What are myeloproliferative disorders? | Hematologic System Diseases | NCLEX-RN | Khan Academy

[@laurelharris7244]

Neoplasms have been the term of art for more than a decade. Classic MPNs can go from ET to PV to MF. These videos are great!

[@ingorichter649]

The best and clearest education regarding to this complex medically important biology in my opinion! Many thanks from Berlin 🙏

[@kamelkachin7848]

Easy way to memorize it !!!!!!!!!!!!!!!!!!!!!!! It 's crafted Thank you so much .

[@sabrinazeleke7083]

Thank you!!!!!! I learned more from this video than I did from my four-hour lecture

[@damiettes7140]

This is a FANTASTIC explanation ❤

[@HafizahHoshni]

Awesomely informative and perfectly explained! Thank you so much! 😊😊 20/7/2019

[@heemvaniawala4740]

Hello! I study Regenerative Medicine at Case Western and I noticed you defined the bone marrow stem cells as pluripotent. Thats not quite right, they are actually multipotent. The difference is that pluripotent means they have the ability to differentiate into all kinds of cells including embryonic cells. When people age, your stem cells will lose they differentiability which makes them mulitipotent. Thanks for reading and I hope this helps!

[@heemvaniawala4740]

@@Ab_43336 Hey RT! Thanks for being so honest about what you are going through. I would suggest you investigate which bone marrow transplant options are possible for you. It is a little daunting to think about, but there are amazing therapies that can possibly help you. Cord blood has a very rich source of hematopoietic stem cells, which are the best options for transplants. The Cleveland Clinic, Mayo Clinic, and some west coast hospitals are involved with many regenerative therapies. They may not give you a treatment since cord blood has not been FDA approved for thrombocytopenia, but it is worth a try if you feel like your quality of life is suffering!

[@HollySnagletooth]

This was so helpful, thank you soooo much! You make the best videos!

[@Even_cats_smile]

Life saver!

[@unsasajjad4895]

Really amazing channel khanacademy.....🤗 very helpfull lectures to understand hectic topic

[@serra-nw8ce]

Oh my gooood that was helpful

[@aliberapinarbasi7859]

thx 4 the great work Khan this videos are really helpful for me to learn

[@StanleyMcdude]

The point about essential thrombocythaemia never transforming is not strictly correct. It can happen, but just very rarely: ‘The 15-year cumulative risk of transformation to AML [of essential thrombocythaemia] has been reported to be in the range of 2% to 5.3%’ - BMJ best practice

[@Asooy22]

Thank you 👍

[@lisek2750]

I don't understand what you mean by acute leukaemias having to have a defect before the leukocytes are put out the bloodstream? Why does not essential thrombocytopaenia have an associated acute leukaemia?

[@nurulasyiqin1654]

me too

[@AymanSmairat]

i searched about this , i found that AML is involved in essential thrombocytopenia in 10% of cases

[@Persason]

@@AymanSmairat Yes but most likely because ET can progress to PV (Polycythemia vera) which is associated to AML. Both ET and PV are as a result of a JAK2 kinase mutation. Also AML has many subtypes it can be a monoblast, myoloblast, megakaryoblast and even rarely proerythroblast AML. It doesn't always have to be in the myoloblast line. So in theory an Acute megakaryoblastic leukemia could also be able to take when you have ET. I may be wrong in all of this though. But these videos are often somewhat simplified.

[@carolweaver3269]

Thrombocytopenia is like Neutropenia, Leukopenia etc. The Thrombocytopenia is the platelet count. The Leukopenia the White Count being low, and Neutropenia is more fungus related. There are a few. But they are something watched, but a doctor as it could turn to the Leukopenia. But it may not, as well. So they watch it closely over time. These things can turn into acute Leukemia. Cancer of the blood. This is my understanding. i have Leukopenia and I read alot to check things out and on You Tube plus make the Dr's talk with me, and explain it all to me, as I do want to understand. I have several problems and I am in my 70's, but just want to know where I stand.

[@aparnasahu7513]

order of formation of cells are RBC > leukocytes > monocyte > platelet ??????

[@christinagurrola5335]

Will a flow cytometry pick this up? I have enlarged liver and I don’t get answers as to why. I don’t drink and eat very carefully.

[@laurelharris7244]

Doctors don’t think rare cancer. Get a JAK2 test if your spleen is also enlarged.

[@kozhyarazad4024]

❤

[@beginnerstimelapse5707]

This is not true that a megakaryocyte produces only 6 platelets!!!

[@hajirazaka9066]

👍🏻👍🏻👍🏻👍🏻👍🏻👍🏻

[@fatimaalarabi5581]

Thank you 💗