Extending lifespan by rejuvenating mitochondrial membrane potential - Dr Brandon Berry

  Рет қаралды 15,138

The Sheekey Science Show

The Sheekey Science Show

Күн бұрын

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@TheSheekeyScienceShow
@TheSheekeyScienceShow Жыл бұрын
Mitochondria! Thanks Brandon for coming on the show!
@KenOtwell
@KenOtwell Жыл бұрын
What about PQQ (PQQ Pyrroloquinoline Quinone) --- how does it work to support mitochondria?
@MrVladanbajic
@MrVladanbajic Жыл бұрын
Methylen Blue would be interesting to discuss (mitochondria versus NO)..
@alexforget
@alexforget Жыл бұрын
Did you test the effect of far infrared on the health of mitochondria? It is now know that far infrared is used by mitochondria to make melatonin that scoop up the oxidative stress inside of mitochondria. Our melatonin done inside the brain is merely the backup plan for the night, the main source is inside each mitochondria but need infrared to be produced correctly.
@eugeniebreida
@eugeniebreida Жыл бұрын
Are you sure far? I had thought NIR was more effective here.
@paintbynumber9493
@paintbynumber9493 Жыл бұрын
Would you be willing to include a slightly dumbed down recap/take aways at the end of these videos for some practical ways to incorporate the info learned? I would love that! Thank you for this consideration.
@Brickkzz
@Brickkzz Жыл бұрын
None of this has practical implications until proven to be clinically relevant in trials
@Brickkzz
@Brickkzz Жыл бұрын
Unless you're a scientist, of course!
@tadmarshall2739
@tadmarshall2739 Жыл бұрын
You (or Brandon) mentioned Co-Q10 ... I was just learning about MitoQ, which supposedly boosts Co-Q10 INSIDE MITOCHONDRIA, which apparently does not happen with regular Co-Q10. Some research seems to suggest that this can help with energy production in the mitochondria, presumably a good thing for the cell and for the organism. I'm curious what you think about this (MitoQ) as a potential longevity tool. Thanks for a great interview!
@chadcooper6976
@chadcooper6976 Жыл бұрын
Thank you so much, I love your material, I use it in the AP Biology class I teach all the time. It can be difficult to get high school kids to read primary research however, they will listen to your videos. It really gets them excited and also gets them to start thinking like a scientist.
@walk-with-Walz
@walk-with-Walz Жыл бұрын
well done!!
@DarinJP0
@DarinJP0 Жыл бұрын
Super interesting! I love following the REAL cutting edge of science! Keep on informing! :)
@randallhesse5011
@randallhesse5011 Жыл бұрын
I'm not so much thinking on the line of anti-aging. I'm more thinking on the line of overcoming ME/CFS, and I have a potential hypothesis that mitochondria autophagy maybe might possibly be a potential key to overcome ME/CFS. I'm looking into such supplements as Huperzine-A, berberine, glutathione, D-Ribose, methylene blue, etc.
@rhyothemisprinceps1617
@rhyothemisprinceps1617 Жыл бұрын
It would be great if Brandon would take a look at ME/CFS. Perhaps the reason we have so little understanding of this disease is because there's something missing in our understanding of mitochondrial metabolism.
@zber9043
@zber9043 Жыл бұрын
ketogenic diet is the best way to improve mitophagy and clear out defective mitochondria
@oscarcarrillo2016
@oscarcarrillo2016 Жыл бұрын
Great combining optogenetics with mitochondria research. I’ll try and follow this researcher. Thx for the interview.
@alexforget
@alexforget Жыл бұрын
Awesome content. Please increase the quality of production (audio in particular) to increase your reach.
@toomanymarys7355
@toomanymarys7355 Жыл бұрын
It's his audio that isn't good.
@eugeniebreida
@eugeniebreida Жыл бұрын
Yes, HIS audio is rather weak, but at least clear…
@monnoo8221
@monnoo8221 Жыл бұрын
