Type II hypersensitivity (cytotoxic hypersensitivity) - causes, symptoms, & pathology

What is type II hypersensitivity? Type II hypersensitivity is an immune response in which host cells are damaged due to antibodies binding to the cell surface. Find our full video library only on Osmosis: osms.it/more.
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[@rubymusqan3792]

just a summary...so i can come back and revise too Type 2 hypersensitivity mechanism of action: 1.Activation of complement system: C1 binds to Fc portion of the antibody. Activated C3,C4,C5 - atrracts neutrophils, degranulation, cell lysis. 2. Membrane Attack complex - disturbance in osmotic gradient - cell lysis 3.C3 associated opsonization and phagocytosis 4. ADCC - antibody dependent cellmediated toxicity - NK cells NONCYTOTOXIC MECHANISM: Antibody mediated cellular dysfunction. eg..Graves disease, myasthenia gravis.

[@098yatinder4]

Come back and revise it for the 31st time. xD

[@angeknowsit]

I just love it when the neutrophil comes up and vomits all kind of enzymes and stuff .

[@rajdeepsamadder2000]

yeah u r right🤣🤣🤣

[@kratikadubey3192]

Very creative 😅

[@Zain.Basi1]

4:38 I adore the sound effect when the cell bursts, it's so damn satisfying!

[@dylancameron2731]

I cant believe how specific these videos are. There's more detail in this video than there is in my lecture notes lol and I'm in second year of uni.

[@parfoisbaker]

same

[@jemy_tube]

Have u graduated now dude 🤔😃

[@muntazirhasan8494]

@@jemy_tube 😂😂😂

[@thephilosophersjourney2595]

Are you a doctor now?

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​@@thephilosophersjourney2595hopefully

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These videos are so helpful that I feel bad for all the medical students who had to learn these materials without the Osmosis’ help. I feel very fortunate!!

[@judesjewels7831]

You guys are awesome! Putting these videos together helps link everything we learn into a smooth progressive piece to remember and understand processes better. It makes the various lessons on a subject cone together into a whole. Thanks SO MUCH!

[@osmosis]

Thanks!

[@whitneyjordan14]

I'm currently in medical school and am very happy that I found your channel! Thanks for simplifying so many topics in such simple ways!

[@osmosis]

Thanks, Whitney! We’re glad you like the videos. If you want to further enhance your medical studies, check us out on our website! In addition to having exclusive access unreleased videos (which include an 8-part series on ECG, a series on embryology, and unreleased videos on physiology and pathophysiology) Osmosis Prime members have access to thousands of board-style quiz questions and flashcards, study scheduling tools, and much, much more! Check us out here: bit.ly/2ut5ZEJ

[@mr.k2944]

Please never stop making such amazing videos! Your videos are actually better than reading the notes. Just simple and understandable! You guys are outstanding! I always recommend watching your videos to my friends and they too really like it. Thank you so much!

[@uzamatfatimat3243]

This really makes it so simple. Thanks a lot guys.

[@jamunaprabhu96]

the visuals are amazing! great job:)

[@cathyoniel6159]

People who make videos like this make this earth a better place. So helpful, thank you :)

[@MrRss334]

red blood cell : guys believe me i am on your side :(

[@gulfamjameel1703]

the immune system itself is the imposter

[@fazramahalli]

i love how the cells are mostly either looks innocent or make me pity them

[@LAisyourgirl]

Thank you so much for making these videos! They have just the right amount of depth without being overwhelming.

[@osmosis]

Thanks for the kind words, LAisyourgirl! Did you know that if you like & review us on Facebook then you’ll get access to our videos a day before they’re published on KZbin? Check it out here: bit.ly/2u35D6J

[@med8523]

Best explanation of the topic in youtube. Thank you

[@xatianaroushvili8516]

perfect videos,simply explaining everything,so easy to understand...good luck...

[@yordankuzev4224]

It was very helpfull!!! Also great, funny animations. Keep up the good work!

[@osmosis]

Thanks!

[@munirhabdullah3251]

tomorrow is my immunology quiz and this video is verrrrry helpful! thank you so much guys :)

[@mennaelradad1945]

This channel is genius! Thank you, this was very helpful

[@sofiaaa3346]

wowow this is SUCH a good video ! Thankyou!

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thank u so much , it is such an accomplished work . Ammmmmazing .

[@majda2992]

This is so helpful! Thank you

[@goksuavar4809]

Really neat and helpful, thank you.

