VEGF to extend lifespan? (targeting vascular aging)

[@TheSheekeyScienceShow]

What artery going to do? :D

[@brewhog]

Keep things lighthearted

[@TheSheekeyScienceShow]

Exactly!

[@thewisegirl6459]

Not research longevity "in vein"

[@rfbead321]

Don't worry about tumor, only today.

[@elliottrubenstein1746]

Very funny. Cheerio.

[@eaappell]

Just a cursory search for VEGF and NMN suggests that exercise plus NMN may be so effective in its rejuvenation effects due in part to VEGF stimulation. It's all coming together. Thank you, Sheekey!

[@monnoo8221]

As the Chinese (TCM) wisely say: Where you have no flow you have pain. The yogis of India know several exercises to induce systemic hypoxia, by kind of not breathing. The youthfulness of the vascular and the circulatory system is a central part of staying young. Reducing to VEGF is kind of.... Instead the interaction between blood and vessels, immune system cells and vessels, general care about collagenic compartment (vit C etc) and exercise (strength + flexibility) have to be considered. It is great to perform research on the level of biochemistry, but without anchoring it on the systemic level it becomes a fetish. That link is what seems currently missing. A living organism is not a pile of individual facts. Btw, the vascular system is not equal to the circulatory system. The latter includes the lymphatic system as well

[@peterz53]

Thanks! Another Excellent presentation. Glad you brought up the cancer connection. FYI, Dr. Williams Li runs the Angiogenesis foundation which has done research on how foods affect angiogenesis and the connection to controlling cancer growth. A good source of information. On the problems of interpreting mouse data, there was a very interesting recent discussion (starts at 30 minutes in) between Peter Attia and Steve Austad (U of A Prof and Director of Agiing Center) (Episode 171 on KZbin). Fairly surprising just how different lab mice are from wild mice. Prof Austad likened them to a different species.

[@marilialevacov2939]

As usual, extremely interesting and well done.

[@SamsaraRevolves]

I wonder if Wim Hoff breathing & cold exposure, long duration aerobic activity or, high altitude exposure will increase VEGF.

[@jordanh9668]

What about “amino acids” like citrulline? Of course it aids in the reduction of arterial hardening, via the urea cycle and it’s production of nitric oxide. Not to mention it help get rid of waste in blood and (also through the urea cycle) turn ammonia into urea. I’m curious if it would have some anti-aging effects as well.

[@deagingguru]

"A man is as old as his arteries" - according to the AtCor Pulse Wave Analysis (arterial elasticity) mine are 26. Not bad given that my passport says I'm 49 (i.e. -23yrs). But I am not alone. My FitRX gym members have achieved upto a staggering -35yrs. The lady in question has a passport age of 55, but has the arteries of a 20yr old. The tests are administered by Prof Brian Kennedy's NUS Centre for Healthy Longevity lab under the ABIOS (Ageing BIOmarker Study in Singaporeans). Like the epigenetic clock, this is clearly an important biomarker to determine overall biological age.

[@brewhog]

VEGF "Commonly upregulated in cancer". More reason to keep studying P53 it seems :D

[@hankfowler8194]

I think fibrinogen levels rise in the sedentary individual which increases the potential for stroke, so exercise is most definitely helpful for vascularity.

[@manmoth4]

One thing I'm confused about is that ashwagandha is supposed to exert beneficial properties by inhibiting angiogenesis... maybe this is specific to cancer cells

[@vanesako]

Dr. Li mentioned in this last book that there are foods and supplements that can do either one or the other, and its safe to use them. His rather vague explanation (If I can recall correctly) was that the body knows when to use each capability. I believe there is plenty to be done in this area of research.

[@viracocha2021]

Wow! From my limited understanding, 48% is the maximum life extension it has ever been achieved in mice, isn't it? As you said in the video Vascular Health seem to be at the top of a good longevity strategy.

[@TheSheekeyScienceShow]

Yes, one of the greatest i think BUT would like to see it replicated in other mouse strains

[@manmoth4]

Citrus bergamot is underrated for vascular health too. Lowers LDL, raises HDL, lowers triglycerides, inflammation, and fasting blood glucose.

[@smb2735]

No, they've increased it much more than 48%. It depends on the mouse model though as induced aging is a bad model.

[@carystus675]

Why haven't I thought of that? It was only VEGF inhibition for purpose of disease mitigation that was on my horizon. If there was a way to over express VEGF in a controlled manner, and make sure not to get cancer, then that would be the way to go, I guess. We will see if the life extension pans out, but I'm convinced it's a good thing for healthspan. Just keep in mind that the body works by checks and balances, so mindless up- or downregulation is foreign to the way the body works. PS I like your choice of sponsor, where e.g. I get to read about Yakult. I am using Yakult; unfortunately it is made with lots of glucose-fructose syrup and sucrose, so I use it as a starter for further fermentation.

[@hopeforescape884]

I found it very interesting that you mentioned that VEGF increases with hypoxia, since I recall coming across a study claiming that mice in a low oxygen environment lived longer than mice a standard oxygen atmosphere. Could VEGF be involved? it would be interesting to look at people who live at higher altitudes since the amount of oxygen decreases the further you get from sea level.

[@randallhesse5011]

VEGF would nitric oxide production be good for this. Maybe beet root powder, L-arginine, galangal, etc. Some people also say that Pau d'arco fits in this category.

