TWiV 1073: Taming the shrew and barring Epstein-Barr virus

TWiV explains a study showing that ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews, and development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus.
Show notes at www.microbe.tv/twiv/twiv-1073/
Become a patron of TWiV at microbe.tv/contribute
----------- CONNECT -----------
🎯 Subscribe! bit.ly/2HOYdNP
Instagram: @profvrr and @microbe.tv
Twitter: @profvrr
TikTok: / microbe.tv
Facebook: / thisweekinvirology
Our Podcasts: microbe.tv
Contribute: www.microbe.tv/contribute/
----------- MORE VIROLOGY -----------
•My Virology Course virology.ws/course
•Virology Blog: www.virology.ws
•Virus Watch bit.ly/3ngvQIM
•Principles of Virology textbook amzn.to/34onDtg
----------- OUR SCIENCE PODCASTS -----------
•This Week in Virology bit.ly/30uUhrX
This Week in Parasitism bit.ly/3ndUNUZ
•This Week in Microbiology bit.ly/33tOUeO
•Urban Agriculture microbe.tv/urbanag
•This Week in Evolution bit.ly/3ne1bf5
•Immune bit.ly/2HOyCVb
•This Week in Neuroscience bit.ly/2So12Yd
•Infectious Disease Puscast bit.ly/3K4EKF0
- Who Am I? -
I’m Vincent Racaniello, Earth’s Virology Professor.
I’m also a professor of virology at Columbia University in New York. I’ve been doing research on viruses since 1976, and teaching virology in classrooms and online since 1999. On this KZbin channel I share videos of my lectures, podcasts, and more.
New videos are uploaded several times each week.
I do not run ads on our work as it is disruptive to learning. We depend on your support.
If you would like to support our work, go over to www.microbe.tv/contribute/
-----------------------
#microbe #viruses #coronavirus #pandemic
-----------------------

[@lesfaby8997]

_KZbin timestamps by Les_ 03:09 Please contribute and get it doubled 04:49 ASV 2024 announcement 06:36 Position available at Amy Rosenfeld's Lab 07:06 Dixon's book makes the perfect gift Peter Schwartz: Cities are one of the biggest polluters. Can we re-imagine them as more sustainable? www.chicagotribune.com/opinion/commentary/ct-opinion-climate-change-new-city-urban-design-sustainability-20231222-qqurhoipwnetra7zsgzp4t2rgy-story.html *Dixon will be the guest live and in color* On *KZbin "Office Hours...." Wednesday at 8PM Eastern* 08:37 Honoring the memory of virologist Brett Lindenbach medicine.yale.edu/profile/brett-lindenbach/ 10:11 ost traits shape virome composition and virus transmission in wild bats, rodents, and shrews (Cell) 45:45 development of a gB nanoparticle vaccine that elicits a protective neutralizing antibody response against Epstein-Barr virus (Cell host microbe) 1:13:56 *Emails answered* see www.microbe.tv/twiv/twiv-1073-letters/ 1:14:07 Amir 1:15:23 Jeffrey 1:19:21 Bill 1:22:18 Anthony 1:24:15 Debbie 1:25:59 Michael 1:26:44 Bob *PICKS* 1:28:56 Dixon 1:31:54 Kathy 1:33:18 Vincent 1:35:33 *Listener Picks* _Audio podcast timestamps by Jolene. Thanks._

[@JillKnapp]

I just stumbled upon @MicrobeTV this year, and I can't tell you how much I love it, especially TWIV. Thank you for all your hard work on the channel, and for your collective passion for teaching. Also: Studio musician/voiceover artist here: The "foam rubber thing" on the end of Dickson's headset mic only helps protect against plosives ("popped Ps") and very light breezes; but it won't do diddly for the sound of someone inhaling or exhaling. Headset mics tend to be breath-heavy because the mic is so close to the mouth. With that, we hope David will have to keep editing Dickson's breathing for a very, very, very long time. It's money well spent. ❤

[@traceybell3673]

You listened to the very end! 😊

[@camresearch5120]

Merry Christmas 🎄 Vincent , TWiV team and Mods.🎉

[@demonbunnny]

Vincent: I've definitely been listening/watching every minute. Shrews are cute, and I'm very interested in EBV. It's honestly a lovely episode for the day before we all go to swap viruses with our families over the next few days 😂

[@LemonLadyRecords]

Exciting about the EBV vax. I have had latency and chronic activations off and on since I got mono in 1977. Now it's activation and severe illness 100% of the time, which seems due to other issues keeping it going and also long covid. Thus I don't get EBV remissions anymore (activation used to have a 3mo course, then back to baseline which wasn't totally healthy, but I had a life). So my interest in a vax is to help the latency, not initial infection, although it wasn't clear which is the goal. I would volunteer for the latent study! I would think that chronic/latency would be the most helpful, as it causes a lot of disability and suffering beginning in young life. Of course malignancies, and related things like shingles, which are in the back of my mind, but improving even 10% of my daily health would be miraculous! I'm 70, so I don't expect a cure or vax in my lifetime. And the covid vax hasn't helped my long covid. I know the EBV is a different vax, but I can hope it works on the latency/activation cycle.

