What is polycythemia vera? | Hematologic System Diseases | NCLEX-RN | Khan Academy

[@atharareeb]

I just discovered your channel and I can't stop watching. It's like a whole new world of information has opened up to me. Your explanations are very vivid and make concepts crystal clear without putting too much pressure on the cortex. Much love. And huge thank you.

[@googleuser9266]

I SOOOO HAVE TO SHOW THIS TO MY PROFESSOR TOMORROW.... GREAT WORK!! VERY CONFIDENT ABOUT MY TEST TOMORROW!! THANKS SO MUCH...

[@JuicyCharon]

My Mneumonic for PV = *POLycyTHEMIA V* P = Pruritus, Petic ulcer O = Osteoporosis L = ↑Load on Heart → Hypertrophy and failure y c y T = Thrombosis (Stroke, MI, DVT, Hepatic Vein, Retinal Vein) H = Hepatosplenomegaly, Hypertension, Headaches E = Erythromelalgia (Hand and foot pain) M = Myeloproliferative disease I = IFN Alpha A = Arthritis (Gouty - destruction of Red cells leads to increased release of Uric acid) V = ↑Viscosity (Hematocrit ↑), Venesection

[@natashakandy5384]

Very nice....👍

[@christinevakas92]

Thank you so much - drawing and correct spelling information on the slides helps with clear memory recall. Greatly appreciated.

[@imvk9861]

well prepared, direct, informative video. As a med student(intern) i didn't expect that. Really good job . hope you keep uploading thanks :)

[@maryweist-izar9850]

This is a treasure, thank you!

[@othoncezar]

For treatment, add also Aspirin

[@donnieray6568]

and give blood the dr told me but im not

[@FlipMacz]

Yesssss

[@uliceacosta2551]

It’s a very very good explanation about PV. Really good video to understand how the disease is set up. What I would suggest is to talk about the main first factor that influences the expression of PV, which is the hypoxia detected by kidneys.

[@robertshrewsbury2891]

I had Polycythemia and had to get a phlebotomy about once a month, because my Hemoglobin was around 55 g/dl and my Doctor ordered it. Finally I wondered about people with Anemia that were short of red-blood-cells analogously like an opposite to Polycythemia! Then I looked up the foods that people with Anemia do not eat because they are iron blockers. Many of these foods are called Oxalate's and absorb Iron. So then I started eating these foods (with Oxalate s) abundantly and after a few weeks I had my Hemoglobin checked by my Doctor and my Hemoglobin was down to 16 g/dl and now over a year later my Hemoglobin is still 16 g/dl. That is a drop of 39 g/dl’s in a very short time and it held good. Sometimes just a simple procedures are workable. Of course I believe that my mental procedures, meditations & thoughts had something added to this procedure that was synergy related that made it more effective. Make it clear that I am not prescribing anything to anyone, but expressing my own thoughts and experience. However I would recommend that medical personnel investigate this. Cordially, Robert Shrewsbury

[@clarissaespinoza9234]

Can you give some examples of foods that you have been eating? I just got diagnosed with PV and my doctors haven’t really given me anything to help my symptoms. I’m really frustrated rn because it’s impacting my day to day life.

[@robertshrewsbury9344]

@@clarissaespinoza9234 I lost some files when my hard-drive went bad and do not have these foods available anymore. The way I found them was to put in the phrase (on the web) "foods that anemic people should not eat" and it came up with a big list of foods not to eat because they are iron absorbers, sop my extrapolation was that these foods would absorb enough of my iron to help me and it worked for me. It has been two years now and my hemoglobin is still 16 gdl's, instead of 55 gdl's and I was only on these foods for a short time. I uses to use Oxalic acid in my laboratory to take the iron out of ore. Good luck Robert

[@mysurfing3550]

I have pv, but have iron decency I'm making a ton of rbc, if I had few Id be anemic, but I just have a ton of "anemic" cells....

[@robertshrewsbury9344]

@@mysurfing3550 Good luck!

[@dantheisen35]

@Robert Shrewsbury same here

[@paulojustinianookubo]

Amazing explanation !! You have the talent to be a teacher !!

