The Aging but Resilient Brain: Keeping Neurons Happy

[@marileneduarte9000]

Some people make a difference in the world!!!! I am very grateful to YOU ....Brilliant Doctor

[@squaretriangle9208]

good stuff! the internet brought about some very good things - listening to a presentation that was done a decade ago on another continent (I´m from Europe) in the pandemic. is simply wonderful!!

[@hascleavrahmbenyoseph7186]

I started walking more in the last few months and I thought I had noticed a slight improvement in my memory. This video confirms that I may be right about memory improvement. Thanks Proff. Kramer for this educational video. 👍👍

[@tads5935]

Wonderful I am 69 years old and I realized that I am beginning to have symptoms of all timers so i welcome all study's teachings, and info thank you very much I hope I could start a hold steady program good work

[@benildaarcilla9411]

The presentation is gentle and happy. Very understandable even to person like me 77 yrs old and no medical background. Honestly though I have to listen and watch closely again. Very interesting. Thank you.

[@tammysims8716]

Benilda... thanks, encouraging and helpful comment.

[@alysononoahu8702]

Me 2 but it's fascinating

[@derekturnswood]

It would be nice to see an update of this 10 year old presentation to get the latest research

[@zhinan888]

My grandma from mother's side lived till 99 (and grandma from father's side lived till 96) and her mind was clear and sharp till the very end. She always had a positive look on life and nothing ever got to her. She smoked 2 pack a day. 😀

[@donalee1975]

Excellent study topic for me. Plus learning how cognitive behavior therapy has been beneficial for me. I am a sedentary 75 year female with many of the Constraints to my memory, yet still functioning. Happy to know reading puzzles and lifelong learning on my own has been my habit. Thank you so much for the delivery of Dr Joel Kramer, whose charts and comedy were very pleasant for the listener. Dona, CALGARY, 🇨🇦

[@onedirectionlover08]

Thank you very UCTV, for such a great service, really appreciated.

[@howellwong11]

I'm 89 years old and my cognitive ability is still intact, but retaining my short term memory is the problem.

[@larainehruby1376]

I’m 78 and have noticed this since age 77. Still haven’t discovered why this memory loss happens and if it is good or bad. We are beings that exist in the past, present, and future through memory, cognition and planning and imagining outcomes.

[@howellwong11]

@@larainehruby1376 I think that shot term memory loss is normal, but I also hear that it is a sign of dementia. I guess that we all will experience dementia. It is just the matter of how bad it is. I hope that my dementia is mild.

[@AP-nx6xo]

Hello… my dad takes B12 1200mcg a day sublingually. He’s 90 and sharp as a whip. All the best 👍🏻

[@howellwong11]

@@AP-nx6xo He has good genes. Most needs help, some don't.

[@conradmish7875]

Thank you. I am 60 years young and am trying to preserve my memory and brain function. I know the brain is bio-electric and runs on circuits and connections. I sleep with an earthing sheet which improves my sleep, but the bladder is what is awakening me. I am a firm believer that the body should be connected to the earth to keep a flow of negative charge flowing. It reduces inflammation. I love studying cell signalling so your lecture has been very informative and exciting. conrad

[@velvetpaws999]

Conrad, if your bladder makes you go at night, try to drink less before going to bed, lol. As for me, I have a water bottle in my bed, and sometimes, I wake up half, drink a sip and resume sleeping. I go once every night, I get up, pee, then back to bed and 10 seconds later, I am back to being sound asleep! It's really all a matter of mind over body!

[@ytcarol]

Yes, drinking during the day is essential!

[@John-ys7zz]

Helps me to stop drinking anything after 6 PM.

[@jrhunter007]

What evidence do you have that the body "should be connected to the earth" or that it reduces inflammation, and how do you explain that? It sounds like a notion to me, and not based on fact.

[@bryanjackson8917]

That's funny, because I am firm believer in just the opposite. That is, that the body should be disconnected from the earth as much as possible (e.g., insulated by wearing shoes with rubber soles, sleeping on rubber sheets, etc.) so that our energy is not drained away.

