What is a Protein? (from PDB-101)

Proteins play countless roles throughout the biological world, from catalyzing chemical reactions to building the structures of all living things. Despite this wide range of functions, all proteins are made out of the same twenty one amino acids, but combined in different ways. The way these twenty amino acids are arranged dictates the folding of the protein into its unique final shape. Since protein function is based on the ability to recognize and bind to specific molecules, having the correct shape is critical for proteins to do their jobs correctly.
Visit PDB-101 (pdb101.rcsb.org/learn/videos/w...) to download related teaching and learning materials, including a presentation summarizing the content of this video and a flyer with abbreviated version of the content.
Closed captions are available in English, Italian, and Romanian.
To contribute subtitles in your language, use this link: kzbin.info_vide...
Story by: David S. Goodsell and Maria Voigt
Animation and Editing by: Maria Voigt
Narration by: Brian Hudson

[@RCSBProteinDataBank]

To contribute closed captions for this video in your language, use this link kzbin.info_video?v=wvTv8TqWC48&ref=share

[@hvitorchid8349]

RCSBProteinDataBank ٥

[@arhanya8552]

pls contribute good audio first. Had to exert ears to hear it.

[@joshuajoseph1630]

👍

[@seemlyme]

RCSBProteinDataBank `great

[@haidarmuhannad3592]

RCSBProteinDataBank What is ribosome?

[@TCPUDPATM]

Very informative for the average lay person. Now I just need to watch it 10 times over to absorb it all.

[@HanadiH]

Even the non-lay biochem student has to watch these videos a few times. No one is born with this knowledge. It's not intuitive.

[@avieus]

Make that 100 for me

[@delq]

@@HanadiH is it possible to even build comprehension around these at all ? I seem to simply cant find a logical structure to capture all of these information together.

[@HanadiH]

@@delq I'm also a biology tutor. Hit me up on insta @hanadihoblos

[@TheMinecraftCK]

@@delq It is. It just takes time to understand how biology works. After enough time assaulting your brain with the information, the concepts become apparent

[@Coachnickhawley1]

It's totally mind blowing to think about all the complexity involved in just living day to day. It makes me appreciate life more when I watch things like this. Thank you for putting the effort into this incredibly thoughtful video.

[@almustafaaraz2073]

Coach Nick Hawley you must watch how our immune system protects our bodies. And how our dna creates proteins

[@DanaWebb2017]

It's mind-boggling to consider the process of figure everything out.

[@TheMounir4]

This is a sign that all this is designed by a designer . I can't see a way other than the life is engineered by chemistry.

[@AA-xr3le]

@@TheMounir4 I believe that there is God and He is super power and intelligent beyond our magination.

[@IrishRepoMan]

@@TheMounir4 It's just order. Given enough time, order comes about. Atoms bumping into each other leads to the creation of molecules, which leads to the creation of amino acids, which leads to the creation of proteins, which leads to the creation of life.

[@kummer45]

This material can be considered an oracle. Animating the processes and the logic of how molecules rearrange is illuminating. The illustrations are of top quality.

[@chloroplast8611]

WOW THE ANIMATIONS ARE AWESOME!!!!

[@fernandoraphael95]

Chloroplast you're awesome.

[@JanetStarChild]

_uh-oh, HOTDOG!_

[@deepanshug5727]

Fernando Rafael 😂😂

[@justacatwhoneedstherapy4095]

Fernando Rafael lol

[@blackcatsmovies5256]

Chloroplast ✔ yes but too fast

[@tylerpedigo2938]

This video is incredible. Great work on the simulations.

[@Aerospacedu]

I don't think many people realize the extraordinary activity that goes on inside our bodies for the entirety of our lives.😎

[@futureshock382]

hahaha the simulations are so good now its almost like its real life

[@regulate.artificer_g23.mdctlsk]

This is just an animation; not a simulation.

[@louistournas120]

@@regulate.artificer_g23.mdctlsk Perhaps it is a simulation. In other words, they have used software to model the atomic attractions between the various atoms. The only problem is that the number of atoms that make up the protein, plus the surrounding water, the bilipid layer of the cell membrane.. simulating all that requires a lot of CPU time.