very interesting, thanks for this interview. One pint which stroke me most is when Brandon mentioned the contrast of 2 phenomena. First, mitochondria are highly preserved, and second, they loose membrane potential already in early adulthood. Yet, offspring organisms spawned in later adulthood start with fully capable mitochondria. this clearly points to causation outside of mitochondria, in both ways, poisoning and restring reconfiguration. ...ultimately it comes down to a deterioration of the genetic outsourcing model, and the communication\transport between the host cell and the mitochondria. My guess would be that the effect of the outsourced genes deteriorates, either by lower activity or simply by a loss of transport capacity towards the little guys. And I also think that the electrochemical differential in the cytosol and around mitochondria is rather important here.
@imtryinghere1
@imtryinghere1 Жыл бұрын
Good discussion, but I wish we would have heard a discussion that contrasts more the benefits of higher a membrane potential with pro-longevity benefits driven by inhibition of ATP synthase. How can we reconcile these two differences?
@emmasnow29
@emmasnow29 Жыл бұрын
Interesting talk!
@peterz53
@peterz53 Жыл бұрын
Very imteresting. Vaguely recall that lipid composition of mito membrane changes with aging so would make sense that membrane potential would change based on this alone. Not sure if dietary interventions have been tested to explore partially rejuvinating the membrane. Brandons techniques could probably test this.
@awestphal9602
@awestphal9602 Жыл бұрын
What is the practical application of this research to human lifespan? Take more NMN? PQQ? Fasting? Infrared Light? more Lipids?
@soaring9406
@soaring9406 Жыл бұрын
Infrared light and grounding.
@Schutzmassnahmen
@Schutzmassnahmen Жыл бұрын
And Potassium Chlorid After and before every meal and walking and valin Vitamin k infrared
@relativityboy
@relativityboy Жыл бұрын
Fantastic, informative video!
@chadcooper6976
@chadcooper6976 Жыл бұрын
What about methylene blue? I've heard it's great for your mitochondria.
@theatheistpaladin
@theatheistpaladin Жыл бұрын
It's great for a lot of things.
@alessandrofalcone5392
@alessandrofalcone5392 Жыл бұрын
It would be really valuable if you could post these interviews as podcasts on Spotify 🙌🏻
@rui-9-cs315
@rui-9-cs315 Жыл бұрын
mitochondrial is the key, if we could reduce oxidative stress to a minimum, life span could up to 200%
@soaring9406
@soaring9406 Жыл бұрын
Walk slowly for 20-30 minutes after each meal. This will reduce oxy damage from first link in Electron Transport Chain after meals! IMHO
@rui-9-cs315
@rui-9-cs315 Жыл бұрын
@@soaring9406 supply and demand balance...
@Schutzmassnahmen
@Schutzmassnahmen Жыл бұрын
Potassium Chlorid before and After meal as well as valin
@johnm6866
@johnm6866 Жыл бұрын
​@ammalealaura8923 Can you please recommend any articles on taking potassium Chloride and Valin? Or did you mean valine? Thanks
@Schutzmassnahmen
@Schutzmassnahmen Жыл бұрын
@@johnm6866 sorry my English is bad I have no article and I tried it and it works to stable my bloodsugar and yes I meant valine I am 42 and everybody thinks I am in my 20 so that’s why I know it works well 🏆🍀🎁
@HiTechFX
@HiTechFX Жыл бұрын
Awesome interview, thank you!
@lookupjackkruseonyoutube
@lookupjackkruseonyoutube Жыл бұрын
Are you familiar with Dr. Jack Kruse? Would love to see you interview him, he's all about mitochondria from a biophysics perspective.
@garyrucker9019
@garyrucker9019 Жыл бұрын
Is there any testing on taking ATP as a supplement?
@TheSheekeyScienceShow
@TheSheekeyScienceShow Жыл бұрын
A related topic I may look into for a video is creatine
@sustainablelife1st
@sustainablelife1st Жыл бұрын
your body makes 100 +/- lb of ATP per day. Just optimize the system.
@allurbase
@allurbase Жыл бұрын
Could you put more copies to over charge it?
@supportadmin7735
@supportadmin7735 Жыл бұрын
What about red light 650 to 800nm
@KhanKhan-lw8fw
@KhanKhan-lw8fw Жыл бұрын
What's good for mitochondria then
@Schutzmassnahmen
@Schutzmassnahmen Жыл бұрын
Potassium Chlorid After and before every meal and valin
@lucaskazama878
@lucaskazama878 Жыл бұрын
hello eleonor . I dont know what protocol you are using, but its working. look like 20 years old. I envy you. lol, I know its just genetics plus healthy life, but congratulations. I'm still waiting you to get rich before I get too much old.
@frankiesierra7218
@frankiesierra7218 Жыл бұрын
