Understanding Pernicious Anaemia (B12 Deficiency)

This video contains an explanation of pernicious anaemia, aimed at helping students of medicine and healthcare professionals prepare for exams.
Written notes and diagrams about pernicious anaemia are available on the website at:
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DISCLAIMER: This video is for education and entertainment only, and is not medical advice. This video should NOT be used for medical advice or to guide clinical practice. The Zero to Finals content should not be used in any way to guide medical decision making. Zero to Finals takes no responsibility for any actions taken or not taken based on the information provided. Local and national guidelines and senior clinicians are there to help you make decisions, not KZbin videos. If you need medical advice or information, seek it from an appropriately trained and licenced doctor or healthcare provider that can address your individual needs. Zero to Finals cannot guarantee the accuracy of information in this video. Please highlight any errors you notice in the comments below - thank you.

[@ananya5679]

JUST CAME I ACROSS THIS CHANNEL...AND I AM ABSOLUTELY LOVING IT!!! Although I am high school student but I still just love watching these videos....amazing explanation!!! Thank youuu

[@aleesheee]

A lot of people here are having huge neurological issues and brain fog/ confusion which makes things harder to grasp when our brains keep shutting off and personally I have vestibular migraines too which completely disable me for weeks, so I really appreciate the pace of the author and the free information 🙏😉 I just wanted to share my thoughts and give thanks, blessings and healing to all who are struggling ❤

[@mrgringo7289]

I had to put on 1.25x lol

[@xxxicequeenxxx]

I’ve had neurological issues for over a year now and my doctors finally just told me that I am anemic after many blood test. I was sent to every kind of specialist I was given so many tests, and now they found out finally. I have to see a hematologist. I’m wondering if the symptoms can get better and improve currently, I am unable to use my limbs at times the pain is so bad I’ve been in pain every day for a whole year and I’m not able to walk much or hold things I’m in my late 20s. I hope and pray that anyone suffering from this or any illness gets better God bless. I’ve been on B12 supplements for months now. I’m not sure about the folic part. I’ll have to make sure but hopefully my hematologist will help me.

[@xxxicequeenxxx]

Update I have pernicious anemia and will start Iv iron treatments and b-12 injections. Seeing a team of Covid specialist at a Covid recovery center soon.

[@hatimbearingwala7189]

Hey suffering from vitamin b12 deficiency from childhood Can we talk more about your symptoms that could help me in my diagnosis Thanks

[@xxxicequeenxxx]

@@hatimbearingwala7189 yes I’m open to talking

[@brightyourthinking8603]

May God get well soon dear 🙂🙂

[@aliyahrashid706]

Hi.. how are you feeling now? Hope your better❤

[@rahulrahula4527]

Your videos are criminally underliked! Brilliant levels of detail and clarity of explanation. Very happy!!

[@ZeroToFinals]

Thank you!

[@graceusa3942]

This teaching is simply, clearly, easy to follow and the best. Thank you .

[@binathere2574]

But testing does not always reveal true condition of the patient. It's best to go by symptoms. Treat the patient not the numbers.

[@B3bita1215]

Absolutely amazing explanation. Thank you!!

[@UpgradeyourHealth]

This is amazing! I was just diagnosed as a adult, so I'm striving to absorb all the knowledge I can gather.

[@esterherschkovich6499]

Excellent video(I am a Nurse) I have Pernicious anaemia 😑the injections are not enough 🤔I take B12 sublingual they are brilliant but I suffer..Bad mussey headaches,totally drain,face looks white+breathing problems...to name a few..have this now.Fatigue too.

[@jk9719]

What dose do you take for the sublingual b12?

[@lovelyrics3656]

Same here

[@mihaeraaboud9548]

May god heal you💗💗💗🥺🥺🥺

[@brasshound4442]

My doctor had me stop taking the extra B12 and shots I was on and just do the 1000mcg she recommended. A year later and I've been in agony not knowing what happened, tested for everything, and finally just took my 10,000mcg of sublingual and instantly felt some relief. I suffered so much for no reason. I'm going to demand my injections again.

