USMLE BIOCHEMISTRY

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Күн бұрын

Пікірлер: 23

@blapspblamaster Жыл бұрын

Correct in theory but there is a mistake in the stem - phenylalanine restriction alone wouldn't get us past the PKU issue if there was one. That would be tyrosine supplementation.

@aleenawaseem9970 4 ай бұрын

Excellent sample question and explanation 💫

@RandyNeilMD 3 ай бұрын

Glad it was helpful!

@parpar7878 Жыл бұрын

I still do not understand why the answer is not A...I need help

@shsfehyr Жыл бұрын

Because his phenylalanine restricted diet should result in no symptoms but he is still showing them so it’s c

@crazysingerr Жыл бұрын

Basically PKU Is due to either deficiency of Phenylalanine hydroxylase (most common )or deficiency of its cofactor BH4. Let’s say he is on a phenylalanine restricted diet so phenylalanine levels coming to normalcy, yet he is showing symptoms as in this case high prolactin levels….means to say the PKU is due to deficiency of BH4 …..as BH4 is also needed for conversion of tyrosine to dopa. Decreased dopamine increases prolactin. As dopamine is a natural inbitor of prolactin. Phenylalanine ➡️ tyrosine➡️ Dopa➡️dopamine ➡️Ne

@ridsasim4685 10 ай бұрын

Thank you!!

@aziznicola7674 Жыл бұрын

Thanks a lot🙏🏼 u r the best 🙏🏼

@RandyNeilMD Жыл бұрын

Thank you Aziz. KEEP STUDYING HARD!!

@JayAnam1997 Жыл бұрын

Thankyou sir!

@RandyNeilMD Жыл бұрын

You are welcome.

@derkies2133 Жыл бұрын

What Step exam is that? 2ck? Oder 1?

@jameswadsoniloveyoujesusfo4429 Жыл бұрын

Answer is C

@urjasanghvi5733 Жыл бұрын

Sir, why not dopamine carboxylate?

@jamilaweatherly5376 Жыл бұрын

The dopamine carboxylase is less likely given the presentation. The patient is mostly demonstrating a PKU pattern . Basically since the diet was accounted for , the only other plausible deficiency is the DHR. The patient is already limiting the phenylalanine that would need to be processed. :)