TWiV 1144: Clinical update with Dr. Daniel Griffin

[@drj6418]

As a physician, while I always enjoy your podcasts, it would really be helpful if you could possibly timestamp each of the topics as many of the other top shelf podcasts and channels do, as many/most of us are unable to listen/watch the entire episode and this would help us pick and choose those subjects we have the most interest in. Thank you!

[@MissesRobot]

This!

[@pausenthink3524]

The podcast has links for all the research papers. While there isn’t a timestamp, everything is listed in the order that it’s discussed.

[@pausenthink3524]

On the podcast, there is also a link to the episode website which has even more information.

[@Turtledove2009]

So glad that Daniel is interested in, and tackling Long Covid. This is a long term issue that needs research. My heart goes out to sufferers.

[@regbhyyu]

Thank you

[@chrisbradley3224]

It’s disgraceful how uneducated most physicians are today on COVID and treatment practices. I know someone age 68 denied paxlovid last month because they weren’t “high risk”.

[@5amiann]

It's just awful . The AMA has fallen down completely on this issue. It shouldn't be Russian roulette to get treatment.

[@Katherine-g1r]

Do you guys ever sleep? Ha.

[@bethmendoza1847]

My daughter and I both had West Nile virus disease many years ago. It was the absolute sickest we’ve ever been.

[@JW4REnvironment]

Good to know that the new Novavax protein based vaccine will be available soon. It sounds like it should be less reactogenic than the Moderna or Pfizer BioNTech mRNA versions…Glad to hear Vincent believes that the Novavax should be as effective though not based on the KP 1 variant…

[@MarkBoolootian]

I'm a very strong reactor and was hoping to get Novovax, but we're traveling next week, so I got Moderna three days ago. Oy. mRNA seems to consistently give me three days of fever, malaise, body pain, headache. It may be a small price to pay, but I look forward to trying Novovax down the road.

[@razerginn]

Thanks for doing this.

[@BJ_PLATZ]

Thank you for your podcasts! I try to watch it every week.

[@Logotic]

Dr. Griffin's paper on long covid is linked in the show notes and it's terrific! Thorough but succint and not hard to read, at least not for a TWIV fan. And it's not hyperbolic or doomy, it's just an evidence-based framework. Much recommended and appreciated! 🤘

[@WillNewcomb]

As an elderly ignorant layperson I'm so grateful to Dr Griffin since it covers so much of the current understanding of the condition in a way that can be referenced and passed on to others interested. I'm sure there's plenty here for the medically trained as there is for others like me.

[@Polkadotpup]

Great…as always.

[@tmy1065]

Thank you for these podcasts. The information is helping to keep my immune compromised and older relatives safe from Covid-19.

[@patriciahoke4722]

WaPo has an article about vaccinations in Gaza. I wanted to comment, citing TWiV, but for some reason, comments closed super early. There are three writers on the story. I encourage everyone to email them to encourage their checking in with TWiV about the dangers of OPV and the advisability of IPV.

[@kimm31..43..]

Do you think that they do not already know?

[@patriciahoke4722]

@@kimm31..43.. I do not think they know.

[@kimm31..43..]

The Polio vaccine in Gaza - so what does this mean - is this endangering more Polio unvaccinated people??

[@Bete-Bete-Bete]

What if we actually focused on prevention so that people don’t get long Covid?

[@saliksayyar9793]

Israel will not allow needles or syringes

[@francesschaefer]

Terrible...

[@slashtrio]

Hello, 50 year old white male who currently has covid. My entire family is sick. I began having symptoms 4 days ago. It’s mainly been fairly mild but I do keep spiking fevers of 100 to 102, but they go down after taking ibuprofen. I don’t have many risk factors: have fit healthy body weight and lifestyle, don’t smoke or drugs, drink alcohol mildly, no chronic illnesses. I only had the initial vaccine and booster (moderna) back in 2021 or so. My question is should I take paxlovid ? My doc is willing to prescribe but seemed to suggest that they didn’t think I was a great candidate for it given my lack of risk factors. Any feedback wound be greatly appreciated.

[@stormwalker321]

Thank you, thank you , thank you both...🙏

[@patriciahoke4722]

what is the difference between the 2023/24 Novavax, and the latest Novavax??

[@GertrueKate]

Excellent podcast full of important data, many thanks as always!

[@emilythechef]

I look forward to this podcast, thank you so much for your hard work 🎉❤😊

[@cyberanswer]

Sabine Polio vaccine - no one talks about ME/CFS, which used to be called the New Polio, has almost identical symptoms to Polio but different as the vax contains the Coxackie virus which is in the same family but slightly different. And identical to Gulf War Syndrome (they were highly vaxxed) and 'Long Covid' of which a side effect of the shot is ME/CFS and MS (which they believe is caused by the same thing as ME/CFS but a slightly different manifestation of symptoms). All of this points back to v injury. And in the case of ME/CFS, it can be delayed many years, e.g. 10 years, like the paralysis described in this podcast.