[@ScarlettDuchess]

I have autoimmune PA too. I do great on 2000 mcg daily of sublingual B12 spray. I only had 4 B12 injections before I switched over to sublingual. So much better! I’ve been on sublingual daily for 14 years. If I stop my B12 spray then symptoms start coming back in a day or so.

[@mariaraluca4744]

Finaly it makes a lot more sense! Thank you, Tom!

[@sinepsis9578]

Love this! I was recently diagnosed as a young adult, so I’m trying to learn everything I can!

[@charlyrogers5711]

Same! Can you describe your symptoms for me? Curious to see if we all match up. Also, how are you feeling now?

[@sinepsis9578]

@@charlyrogers5711 Of course! My pernicious anemia developed as result of Malabsorption Syndrome and is comorbid with gastric disease, so I have a lot of gastric symptoms like nausea, vomiting, abdominal cramping, and severe weight loss that may not be caused by the anemia, but CAN be. The doctor thinks they are exacerbated with it in my case. I also experienced extreme fatigue, dizziness, loss of balance and confusion. It was these symptoms in particular that got our attention. We did a blood panel, and my B12 measured at 82 pg/mL. I now do weekly injections of 1000mcg and as of three weeks ago have a B12 level of 212 pg/mL. I still suffer severe gastric symptoms but do have periods when I’m much better. I am still a bit unsteady as well but the other neurological symptoms have disappeared. How about you?

[@sinepsis9578]

@@vapemcvaperson I’m so sorry to hear you’re struggling as well! Ironically, I’m about to start seeing my doctor for routine examination because of bleeding as well. I have Cyanocobalamin 1000mcg and use sterile single-package syringes to inject it weekly. Have you looked into seeing if you may qualify for free health insurance? I know it varies as to where you live/your situation, but if you do end up ordering it, please check into the company! I would still purchase my syringes from a pharmacy vs ordering so you can ensure they are sterile and not broken.

[@ghanshyamjagada6643]

What was your b12 level when diagnosed?

[@sinepsis9578]

@@ghanshyamjagada6643 57 - I am proud to say I am at about 400 now after months of weekly injections.

[@alexbarnwell6397]

Great video! Thank you for making these!

[@kimsordyl]

reading about this condition now, really nicely explained! Thanks :)

[@dannif6479]

Loving the consistency of uploads !!

[@ZeroToFinals]

Thanks - I'll keep them coming!

[@johnjackson8783]

Thank you for making this video. It's very helpful.

[@koshycherian7140]

Simple yet amazing

[@floorgang5027]

Sir you are doing a great job thank you for making these concepts so easy to understand !!!! Thank you ☺️☺️

[@ZeroToFinals]

Thank you!

[@chinthalewkebandara2358]

This is perfect. Thank you.

[@areebzahid8404]

very interesting knowlegde,thanks for making.

[@manarsmaan2624]

Can you make video on other kinds of anemia . Thank you so much, it is very helpful and great explanation

[@daudyusufirbad1940]

Concise and clear thank you very much.

[@MrSatheeshdent]

The best as for pernicious anemia

[@MrJake11297]

love this flurry of videos coming out in 2021! just before my exams haha

[@ZeroToFinals]

Good luck!

[@poeticvilla8139]

Very accurate n informative thankyou so much 😊

[@tatendatakaendisa273]

Great video, really informative yet concise.

[@binathere2574]

But not complete

[@topperbooks2331]

This video is great!

[@Pruzar14]

The music changed ahahah.... ngl makes a nice change when im powering through listening to all your videos ahah!

[@ZeroToFinals]

haha glad you like it, it was time for a change!

[@yeseniaorozco8981]

this was nicely explained thanks

[@sayanss4]

Great as always!

[@ZeroToFinals]

Thank you!

