Prions | Mechanisms and Theories of Alzheimers Disease (Amyloid & Tau)

[@chineduachimalo391]

The intro killed me😂

[@israelduarte1189]

It's stupid

[@rafnavi4500]

@@israelduarte1189 and that's why it's (somehow) funny

[@palwashasahar1146]

Very well explained both pathways, thank you

[@MuhammadNaeem-lr4vp]

well, as per my knowledge you have missed the work of secretases as Alpha and Gamma secretases cause a healthy breakdown of protein while beta cleavage is misdirected. But in the video, you said gamma-secretase cleavage cause disturbance that's not true. Please go through the latest articles and correct me if I am wrong. Thanks

[@NMKL211]

Means a lot to me. Thank you respected sir for such an informative video it really helps me a lot in clearing my confusion and in my assignment making.

[@auroradiaz3148]

Muy buen video ! Thank you so much ...greetings from Perú :)

[@CatalystUniversity]

Thank you, Aurora!

[@dartholiver]

Hey Kevin, could you post a link to the articles that you used for this video, i would like to credit the pictures :)

[@CatalystUniversity]

No problem: 1) molecular characteristics of alzheimer's disease: science.sciencemag.org/content/358/6359/45/tab-figures-data 2) Tau microtubules: www.sciencedirect.com/science/article/pii/S0531556516305800 Other picture: 3) molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-2-22

[@timblackburn1593]

Fantastic summary, thank you

[@killianpapail9324]

Hi, very good work, thank you. I have a question : what is the link between Tau misfloding and hyperphosphorylation of Tau ? Does Tau is hyperphosphorylated because it is misfloding ? If someone anserw to my question, I thank him in advance. Happy new year 2022!

[@omargarciafernandez7376]

I was wondering, why does the calcium influx cause apoptosis and not necrosis?

[@veccio]

Because the Ca+ itself is considered an apoptosis signaller at a certain level, I think. pmc.ncbi.nlm.nih.gov/articles/PMC1569591/

[@trebleclef3886]

50% of patients with the plaques do not exhibit Alzheimers symptoms so I would rule that cause out. How does a prion develop? That is the question.

[@hydrocarrot229]

Thanks man, but I have a question what is sAPP

[@leila189]

merci beaucoup !

[@atijorogloria4070]

So helpful

[@rivamuhammad794]

Thank you soooo much

[@ryanrohrbacker7431]

this is honestly not right at all in regards to pathophysiology and microphysiology of how plaques and tangles are caused . The basics are mentioned just not the intricacies on how everything comes together. for example tau proteins don't unfold , they’re hyper polarized through hyperphosphorylation from the amyloid beta plaques outside the neurons themselves causing clumps giving a weak cytoskeleton within the neuron. Then with the weak and half dead neurons they clump up and cause neurofibrillary tangles. Amyloid beta plaques are a whole other beast, they’re outside the neuron not within the neuron.

[@celinat8622]

Had exactly this doubt, I'm learning about prions and the diseases they cause. I think the PrP protein has nothing to do with tau and amyloid beta right?

[@bonnenaturel6688]

@@celinat8622 Other resources say it is double prion disease involving tau prions and amyloid prions, which is difficult to believe. I believe the researcher is Prusiner.

[@johnmandrake8829]

the intro made me question everything

[@liamflaherty6362]

Thanks for the informative video, the intro is a bit fucked but everything else is gold. Cheers Cobba

[@kandiceblu1]

Is ALS a Prion Disease?

[@robertchampy3489]

Filamin A