emphasizes the complexity of skin biology, highlighting the bidirectional communication between fibroblasts and the surrounding environment, the need for further research to optimize the therapy, and the potential role of epigenetic reprogramming in controlling cell fate and tissue identity. Dr. Garza further discusses his lab's research on hair follicle regeneration in response to wounding, specifically focusing on the role of the innate immune system and the potential of double-stranded RNA to stimulate this process. The interview concludes with Dr. Garza emphasizing the importance of scientific collaboration, taking risks, and communicating research findings to a broader audience.

[@Seanonyoutube]

@@GeorginaJett lol i’m sure it’s enjoyable, I just have ADD and have a hard time focusing for that long..

[@rhyothemisprinceps1617]

It was mostly basic research. There was some discussion of why autologous fibroblast seeding is not used in cosmetic dermatology for wrinkle reduction - it was just too expensive compared to competing treatments (fillers). It sounds like it would be better than fillers, though. My comment: if you are rich, maybe you could try to find a doctor willing to do some sort of DIY version. They are working on RNA for hair follicle generation. My comment: if you are rich, maybe you can get this type of treatment at an offshore clinic. A horrible skin condition called hidradenitis suppurativa is on the rise; it may be related to modern lifestyle factors or environmental exposures. ~ For me this was probably a life-changing video, but I get that it's probably not everyone's cup of tea.

[@rhyothemisprinceps1617]

Wow! I'm just gobsmacked by the oxygen sensing role of the skin - I wish you had had the chance to discuss in more detail. I'll be reading up on it. I found the whole talk to be super interesting. Do you think it would be okay to contact Dr Garza with questions about related topics? I don't want to be annoying. I'm not a researcher so he might regard it as a waste of time.

[@drosphiliamelanogaster3755]

Do it! Researchers are the real super stars that should be rich and famous! Just no stalkers!!! hahaha :p

[@drosphiliamelanogaster3755]

To find his research papers you can search google for "luis garza pubmed"

[@sergiootero5904]

Your usn is spelled wrong

[@mariorodriguez2299]

Very interesting and refreshing ingormation !!!🙏🏼🇲🇽✌🏼

[@fanOmry]

Umm. Here's what I'm thinking... Whole high availability protein + Collagen peptides + Vitamin C + Healthy fats(I'm thinking butter and whole eggs) After a fast and/ High expenditure exercise... Would stimulate just that.

[@tonycollyweston6182]

How can butter with all that saturated fat be healthy, the body can make its own when needed. Excess saturated fats forces the liver to produce Apo-b.

[@leonardodavinci7425]

​@@tonycollyweston6182Because he's a fool

[@fanOmry]

@@tonycollyweston6182 Very context dependant. And *I made it very blunt* that in this case, the body is with low energy reserves. And... There's little to no Carbs in the food. The things that Stimulate Insulin here are the proteins, and Vitamin C. And fat only does any harm when the body cannot process it. Carbs beyond a certain point damage the blood vessels, which triggers *Bad Cholesterol...* to a chronic level, which triggers all the bad stuff(Clogged arteries and the like). And it makes the body ignore Leptin messaging in favor of insulin. minimum Carbs with fat and proteins, makes you satiety mechanism dependable. Which on it's own makes the fat safer. As for Butter in particular... C15.

[@betzib8021]

Let's see how well your high intensity exercise goes when your LAD clogs up from atherosclerosis

[@fanOmry]

@@tonycollyweston6182 Thought I answered. Butter has C15. Which helps your Mitochondria. LDL is harmful when it is released in a chronic consistency. Which comes from having too much carbs. Glucose is bad for cell walls in general, and blood vessels in particular. Which is Why Insulin takes president(?) over Leptin. No carbs, You satiety mechanism is more reliable. So chronic LDL is much less likely.