[@patybarron5445]

Best video I’ve watch by far!! Thank you

[@silentrefusal9911]

Can't thank you enough. God bless you guys... You really really are a great help.

[@yeetengkhu1692]

this is awesome, thank you so much for the videos !!! Really appreciate it !!

[@swadeepkumar3579]

well explained..I've come across this channel for the first time as it's a recently launched one..but I must really appreciate u people for both the quality quantity of videos you have put up..n the best part is that u give a broad overview of the topic in a short time using simple animations..this is especially going to help the students correlate and interconnect various topics..thank you..n keep going.

[@lessymtonga8781]

Give thanks to youpeople this video has really help me.ready to write my exams tomorrow

[@mariaya6645]

Can u plz make a vid for the complement system ?

[@Fireretro]

I LOVE your videos. Really helpful than every page on the internet I combed through to find answers :D Btw, just one thing. Myasthenia Gravis and Grave's disease are classified as Type V hypersensitivity now right? Functional disorders?

[@dineshraja7121]

Thanks man! It was an amazing video!:)

[@GSJSTP]

amazing Mann.. thanks for this

[@osamaaamir7743]

Very cool! Helped me a lot! Keep up the good work.

[@dwaithasivadas2421]

You are too good 😊 Thank you for this!

[@maymuhamad777]

guys u really made it easy god bless u

[@Max-sn2qi]

such good quality. thank you

[@chrispinngosa8596]

wow just wow!!! am in second year of university, persuing a pharmacy degree and am watching from zambia, africa......and personally this is the best detailed explanation of the the type 2 hypersensivity. am sure to follow up of the rest of the types and hopefully hope for more videos on pathology

[@Ahmadhanai]

you guys dominated the lane, thnx

[@lovestrike940]

OMG! i can't thank u enough this is great keep up the good work

[@emanbenyahia5073]

You guys are the best this was veryyyyy helpful and in only 9 minutes AWESOME ♥ THANK YOU endlessly

[@yourfavmovie9555]

Thanks! It helps me!

[@anjalyr8946]

It was helpful thank you

[@novaduh]

DUDE!!!! You are the man! Taking Immunology and I swear my professor is leaving us high and dry. Thank you for breaking this down into easy to understand terms. You saved me my dude!

[@osmosis]

Always our pleasure to help! 🙌🏼

[@thefallenking1]

You are simply a genius

[@devinadesai8014]

Very very useful video!

[@imdavid2709]

Really Great.....Easy to get the Point

[@helinp.7616]

It is absolutely perfect for who learns easier with visual objects and games.Thnx ozmos

[@chriscash7779]

True...at times having an example visually demonstrated helps so much.! SLAINTE N take care.👍

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These videos are so helpful

[@D1trox]

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[@deiaarahma8729]

excellent work. thanks

[@osmosis]

Thanks!!

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[@rubaabdulrahman7196]

Why there is one like to give for each video☹️ .. You guys deserve thousands 😍❤️❤️

[@hindadnan23]

Nice explanation Thanks

[@pradipdesai3365]

I like the summary part for quick review.

[@osmosis]

Great suggestion! We're going to look into doing this more often for future videos!

[@apeleldada2406]

Very clear and well explained video !! Thanks a lot !!💪👌

[@osmosis]

Glad to help, Apelel! 💫 🥰 💖

[@betinagore2552]

This is awesome. Been staring at powerpoint slides trying to learn this forever before looking here and everything makes so much more sense now. Thank you for making veterinary school just a little bit easier!!!

[@Tariqt4]

you are the best

[@raghad7131]

Thank you so much

[@balajiramatchandrin4472]

awesome work :):)

[@lolamarine4155]

Thank you so much ❤️

[@techsohel2450]

good tutorial...

[@hasnabasheer1848]

This channel helps to simplify a lot of difficult portions for me❤

[@osmosis]

Happy to hear that, Hasna! 😊

[@sundasshareef8691]

i fell in love with the cute cells illustrations in this video..haha.. it is really helpful BTW.

[@good2know11]

Couldn't be better than this. Just Wonderful !!

[@osmosis]

Glad you like it!

[@aboutstudies766]

Thank you Sir.

[@sumeyyekelber4103]

Excellent 👍 Keep up working plssss

[@AhmedEkri]

You guys are great, I have a friend of mine that is always recommending you to me and here I am, listening to his advice. Just wanted to drop this comment about 3:00, the complement proteins (C1q) does not bind to the Fc portion of the antibody, rather it bind to the antigen binding side which is found on the constant region of IgG and it is above and different than the Fc portion.

