Weekly Research Updates for June 29, 2024

00:00 Introduction and Dad Jokes
01:02 Expert review of nonstimulant medications for adult ADHD
06:14 Review of effectiveness of monoamine oxidase inhibitors in ADHD
08:01 Gaming addiction and ADHD
10:35 All-cause mortality and suicide in ADHD
14:00 Exercise intensity and improvements in executive functions in ADHD
15:32 Conclusion
Research Discussed in the Video
Current nonstimulant medications for adults with attention-deficit/hyperactivity disorder
GE Brancati, A Magnesa, D Acierno, M Carli… - Expert Review of …, 2024
doi.org/10.1080/14737175.2024...
Efficacy and safety of monoamine reuptake inhibitors in attention deficit hyperactivity disorder: A Bayesian network meta-analysis
S Maji, A Mishra, MK Ramasubbu, D Mohapatra… - Journal of Psychiatric …, 2024
doi.org/10.1016/j.jpsychires....
Problematic gaming, psychiatric comorbidities, and adolescence: A systematic review of the literature
R Coutelle, J Balzer, J Rolling, L Lalanne - Addictive Behaviors, 2024
doi.org/10.1016/j.addbeh.2024...
Longitudinal study on all-cause and suicide mortality among individuals with attention deficit hyperactivity disorder
JS Jeng, HH Huang, WH Chang, CM Cheng, TP Su… - European child & adolescent …
DOI: 10.1007/s00787-024-02511-w
Optimal exercise intensity for improving executive function in patients with attention deficit hyperactivity disorder: systematic review and network meta-analysis
JW Chen, WQ Du, K Zhu - European Child & Adolescent Psychiatry, 2024
link.springer.com/article/10....

[@cflam939]

Dr. Barkley, just a minor correction for the second paper. The monoamine reuptake inhibitors (MRI) are not monoamine oxidase inhibitors (MAOI). For example, venlafaxine and duloxetine are SNRI and bupropion is an NDRI. MAOI is another class of drug, which include drug like selegiline. Usually when I see 'monoamine xxxx inhibitors' I would assume it is MAOI too, so it explains the confusion. I hope I don't come across as nitpicky. Thank you for your work as always!

[@Dietconsulting]

Having been on all 3 classes I appreciate the nitpicking

[@Keddlecorn]

I've always been sick of people insisting that video games are dangerous, cause violence etc, but then I remembered that at the height of my world of warcraft adventures I often forgot to eat, sleep and bathe lmao. I guess people dont generally do that with other hobbies, severe adhd here. I used video games to cope and escape.

[@trinesrensen560]

Also ADHD here, and pretty much my entire adult network of friends and aquaintances are ADHD or some kind of autistic with ADHD. This is something that we do when we get absorbed into our hobbies regardless of what they are. Ever almost peed yourself on the way to the toilet because your book was too interesting to put down? Haha, the book that you can perfectly well take with you if you want to even XD

[@courtneyriley185]

That was because of your ADHD....it wasn't the game. Stop blaming games and blame yourself

[@ChristianConstitutionalist3192]

There's nothing dangerous about playing video games.

[@thejb8232]

Dr. barkley Thanks for your insights . But can you also comment on quality of these research papers.

[@stephensmith1461]

How about Modafinil? . this drug is widely prescribed off label for people with ADHD but you haven't ever spoken about it

[@kenhaze5230]

The evidence for it is very poor and it is plausibly completely worthless for this indication. I'm agnostic, but I think it's plausible it's used for simplistic mechanistic reasons-it targets, in part, the dopamine transporter-and is Schedule IV, making it less of a headache.

[@Herfinnur]

He’s mentioned it quite often through the years

[@stephensmith1461]

@@Herfinnur could you please drop a link of a video he mentioned Modafinil in it ?

[@kalibininsabunu]

I use Bupropiyon and Atomexetine on a daily basis they work just fine when used together with supplanted with Omega 3. I am not against stimulants I used them too - and still using- but on long term my body develops tolerance those trio prevents tolerance. 👍🏻 ☺️

[@trewdat361]

Thank you for dad jokes and adhd information!

[@Millennial_Manc]

5:52 Interesting that agomelatine and modafinil don’t feature on such a long list.

[@samaug406]

Thank you Dr. Barkley

[@piotr780]

what about problematic internet use ? It could be more common among adulths with ADHD then gaming addiction and is somehow similar

[@Thebodymechanikk]

Thanks Dr Barkley !

[@AzilizAziza]

Playing videos is not about ‘poor impulse control’. It is about self-medicating: video games are designed to deliver dopamine to the brain in copious amounts. The brain will seek a way to meet its needs and double down on whatever works.

[@sonyaparkin7841]

Thank you Dr. Barkley! 💚

[@nurikeeyuki9828]

I feel like I have SCT and ADHD, no medications have really worked for me, but some strains of Sativa Cannabis worked to solve my issues, might be some chemicals in the cannabis cocktail that need to be looked into.

[@DavidEllsworth-fb4rz]

Thanks Dr. for your insight.

[@amg8430]

This is gold🙌thank you for what you do

[@chantelleknight566]

Russell can you do a handful of current studies on the efficacy of psilocybin for ADHD ❤

[@dougdean8996]

I have tried different meds for my adhd. I’m 68 and with the meds I had to stop because they made me have a sense of wanting to go the bathroom all the time. My pharmacist suggested I take one pill every third day so my body becomes used to it and gradually take it every second day and if all goes well every day. Can you offer my your opinion on this approach.