[@regulate.artificer_g23.mdctlsk]

@@louistournas120 if you wanna see what a simulation really looks like, check out this playlist: kzbin.info/aero/PLwMp3bZnXMPBhmZvzPJ3ywfufTJlVuCzg - specifically videos 1, 4, 5, 7-11, 13 and especially video 26 and 22

[@MultiSciGeek]

Perfect explanation and top grade simulations!

[@TrishTruitt]

This is excellent! I learned more in this short video that in a 50 minute biology class. Great animations, narration and sound effects.

[@artofchickens]

This video is much better than the other "What is a Protein" video. Thanks so much!

[@paulwalsh2344]

WHERE HAS THIS VIDEO BEEN ALL MY LIFE ? ! So much information, so well explained ! Well done, thank you !

[@kristyanne719]

One of the most interesting and informative videos I have seen in a long time! Really explains it in easy to understand terms.

[@asdf8asdf8asdf8asdf]

…one of the best videos I’ve seen on protein definition, structure, and function. A lot of work went into making this look simple Hats off to the team involved.

[@let4be]

This. Is. Amazing. Adding to a list of videos I will be rewatching repeatedly to absorb this material. Thanks!

[@nofurtherwest3474]

i feel like i've learned more than in my entire biology class

[@sebipalma4189]

This is such an informative video and I love it. The animations are incredible and extremely helpful.

[@handsonfire6113]

this video was absoulutly stunning, thank you so much for all of the time and effort you put in to make it as comprehensive and concise as you did.

[@kodiak71gene]

I am a protein scientist and this is the BEST video I have seen for an introduction to protein construction, structure, and functionality. It requires a basic understanding of chemistry for hydrophobic, hydrogen, polar, and ionic interactions. VERY IMPRESSIVE

[@OmegaUberDeathbot]

The first time I have seen a accurate representation of protein functions without losing important points. I finally understand protein folding!

[@HiAdrian]

Such a concise and well made presentation, thank you!

[@yahonathanroden2681]

Utterly amazing. I like how the different amino acids were arranged like trading cards. A science education card game maybe? Just an idea :)

[@MisterK9739]

Ork Trukk Drivah I‘m glad you are excited about the topic, but you got it all wrong :) amino acids don‘t form cells, they form proteins. cells are the smallest examples for life, they use proteins to signal, create, destroy, metabolite etc. And vitamines aren‘t amino acids. They aren‘t used as building blocks for proteins but rather as regulators or signaling molecules. Hope that was ubderstandable ^^

[@DizzyDoduo]

So THAT'S how DNA does it! I see now, each marker encodes building blocks for a type of protein. With enough proteins you can make a cell, then finally with enough cells, make a whole organism. Fascinating! It's such a simple mechanism yet it drives our whole living world!

[@machinmon.]

Not exactly that simple..

[@MICHELGOMES-mt3ee]

@@machinmon. çcçcci77ifi8

[@user-jm7mo5ll4t]

good idea！

[@kuhataparunks]

Thank you so much for the animations they really help clarify the bland photos of the books

[@madalchemist31]

Excellent video for people taking a level biology in igcse. The animations are amazing, the sound effects visualise everything in our head and the music is really cool! The proteins look very accurate to what a stereotypical protein would look like.

[@lucasfc4587]

WOW the production and scripting value in this was perfect! It is concise but just enough for the casual viewer, great!

[@oguzhanturkuzel8163]

It's really amazing how many things happen in our bodies while we live normally. The existence of humanity is not an accident.

[@lrvfb]

these proteins aren´t only in humans. Even the most basic cells have proteins, some even exactly the same as in humans. Its just a product of evolution, even though thats pretty hard to grasp.

[@oguzhanturkuzel8163]

@@lrvfb evolution might be real but creation is real too ı guess.