[@drosphiliamelanogaster3755]

Blastema tissue formation is the key to regenerative organogenesis. Rollout of a cyto-transgenerational program would be key. I wish you all the best! Love you! ♥

[@33Crazydude]

Could the change in the cells Identity be explained by Michael Levins bio electricity perspective

[@drosphiliamelanogaster3755]

I would say it is probably more from the exosomes. But mechanobiology has some influence on bioelectric influence from the semiconductive and piezoelectric effects of the collagen apatite junctions on the cell membrane electric potentials.

[@rhyothemisprinceps1617]

@@drosphiliamelanogaster3755 There has to be a reason for differences in exosome excretion at different locations, though. Palm skin is different from back of hand skin, but I don't think there's much exposure to pressure on the palms like there is on the soles of the feet. So what accounts for the differences? I think it is probably due to nerve signals - innervation is different in the palms vs. back of hands. I also note differences in the skin between inner arms vs. outer - some differences might be due to sun exposure, but I don't think light exposure can account for all he differences, same as pressure exposure can't account for all the differences between soles of feet and skin elsewhere.

[@rhyothemisprinceps1617]

Shisedo has done some research on sensory nerves and collagen production; they have a press release titled 'Shiseido Discovers Nerve Involvement in Skin Elasticity'

[@drosphiliamelanogaster3755]

Hidradenitis Suppurativa Statpearl is available.

[@rhyothemisprinceps1617]

thanks!

[@georgbrindlinger1008]

Interesting chat, thank you!

[@ronaldreeves421]

We learn alot but it doesnt seem to change FDA, AMA or our food, they resist new science. Things do happen but are extremely slow to implement. We need to fix AMA, FDA and encourage faster incorporation of modern research.

[@WILLIAMMALO-kv5gz]

I think we need integration of our growing knowledge of "Bio-Electricity" and this knowledge base. Apparently there is a copy of us hidden in the 'Electrobiom' (a word I had to make up) and morphospace. We need to find it. Good talk thanks.

[@yannaubin7617]

Hi. I like your channel. But your voice is not clear. You definitely speak too fast . Nobody is chasing you. Thanks😊

[@rhyothemisprinceps1617]

I just read news of a massive PFAS spill at the US military base on Okinawa. I'm guessing it isn't the first spill, just the 1st to be publicized. Fish also tend to accumulate PFAS since it binds to proteins such as parvalbumin. Perhaps there's a connection between hidradenitis suppurativa and PFAS exposure.

[@Joao_133]

a link to the paper would be appropriate

[@Hansulf]

There is

[@patrickday4206]

Become a stoic and you'll get a thicker skin 😂

[@fooballers7883]

thank you for an excellent presentation.

[@bg5760]

Do you or can you look at dupuytrens disease? Thanks for your work 🙏👍

[@BlahBlahPoop617]

Until the mean time, until a treatment that works and is affordable comes around, best thing you can do is wear sunscreen DAILY. UVA rays account for the majority of skin aging. 50 SPF at least. Make sure it is broad spectrum so it protects against UVA rays (which mainly age the skin) and not just UVB rays (which do, but not to the same degree). Probably that and maybe tretijoin are the only proven things. Also weights too as some recent data suggests it helps with skin aging.

[@lauchlanguddy1004]

and deplete vital Vit D. So many problems these days from low vit D. RESEARCH !!!

[@betzib8021]

​@lauchlanguddy1004 then take it. As an older person who didn't wear sunscreen for yesrs...your skin will bruise and tear from long accumulated sun damage. It's awful. If you aren't going to wear it...move to the arctic.

[@betzib8021]

​@@lauchlanguddy1004 if you don't wear sunscreen I suggest you move to the arctic...bec when you are older your unprotected skin will bruise and tear from the slightest impact bec MMPs are so active.

[@timmiet47321]

Why would you intentionally apply all those chemicals and allow them to be absorbed through your skin? Ugh.

[@betzib8021]

@timmiet47321 because the difference between areas of skin where sunscreen has been applied...and areas that have not had sunscreen applied...is absolutely incredible. Not only does sunscreen protect you cosmetically...but it protects you from skin breakdown as you get older. Without sunscreen..as you age... skin becomes thin and tears so easily you cant let it touch anything. It bruises with the slightest impact and it becomes a painful organ. Our ancestors did not develop protection against UV rays because they only lived to about 40. If you plan to check out in your 40s...I wouldn't wear it.

