What is the life-threatening side-effect of clozapine?

The life-threatening side-effects of some of the second generation antipsychotics are useful to know. Schizophrenia treatment with antipsychotic specially second generation antipsychotics including drugs like clozapine can cause a granulocytosis. Life-threatening cases of agranulocytosis require urgent treatment and urgent vigilance. For medical students it’s important to understand that clozapine can cause a granulocytosis, what are the signs in a patient that my present with a granulocytosis