[@medicmandan2554]

really helpful, thanks

[@sharonborman6513]

Thank you🙏🙏🙏

[@parintornnoonsang6989]

love it!

[@Doctor_DDrr]

جماااال الشرح🤩

[@jennyinthemorning]

THANK YOU

[@asemabodaber7265]

easy and great ...thx

[@bobbyjoe8900]

Was diagnosed with Pernicious Anemia. Was told that you can't over take B12. What your body doesn't need it will get rid of. Through your urine.

[@Chozenfew73]

just a quick question, did your diagnosis get picked up in a random blood test or were they looking for Pernicious Anaemia to start with ? Thanks

[@bobbyjoe8900]

@@Chozenfew73 Went to the emergency room. I had passed out and was going to the ER to find out what happened. Through all the tests they found out I was completely out of B12. I was in the hospital for four days.

[@larrainebrownlow4937]

Thank you

[@reaganscarborough3143]

first nursing exam tomorrow and this video really helped get the concept down !!

[@Hydra_iiix]

Best of luck for your future

[@Tonnie31]

So helpful

[@auroraveneziacarlislemakea8186]

Thank you so much for this video 💖 I am Pernicious Anaemia patient born with it and was given iron supplements for 40years instead of B12 ferinject or what you have written on this video

[@rogerthat6221]

Can I ask what your recovery has been like ? A friend is dealing with the same thing rite now. She is 38

[@thomassvensson1523]

Ferinject is iron

[@ScarlettDuchess]

I have autoimmune PA with both intrinsic factor antibodies and parietal cell antibodies. I need B12 daily! I first was given B12 injections once a week. A terrible rollcoaster of feeling better then feeling worse. Ugh. And the side effects of an acne rash over my face and chest (took 4 months to go away after stopping injections) and shortness of breath. I switched to sublingual to see if that worked and wow! amazing!! I use 2000 mcg bioceuticals sublingual B12 spray every day. I could not imagine going 3 months without B12. 🤯 I once did not have my spray for 3 weeks. OMG!! Horrendous! The most insanely severe unliveable brainfog, extreme fatigue, white spots started reappearing on my forearms again, body odour….etc. Within 5 minutes of taking my B12 sublingual spray the brain fog disappeared. My God the relief was intense!!!! 🙌🥳 But after not having any B12 for 3 weeks I had a headache as a side effect for a few days. Whoever wrote the treatment for PA is B12 every 3 months needs to a good kick up the…lol

[@binathere2574]

It's not possible for someone with PA to absorb sublingual B12 you don't have the ability to absorb if you have intrinsic factor antibodies or parietal cell antibodies . Something is not correct in your diagnosis.

[@Emptywhitez]

Waooo great Can you plz tell me which app you are using for making the videos????

[@PinkFlowers365]

thanks a lot

[@chelseap938]

Very usefull thannk you!!!

[@sandrayates5446]

This most helpful. I've recently been diagnosed low diabetes, low oxygen levels, low B12, pernicious anaemia, low blood pressure, pulse missing beats. Ive been prescribed Ferrous Fumarate 305mg, Folic Acid 5mg and Cyanocominn 50mg. Now I'm worried about taking thd Folic Acid. I think I'll have to talk to my GP about that, it's got me thinking. Ive still got all the symptoms as described in video. I've only been on these meds about 2-3 weeks.

[@binathere2574]

You need folic acid for Utilisation of B12 and you need B12 for the utilisation of folic acid. They work synergistically

[@kushalbhardwaj3026]

Very nice...

[@humairaalam2226]

Very Interesting...😃😃 Thank you sir..

[@ZeroToFinals]

Thanks!

[@michellecheatley1214]

Example 1. 3 times a week for 2 weeks, then every 3 months, Standard NHS treatment. Example 2. Where neurological symptoms are involved, 1mg every other day untill symptoms improve at that stage ''you are more that likely self injecting, treating your symptoms as they arise & keeping them at bay.