[@tekpacliffrd8372]

Well explained 😊 Thanks for your great work 💯

[@jglezpr]

The best informative video I have seen in regards to this subject. Been trying to understand what is PV. Now I need to know what is the JAK2 test. 😂 Thanks

[@sausalitoindaylesford1260]

All of the MPNs are rare blood cancers, and have been called Myeloproliferative Neoplasms, as opposed to 'Disorders', since 2008. It would be great for this to all be amended on Khan Academy. Cheers. Otherwise, these are fab videos and I thank you.

[@pauletteshoemaker]

Zillor

[@jellybeanpower6269]

I have this disease! It's nice to know a bit more about it :) (PS. The first time my doctor told me about it I felt like a Teenage Mutant Ninja Turtle because of the JAK2-mutation)

[@leavemealone6100]

u can get heart attack or a stroke

[@natelindsey7778]

How are you doing now?

[@jellybeanpower6269]

@@natelindsey7778 I am doing quite great regarding my polycythemia vera :) ever since I switched to the newest treatment my blood counts have been exceptionally good - like a healthy human! The only problem I have is the remains of when I was untreated, before I could get a diagnose and medication. I suffered a blood clot inside my liver at 15 years because of the thick blood and developed a liver disease. So really, if I only had polycythemia vera and if it was caught earlier I wouldn't have any major problems right now. But my liver is not doing too well and it affects my whole body and I don't think I will be able to bear children in the future, my body just might not be able to handle it. This story went from positive to kinda sad hehe, but i guess it's a disease that can be devastating if not treated. I hope you are alright?

[@natelindsey7778]

@@jellybeanpower6269 I’m glad to hear that you’re doing well from this disease & hope for better outcomes with your liver soon. I was just curious cause I’m only 26 years old & went for a physical and found that my RBC’s, hemoglobin, and hematocrit were barely over the elevated range. I have been pretty worried about potentially having this disease at such a young age

[@jellybeanpower6269]

@@natelindsey7778 the disease normally hits in the 50s but I am living proof that it can happen at any age although it is very rare for younger people to get PV. I am 25 right now and have been living with PV for 10+ years. If you are worried then maybe ask your doctor about it and the quickest way to rule it out is to do a simple blood test to check for the JAK2 mutation. Don't worry yourself too much until then 🫶

[@teateekg6829]

Thanks so much for the lesson. I'm going to do a PV pathology test next month. 🔮 and see what happens

[@robertshrewsbury2891]

I had Polycythemia and had to get a phlebotomy about once a month, because my Hemoglobin was around 55 g/dl and my Doctor ordered it. Finally I wondered about people with Anemia that were short of red-blood-cells analogously like an opposite to Polycythemia! Then I looked up the foods that people with Anemia do not eat because they are iron blockers. Many of these foods are called Oxalates and absorb Iron. So then I started eating these foods (with Oxalates) abundantly and after a few weeks I had my Hemoglobin checked by my Doctor and my Hemoglobin was down to 16 g/dl and now over a year later my Hemoglobin is still 16 g/dl. That is a drop of 39 g/dl’s in a very short time and it held good. Sometimes just a simple procedures are workable. Of course I believe that my mental procedures, meditations & thoughts had something added to this procedure that was synergy related that made it more effective. Make it clear that I am not prescribing anything to anyone, but expressing my own thoughts and experience. However I would recommend that medical personnel investigate this. Cordially, Robert Shrewsbury

[@dineshreddy5037]

@@robertshrewsbury2891 Can you name that foods please:)

[@robertshrewsbury2891]

​@@dineshreddy5037 The names of the iron reduction foods are called Oxalates. My hard drive went bad on me and I lost the data on the exact names of these foods. You can get on the web and type in "foods that people with Anemic Anemia should not eat" I know one person that diluted Oxalic acid to 6 on the Ph scale and drank it, a spoonful or two per day and it dropped his hemoglobin down for two days at a time and fast. He had his blood tested after 3 days and it dropped 20 gdl's so I would be very careful. There is no Doctors in their right minds that would indorse this and I suspect that the Spleen can get overloaded"?? By the way I had another blood test on Jan 26th 2021 (two years after I got well) and my hemoglobin is 15.9 gdl's. Keep in mind that I flanked this procedure with a metaphysical/spiritual process where I sent a message to my femurs to stop producing so much iron and reduce it down to 16 gdl's and I focused on my Femurs and repeated this a number of times. This worked for me and I am still experiencing the benefits. Cordially, Robert

[@sugarrayleonard7162]

@@robertshrewsbury2891 bro.I think I had this kind of disease.How are you today? If you dont mind, I would want to get some tips from you to reduce my RBC.