[@harshvardhanjajoo1187]

Prof Joel, This is a fantastic crisp delivery. Thank you for enriching. Harsh

[@meandcadasil7093]

I have CADASIL. Simply fantastic video, nicely structured, explained in an easy to understand style, beautifully presented in a very engaging manner. Congratulations to the whole team involved in putting this together.

[@TheVtecpwrd]

Great presentation . I learned a lot and enjoyed the ease of his presentation . I am grateful, and a big Thank you for teaching us.

[@solomit1]

Meditation keeps the mind young fresh observing yourself everyday renews the mind so does not accumulate memories live in present moment not the past.

[@johnhoover2569]

Excellent communicator.... Loved the message and the summary..... Learned a lot... and recommend this video to everyone over the age of 30.....

[@문송희-h2e]

30년 나 며느리일때 너 며느리일때.. 엊그제 평안함을 느꼈다. 평안..감사합니다

[@TheGypsyJewess]

love the presentation, well done. Thanks Prof Kramer.

[@naftalibendavid]

1:02. Genes. Exercise. Think. Socialize. Sleep. Minimize inflammation. That is about it.

[@steshaw6510]

Only glucose? "The brain is dependent on glucose as a primary energy substrate, but is capable of utilizing ketones such as β-hydroxybutyrate (βHB) and acetoacetate (AcAc)"

[@reinamacaren-a4132]

🤯😲😱😨🤔 I'm a lil 9vet 9min in. We he said the brain only takes in glucose, I ran straight to the comments. Dr Eric Berg, KZbin Keto Guru, would have a massive keto attack if he was in the audience 😂 I think I'm going to hold off on watching the remainder of this video🤯

[@sleepsmartsmashstress8705]

My brain is capable of utilizing ethanol to run

[@joereidy5732]

@@sleepsmartsmashstress8705 You must be a millenial

[@sleepsmartsmashstress8705]

@@joereidy5732 65 but feel 25 U R right

[@joereidy5732]

@@sleepsmartsmashstress8705 Congratulations just be glad you don't think like a 25 year old. 🙂

[@anonymousAJ]

37:30 "If you take a sample of individuals who've died and gone on on to autopsy, you'll find that a large percentage, 15, 20 percent of people who were perfectly normal at the time of their death have under the microscope the changes that we associated with Alzheimer's disease." How strong is this as evidence against the theory that beta-amyloid plaques cause Alzheimer's? Could these plaques be one symptom of Alzheimer's rather than the cause?

[@Psalm146-2]

I can tell that when I consume too much sugar I get more forgetful. And I’ve noticed that when I cut back sugar sharply it takes me two weeks + to get back to my “normal.”

[@farnooshsadeghi3673]

While wisdom is increasing with age, is it wise to say we are getting older even in brain cells? Or is it due to psychologically becoming more vulnerable?

[@AP-nx6xo]

I’m 60 years young woman ..I look 40 so I’m told lol. My secret is : light weight training , melatonin for sleep, B12 1200 mcg sublingually ( my legs were going numb…. Memory was getting bad.. I was very concerned). Blood work showed deficiency) codliver oil, omega 3s, no sugar, ketogenic diet with healthy fats ( olive oil, MCT Oil( energy and cognition) coconut oil) salt, lutein to prevent macular degeneration which my dad has, vitamin D. It’s easy to live this way because it pays off . All the best to every one !

[@aremedyproject9569]

He seemed embarrassed about the statin question and right then a chunk of the talk was edited out. I feel bad for doctors and scientists today because funding is so attached to the Pharma industry. If you know how to look, there is plenty of good science out there. Research journals from all over the world are accessible to everybody now. Still, one should note who's behind the journals. Learn about study design, possible motives for doing a study, and the arguments for and against in vivo vs in vitro studies (for example). We're certainly more empowered as consumers than we used to be. Cheers! ✌️😎🇨🇦

[@lt9316]

Statins are killers. A quick research of public comment sharing horror stories is done by going to Amazon books, search Dangers of Statins, and then read the comments.... another proof is observing friends, family, neighbors, and the steady decline of health ( w bigger bags of meds from the pharmacy/ more specialists) they require because of "aging." Doctors should be ashamed. Get off processed food, statins, corn oil, corn syrup, use coconut oil for starters! FDA food pyramid belongs in trash w statins....