[@steffen7451]

oğuzhan türküzel Evolution is creation

[@chinar2593]

@@oguzhanturkuzel8163 yaratılış yalan

[@oguzhanturkuzel8163]

@@chinar2593 bence değil

[@MayBeeWheelSea123]

I’ve been studying nutrition/exercise science for the last decade and this beautiful video helped me conceptualize it all in a mind blowing way. I love you

[@christianmendoza2865]

This video was so much more helpful than my anatomy book and teacher 😭🙌🏻😭 no shade dr mcnulty

[@xueyixie897]

Why you learn protein in anatomy class😂

[@ZeusMcKraken]

These are fantastic visualization! Really opens up the knowledge you already have and adds new information.

[@yoso585]

This video has been made possible by countless individuals, over generations, who took the study of the sciences to heart and expanded upon that knowledge.

[@yoso585]

And I might add, a seemingly infinite number of protein builds.

[@studygodsword5937]

@@yoso585 this video show such complexity that there must have been a designer !It and many other parts of science have proven evolution to be a fraud !

[@classic1919f]

this video is amazing typically it's a great job ilked creativity in content explain and wonderful animation. keep going. thank you

[@RebeliousSapien]

this video is amazing!! .. I learned more in this video than what I learned this whole semester in my bioinformatics class !!

[@renatobalestra9971]

Thanks everyone that helped and support to produce this amazing video!!!

[@szym1]

Outstanding. Superb. Excellent. Thank you so much for making this. So dense, yet so easy to understand. Loved every second of it.

[@MrBennyBBQ]

That was mind-blowing; thank you!

[@KABSOOLH1]

This explaination if perfect! students needs this before they start going in details in their studies! it gives them a real understanding the way the subject is here explained how reality is. not like the simplified pictures that we see everyday which does not really represent the reality.

[@gregoryashton]

The most succinct video I’ve ever seen on proteins. Thank you 🙏🏼

[@architectinth]

Nice VO. Straight-forward, clean, and easy to follow.

[@daveg5857]

A semester of biology in 7 mins. Awesome!

[@Mellowman468]

Wow my mind is blown...im fascinated with how everything works so perfectly together. Geez

[@Lunuwara]

This is great evidence for the existence of God

[@mook5tar]

Beautifully explained, both visually and spoken.

[@mrshah2043]

Absolutely fantastic stuff right here. Thank you for making and posting it.

[@vlaw7103]

Love the narrator's voice.

[@xxxsmoke4lifexxx]

This is a very good video. the animations are spot on. Regards from a MSc in biotechnology :)

[@lightcone7854]

The best AV profiles about Protein ever seen in KZbin!

[@noahwilliams8996]

That was one of the best videos on molecular biology I've seen.

[@masterbaiter5533]

From vastness of space to this. I really am a wholesome guy

[@kailashkakade5268]

thanks for helping us

[@NeoAF10]

It's overwhelming to see so many well deserved positive comments!!! Excellent job!!!

[@lordofthecats6397]

I found the RCSB PBD a few years ago, I check it every few weeks for the molecule of the month! Proteins are fascinating

[@jhyland87]

This cleared up what that ribbon structure represents.

[@icaromoraes6665]

Simplesmente perfeito

[@markobabic487]

Dr Maria Voigt, I just want to say, these are some excellent animations. You have a true gift.

[@Alternativedwellings]

This is the trippiest video I've ever seen.

[@MichaelHenderson59]

But why. Like... Why? I get survival of the fittest and evolution etc. but, I feel like the more I discover about microchemistry like this protein video, the more I think why would atoms behave like this? I know they're all effectively machines, just doing chemical processes, but it makes me wonder that there must have been countless types of proteins in previous years that did do something but it never lead to the survival of their environment, therefore they "died" (fell apart). It just seems so infinitely complicated and so intoxicating for our small human brains to even comprehend the sheer exquisitely definite nature of the things we can't see. I'm so happy we are discovering more and more but to some I feel like it becomes more like we're learning stuff we never should know. Does that make sense?

[@rsrt6910]

Mostly it's because most people can't comprehend the time periods involved in the process.

