What Does My Tumor Grade Mean for Breast Cancer? Expert Insights

[@merabakr7954]

She is not only explaining some complex idea in simple words and terms, but also makes one calm down with the way she talks and presents the facts. Well done!

[@yerbba]

Thank you for your kind words and positive feedback. Your support means a lot to us!

[@sindeekaye2223]

I learned more from this video than 3 doctors I’ve seen. 👌🏽

[@yerbba]

Glad it was helpful.

[@carolynspencer789]

Glad i came across this video . I have NEVER heard any explanation about grade3 like this. Thank you

[@yerbba]

We're so glad the explanation helped! Grade 3 can sound scary, but understanding the details makes it less overwhelming.

[@gabrielladegollado]

Amazing explanation of breast cancer, wish every doctor was careful with words.

[@yerbba]

Thank you for your kind words! We're glad you found the explanation helpful and supportive.

[@charlottekiziuk6246]

Thank you so much for creating these videos. They really break things down for the lay person to understand and are very thoughtful towards use of language. I've really valued these as I've moved through my cancer journey. ❤ I only wish the yerbba report linked in for UK health systems. I'm going to ask for a copy of my histology report. 😊

[@yerbba]

Thank you so much for the kind words. We're glad the videos have been helpful to you on your journey. It’s great that you’re planning to ask for a copy of your histology report-it’s so empowering to have all the information in your hands. We hope to expand the availability of the Yerbba Report in the future.

[@rhondacolombo5129]

I learned more from this doctor than mine. I’ve been through surgery and radiation. Now I’m supposed to take arimidex and I am concerned about side effects.

[@yerbba]

It's completely normal to worry about side effects from a new medication, especially one that has a bad reputation for side effects. Many people who have side effects on one aromatase inhibitor do really well on another one--even though they work the same way. Here's hoping that you feel okay on it. If it helps to know this...endocrine therapy is even more effective than chemotherapy in people with hormone receptor-positive breast cancer. Work with your medical team if you get side effects. We have an upcoming video on the aromatase inhibitors. Thanks for watching.

[@rolandholtz8250]

I am here to search for information, not to listen to music. The clarity of speech is more important than tunes. In delivering such information, there is no need for entertainment, whatsoever. You as a person are affectionate and empathetic. The way you speak out is good, there is no need for anything else.

[@yerbba]

Thank you for watching and your positive feedback. We've taken away music from all of our more recent videos.

[@realtalk8730]

Thanks so very much for this very informative information.

[@yerbba]

Thank you for watching and your comment. We appreciate your support!

[@user-cy5ls9ge8w]

Mam i am diagnosed with T1N0M0 WITH DCIS MACROPAPILLARY last year . Mam what sre the chances of reocurancee tumour is 1-1.5cm negative lumph nodes no invasion and doctor have done left mastectomy

[@yerbba]

With ductal carcinoma in situ (DCIS), the prognosis is excellent.

[@user-gr6xz7ri8b]

I had stage 1, tumor grade 3 TNBC. Invasive. Chemotherapy,surgery, chemotherapy. KI 67-50%.

[@yerbba]

Thanks for writing. Wishing you all the best.

[@dmarchetti4093]

Just found via 3d Mammo and ultrasound a blocked milk duct, having a needle biopsy soon Thank you your videos are easy to understand

[@yerbba]

Thanks for watching. Let us know if you have ideas for other videos.

[@gracegellacone7768]

Well explained❤

[@yerbba]

Thank you for the positive feedback!

[@jeanniesabol5410]

If DCIS can't spread, why treat it? Or, it hasn't yet sprea and can' spread if it isn't treated?

[@yerbba]

Such a good question. Although it cannot spread to other parts of the body, if left untreated, DCIS may progress to invasive cancer, which can spread. Thank you for watching.

[@ParchamKurda]

Hi dear doctor my mom has (1.9cm)breast cancer Three lymph node was positive (ER+ & PR+)Allred score 8/8 & her2 - grade one Oncotype 19 Age 58 what is your treatment option?! And I’m overthinking about distant recurrence😢.

[@yerbba]

In someone who is postmenopausal with these features, endocrine (hormonal) therapy is generally recommended. We can't make specific recommendations regarding someone's care without being part of your mother's care team, but this is what you are likely to hear from her oncologist. Your mother is fortunate to have you.