[@AlexM-jd2ro]

Yeah...but what can we do? My doctor almost killed me on the operating table for an elective surgery, and insurance still paid him a lot of money...they push statins and metformin while simple barberine can take care of both issues...poor mankind...we deserve covid...

[@iwnunn7999]

You misunderstood. I was amazed that someone in the audience didn't know what rem sleep was

[@ESTELLE1139]

My guess is that curcumin and fish oil would be healthier than NSAIDS for anti-inflamatories to help cognitive health.

[@erzsebetnilsson580]

Loved to acknowledge your information. LOVE BOTH THE NUTRITIANCE and THE DOCTORS and THE OLD PEOPLES treatment for various illness.

[@Ullbritt]

thx a lot, i love UCtelevision

[@mandyhamilton8083]

Awesome video; truly amazing. Thanks a bunch :-)

[@Joebethere7]

Is neural inflammation caused by trauma? If not, what causes it? Explaining this would be helpful

[@bernadettekennedy2981]

Look up Dr. Bradshaw and tea. Very good for memory and the brain.

[@diannefitzmaurice9813]

Good presentation but sound quality is very poor .

[@shellyjose1967]

Great Presentation....

[@KEEBLERVET]

Fascinating ... Shared on Google and recommended

[@martinirving3824]

"Central obesity" associated with the highest risk for dementia? You might as well say "insulin resistance" is associated with the highest risk for dementia. Subcutaneous fat is actually protective.

[@vincentanguoni8938]

This is 6 years old..

[@velvetpaws999]

That memory test would work or not work for me, depending on how one sees it: If I wanted to memorize it, because it is important, or just for game, as a challenge, I would. If I feel that it has no relevance, I would discard it and never think of it again. Other than that, I have found that my memory is improving: I can now remember all my credit card numbers, I can read entire lines of information and remember them exactly, like phone numbers or paragraphs of text. So no aging here, it seems to me. In April, I will have lived 36,792,000 minutes. You can figure this one out!

[@thomaslucas867]

When I was in training fifty years ago, it seemed in psychiatry the main people presented with memory loss, was wernicke's syndrome secondary to alcohol abuse. Alzheimers was not mentioned at that time. We did have loder people then! We may have envirmental factors that impact the epidemology of alzheimer's. Could the pathologic and chemical changes be secondary to physical exposures?.

[@buffsol1969]

VERY GOOD,I SUGGEST THAT EVERYONE SHOULD SEE THIS..

[@MarcellaSmithVegan]

Really enjoyed, thank you!

[@johngilmour8945]

It Matters Not What Age You Are, You can Still Place Important Information into Your Long Term Memory Archives, HOW? by reading the subject matter, ''FOUR PAGES PER NIGHT JUST BEFORE SLEEP"" this is a THEORY I developed and Validated to myself over my lifetime! Respectfully zYours, John Gilmour Toronto Canada!

[@pushkalapalanivelu9507]

Very interesting.Very simple e xplanation about brain with aging. Ofcourse its very useful for aged ones likee

[@joanheaney4103]

Great presentation......learned alot!

[@joereidy5732]

Please tell me what you learned ....just three things so I don't have to watch this borefest. Thanks

[@janeyd5280]

@Joe Reidy agree 👍 I can't take it all in.!

[@joereidy5732]

@@janeyd5280 Dang we need someone with some patience ...LOL

[@NyanKitty01Kawaii]

This was a interesting study. I'm GlaD to know this now at an early age because complications in memory seem to run on my moms side, it's kind of scary. Hopefully I can help my mom out and improve my cognition to avoid this.

[@AdventureAwaits972]

I am very surprised that supplements like vitamin D3 and Omega 3 in the form of DHA + EPA were treated as trivial in this talk. Both have been studied for decades. There has been very clear compelling research showing the correlation between Alzheimer's disease (AD) and people with inadequate amounts. I am puzzled.

[@twentyfourinvest]

Because pharma owns this lecture.

