TNF-α Signaling || 4K Animation

In this animation video, you will learn about TNF-α signaling, a key process that controls whether a cell lives or dies. TNF-α is a molecule that can trigger inflammation and immune responses, but also influence the fate of the cell by activating the TNF receptor. The TNF receptor can initiate two different pathways: one that leads to apoptosis, or programmed cell death, and another that leads to cell survival. The outcome depends on the interaction of various proteins, such as TRADD, FADD, caspase 8, caspase 3, TRAF2, RIP, NIK, IKK, IκBα, and NFκB. These proteins form complexes, phosphorylate each other, cleave each other, and regulate gene expression. The balance between these pathways is essential for maintaining the health and function of tissues and organs, and preventing diseases such as cancer and autoimmune disorders. Watch this video to understand how TNF-α signaling works and why it is important for biology and medicine.

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