[@azamqureshi8963]

What form of b12? Injection

[@michellecheatley1214]

@@azamqureshi8963 NHS use Hydrox

[@lapislazuli7876]

Can you drink Apple cider vinegar in water during a meal? I thought we weren’t meant to drink while eating? Or is that ok? Or should the ACV be consumed just before a meal? Please advise.

[@thehungrynutritionist]

Could methyl cobalamin injections be used ? Would it be effective ? Does the dosing differ

[@fahad73453]

Nice video

[@nadinedavid139]

Feel like forwarding this to my GP😢 thank you

[@Maureen-vg7dx]

Tell ur gp to go to the pernicious anemia society uk on u tube all uk gpsdr chris steel from this morning they have videos of seriousness of this b12 deficiency pernicious anemia u can fone up pernicious anemia society uk as well have seen Charlotte's story on u tube its called Charlotte's story she sued the nhs with slater and gordon solicitors she's in a wheel chair now

[@Nocczz6]

Great content

[@ZeroToFinals]

Thank you

[@goaway7272]

Great I was treated with folate first for years and b12 was ignored now I'm still on folate and was on b12 ingections monthly and have been reduced to 3 months which I think is a massive mistake I wish I could find someone who would actually help me fully.

[@esterherschkovich6499]

Hi.I find the 3 monthly injections not enough and a real battle to get more.Your blood results say all is well but you still suffer with debilitating symptoms 😢 An anaesthetic Doctor I worked with recommended B12 sublingual tablets..Great help..Good luck.

[@goaway7272]

@@esterherschkovich6499 its not enough after 3 weeks symptoms start returning I've tried sublingual and tablet neither do anything unfortunately but I'm trying a few workarounds I can not go back to living like that

[@anthonyman8008]

This video doesn't help?

[@TweetyPAK7]

I wish this went on a little more.

[@NurseJacob360]

ya know, my professor is a genius and has a PHD in biology but somehow this my preferred method! thankss(:

[@ZeroToFinals]

Thanks!

[@Hydra_iiix]

Very helpful 🤡

[@thefourthjhanagautama6583]

But in case of oral intake how much should you take?

[@nikkster01]

bit confused I have had this for 25 years my first and only symptoms were just extreme tiredness all the time no matter how much sleep I got I manage fine with a 3 month injection only because the dr recommended it as keeping levels stable instead of yo-yo up and down

[@bwagner1722]

I have mtrr a66g mutation. White oatches on skin, no energy, ached and pains, numbness and tingling etc. , dr says im fine because my cbc is normal. What can i do to get my dr to take me seriously and actually investigate

[@generalpurpose772]

I’m B12 and folate deficient - waiting on the test for intrinsic factor to come back, but my doctor told me that I could start taking my folate supplement now. Why would she advise that if it might cause me harm?

[@princessriemann5291]

❤❤

[@kushcloud420]

Im having pins An needles right now it started yesterday

[@chandrashekharsharma5800]

Where to get this book in INDIA

[@lunawolf448]

I have it and I’m taking the pills for it. It’s 1000mg and it’s not enough. I get SO weak and can’t even get out of bed.

[@sydneyhunt6681]

Are all 4 b12 IM types good for this

[@dannif6479]

Can you cover acute abdominal complaints this year?

[@ZeroToFinals]

Yes, definitely this year!

[@MsSilver41]

Pernicious anaemia leads to severe abdominal problems hope this will be covered

[@23Fists]

I only ever knew about iron-deficient Anemia, so thank you for the info! On an aside, can B-12 deficiency become a thing from over-using b-12 supplements/drinks? I know a few energy drink brands have like 300% daily value of B12, which I used to drink at least once a day for a few months, but then I passed a kidney stone that split my 'exit' wider (that was both painful and horrifying; thought I got but by a snake or something because I was working as an arborist and was relieving myself by a bush) and quit drinking them except but maybe twice a year, if I'm REALLY needing a pick-me-up..