[@tonaruch8623]

Thanks for the update

[@bettyjaneantanavicius9800]

How safe is latex condom usage VS poxviduses?

[@Rene-uz3eb]

34:39 drug users are highest risk and most likely to be hospitalized, and least likely to receive paxlovid prophylaxis. Also, they excluded people with follow up medication after paxlovid, like antibodies or corticosteroids, you'd think before carting off to the hospital, people would first get some more meds, so getting these is a marker of severity. 41:30 I recommend everyone look at the absolute numbers in Table 1 of the mental illness study. Monoclonal antibodies seem to work for covid, per a number of meta analyses regarding hospitalizations and mortality.

[@roncarlin3209]

06:30 Is the never-ending cycle of VDPV2 because the Third-world can't afford to jab?

[@christopherrobinson7541]

Yes.

[@WillNewcomb]

Blessings. Thank you so much

[@immortaltyger1569]

Sexually Transmitted Infection Day?

[@traianliviudanciu8665]

In 2020 I see that agglutination can occur at some Covid19 patients If blood temperature decrease. Using warmed oxigen mix at body temperature, oxigen saturation increased more rapidly ( on ambulance)

[@traianliviudanciu8665]

At a Covid19 patient with paradoxal ,, happy hypoxia,,must suspect ,,cold agglutinine,, or cryoglobuline IgM high level.

[@traianliviudanciu8665]

Conjunctival test for cold agglutinine can be used. After 30 s of using ice near eye at oftalmic biomicroscop can see If capillary circulation modify

[@VincentConti-m5j]

Vaccine derived paralysis😮 it is a thing 😮...!!! Polio? Permanent paralysis? As I child in the fifties I remember seeing the giant iron lung machines on the newsreels at the movie theater😮 needless to say pretty much everyone was vaccinated😊😊😊

[@Barbara-li5yb]

Circulating vaccine-derived poliovirus Type II" (cVDPV2) is a real problem, although a rare one. While replicating in vaccinated humans, the live attenuated Type II virus can occasionally throw a mutation to become an infectious disease virus again, and this has been documented many times in different countries. (Science org article)

[@christopherrobinson7541]

@@Barbara-li5yb Incorrect.The OPV always reverts and can be shed and infect others who have not been vaccinated. However the infection often does not show symptoms and only in a few cases does it result in disease which causes paralysis. The latest versions of OPV (OPV2 etc) require more replication cycles to revert, but they all revert.

[@VincentConti-m5j]

@@Barbara-li5yb thanks

[@VincentConti-m5j]

@@christopherrobinson7541 thanks

[@Idahomie]

Himm ..Dr Stern Face ?

[@patriciahoke4722]

I want(ed) to get Novavax due to no side effects afterwards. But my goodness - I agree: how in the world did they get away with not having to do KP blah blah like Pfizer and Moderna? Rip off!!!

[@gribbler1695]

Novavax can have the typical side effects of the other vaccines, and some of the serious rare adverse events too. Ref: Notes from the Field: Safety Monitoring of Novavax COVID-19 Vaccine Among Persons Aged ≥12 Years - United States, July 13, 2022-March 13, 2023 (MMWR Morb Mortal Wkly Rep. 2023 Aug)

[@patriciahoke4722]

@@gribbler1695 Nope. Novavax for me had 0 side effects (March 2024). This is precisely the reason I want to take it again.

[@gribbler1695]

@@patriciahoke4722 Same for my 3 doses. But Australia hasn't decided yet to get the new version, due to the poor uptake of the first one.

[@ruthmcbride1778]

Moderna is already delivering

[@rbdesigner725]

Mpox is close contact especially sexual contact.

[@AlbertMark-nb9zo]

Not necessarily. It includes fomites. This clade seems to have a high incidence among infants.

[@rbdesigner725]

@@AlbertMark-nb9zo Yes but spread thus far has been vast majority sexual contact, can it spread otherwise sure.

[@AlbertMark-nb9zo]

@@rbdesigner725 - maybe in the west. But according to Unicef, the Democratic Republic of the Congo is the epicenter of the current clade 1b outbreak, where children under 15 represent more than half of the cases. That may not rule out sexual contact, but it still a significant portion.

[@SimonJackson13]

Is toll receptor mRNA priming cells without ACE2 receptors (or large amounts of)?

[@VincentConti-m5j]

No flu vaccines for this old man. Had all the child vaccines in the fifties. No measles vaccine or chicken pox. Had various injections in the Navy😮😮😮 as I get older I have fewer flu episodes. COVID 19...two or three days mild flu symptoms. Just an anecdote😊 this is all very interesting. I had no idea that all this work was going on😊😊

[@traianliviudanciu8665]

Maybe some antinucleocapside SARS COV2 IgM antibody induced cold agglutination ? Maybe after vaccination this antibody did not occur? If occur, must warm oxigen mix at body temperature.