[@Katmandu29]

Good answer! Big pharma yep.

[@robman2095]

Made 9 years ago. Maybe progress has been made in this area since then.

[@ericfrey2866]

You are 100% correct. This is why this msn is never someone I would go see as a world class practitioner of medicine. He is a theoretician

[@ericfrey2866]

Yes pharma schill

[@anonymousAJ]

9:00 "The brain will only take glucose" Does this mean the brain cannot utilize ketones?

[@Nic7320]

Slide at 11:40 should read time, not processing speed, to show a slowing relationship as we age.

[@JoeEPena]

Looks like you are at the freeze line, hope you warm up!!

[@adamsblanchard836]

How many people say they don't remember as well as they used to and are speaking about the same memories forming 35 years ago and just be too ignorant to recognize like not recognizing idgaf that "and just "be" to ignorant" isn't a proper grammatical illustration of the English language in someone else's opinion.

[@edwardwalsh4454]

12:12 #32 answer is ? E my guess as one element is moved in each frame!

[@edwardwalsh4454]

Sorry is it B as I noticed my mistake

[@anonymousAJ]

19:50 "What happens in Alzheimer's disease is that these proteins are being cut at the wrong spot, and because of the way in which these proteins are becoming misshapen, they start to glom together, and once they start to glom together, they form these plaques, and whether it's the free-floating abnormal proteins or it's the collection of these abnormal proteins is not altogether clear, but there's no doubt that beta-amyloid is playing a role." Is it impossible to have Alzheimer's without these plaques?

[@carleenmejzastrumunderthes4130]

Excellent!

[@graceyow7159]

Just facts about general condition of maybe average individuals. No mention of health condition, lifestyle. I make this comment bec I have read of centenarians who have greater mental faculties than most. They commonly good health and joyfulness about life. Chronological age need not be a trap for biological age.

[@martinirving3824]

2012 this was uploaded? Nonetheless, an expert such as this should've been well aware that a lot of the brain can run on ketones and ever prefers them. And maybe he did know that but was reluctant to say it? Still, it's interesting to see how old paradigms are maintained with concrete rigidity well into a time we should simply know better and accept" new" (old, ignored) science.

[@Darienbeagle]

Excellent! A great speaker, fascinating talk.

[@ivanahumpalot4489]

How do I prevent Brain farts???

[@nydiahernandez6072]

Preparing for the unknown has been underneath experience and a great help to my gold keep up the good work youtube

[@oldsachem]

Dendrite is misspelled at 44:06.

[@sarahtelfer6051]

Very informative but you have a tendency to “uptalk” where your voice goes up at the end of your sentences:)

[@eddiemartin85]

Great

[@carolempie114]

The brain LOVES ketones and is the preferred energy source vs glucose. What’s up with this lack of knowledge? It makes me doubt the whole lecture.

[@amanighamrawi583]

You are awesome thank you

[@OatmealTheCrazy]

Look at the date

[@dhananjayjoshi2206]

Novel problem solving @12:36 is it E?

[@lt9316]

At 57:35? What was the comment made from the man in the audience?

[@oldsachem]

How does Covid affect protein accumulation in the brain? Does anyone know?

[@deb0740]

very good video, i will be recommending it.

[@theguardianaj]

Seriously? You interrupted a lecture to ask what REM sleep is!?

[@janicemims9799]

What about ketones?

[@mscorrell]

Only glucose; no ketones?

[@knr6293]

very poor audio

[@nixodian]

9min11 , brain only take glucose? from what Jason Fung, Dr Berg, and new science says that ketones are the prefered fuel of the brain, not glucose

[@psiclops521]

Inre cognitive exercise, if your work is intellectual and you spend 40 hours a week doing challenging mental work, does that count as cognitive exercise? In addition, does listening to many hours of science lectures on KZbin count?

[@vincentanguoni8938]

Da!!! Lucky you!

[@nguoithichhoasim1233]

In read in an article , the author advices you read and WRITE DOWN what we like , not typing , This will help memory too . And also learning a new language .

[@thefallenone7988]

I heard grass unwires the brain

[@iwnunn7999]

"What is rem sleep?" Who is this audience? No offense to the guy asking the question.

