Biologist Explains One Concept in 5 Levels of Difficulty - CRISPR | WIRED

[@Arrowo]

Level 1 : what you learn Level 5 : what you get on a test

[@deadmanperipherals]

lmao

[@alastairhewitt380]

Find a way to talk about Jurassic Park and you'll be fine.

[@julianacaro496]

@@alastairhewitt380 hahaha you're right

[@jackvanwykay9012]

Level 5: what i learn Level 1: the test fml

[@spcmartin420]

For some reason I keep getting the 666th like of things

[@captainwafflez3630]

Level 1: Explaining Level 2: Deeper Explaining Level 3: Conversation Level 4: Discussion Level 5: *Interview*

[@demodema5192]

Underrated comment there buddy😂😂😂😂😂nice one

[@princessalia6]

Exactly what I was thinking XD He didnt need to explain when the people already knew xD

[@gewuerzgurkeev]

As it should be

[@sohamkarandikar6726]

True af buddy 🤣🤣

[@caisis4929]

I was going to say they just tricked me into watching an interview with two experts on crispr.

[@gummyjellyfishy9430]

"i'm allergic to penicillin and azithromycin" - round of applause for the parents

[@shinesbrighter]

I’m surprised he knows how to say it properly as well! I’m allergic to clindamycin and I always question if I’m saying it correctly lollll

[@anvikomatreddy5666]

The kid said penicillin and amoxicillin

[@angryblobfish570]

666 likes

[@flowerdolphin5648]

@@anvikomatreddy5666 no, he did say azithromycin

[@smileyfacegummies]

I will always be grateful to my parents for teaching me what I'm allergic to and memorizing their phone numbers by the age of 7

[@andee6245]

Level 2: my knowledge before a test Level 5: what my classmates are discussing before a test

[@arsicle]

Underrated AF.😆

[@bhavikakshaj7991]

100% true mate!

[@vindhya8498]

Soo true!!!!😂

[@flowerdolphin5648]

That's how I passed one of my literature exams 😂 eavesdropping on other students' conversations

[@faith9196]

LMAO the accuracy

[@feiyuin4178]

lv 1: teaches CRISPR lv 2: quizzes CRISPR lv 3: surveys CRISPR lv 4: reviews CRISPR lv 5: advertises CRISPR

[@nayantara252]

Wow clever

[@BeingFireRetardant]

Um, this whole thing is an advertisement...

[@reinatr4848]

@@BeingFireRetardant for what? "GET YOUR OWN PERSONAL GENE EDITING TOOL FOR ONLY $49.99 TODAY! DON'T MISS!" or something?

[@hadesdedov8560]

@@reinatr4848 yuh yuh no cap

[@jameson1239]

@@reinatr4848 you can actually do your own gene editing a gene costs roughly .05 cents a base pair which would still be very expensive

[@30for30Freestyle]

kid: “I’m allergic to penicillin and azithromycin” me: *is wondering how i skipped all the way to the grad student*

[@fr-it6iw]

I'd be a bit concerned if you didn't know exactly what you were allergic to even at that age

[@hauntedshadowslegacy2826]

Depending on the severity or prominence of an allergy, kids as young as two may need to know the names of their allergens. Penicillin is pretty common, so of course he'd need to know. One of my allergies is a somewhat uncommon medicine component, and my reaction to it isn't life-threatening, so it took me a few years to nail down the name of it. If I were deathly allergic to, say, peanuts, I'd've had to learn about it before even starting kindergarten.

[@30for30Freestyle]

yall really taking this comment seriously 😳😳

[@vlsparrowlv3396]

I’m also allergic to penicillin

[@mariaa.echeverri2969]

Damien Gallegos Im so proud he knows how to pronounce them

[@rustydynamo1088]

Poor dude, as soon as he gets to lvl 4 and 5, he doesn't even get to talk anymore.

[@springysloth1186]

RustyDynamo Ya, I feel like he was a little embarrassed because they might’ve known more than him in some sections.

[@DanielDavies-StellularNebulla]

He still explained it to us even if it was through asking questions / making statements to the other person and not talking solely by himself.