[@AshishKuliyal31]

My brother is 28 years old.. he had a tumor on his right breast side, biopsy was done but nothing found, then they decided to remove the tumor, they removed and tested it and declared that it had features of invasive carcinoma grade 3, HR and PR positive, Her2neu negative.. now they are going to check the lymph node over his shoulder to check if it was spread or not.. then they will decide chemo and others Could someone help me to understand if they are following the right treatment?

[@yerbba]

From everything you've said, yes, this is the correct course of action. He should also consider seeing a genetic counselor because he is so young. The results of genetic testing could change the treatment he received after chemotherapy. Wishing you both the best.

[@AshishKuliyal31]

@@yerbba thank you so much

[@mssdn8976]

Very informative thank you

[@yerbba]

You're welcome!

[@alechamid235]

Hi, my mom has been diagnosed with stage 2B left breast cancer with 3 lymph nodes positive. Also, Estrogen positive 20%, Progesterone positive 10% and Hers2 negative, and grade 3. The oncologist says it's triple negative, is this correct? How is it triple negative if it's ER and PR positve? Also, what do you think is best treatment for her? She is 82 years old with a pacemaker and diabetes type 2? Your input would be appreciated, thanks.

[@yerbba]

Thank you for writing. While this estrogen receptor level is on the lower side, it's high enough that we would not call this a triple-negative tumor. Same with the progesterone receptor. Endocrine therapy would generally be part of your mother's treatment plan. We try to avoid both overtreating older people, and we also try to avoid undertreatment. Decisions about your mother's treatment need to incorporate her preferences and also her life expectancy. It is hard to make a firm recommendation without being her physician. If you are uncertain about the current recommendation, a second opinion may be helpful in decision making. This is not to say that there is anything wrong with the opinion of her physician but rather that it's helpful to hear things said in another way.

[@alechamid235]

@@yerbba Thank you for your response and recommendations 🙏 👍, God Bless

[@alechamid235]

@@yerbba doc, just had a meeting with the other oncologist today and she explained that tumor in in breast is not the problem, but the axillary lymph node biopsy shows ER negative, PR positive 2%, and Her2 negative and grade 3, So she have 2 different types of cancer cells. That's what makes it complicated and hard to treat. So she recommended chemo with Keytruda, Carboplatin and Taxol at 50% dosage before surgery to see how she will respond and go from there. What is your opinion now with this extra information which I didn't know last time. That info I gave last time applied to her breast tumor only. Thanks

[@shrutikorecha3817]

What about grade2 invasive ductal carcinoma treatment options

[@yerbba]

Grade 2 invasive breast cancer options are the same as with other grades. In addition to grade, other things are taken into account, such as the stage of the tumor, the estrogen receptor (ER) status and the HER2 status. If you are being treated in the US, you can quickly find out what are your treatment options by signing up for a Yerbba Report at www.Yerbba.com . Please note that because Yerbba does not give medical advice, we are not providing a medical opinion.

[@itsdude9866]

Is it treatable?

[@aliciamagcalas899]

Thanks a lot

[@yerbba]

Thank you for watching! We appreciate you.

[@bhanumist]

Thanqu for awareness...

[@yerbba]

You are welcome.

[@easyenglishwithfarah419]

Thank you doctor

[@yerbba]

Thank you for watching--so happy that this information is helpful.

[@magnamaria1790]

I have stage 2 breast cancer... Am 35 yrs now, er posetive, pr posetive, her2 negative, only 1 lymphnode posetive, tumor size 2.5,but ki 67 is 60%. I want knw the risk of recurrence and any hope for second pregnency...

[@yerbba]

In someone with a tumor like this, the prognosis is excellent. Seeing a fertility specialist before getting chemotherapy can let you know about your options.

[@nivethaselvam9838]

Hello mam my mom has reported under usg guided biopsy from lesion in left breast resulted in invasive ductal carcinoma NST grade ll (SBR) grading what treatment can we undergo??

[@yerbba]

Your mother is fortunate to have you helping her through this. The grade is helpful in deciding what treatment to give, but even more important are the tumor size, the number of involved lymph nodes (if any), the hormone receptor (ER and PR) status, and the HER2 status. Once you know all of those, your mother's medical team can make the best recommendations for her care.

[@jovilynalvarez9291]

How to know if stage 4 when the result of my biopsy and mastectomy it doesn't show only grade

[@yerbba]

Thank you for your comment. Your medical team will go over the results with you regarding the stage of the cancer. Tumor size and the lymph node status are two factors that determine stage. Only if someone has a large tumor and more than 3 positive nodes do we go looking for disease in other parts of the body on scans. Some people getting chemotherapy first also have scans, and if you have symptoms that make your medical team concerned about disease disease, your medical team would also likely do scans.