[@enonymuz8627]

God

[@lorenzogiancristofaro9721]

Well you have to consider that all of these functions evolved extremely slowly, the very first organisms didn't have much in terms of biological functions, but they S L O W L Y evolved into increasingly complex cells and organisms. Just imagine that both mitochondria for animals and chloroplasts for plants once were bacteria that randomly got engulfed in the bigger cell

[@TurinTuramber]

Remember you are only looking at successful combinations, many many others had the chance to work but just don't. People whom are especially bad with large numbers will claim God. In truth simple processes scaled up can form beautiful and complex things, no mircicles required.

[@osslayer8976]

Nathan Ellis I’m very good with large numbers and believe in God. The Theory of Evolution only explains how life works, not the origin. God is the creator. He is the Origin

[@adabujiki]

I love this guy’s voice and style of talking.. so meticulous

[@RagehAzzazi]

just imagine the amount of work put by how many people through how many years to reach that level of knowledge

[@user-vu9st6fd7v]

This is INSANELY awesome!!!

[@jupitersaturno6845]

Thank you so much. Life, all kinds, is a poem written with atoms and energy and feelings and ratio, and I don't know what else. Life is beauty. 21022019

[@charusingh2159]

Seeing a body functioning looks like, I have entered a super advanced laboratory employed with it's ultra fine machines.

[@manseder]

Breathtaking, amazing, perfect. Many thanks

[@rodrigoappendino]

Best video about proteins I've ever seen.

[@glennsimonsen8421]

Very well done! Thank you! I think these systems are far too complex to have originated randomly, step by random step. Obviously, there was a massive intelligence behind these mind-blowing, intricate designs.

[@YousufAli-vd6uz]

Incredibley and understandably excellent animation.. I wonder such an intricate complex systematic structure can be evoluted naturally without SOME external willful deliberate INTERVENTION..

[@dudecool7915]

It's honestly crazy how this world works, all of these are just mainly a lot of carbons, oxygens, nitrogens, hydrogens linked together but they somehow all interact to form this crazy thing called life. Biology has always fascinated me since I was a kid, and I definitely plan on pursuing microbiology as a career. Thank you for these great animations.

[@ooraculo223]

My new favorite channel on KZbin.

[@sanskarshrivastava5193]

Who is here from the deep mind's article ?

[@didjterminator808]

my right ear feels lonely and my left ear feels abused

[@carolnorton2551]

it was so interesting I didn't even notice.

[@ernnylund2560]

Best explanation on youtube so far.

[@nomann5244]

I do not understand why youtube does not show this amazing video on the top lists when I searched about protein earlier.

[@ac300]

i'll stick to physics. nice, symmetrical, clean, and easier too.

[@cotton966]

YZ 😂😂😂

[@HostileLemons]

Well there is physics involved in these proteins

[@keerthi3086]

Biology is applied physics.

[@jpenneymrcoin6851]

yep, one of the easy sciences.

[@yva4030]

Почему у англоязычных каналов с англоязычными видео стоит русское название и русское описание? Why do English-language channels with English-language videos have a Russian-language name and a Russian-language description?

[@VMac-eg7fb]

Many good things have been given to America by Russian immigrants, we are a nation of immigrants sharing our best with each other, we are a blessed Nation, enjoy and share the best of the good Earth.

[@user-ou7uo8rl5d]

скорее всего по тому что настройки ютьюба русскоязычные а канал или видео имеют русский перевод. настройки определяют какой перевод использовать

[@ASKaaron32]

wow this was way more informative and detailes as expected. All so nicely depicted and put into context. Thx for the amazing video!

[@TheGiulioSeverini]

What an amazing video. Thank you!

[@julianaasdourian3253]

Me throughout the entire video: Is this the life-cycle of styrofoam?

[@ferdrewflores3612]

😁😁

[@kahvac]

Thanks to all the people that helped to make this video ! A great explanation for a complicated subject. Thanks again.

[@keyspark]

the satisfying sounds effects in this video is incredibly motivating

[@Cod4Wii]

THE MITOCHONDRIA IS THE POWERHOUSE OF THE CELL.

[@lucid212]

And they come and say: "No creator".

[@labibbidabibbadum]

I know right, while amino acids are right there in front of them.

[@subject8332]

"This seems pretty complex to me, therefore goddunit!"