[@nurikeeyuki9828]

Whats the difference in ADHD and SCT with links to Aphantasia?

[@ethimself5064]

I came across a newer stimulant a year or two ago that is only used under certain circumstances, Can not remember the name as it is not approved in Canada. From what I remember it was a prescribed metathatmine(crystal meth). Does anyone know the name of it as I can check at my pharmacy to see if it has been approved by Health Canada. In short I have been diagnosed with a neuropathway blockage for the regular stimulants. I refuse to take antidepressants as they all failed miserably with bad experiences. Thanks all

[@RoSa-kr8hy]

The drug is called methamphetamine. In the US, the branded name is Desoxyn, but I don’t know of that’s the same in Canada.

[@ethimself5064]

@@RoSa-kr8hy Thanks, I will check out

[@ginaorange]

It’s common to be prescribed a combo of bupropion and a stimulant for ADHD, but curious, do people ever get treated with atamoxetine and a stimulant at the same time?

[@orangez1986]

My doc recently suggested I could take both

[@ginaorange]

Thanks, that’s interesting and good to know!

[@jhmstagg9104]

Interesting, interesting. Thank you

[@jobrown04]

Quick question, what's the definition of problematic gaming? Is this defined equally in the papers?

[@jophillipsillustration]

It baffles 🤯me why anyone with ADHD wouldn’t try medication with these amazing results and your research ! It has been utterly life changing for me. I get their maybe medical issues where you can’t take them, but to just say you can’t to try herbal thing… it just, I can’t seem to get my head around it!?

[@cassiemcleod5397]

I am convinced it must not be that severe. Perhaps this is just my snap judgement but I am in the thick of it right now with 2/3 kids severely impaired by ADHD plus myself and my partner...I've never been a person who was quick to medical intervention, but I am sure that I would not be here today without it. Even on combination therapy...we are barely living at all. Just existing. I don't have the luxury to look for "alternatives". Sorry, I am in a bit of a funk right now with what seems to be a trend of people jumping on the ADHD bandwagon and in my opinion it's worse than the traditional stigma around ADHD. So the highly judgemental position I've taken (and I realize it's not accurate) is if you feel the meds are optional, then...it's likely not ADHD.

[@jophillipsillustration]

I can understand your point of view. Do you have people around to give you breaks? It sounds a real struggle. I am utterly astonished (still) with how effective this meditation is for me! I’ve just started ADHD therapy/coaching too now and I’m feeling positive about the future and a possible career (at 48!) Hang in there, little ones are a joy but also overwhelming, even without everything that comes on top with neurodivergence! ❤x

[@CarlosAlmadaPsi]

Dr. Barkley, I'm doing research on the sexual behavior of people with ADHD. Could you make a video about this or point me to some reliable articles on the subject?

[@russellbarkleyphd2023]

See my short video here on risky sexual behavior and ADHD. You can also find it using Google Scholar to search the journals.

[@CarlosAlmadaPsi]

@@russellbarkleyphd2023 Love You!!!

[@CarlosAlmadaPsi]

@@russellbarkleyphd2023 Hello doctor. I watched your extraordinary video about the sexual behavior of people with ADHD. And I went to Google Scholar to search for the articles. It turns out that in my article I need to cite other publications, and in your video references to the data presented do not appear, even though I understand that you are the greatest reference on the topic that we have today. Thousands of papers appear on Google Scholar, but most are not relevant to my article. Could you help me with some references, please?

[@capgains]

Peptides like Semax, Selank etc are getting some attention and interesting testimonies. Also Cerebrolysin looks promising for adhd based on reviews

[@trewdat361]

Has Dr. Barkley ever discussed potential relationships between adhd and marijuana use?

[@megzin00]

I don't recall one from Dr. Barkley, but perhaps I just don't remember it ...though the research has been done and is available

[@zachhanks4399]

FWIW, IIRC, in a conference lecture a decade or so ago (a video of which is among his most popular, I think it’s the “30 Essential Ideas” playlist), in talking about ADHD and *substance abuse,* I think he said that of all the drugs of abuse, marijuana was the most pernicious for people with ADHD. To be clear, that’s an indictment of *recreational marijuana use and abuse.* Whether or not cannabinoids have medicinal potential for ADHD symptom reduction under more controlled conditions (dosage, etc.), is a separate issue.

[@trewdat361]

@zachhanks4399 ahh thank you

[@RebeccaLynnMusic]

Is anyone else on trintellix and Ritalin? I would like to discuss this with you.

[@courtneyriley185]

if they need a study on weed and ADHD benefits, ill volunteer. It got me off all meds for depression and ADHD. I smoke three times a day sometimes just twice .

[@Deviliza]

"Even if you make it to midlife"?! 😮 LOL - that is just about the worst sentence. You make it sound like only about 3 out of 100 people with ADHD will make it so far. It's not Halloween yet 😆

[@kimdennis3259]

Auvelity off label for ADHD.

[@ChristianConstitutionalist3192]

Caffeine, nicotine, Marijuana, video games, going to the range, and working are the best for ADHD.

[@ChristianConstitutionalist3192]

I've already been treated for ADHD and other disorders; I Do Not Need Treatment. Getting Treatment is For Minors and Women.

[@pldean]

If caffeine, nicotine, marijuana, video games, going to the range, and working are 'the best' treatments, are you advocating the same for children? And, either you are a child or a woman, or by your own words you should not be trying to use your 'treatments'? I'm glad you found some things that help you but why deny other adult males from trying to find medical help?