[@NileshKumar-Dl1wli]

@@sugarrayleonard7162 have you done any tests related this disease

[@MarcusElliot]

Excellent Explanation Video.

[@katentropy]

One of the first symptoms of my dad's PRV was an intense, go-to-bed-3-days, allergic reaction to zucchini and melon. Later in the disease he had severe pruritus that was relieved by UVB light therapy. The allergies to these foods never went away. In fact, he ended up getting comprehensive food allergy testing that showed numerous reactions to food and spices, e.g., garlic and ginger. Mom had to sacrifice the spices in her home chef's cooking repertoire.

[@alijaberi9852]

Thanx for very interrsting information about PV !

[@مودهموده-ش1ع]

Nice & clear illustration. Thank you very much .

[@crazzydaissy7915]

u make my life alot easier thankuuu khans academy😁😁😉😉😉

[@JayRazah]

Great video. Is there any natural food to lower platelets count down?

[@robertshrewsbury4241]

I had Polycythemia/cancer and my g/dl's was 62 g/dl's instead of 16 and I had to get a pint of blood (Phlebotomy) drained out of me a lot. So I started taking oxalate foods until my hemoglobin was back down to normal at 16 g/dl's Strawberries are good oxalated, but so is rhubarb, but I thought rhubarb was too much Oxalate, so I stuck with strawberries. I am aware that too much oxalic can also be harmful.

[@Med_Onc]

2 issues #1-mispronounces polycythemia immediately and is reflected in closed captioning #2-he points to a “shaft of long bone” when referring to hematopoietic cells, long bones have mostly yellow (fatty marrow), not red marrow which is found in the thick bones (pelvis)

[@verahealth8045]

Med_Onc1979 glad someone else noticed this, I was about to call him out for using the shaft of the femur, that clearly has yellow bone marrow in most healthy individuals. If he wanted to use the femur as an example he should of talked about the epiphysis regions, those have red bone marrow.

[@campingman1942]

And the hip ( lower right side of back/ pelvis ) . is where they did my bone marrow , not legs or arm bones.

[@ghaithsattout2512]

Can't thank you enough !

[@مسكالختاممحمد]

Oh my goooood you are the best 💕💕💕💕💕💕💕💕💕💕💕

[@EyeintheSky999]

Like to see an update talk about the drug Jakafi and what it does to the body. By stopping all bone marrow production. It was a hell of a ride for me. You also forgot about low EPO as another marker while not the gold standard definitely needs to be considered in treatment. Blood letting is a double edge sword. Take some out body freaks and send orders to make more blood on top of what is being already made. Then we have the headaches and numbness from blood to thoick to flow into some of the smaller places.

[@natelindsey7778]

Are you on Jakafi now?

[@TT-ho5xc]

very interesting

[@assiaaajal4279]

Amazing.. Thank you :))

[@TheYazankooo]

Thank you sooooooooo much :) ♥

[@danieltschull544]

Danke

[@cyndibunnell7479]

You need to add Jakafi to the treatment plan.

[@iqrasalim134]

please change the writing style to a simpler one, its hard to read. thankyou

[@hilalelgargini1846]

Can I expect jaundice in polycythemia vera? Since there's there's an excessive destruction of RBCs.

[@dantheisen35]

Jaundice? Dang I hope not but if you read my comment this is what I’ve felt so far good luck 👍

[@dantheisen35]

I have polycythemia and was diagnosed like 2 months ago… it’s been getting very hard they’re giving me some kind of medication I can’t pronounce … and they have given me 4 treatments and 4 phlebotomys since the treatments were starting I’ve been feeling pretty bad … very verrrrry tired all the time and dizziness nauseous and extremely horrible headaches the worst symptom I’ve had is reoccurring pretty much every day is a kind of vertigo? I get very dizzy (ears ringing and see spots or whatever and like very close to passing out) when I stand up from laying down or sitting for awhile this and huge headaches they’ve taken out 4 500 milliliters of blood in 4 weeks and they just told me I will have to get a phlebotomy every month until my red blood cells are down. It has gotten better and doctors were afraid of me having a heart attack or stroke from the blood being so thick … and I am not positive yet but it could be secondary polycythemia? I don’t have the jak gene or whatever. Anyway I appreciate your video sharing and I was just trying to share my personal experience with this thank you 🙏

[@itbelikethat9031]

What where your numbers like hemoglobin???

