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Learning objectives
Understand the role of microtubules in the brain and their importance in neuronal function.
Describe the function of tau protein in healthy neurons and how it stabilizes microtubules.
Explain why tau is phosphorylated in healthy individuals and how this process helps neuronal plasticity.
Understand the process of hyperphosphorylation in tau and its connection to Alzheimer's disease.
Describe how tau tangles form and spread throughout the brain in Alzheimer's disease.
Discuss other diseases in which tau pathologies are present and how they differ from Alzheimer's disease.
Understand the relationship between tau phosphorylation and inflammation in the brain.
By the end of this video, viewers should be able to explain the critical role of tau protein in the brain, how its abnormal hyperphosphorylation leads to neurodegeneration, and the link between inflammation and Tau phosphorylation.