[@lightdark00]

Yep, this is proof of no creator. The genesis of life just started with the right chemicals in close contact in the right environment. Evolution stuck with what worked best of the random things that happened.

[@VMac-eg7fb]

Our creator's vital force is in every particle He places every thing together in order, you don't see , for instance, monkies transitioning into humans, we did not evolve from monkies or apes.

[@SpaceCadet4Jesus]

@@lightdark00 Evolution is merely the coded variation that can occur in a preprogrammed entity. Miscoding results in disease or death of the entity, not life. Who or what coded the extreme complexity contained in the DNA and RNA which by itself is useless without the proper working machinery to carry out the code? Creation did not create itself nor does chance or chaos have the time or conditions or understanding to create.

[@julielabelle2783]

Beautiful work, thank you for sharing.

[@fdgranados1]

Top class material, information clarity and animation, love it thanks a lot, keep on going like that

[@Horses4life1001]

Wow. What a wonderful creation of my God- Jesus

[@bigmac8574]

Horses4life1001 you mean Nature. It’s fine, lots of people get that wrong.

[@mercytomankind9803]

Try calling Jesus for help when you're in trouble and he won't answer you because he is Not God! He is a fine Prophet and messenger of God Almighty Allah to the Jews. Read the Quran CH: 19 to find the truth about Jesus.

[@subject8332]

You shouldn't have skipped school!

[@otmaneelbourki3663]

R.I.P EVOLUTION

[@subject8332]

Evolution is a fact of phylogeny it cannot die as a living organism!

[@timothybolton7852]

That hands down was the easiest I have ever digested this info. Course... I am a visual person and these graphics make it just click! Thank you! Subscribed!

[@user-ix7sd8lc9t]

단백질에 대한 이해를 하는 도움이 되는 좋은 자료 입니다. 감사합니다.

[@Crazywaffle5150]

I am nothing but a bunch of chemical reactions created by a fluke of atomic attractions.. All of that weirdness is happening inside me.

[@AnswerEasy]

You do realize that the complexity of these systems puts our most advanced technologies to utter shame right? I suggest you to look into structuralism, a much saner and less psychotic hysterical deluded theory than "two particles smash in the cosmos, here I am".

[@rsrt6910]

Yeah, pretty much.

[@MrTeddy12397]

hypocrite that you are, for you trust the chemicals in your brain to tell you they are chemicals. all knowledge is ultimately based on that which we cannot prove. will you fight? or will you perish like a dog?

[@Puelof]

My dear friend. While it may seem so easy to just believe in the "big bang" (assuming that is your origin belief) but with this, if you stop there, you may miss something grander than the physical universe. An originator perhaps? Is the universe the creation or what creates by it's own account, did creation then create its self? I would like to suggest two books side by side, God's Debris (non-religious more philosophical approach to "god") and Mere Christianity (Theological discussion on moral law and other such present issues, coming through with a more proper way to understand possible misconceptions of the Bible) When you have the (based on your apparent belief) illusion of free-will, do you really want to bet your life on the unproven faithful belief that you are just in a sense atomic chemical code, programed by a universe that just appeared? God loves you, start over my friend, I think you missed something.

[@rsrt6910]

@@Puelof Or not.

[@christianchris1517]

I find it impossible to reconcile these findings with the "chance" attributed with their coming into being, let alone higher-level and more complex ones. It amazes me how the community that works the closest with the wonders of life are the most skeptical towards the existence of the divine and eternally powerful Creator!

[@CreativelyShay]

Amen! It is crazy to me that people think that such complexity and organization came from a act of randomness.

[@dillonfelty7783]

@@CreativelyShay it has taken hundreds of thousands of years of constant evolution and natural selection in an ever changing environment to have arrived where we are today. Skeptics of divinity require evidence. When a divine being appears and shows some type of powers unexplainable by science then all skepticism would be put to bed. Until then, I don't think that will change.