[@margaritaorlova6697]

+IW Nunn, I have googled for you {rem sleep} = "Rapid eye movement sleep (REM sleep, REMS) is a unique phase of mammalian sleep characterized by random movement of the eyes, low muscle tone throughout the body, and the propensity of the sleeper to dream vividly."

[@anthonyjerome2297]

I asked myself the same question. This seems like an advance class. It's unlikely for someone to not know.

[@juliensorel1427]

Isn't this old info?

[@wonderwagon3304]

The lecture is 10 years old.

[@casiandsouza7031]

My personal experience is that waking frequently should be used to get up and facilitate circulation. I sleep better later.

[@mscorrell]

I've had a stroke, which has given me a greater appreciation of The Simpsons.

[@kevin.afton_]

Cant burn lipids? So how did the eskimos stay alive?

[@davo4000]

The brain can use ketones and is a cleaner burn than glucose.

[@rooseveltbrown3rdandterrible]

Creation not evolution

[@mylucidlife495]

"At some point evolution figured out..." good job, evolution! 😂

[@ceecee6679]

opening music is gonna make me h9mocidal

[@chrislecky710]

Grey hair before the age it meant to appear is a mutation, your eye colour can similarly mutate. these are signs of ancient DNA..

[@LeslieDaCostaJr]

54:02 Cognitive exercises

[@martinirving3824]

Lack of sleep contributes to insulin resistance.

[@traceler]

How can he say brain only takes glucose and can't burn lipids or fats ( 9.11)? that is not correct, brain goes very well in ketones

[@someonelse48]

+traceler the body can convert amino acids into glucose... so you don't really need any carbs

[@Mistral434]

+Tom Schultz of course you do. the body can only handle a small amount of oils, fats, and protein. Getting any more than 40% of calories from any of those sources leads to chronic disease, as thousands of scientific studies have long proven. Therefore the only way to get enough calories to sustain a healthy body is to get the majority of them in the form of carbohydrates, ideally fresh fruits and vegetables. Ketosis is the body's "last resort" mechanism for survival. It technically can work in the short term but its only actual benefit is with treating epilepsy.

[@Mistral434]

+traceler The reason he says that is because he gets his information from actual scientific journals, and not fad diet junk scientists.

[@coastaltoaster1371]

@9:00 9min in, needs a edit. Not the whole video just the part about energy consumption. - The brain runs on BetaHydroxyButarate Keytones and glucose. The brain is not solely consuming glucose.

[@paulhand5015]

articulate but some fundamentals wrong obligate glucose ... no new cells ....

[@aveng006]

How do you test the rats memory?

[@rayleneevans4166]

With a maze. If they forget where the exit is, or if they can find it (again) fast.

[@adamsblanchard836]

Tip: discrepancy in description, tips were not of dindritic spines Dr. Sally....

[@rowanwindsong]

I'm just trying to understand how this is true regarding the brains use of glucose when I have seen videos of people with Alzheimer's who began eating a keto diet primarily coconut oil and had a drastic reduction in symptoms due to the brains use of lipids instead of glucose

[@prakashpatel1207]

Summary is "we know NOTHING for sure"!!!

[@claudio9788]

sub it in spanish please. thanks!

[@ClarkAve321]

@25:25 Someone please give me a thumbs up when you realize... haha

[@LM-xs1qh]

Brain only takes glucose? What about ketones?

[@ceecee6679]

Just here to see what the 'experts' say so I can do the opposite.

[@Theranchhouse1]

nope 'evolution didnt figure anything out...God MADE us this way.....its a shame he is head/book smart...but dosent even understand creation from a living loving Father God...

[@CC-kl4nh]

Oh great…,

[@martinirving3824]

"Protein aggregation: neurodegenerative diseases." "Insidious onset. Gradual progression" Why, that sounds very similar to type 2 diabetes, aka, insulin resistance. (sarcasm intended). July, 2019.

[@Isagine]

Traduction en français S.V.P

[@aviewer390]

Low fat?? Wrong! Eat as much coconut oil as you can stand!

[@jef_freely]

This guys battin for statins