[@briggettecammett6181]

Do u see women who have lumpectomy with grade 1, stage 1, clear margins, 1.1 cm tumor mucinin who don’t do radiation? (Lymph node negative, progesterone and estrogen positive).

[@yerbba]

Omitting radiation therapy is a consideration for people over the age of 70 years who have a wide surgical margins and the other tumor characteristics you describe.

[@prasadparab6050]

Hi my mother reported biospy. Grade 3 is reported and tumour size is 1.5cm and nodes are total 8. Can you please assist as chemotherapy is necessary or can go for suregery immediately.

[@yerbba]

Chemotherapy can be given either before or after surgery. With a primary tumor that size (relatively small) and the lymph nodes removed, there is most likely not an advantage of chemotherapy first but it is not possible to provide more specific guidance without being part of your mother's medical team.

[@prasadparab6050]

@@yerbba Thanku very much for reply

[@tessyk5571]

Madam, what do stage3c means?Is it more serious among stage3 cancers?

[@yerbba]

Stage III (3) breast cancer is either a tumor over 5 cm and/or 4 or more positive lymph nodes. We have a Stage III breast cancer video in production as I write this, so keep coming back to our channel.

[@Handicraft93]

I have an Invasive Ductal Carcinoma of my left breast, and the size of the lump is 4mm. I have 2 surgeries to removed the lump and some of lymph nodes ( under my arm). All the lymph nodes are negative with cancer. I really need an advice that what I have to do after the surgeries. Chemotherapy or I just do radiation? Please give me an idea. I’m 52 years old, have 2 kids, who is 15 and 11. Thanks and waiting for your advice.

[@yerbba]

Although I can't give specific advice, it does appear that the stage of your tumor was low. Other things, such as the hormone receptor status, HER2, and grade play a role in chemotherapy decision making. I hope you've had some more information since you wrote. All the best to you.

[@gena.9564]

Someone survived grade 3 hormonal breast cancer pls?

[@yerbba]

Oh yes, absolutely. The goal of treatment is to cure this kind of cancer, and we are extremely successful with current treatments.

[@dazellvillamater2451]

Hello my mom undergo radiation theraphy with a grade 2, is it okay or no need? Thank you for your response?

[@yerbba]

Tumor grade is one factor that determines treatment options. When we make recommendations for radiation therapy, we consider the age of the patient, the size of the tumor, the width of the margins, and the presence or absence of hormone receptors. Check out our blog post for more information about which patients may be able to omit radiation therapy. blog.yerbba.com/how-to-understand-if-radiation-can-be-skipped-for-breast-cancer-treatment-2022-guidelines/

[@glassbottle15]

I don't think they won't be able to provide direct specific medical treatment suggestions, as your mother hasn't been examined by them and they haven't seen the reports and pathology from her case. You'd need to see another doctor in person to begin asking for a second opinion.

[@jumjumjumuk]

Thank you

[@yerbba]

You're welcome

[@dottiestaxx]

Thank u for this

[@yerbba]

Thank you for watching! Yerbba appreciates your support.

[@SitaRam-cd4xu]

My mom cyst size is 2.5*2. Invasive breast carcinoma grade1. How to say stage.. what are the treatment required.please reply

[@yerbba]

We can't give specific medical advice on our KZbin channel because there are many details that are necessary to make a firm recommendation.

[@gaurikris9420]

I have a doubt can the grade of the tumour change ie : can big tumour 6cm which is grade 3 be node negative.is this a common scenario or a rare one because my doubt is if it is grade 3 how does it remain node negative and without spread for a relatively large tumour.is it because grade changes from 1 to 2 and 3 after a long time before diagnosing just like the stages is that a possibility?

[@yerbba]

Such a great question and a common area of confusion. The grade of the tumor is a description of the tumor characteristics under the microscope. The stage of the cancer is a different thing and refers to how much disease there is. So people can have a Stage IV, grade 1 cancer or a Stage I, grade 3 cancer. The stage and grade are not really related to one another.

[@anetawojtach4257]

Thank You so much.

[@yerbba]

You're most welcome.

[@kcontreras77]

I was just diagnosed with invasive ductal carcinoma on my left breast. 1.5 cm, moderately to poorly differentiated. I have to consult a surgeon now. The pathology report didn't state grade or stage, which worries me... was this caught early or am I in big trouble ahead?

