Transcription and mRNA Processing (EVERYTHING YOU NEED TO KNOW FOR MCAT)

[@Smacy]

The most underrated MCAT study channel on KZbin, you do a great job of focusing on the important points, and giving us the "big picture" so we can see where all of these things fit in. I also like that you will continually repeat the overall process instead of getting too hung up in the little details that don't really help with understanding of the mechanism. The GOAT, seriously....

[@brody2642]

Thanks a ton for these videos. You have no idea how much they're recommended on the MCAT subreddit. I hope you're doing well in medical school or whatever path you decided to pursue.

[@FirstLast-sb8fl]

I'm easily distracted most times and your voice keeps me focused! Excellent videos! I've learned more here than in my entire undergrad.

[@danielrosero9425]

I have always struggled with this concept for whatever reason. 4 minutes into this video, and I am literally full of hope because everything is clicking in. You are such a great teacher! Thank you!!!

[@sciencesimplified3890]

Hello Hassan, thanks for the view! Here is a link en.m.wikipedia.org/wiki/RNA_splicing#Biochemical_mechanism My understanding is that the splice signals are within the introns, as shown in the link.. Also, an Exon can be spliced out if it was between 2 introns that were spliced out... for example imagine Exon 1 - Intron 1 - Exon 2 - Intron 2 - Exon 3 - Intron 3 - Exon 4 - Intron 4 - Exon 5 Then imagine splicing this into Exon 1 - Intron 1 - Exon 2 - Exon 4 - Intron 4 - Exon 5 So in this case, Exon 3 has been spliced out... I’m not 100% confident about the mutation question... perhaps mutations in the introns can affect this process, although this is purely speculative. One thing I can say with confidence is that the MCAT will only ask for big picture concepts, however they do an outstanding job in really making sure you deeply understand those big picture concepts and can apply them during novel contexts. Any esoteric and highly detailed questions will have their answer somewhere in the passage.

[@RockinRocketScience]

Poor guy will never see ot

[@kayla3055533]

I just discovered these videos. On my 3rd take for MCAT and this is by far the BEST explanations I have seen. Thank you taking the time to make these videos. I read your bio and congrats on 4th year!

[@whard9961]

i'm testing 3/22 and this guy is absolutely saving my C/P scores rn

[@Mslilli1000]

I love these videos! Your voice gets stuck in my head and it helps me remember the content! :)

[@user-ei9qe9py6h]

This guy here makes my dream a reality. Mcat I am coming for you.

[@tamshari9212]

Yes, all the time. Stay open minded.

[@jake9340]

I love how you're so excited about the science that you're almost yelling haha that's how I am too when explaining. Great work on these keep it up!

[@huchehu2564]

really helpful! Wonderful voice and enthusiasm

[@pranaymaniar1468]

I thought exons can be spliced out during alternative splicing to create different isoforms and introns can never be in the final mRNA. Alternative splicing comes from different mRNA exon combinations and the introns are always spliced out. Is that correct?

[@michelleserrano1601]

The most detailed video I’ve seen thank you so much !

[@rickriordan6565]

this is the greatest video ive ever watched thx

[@sunairaahmed3720]

I literally love u

[@siddheshkolambkar9186]

Awesomely explained.

[@lois4544]

Geez... this video is awesome. Thank you so much

[@shawnanderson4496]

You are absolutely goated

[@biplovsarkar1109]

very impressive.

[@snowron7497]

love this guy!

[@Eleniesworld]

Awesome explanation 😊

[@user-iu5qi8jh8s]

i think im in love

[@jamilah1534]

thank you you are amazing

[@bubblegum6394]

Are spliceosome sites located on the introns? Also how can a mutation in an intron sequence cause an exon to be omitted from the final mRNA transcript? (question from one of the AAMC tests). Great video

[@DanielSmith-vj3qt]

Late response lol but for anyone curious. Yes these splice sites are located at the beginning and ends of introns

[@Equinoxus]

Huge Thanks ❤❤❤

[@imosdefinite]

u don't miss!!

[@samirnacer9206]

amazing

[@destinyallred7674]

Very helpful! Thank you!

[@mrithulajothi1838]

ily

[@MansurMehdiyev-cx1uv]

Is the utr on the mature m rna?

[@QuerenciaOfficial]

I love your voice! You sound a lot like Zenitsu (English Dub) from Demon Slayer