[@osmosis]

Can you share with us a credible source that supports the correction? Thanks!

[@AhmedEkri]

Hello, I just double checked from many journals articles, what you have said is true. The Fc portion on an IgG is divided into two compartments, upper one for complement and lower one for membranes or receptors. Thanks for your reply.

[@julianaortiz09]

your videos are AWESOME. English is not my first language and I'm studying medicine and I didn't understood my proffesors video but I did with yours! THANK YOU!

[@osmosis]

Glad to help, Juliana! 💫 🥰 💖

[@shkokurda2098]

Thank you very much dear

[@ayushkherde2069]

Thank you so much for making such useful videos. After seeing these videos topics seem to be very easy.

[@osmosis]

You are most welcome, Kherde! Glad to help! 😊

[@zanygee]

please make a video about organ transplant rejection types

[@osmosis]

We will eventually! You can vote for upcoming videos by becoming a Patreon subscriber. www.patreon.com/osmosis

[@rukiee.b.ovwigho5709]

Thank you Osmosis 👏

[@osmosis]

Our pleasure, Rukiee! 😊

[@uncomfortablereality]

You are awesome thankyou so much for making these videos very helful

[@osmosis]

Thanks for watching, Saba! We're glad you're finding our videos useful. If you haven't yet checked out our educational platform we have a bunch of tools that we think you'd like. These include unreleased videos, tens of thousands of flashcards and multiple-choice practice questions, study workspaces, and daily exam schedule organizers to help you learn medicine. You can sign up for a free trial of Osmosis Prime here: bit.ly/2ut5ZEJ

[@yoni4614]

Love love looooveee your videos ! They are so helpful ! But would you maybe be so kind to talk a bit slower, for the non-native english speaking students ? Thank you in advance !

[@mokomomcilovic4342]

You are great!

[@evagold5221]

excellent work !

[@osmosis]

Thanks!

[@zeynepbasllar9685]

THANK YOU

[@rayanm114]

Thank u so much 👍🏾

[@romaissamekhenef4916]

you are the best !😍😍😍 thank u so much

[@osmosis]

Thanks for the kind words! It would be awesome if you and your friends could review us on our Facebook page. facebook.com/pg/OsmoseIt

[@maliksalim9060]

Itz really good to watch....

[@Torrorosso.]

Thank you 😍

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Thank you

[@atirahjefri4129]

Thank youuuuu ❤️❤️❤️❤️❤️

[@eyyao]

thanks for the video, is there a very distinct summary comparison between type 1-4. i have watched the 4 video however i just couldnt really distinguist them as basically they all involve with antibody, etc

[@DahenKike]

Lordy... I love these videos.

[@missst4289]

Very easily explained....

[@osmosis]

Thank you, Safoora! If you’re interested in getting early access to our videos, check us out on Facebook: bit.ly/2u35D6J, or, even better, get exclusive access to dozens of our unreleased videos now at our website: bit.ly/2ut5ZEJ.

[@blossomslife6016]

Thank you for this 💗

[@osmosis]

You're welcome! 💖 💖 💖

[@nikamirull2550]

wht a nice vid , thanks

[@chimaobihillary-mu5rn]

Pls any video on type IV

[@harryin._]

Please make videos on leprosy ASAP 😟 and complement pathway

[@user-fy4yk8vi9i]

You are really great thank you from my heart 😢

[@osmosis]

You're welcome! 😊

[@RajeshSharma-jl2yk]

Plz make videos on all topics of patho.

[@adamadvil1410]

you are awesome mate keep up the good work

[@osmosis]

Thanks so much! It would be awesome if you could review us on our Facebook page. facebook.com/OsmoseIt/

[@luisegarciaflores4903]

I love your videos. Could you tell which programm do you use to this? I´ve got to do one similar for my inmunology class

[@tajwarhussain2698]

Thank you. . You are awsome

[@osmosis]

You rock! 😎

[@feisalalrubaei9157]

Thank you very much, for making these videos they're really helpful. but in case of myasthenia gravis I looked into different sources and I found that actually the complement system is activated when the anti-AChr is attached to the AChR and it leads to decline in numbers of AChR

[@osmosis]

Could you share with us those sources? Thanks!

[@Meghna00]

very helpful

[@marielpacheco]

Excellent! thanks!

[@osmosis]

Thanks!

[@shadyhamdy7086]

Great videos .thanks alot. Can one help me ,I a'm confused! Is there difference between mechanism one and three , aren't both of them opsonization?

[@carolshumaker8348]

Do you do a video on fibromyalgia?