[@kamanashisroy]

I like you mentioned exercise with VEGF

[@BrentNally]

Bravo Eleanor!

[@TheSheekeyScienceShow]

Hey brent, hope things are well with you!

[@BrentNally]

@@TheSheekeyScienceShow Yes, things are going well. We've made progress with Longevity Plan and I would love to chat with you soon about it.

[@sayiprasadvummarao8792]

So high endurance exercise which creates hypoxia are good can release VEGF?

[@raeRenae1]

I had a IBD screen and my VEFG is high. Is that bad?

[@luckssj]

Have you looked at CD38 and how it affects the aging process of the arteries?

[@allencrider]

VEGF won't solve the ischemia problem that old meatheads have and it won't lower blood pressure. We would need to take away our salt, cholesterol-laden food, and perhaps figure out a way to increase our endothelium's ability to produce nitric oxide synthase to fix that.

[@royzlatanestevez9843]

Help I am aging. What can I do???

[@bridgepoc]

You said Hypoxia increases VEGF. Species with lower breathing frequency per minute live longer too. I wonder if taking less breaths is a good idea?

[@roboslug7582]

Or maybe sleep in an altitude chamber, like some of the elite endurance athletes do. There are fairly affordable systems now that simulate high altitude by scrubbing oxygen out of the air. They can even convert an entire room in your house to an altitude chamber. For a full conversion it's around $25K, but if you're really committed to either endurance sports or just general cellular health, maybe that's a worthwhile investment.

[@ascended17]

@@roboslug7582 or you can just simply move to an Andean country and go for jogs at 2700mts above sea level

[@platos9054]

I was hospitalized 2 weeks with Covid pneumonia and Myocarditis. Long story short, my doctor told me to get cytokines test. My VEGF WAS through the roof, 10.7 above the Maximum limit. It’s been a year and VEGF still super high.

[@Earwaxfire909]

Some sirtuins cause cancer and some extend life spans. Perhaps like sirtuins there are some forms of or modifications of VEGF that feed cancers and some that have positive affects? Would be interesting to look at the PTM's of young verse old to suggests tests.

[@kral3046]

Wish Extracellular Matrix Stiffening got some attention too, also Japanese subtitles are lit!

[@robertrowan9893]

And your's truly only really associated it with serious eye problems. Maybe in time, it will become my serrapeptase complex's brother in arms. And while we're on the subject of blood, is any adjunct to breaking down microplastics in the body bearing fruit? Can't see those little critters helping matters much in this respect.

[@kebugcheck]

what software and hardware you use to make these videos where you can write and draw on screen?

[@chuteboxegod]

my VEGF is 46.7 pg/mL. Is this bad?

[@radar5464]

Believe it's supposed to be roughly between 30 and 80

[@rhyothemisprinceps1617]

3:06 that aging plasma proteome thing looks nifty

[@KenOtwell]

What's the data on best VEGF-inducing exercise? SIT/HIIT is most efficient for VO2 increase... would that imply it's also best for VEGF stimulation?

[@rhyothemisprinceps1617]

Yes ( HIIT ups PGC1 alpha)

[@2piecesofwood1pieceofrope]

The Kiveloff isometric technique was designed by a doctor to support the vascular system. It’s quite effective

[@jackbuaer3828]

Regular aerobic exercise increased VEGF levels pubmed.ncbi.nlm.nih.gov/33949164/

[@rylaczero3740]

Someday some mouse is going to be living for a really long time for all the sacrifices their species have been making for these experiments.

[@terjeoseberg990]

We can already cure every cancer in mice, and if they’re run over by a car, we can make their spine grow back. We know everything there is to know about mice.

[@neilchristensen538]

Interesting!

[@BigHelianthus]

Is Hypoxia the only thing that seems to induce VEGF? I'd be curious to see if it can be induced by other things like prolonged fasting. I know prolonged fasting can turn SIRTUIN pathways on (totally unrelated to VEGF but hey, maybe?)

[@rhyothemisprinceps1617]

PGC1 alpha, then there are things that induce HIF signaling without hypoxia like lactoferrin and possibly anthocyanins; I think inhibiting prolyl hydroxyprolylase would do it. Then Aviv Clinics' method of intermittent HBOT is supposed to mimic hypoxia (there's a Popular Science article on it you can google).

[@jackbuaer3828]

I don't know if there is a study on prolonged fasting. However, there is one on intermittent fasting with respect to adipose-vegf. Intermittent fasting induced adipose vegf in this study. I am not sure how relevant it is. Reference: Kim, K-H. et al (2017). Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage, Cell Research DOI: doi:10.1038/cr.2017.126

[@BigHelianthus]

​ @jack buaer ​ @Rhyothemis princeps Wow, thank you both for your insightful replies!

[@rhyothemisprinceps1617]

I just came across an article that reported increase in HIF signalling by prolyl-hydroxyproline, a collagen peptide - which resulted in more EPO and less hepcidin, correction of anemia - Zhu et al 2020

[@manmoth4]

BPC 157 is known to be very pro-angiogenesis

[@raeRenae1]

Making smoking caused it to be high

[@Anne_Onymous]

5:30 (?) .....Why?

[@raeRenae1]

488 pg/ml

[@songshen9841]

Woah.... Isn't this +48% of maximum lifespan dead close to what Aubrey de Grey calls "robust mouse rejuvenation"?

[@hawkeyeplank]

Slowly but surely squashing all the bugs in the human genome