Why do thiazides cause hypercalcaemia?

[@honeybellebuzlucay5867]

You're great!❤😊

[@kristeenbarker]

@honeybellebuzlucay5867 - OMG you're great! Thank you so much for stopping by and taking the time to comment. I'm so excited you found it useful :) So much love

[@Doctor_Codon]

Please become a teacher in my medschool!😭🤌🏻

[@kristeenbarker]

This sounds so fun - I'd be delighted to give a talk!

[@TheJishu4loveworld]

why doesn't that happen with loops?

[@kristeenbarker]

Oh my goodness I LOVE THIS QUESTION!!! So...as you know frusemide blocks the NaKCl2 transporter in the loop of henle which is a key part of the 'rig' in the loop of henle - helping it to do TWO things - 1. create a concentration gradient AND also 2.help with calcium and magnesium reabsorption. So when we block this transporter, we upset the "rig" and we lose more calcium in the urine. So thats why loop diuretics don't lead to to retention of calcium. If you ever want to nerd out on this with me - i have a beautiful wee series called "tubule school" over on the website which unpacks everything in a very joyful way. Its an absolute blast! But otherwise I hope that answers your question :) 🤓