Walyon J. Hastings & Christian Behrens @ 2024 Biomarkers of Aging Conference

Waylon J. Hastings and Christian Behrens discuss Bayer Pharma's Hurdle Project, focusing on translational biomarkers of inflammaging for precision health. They highlight the project's collaborative development, omics-based quantification of SCI biomarkers, and the integration of the InflammAge clock, which outperforms traditional cytokine and DNAm clocks, with future support through the Biolearn platform.
Timestamps:
[00:00:13] Christian Behrens on the translational biomarkers of inflammaging for precision health
[00:02:12] Waylon J. Hastings on how partnerships came together to develop the Hurdle project
[00:03:20] Omic-based quantification of SCI biomarkers (inflammation)
[00:05:04] The Hurdle Project: collaboration breeds success
[00:06:48] The Hurdle Framework
[00:10:15] Testing Hurdle datasets with the InflammAge clock to predict SCI outcomes
[00:12:08] InflammAge outperforms blood cytokines and untargeted DNAm clocks
[00:13:07] Conclusions and future directions including Biolearn integration
Dr. Waylon J. Hastings, Assistant Professor in the Department of Nutrition at Texas A&M University, specializes in developing and validating methods to measure biological age and functional decline. With a dual-title PhD from Penn State, he collaborates with the Telomere Research Network, CALERIE™ Clinical Trial, and COMETS to explore the impact of stress and metabolism on aging mechanisms. His work, featured in outlets like Science Daily and the New York Post, aims to enhance interventions for improving healthspan.
Dr. Christian Behrens is an Associate Director of Medical Affairs at Bayer Pharmaceuticals.
Learn more about the Hurdle project here: hurdle.bio/