[@donnazukadley7300]

The C0vid vax reactivated my REBV

[@markbelluo8841]

Wow you had it 46 years. What was the qorstt part of ebv. I caught in 8 months ago. Can you tell me best way to eat live and supplement

[@demonbunnny]

Managed to get away from the family and listened to this in a nice, fragrant, lie-down bath. On Christmas eve. Merry Christmas and a wonderful new year to you all🎉

[@PatrickSalsbury]

This is fascinating. Thanks so much!

[@cky5573]

Isn't the rate of EBV infection high - 50% of children and over 90% of adults? Scary if it is associated with the development of some cancers especially if many children have had it.

[@LisaMartinez-ri6ve]

Listened to this episode while driving. Certainly made my travels much more interesting. Fascinating episode. Thank you.

[@TheodoreKiakidis]

1:00:44 taking into account that the incubation period of EBV is 2 to 3 months,even if the antibodies drop, won't the vaccine prevent the disease / break the chain of transmission? 1:11:20 Could the vaccine be used as a prevention tool after a known exposure to EBV?

[@MRCAGR1]

The problem is that EBV takes up residence in the nuclei of B cells in an inert state. It can reactivate under certain conditions like stress, but the person may not have symptoms but are actively shedding virus, this has been shown in astronauts returning from various space missions. Mehta (the only name I can remember without digging further) has published several studies on this.

[@emilythechef]

I just made a $50 donation through PWB so you'll both benefit. I'm honestly not sure how MicrobeTV isn't the biggest and best KZbin channel! These educational podcasts are much appreciated by me (and only 125k others, don't know why you don't have millions of followers!). This channel is a hidden gem for sure! I'm just a regular Joe Shmoe, not in the science or medical field, but I still find (most of) your podcasts easy enough to understand and learn from. 😘

[@chriswilliams2957]

Oh yes we are listening

[@user-jo1dt5uz2y]

Recently I thought I read an article linking Anorexia Nervosa with EBV infection/expression. Would you be willing to shine some light on that? Thank you!

[@pennynealeigh6557]

The shrews are consumed by the soil organisms. 51:10 51:10 cats as well as any opportunistic consumers will eat all 3.

[@bjoburn7821]

Thanks for all the Info Shared Blessings

[@kathrynlove8252]

I have listened even at 0.5 speed and cannot understand your explanation of how those who seroconvert and do or don’t get MS depends on ?natural killer cells taking out the auto reactive B cells. According to what you said, these B cells produce antibodies against the viral protein that cross reacts with neuronal protein presumably to cause demyelination. Wouldn’t that be a good thing?

[@montrealtendencies]

I think Dickson’s egg nog was a bit more “spiked” than usual.

[@jamesmadison4834]

Happy Holidays MicrobeTV and friends, another year of amazing infectious science has gone by.

[@luisfernando-mm3jt]

Lollll i am with heaphones listen to this doing rudiments.... Its christmas eve ....Happy christmas

[@donbruhn3037]

Mery christmass. And. Good health. To. All

[@chriswilliams2957]

Happy Christmas to you all. Thank you. Yes dixons book is on my list

[@tiagomarques715]

Also the animal poxviruses like orf and cowpox

[@stormwalker321]

Very great show today, thanks all...had a very bad case of mono while in college....terrible illness...

[@vevenaneathna]

24:00 hmmm blood has more immune surveillance than most of the other places they looked. idk if that matters.

[@CraigCounterman]

The shrew order is Eulipotyphla (/ˌjuːlɪpoʊˈtɪflə/, eu lipo typhla - "truly fat and blind"

[@tomsteinberg8106]

The articles are paywalled. Bummer. But some of the references & related articles listed below the references in the links are open access. A bit hard to believe that VR had trouble thinking of what animal would eat a mouse -- we can start with cats & dogs & go through every carnivore: from wolves down to and including shews. Birds eat mice. Reptiles eat mice. In general, rodents are prey for any carnivore and one would expect, perhaps that they could harbor viruses that could also infect very distantly related species.

[@Ladyjlowe]

Thanks!

[@marg716]

🧑‍🎄🎄👏👏👏

[@AzIbra16]

1:40:18 Vincent, stop bullying Dickson. 😂

[@terrycojones]

Yeah, there were half a dozen moments in this episode where I was wondering if maybe Vincent and Dickson had some issue (with the former being short with the latter).

[@donbruhn3037]

Deer. Mice. And. Deer. Spreading. Some. How. L. O. L

[@TheGuinever]

Bring your horse paste 🤪😁