[@ilaila3504]

i was going to say something similar. I would not ask a religious person to agree, but I would ask a religious person who is struggling to understand why scientists are skeptical about the existence of god based on the amazing wonders of life - to just understand that it is because of the scientific evidence that points towards natural selection. Natural Selection does not mean a little bit of accident now and then, it means every single nano second of creation inside all living cells for example - constantly trying to recreate replica's or improved copies (virus cells ) and making many mistakes along the way. Some stay - some don't survive, some are good and some are bad. It really just depends on the success of the alteration and the drive for survival - mitochondria within a cell, has it's own dna seperate from the dna of the cell it resides in. That dna tells us that it was more likely once a bacteria cell that was ingested by an animal cell which instead of destoying it - realised it's energy creating potential and kept it! that's a very simplified description as I am only 1st year at uni but there's my answer to your baffllement. Don't be surprised, scientists believe in natural selection and that is why they don't believe in God being responsible for the atomic and molecular changes in every cell happening to all life every single millisecond.

[@christianchris1517]

@@dillonfelty7783 Evidence for God is plentiful. All created things are evidences, not just the biological ones. The physics of our universe are such that (mass+energy) is conserved: _they cannot naturally appear_ nor disappear. Their existence (and sheer scale) is thunderous evidence for the existence of a being above physics, above nature that cause everything to exist. Thus His invisible attributes of eternal power and divine nature are clearly understandable and within reach of everyone. My amazement is about the hardness of the human heart, since many that work in fields such as Physics and Biology frequently come across multiple, clear, and "in-your-face" evidences for God but simply reject him (a deliberate choice). Even in appearances of God like the one you proposed, hardened people will still dismiss the evidence, evoking the most ludicrous arguments.

[@christianchris1517]

@@ilaila3504 So... a supposedly more evolved animal supposedly had to keep a bacteria's mitochondria for its energy production? How did the animal and its many many ancestors manage to energetically survive with that deficiency before the encounter then? Why didn't the more energy efficient bacteria kill the inefficient animal (according to survival of the fittest?) See? Your drive to dismiss God is such that a flawed circular reasoning like that (with no evidence!) contains enough ear itch to be embraceable. I'm not struggling to understand why most reject God. The answer is very simple: it's a choice. It baffles me seeing the ones provided with most evidence remain mostly skeptical (those that are given more, will take a more severe judgement).

[@emeralds3392]

Amazing comprehensive explanation 😍 Thanks

[@fasterpastor1000]

Great video. Thanks for not mentioning that these all came about by accident.

[@boombot934]

Proteins are wonderful✨😍 creation of our Dear God the Almighty!

[@mattizap2988]

Amen! ✝️❤

[@dougreformed8956]

God is amazing - thanks for the vid!

[@irasthewarrior]

A god is not that smart to create something like that.

[@anassattik2987]

@Gabriel G 😂Hi again, a "day" doesnt always mean a day of 24h, it can also mean a certain amount of time.

[@DGenHero]

Its like building a castle over millions of years.

[@user-lm1jp3xs4g]

고맙습니다. 귀한 영상 올려 주셔서요. 잘 봤습니다. 그럼. Thank you.

[@richricogranada9647]

Very hard to fully understand it even with the superb illustrations, but amazingly interesting. And his voice is very pleasant…

[@willmartin1748]

This is the greatest video I've ever seen

[@dnareplication5593]

excellent rendition.thank u so much 💯🎉

[@hadjmahdaoui1794]

Do you believe i studied all the process and i still repating it in youtube its so awesome to know your body function

[@mituzaman1312]

Outstanding and educative video

[@mesothelioma-cancer]

That's correct! The sequence of amino acids in a protein determines its unique three-dimensional structure, which is essential for its proper function. The folding process is guided by various forces, including hydrogen bonds, van der Waals forces, and hydrophobic interactions, among others. Once a protein has adopted its final shape, it can interact with other molecules in a specific way that is critical to its biological function. Any alteration in the sequence of amino acids or the folding process can result in a dysfunctional protein, which can have serious consequences for the organism.

[@chinmayeechavan5724]

Very nice work. Really improves understanding of how proteins work, . I'm glad I found this video

[@rajns8643]

Amazing video. Thanks for such beautiful animation!

[@macrofage1551]

I barely understand anything, but for sure it is amazing to see how much we got to discover about biochemistery running in living things.