[@fannyalbi9040]

try nattokinase as some comment it works

[@babumanu895]

It takes around 12 - 15 months to stabilise till u become iron deficient and then u may have blood lettings for 3 to 4 months ... Drink 4 litres of water a day minimum

[@natelindsey7778]

What’s is your age

[@toukito_]

MEGA SPLEEN! MEGA LIVER! the only mega evolutions you don't want lol

[@darkestnbl]

mega dick

[@dantheisen35]

Yep. They have checked that and said I didn’t have a enlarged spleen thank goodness

[@srshohagh4374]

Awesome

[@marisamozos5776]

Por favor . Lo pueden po er en Español .?

[@nealpaige3907]

How high should the RBC be in men to worry about this ?

[@2001s]

above 6 milliom

[@noumanakbar4200]

Hg >18.5 in men and 17.5 in womem

[@abdullahkhansafi4500]

Nouman Akbar hi bro

[@subratbeura9798]

@@noumanakbar4200 my hbis 16.4 hct is 47.2.rbc 5.75. From india age 40 male....is it polycethemia ? Plz guide

[@Cazanu417]

@@subratbeura9798 thats normal for male and at 40 is rare

[@ggg3172]

rbc is without nucleus the how its causes gout

[@majadbassam1032]

and why there is thrombtic event??

[@Haiderkhan-eg6vh]

i had a question why nucleus disapper when RBCS become mechaver

[@stephenmcwhorter2755]

The nucleus is expelled when the RBC leaves RBM. The lack of nucleus and biconcave shape allow it is to squeeze through narrow capillaries which are smaller than the 6 - 8 μm of RBC size.

[@Siomey88]

@@stephenmcwhorter2755 u are handsome 😚

[@iftikharayoub1892]

sir why u called polycythemia r very interesting disorders in the start of lecture

[@griggsentertainment6463]

Because it is rare.

[@OriginalChelseaMarie]

I love how you emphasize your words, hahah

[@majadbassam1032]

i did not understand whyvthere is hepatomegaly and gout???

[@justinaunogwu298]

Thank you so much Dr Dagba for curing me of polycythemia vera😭🙏🏼

[@hossainhelal5826]

Can i contact with u

[@skarpengland]

Is the Gout, due to increased nucleic acid breakdown, because the increased production of RBC requires more breakdown of nucleic acids? (Since RBC dont have nuclei anymore)

[@jerrygawronski965]

ok

[@williamhicks9752]

what does vera mean?

[@jellybeanpower6269]

+jedtry LMB It means "true" or "real". That is because Polycythemia (AKA secondary polycythemia vera) is considered "fake" because it is temporary compared to polycythemia vera (primary polycythemia) which is a chronic disease. Polycythemia is caused by outer factors while Polycythemia VERA, like mentioned before in the video, is caused by a mutation in the JAK2-gene. (God I feel so smart, this is unusual)

[@alijaberi9852]

Very informative Thanks for the share.

[@googleuser3360]

മിന്നാരത്തിലെ ശൊഭനക്ക് വന്നത് ഈ അസുഖമാണ്😓🙁

[@syeddshah2710]

My hn level is 19 point .but due to height problem .plz tell me treatment

[@syeddshah2710]

Hb level sorry

[@NileshKumar-Dl1wli]

now hw r you sir..do you take any treatment for this

[@babumanu895]

Stay low

[@surendraraidas7167]

sir hindi me samjhao hamari maa ko h polythysemia vera

[@NileshKumar-Dl1wli]

bhai aap ne kaun sa test karaya tha aur ab kaisi hai aapki ma

[@NileshKumar-Dl1wli]

surendra Ji please reply.... main aap ke samaj se hi hu.... please