Versatility of Modular Antibodies: Rapid Format Switch to Fast Screening of Libraries & Bispecifics

The SpyTag/SpyCatcher protein ligation technology is a versatile method to covalently link two proteins. Addition of the SpyTag protein ligation technology to antibodies creates a modular platform that offers a wide range of new opportunities. In this webinar Dr. Ylera will demonstrate the use of Spytagged antibodies in combination with prefabricated SpyCatcher modules for rapid site-specific labeling, as well as changing antibody valency, species and isotype. Furthermore, Dr. Ylera will present the use of SpyTag for antibody phage display selection (SpyDisplay) and for the generation of prototype bispecific antibodies. The work presented illustrates how these technologies work hand in hand for the generation of new therapeutic lead candidates.
About the speaker
Francisco Ylera is the head of the R&D team that generated the Pioneer Antibody Discovery Platform. He has been with Bio-Rad for over 18 years. Francisco has worked on customer antibody generation projects involving design, selection, antibody characterization, and technical support, as well as method optimizations. Francisco holds a diploma in chemistry from RWTH Aachen University, Germany, and a Ph.D. in Biochemistry from the Free University Berlin, Germany. After his Ph.D., he did a postdoc at the Harvard Institute of Medicine, Boston, USA.

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SpyTag/SpyCatcher is cool technology. Especially the way it can be integrated into different applications looks very attractive.