[@dao-lam]

Did you find out yet?

[@yerbba]

It sounds as if you have had just a biopsy since you haven't seen a surgeon yet. We cannot determine the stage of the tumor until we know the size of the tumor after surgery and whether or not lymph nodes are positive. So I would not be concerned that the report doesn't state the stage. The grade of the tumor is best determined after surgery as well, but "poorly differentiated" usually means higher grade. While this can sound alarming, higher grade tumors can respond more to treatment. I do not see big trouble ahead for you. Thank you so much for writing. The waiting is so hard, isn't it?

[@dao-lam]

@@yerbba When will we find out about ER/PR and HER2 status? Is it also after surgery?

[@arn1983]

Grade 3 tumor curable or not ?

[@yerbba]

Great question. Grade is one aspect of cancers that we look at when determining prognosis, but it's not the only one. Stage of the cancer, hormone receptor status, and HER2 status all play a greater role. In general, the goal of treatment is cure.

[@arn1983]

@@yerbba Her2 negative it is. Can I share my reports with you so that you may check and let me know

[@happydogpaintings2424]

Currently healing from lumpectomy surgery, Grade 2 invasive ductal carcinoma tumor 2.5 cm, 3 nodes removed and came back negative, negative margins. Oncotype score 27 and oncologist is recommending chemo, radiation and hormone therapy 5-10 years. I am 44. ER+ PR+ Her2-. I am wondering if the tumor grade is why they are recommending chemo. I am leaning towards just getting the radiation and possibly hormone therapy. Any advice would be appreciated. Thank you.

[@yerbba]

Thanks for sharing your situation. It is hard to give specific guidance without being part of your medical team. It appears that in women your age with that Oncotype score, there is some benefit from chemotherapy. It is really important that you feel comfortable with your decision and understand the extent of benefit expected. It is not uncommon for oncologists to answer additional questions about the rationale for our recommendations.

[@anonymouscorner4044]

Hello Doctor my mother has Invasive ductal caricanoma Grade 3 MBR Score 8 DCIS is present LVI is absent TIL is 60%. Iam really tensed whether my mom would be cured or not

[@yerbba]

It's hard to know the odds of cure without knowing the tumor size and lymph node status.

[@Terege16]

I was diagnosed with invasive breast cancer on right breast . Had a lumpectomy. Tumor size 1.5 cm , stage 1 grade 3 , 8 of 8 lymph nodes were negative , ER and PR positive, HER2 negative .My oncotype is 20 and I am 48yo . Do I need chemotherapy?? Please

[@yerbba]

In general, an Oncotype score like this in someone with negative nodes does not warrant chemotherapy. We are not able to make specific recommendations regarding your case, however.

[@patriciaameyaw6837]

Can u pls help me out am a mother of two kids and am 48ry History Invasive Carcinoma with sighs of metastasis TECHNIQUE Volume scan of chest was done whihout contrast Ultrahigh resolution scans of both lungs were done segment of right lower lobe. Trachea and bifurcation are normally seen . No bronchial thickening or bronchiectasis is seen. Rest of lung fielder are clear . There are no air space opaities interstitial, fibrosis or emphysematous changes. Both hila appear normal . No significant mediastinal . Iymphnode enlargement or mass lesin is seen. Thoracic esophagus is grossly normal. No pleural effusion is seen on either side . Bony thoracic cage is normal . No lytic or sclerotic lesion on visualized bones. This is the C T C

[@patriciaameyaw6837]

Does it mean that my best cut off

[@patriciaameyaw6837]

I need reply pls

[@yerbba]

Thanks for writing, and this sounds really stressful. From what you've shared, it's hard to tell what your doctors are concerned about. We expect that they will go over your scan results with you soon. Wishing you the best.

[@omi1766]

I was told I was 2B grade 3, I'm BRCA positive,. Triple Negative Breast cancer,

[@yerbba]

Many tumors that are associated with a mutation in one of the BRCA genes are grade 3. We hope you're doing ok.

[@melodymelody3096]

🤗🤗

[@ItsMarronLables]

Grade 5 🥹

[@yerbba]

There are 3 components of grade (tubule formation, nuclear pleomorphism, and mitotic count). Each of those features gets a score of 1 to 3. These those are added up and further groups into grade 1, 2, or 3. There is no grade 5 breast cancer. It can be confusing! If the components of grade equal 5 in your case, this is actually a grade 2 tumor. You may want to ask your doctor to explain your report to you. We hope this is helpful.