[@rogerthat6221]

That’s all they ever tell you. The doctors know and don’t want t to share

[@binathere2574]

It is not possible for B12 to cause toxicity. There is no upper limit according World Health Organisation

[@Sandwich13455]

Your grass snake split?

[@Maureen-vg7dx]

​@@rogerthat6221cos b12 deficiency or pernicious anemia is the cause of mental illness the depo is b12 shots or b12 oral liquid with folate liquid methylation

[@Maureen-vg7dx]

​@@binathere2574b12 and folate have to be level with each other

[@onlyonejupiter]

Diagnosed a year ago been suffering horribly for more than 10 years I was taking once a week... I have next to no memory... my doctor is on leave and I need injections :( I have B12 dementia now

[@alec1113]

You forgot to mention MTHFR MMA and homocysteine tests folate and folic are 2 different vits plus every 3 months for a b12 injection is extremely outdated , not one size fits all . 4 versions of b12 cyanocobalamin, Methylcobalamin,Hydroxocoblalamin and adenosylcobalamin

[@notyourbells9584]

is that a new introooo

[@emma0llew]

This has worried me because I have both b12 and folate deficiency and they have most certainly given me folate tablets first without treating the b12.

[@michaelmoores2654]

I have both too. You need the injection too as far as I know.

[@emma0llew]

@@michaelmoores2654 I don't know why they haven't treated me for the b12 first. They seem to have told me the wrong info.

[@user-fs6ll2wu6o]

the parietal cells at 0:56 kinda looks like among us

[@mala.k4824]

👌👌

[@rachel4339]

Interesting that they don’t discuss the hereditary version.

[@elsagrace3893]

But what about methylmelonoc acid test??

[@pepper419]

Where did you get those eyes?

[@user-gn1zg1xm6t]

Food is fish anx egg❤

[@motownr313]

Please help with suggestions. I am 62, diagnosed with genetic type PA 22 years ago with stomach cancer. Been cancer free after total gastrectomy in 2003. On cyanocobalamin injections since 2002. I have to get Injectifer every now and then because of low blood count. What can I do to naturally get whatever is in that blood building infusion? The treatment is very expensive. What other supplements help keep me healthy besides a b12 regimen with folate (or is it folic acid that i need?)

[@shashankshukla4297]

Bro i have ulcers in my stomach and have problem in absorbing vitaminb 12

[@bettyausten9533]

What have you been able to do about it?

[@katarat544]

Have textbook ?

[@ZeroToFinals]

Yes, you can search Zero to Finals on google or amazon to find everything 😄

[@katarat544]

@@ZeroToFinals i mean textbook pdf

[@ZeroToFinals]

@@katarat544 There is no pdf for the textbook, but you can find notes at zerotofinals.com/learn

[@katarat544]

@@ZeroToFinals @Zero To Finals thank you so much. I want to buy your book but i live in south Korea

[@ZeroToFinals]

@@katarat544 Oh, I see. Don't worry, everything is on the website so you won't miss out by not having the book. You might be able to get it shipped from amazon.com or maybe amazon.co.jp if you really wanted the physical book

[@hameemkhan204]

when he says "Pernicious anemia is the cause of Vitamin B12 deficiency anemia", did he mean it occurs because of vit-B12 deficiency?

[@MichaelMerritt]

Pernicious anemia prevents intrinsic factor from binding to b12 in the intestines, results in the b12 deficiency. The way he said it makes sense to me.

[@user-nw6xh7mn3h]

You speak too slowly. I had to speed this up to 1.25x to make it sound like you were speaking normally.

[@01123heavenlybe]

Thanks 🙏 so much. 🗽🪩🎼🎶

[@user-zs5xn5ir2r]

Thank you

[@gopikrishnavenkatesh7923]

Hi may I know that can neuropathy due to pernicious anemia can be cured ?. It been more than 6 months but still the numbness and pain is still not going .