[@DanielHarrell-y9z]

Isn’t science beautiful!! Thank you.

[@dinomiles7999]

Forget the FLAWED reserch . ❤ Nature's Source Code. Light, water ,magnetism, oxygen, plasma, grounding,and TIME, TIME, TIME ❤! DON'T DIE ❤. ❤❤❤❤❤❤Decentralization ❤

[@veredk4384]

I'm always amused by that persistent myth of Okinawan eating fish and veggies, and the mighty sweet potato. They do eat a bit of that but the main dish is pork! And they cook it in many different ways.

[@leonardodavinci7425]

You're lying

[@leonardodavinci7425]

Traditional Okinwan diet was centered around plants but in recent years they're eating more meat like a western and as a result chronic disease has gone up.

[@rhyothemisprinceps1617]

@@leonardodavinci7425 In this case it might specifically relate to an increase in dairy consumption, as that is known to be a trigger for many people with HS (Dr Garza was talking about increased HS in Okinawa). But triggers aren't necessarily causes. There have been all sorts of changes to diet and lifestyle, as well as environmental exposures, to consider. For instance, there was recently a big PFAS spill at the US military base in Okinawa; I doubt it was the 1st. I'm suspicious of increased dietary oxidized cholesterol intake, especially 25 HC, since it is known to activate inflammatory pathways in skin immune cells. 25 HC is increased in foods by high temp cooking, especially microwaving. I watch an adorable YT channel about a Japanese grandmum and her cat called 'Hana's story'. I wish she were my grandmum - she makes such great food (OTOH I'm allergic to everything so I couldn't eat it anyway...), but I noticed she sometimes microwaves chicken. She also uses plastic a lot when making food - e.g, for molding foods, piping icing, on top of custard, etc. Plasticizers are another problematic exposure that could contribute to immune dysfunction since immune cells are sensitive to thyroid hormone disruption.

[@frank7911]

yep, the data was collected after the war when pig population was gone along with most of the fighting age men. no wonder average age was very high

[@r.guerreiro140]

​@leonardodavinci7425 You are the liar We are designed to eat meat If Okinawans are having healthy problems, there is a plethora of other causes rather than meat

[@veredk4384]

Oh, and maybe the rise in cases of that uncomfortable skin disease has something to do with a certain medical intervention the entire human race was forced to take...just a thought.

[@betzib8021]

Yes...a completely unfounded one that we don't need. We have enough of those.

[@mistermiau9949]

co masz na mśli ciekawi mnie czy podobne mamy spostrzerzenia

[@stanlevox2291]

Honey Badger Skin

[@jennifs6868]

JOHNS HOPKINS, not John Hopkins. Thank you.

[@tammylake6595]

We were never fish we were made in the image of Yahweh Tonight you lost me there

[@WILLIAMMALO-kv5gz]

If by "Yahweh" you mean life and reality? Then are not fish also a refection or product of both??

[@MaryJones-d7e]

Martinez Anthony Lewis Eric Lee Jeffrey

[@XingMai-i9o]

Uhm... and uhm...

[@yenriver5255]

I just got to be thick skin to ask women out.....

[@betzib8021]

This dude is understandable when he begins a sentence but becomes totally garbled when he rushes to cram words together to finish his thought.

[@copisetic1104]

Cartoons?

[@rdavidmurphy1]

Sudio quality is poor

[@gmw3083]

Yah, yah, yah.

[@houndofzoltan]

Human teeth are not keratin based... I'm confused, he's an expert, how could he get that wrong? Perhaps the teeth of some animals?

[@gmalexander722]

PLEASE would you slow down your speech and enunciate clearly. At least for me you are well nigh unintelligible

[@ClodoaldoPintoNeto]

I'm sorry the woman's diction is so bad because everytime she talks it is just to add confusion