is redox potential gradients among mitochondria related to membrane potential?
@carnivore-muscle
@carnivore-muscle Жыл бұрын
Hi there, is your brother called Patrick?
@carnivore-muscle
@carnivore-muscle Жыл бұрын
Yes! I know who you are. I was friends with your brother. I am intrigued that we are both KZbinrs in the health space online. I would love to collaborate with you some time, if possible?
@rustybolts8953
@rustybolts8953 Жыл бұрын
Great video but I'm sick of mice mice mice and worms. People over 70 like myself are facing certain death unless the aging process is stopped and or reversed. What about humans?
@negatron7321
@negatron7321 Жыл бұрын
Thanks, this was great; And I'm only 3 minutes in.
@33Crazydude
@33Crazydude Жыл бұрын
As a guy who is probably average in the intelligence department, I still find these discussions fascinating
@geoffreyhalverson1787
@geoffreyhalverson1787 Жыл бұрын
People should check out Cracking the Aging Code by Josh Mitteldorf and Dorian Sagan. It's a look at the evolution of aging and why aging is adaptive for both the individual and the larger collective.
@pavelchorda8425
@pavelchorda8425 Жыл бұрын
Unfortunately is very difficult for me to understand you.
@Ron-rk6iz
@Ron-rk6iz Жыл бұрын
subtitles, please
@dwdwone
@dwdwone Жыл бұрын
I think a holistic approach would give better results although it would be much harder.
@sustainablelife1st
@sustainablelife1st Жыл бұрын
590 nm is orange, not yellow/green.
@eugeniebreida
@eugeniebreida Жыл бұрын
yellow/orange , def not green . . .
@pitapep
@pitapep Жыл бұрын
According to Dr Gerald Pollack the water itself is able to create an electrical gradient over hydrophilic surfaces, proteins are, dependent on light abortion . Maybe this experiments with light should consider this fact. Consider water does not absorb all frequencies of light.
@eugeniebreida
@eugeniebreida Жыл бұрын
Interesting discussion! (plebe here, w/health issues wherein a bit more applicable concepts woven in would be a fine bonus, as MD’s are a decade or two in the dark. Have hypoxia esp in furthest extremities…)
@VulcanXIV
@VulcanXIV Жыл бұрын
The title makes me think that it sounds similar to the science of good nutrition. The mitochondria membrane gets wrecked when you have intake of polyunsaturated fats, like from cooking oils that are not coconut oil, avocado oil and legitimate extra virgin olive oil. Also, from most processed food, lol.
@DeeneMuada
@DeeneMuada Жыл бұрын
im searching for nt factor phospholipids that are not made out of soy. if anyone knows a brand please let me know.
@zber9043
@zber9043 Жыл бұрын
lecithin is in soy but is not soy
@Schutzmassnahmen
@Schutzmassnahmen Жыл бұрын
Sunflower seeds
@abileleoncino
@abileleoncino Жыл бұрын
do you think we will see people of 70 going back to look like in their 20's ?
@Battery-kf4vu
@Battery-kf4vu Жыл бұрын
Doesn't ubiquinol help for the mitochondrial membrane potential? Study: "The proton pumping mechanism of the bc1 complex"
@Schutzmassnahmen
@Schutzmassnahmen Жыл бұрын
Vitamin k has almost the same form than q10
@Battery-kf4vu
@Battery-kf4vu Жыл бұрын
@@Schutzmassnahmen Interesting. I just read the abstract of a study saying that vitamin K2 has the same kind of effect on mitochondria as Q10. Any idea on how close that kind of effect is to what Dr. Berry is trying to achieve?
@Schutzmassnahmen
@Schutzmassnahmen Жыл бұрын
@@Battery-kf4vu for me it is Clear What i want to achive as Long as i can being Young and Healthy from inside First and than it will Show at the outside ! Fasting !before and After every meal Potassium Chlorid! valin !milk thistle !astraxanthin !Vitamin k !But Not just k2 !walking ! For atp Mangan Kupfer Zinc Sorry for my english i am german i Know you can Not see
@patmccormick9972
@patmccormick9972 5 ай бұрын
Coenzyme A!!!!!!!!
@davida1606
@davida1606 Жыл бұрын
He reminds me of a young Ethan Hawke
@patmccormick9972
@patmccormick9972 Жыл бұрын
COENZYME A!!! ASK THE SALK INSTITUTE!!!
@seanreel5801
@seanreel5801 Жыл бұрын
Great interview and point about NAD. Worth checking out @nuchido and work of @drnicolaconlon
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