[@michaeldgn9813]

The people at level 4 and 5 obviously know what CRISPR is so why would he try to explain it to them? At that level it was just the discussion around the ethics and potential of the technology.

[@DanielDavies-StellularNebulla]

@@michaeldgn9813 He wasn't explaining it to them. THEY were explaining it to US

[@michaeldgn9813]

Stellular Nebulla “Biologist Explains one Concept at 5 levels of difficulty” ...he was the one who was supposed to be, but at the higher levels its not going to be a direct explanation. Why bring in an expert if you are just going to tell them something they already know?

[@JET7C0]

2:44 I love how she just drops the P53 protein knowledge out there all the sudden. Definitely subverted the expectations of a lot of viewers there I bet.

[@viepng]

Definitely an ap bio student

[@andyzhang3683]

Just started uni and that was the first time I've ever heard of that gene...

[@francklin97]

Completely! It's so specific that even here in the comments it almost got no attention. That girl is going places :D

[@sophiisherman7463]

@@viepng if she was an AP bio student she’d probably already know what CRISPR is.

[@amakaokafor7624]

@@sophiisherman7463 I was an AP bio student and I didn't know what CRISPR was until freshman year of college. Then again, I don't know if I can call my AP bio teacher a teacher if he didn't teach...

[@mark7384]

Level 1: Explaining basics Level 2: Asking questions Level 3: Explaining technical level Level 4: Agreeing about everything Expert Level: CRISPR's actually kinda shitty tbh let's talk about Jurassic Park instead homie

[@outwardpeak1764]

Forreal though

[@osiria4877]

Lmao you just made my day

[@asutoshbiswal8906]

This is a great comment.

[@paulinatamez747]

spot on!

[@TianXiaoMao]

Good times were had by all.

[@frann8552]

People: i just don’t think people should be able to use it for cosmetic purposes Scientists: bold of you to assume we know how to do that.

[@boh7816]

Hahahahha🤣🤣

[@harshnaveen5276]

Ikr

[@gotatoka8114]

L Zil that would make it worse the child would be love unconditionally because if you really love your child you wouldn’t changed his facial structure of gene medication for cosmetic

[@Nickiisqueenofrap]

I want to be 7 feet tall like peppa so hopefully crispr will do that to me

[@wonder052]

LMAOO TRUE

[@thisguy8943]

Notice how the video shifts from explaining crispr to debating crispr.

[@HahnenschreidesPositivismus]

It is not really explaining if the people he explains to already now about it. Maybe different people should have been picked like younger or from different fields.

[@ruoweilim7334]

ooh see that's what happens with increasing complexity.

[@FourTwentyMagic]

No, there is much more to CRISPR and all of its variants than what he explained up to the teen. After that it was a discussion in bioethics, which frankly is much broader than CRISPR and gene editing. There are many variants of CRISPR, Cas9 being only one of them, some are nickases others nucleases. They can be used in different scenarios for a desired outcome. There is also a whole lot of research on the precision of CRISPR - cutting only the desired target whilst minimising off-target cuts. This is no easy feat. Then you can look at this at an even deeper level. How does this system actually work, on a molecular dynamics level. What changes occur in the protein from binding the target to the actual process of cutting etc.

[@Rienebiene]

This Guy Hahn I wrote this comment on accident with my wet hair.

[@AdictoALosCantaritos]

i think this is mainly because is more interesting to hear the opinion of an expert rather than the complex and tecnical explanation of how crispr works

[@trashfourlife]

7:17 *Level 5* Me: _hol up....... theres a little under 10 mins left there_

[@aaanawaleh]

You've got to give time to the experts so they can give you their lecture.

[@chrisbotos]

And I am glad there was😂

[@Ascii89]

To kid: have you heard of CRISPR? Do you know what the genome is? To expert: can we have Jurassic Park?

[@TOMMII0108]

Do you have any idea how fun hypothesizing extremes are with fellow scientists??

[@kyallokytty]

Anything you got a lot of knowledge about, imagining the extremes is fun

[@LifeinBonnieland]

😂🏆

[@ricobrinson6198]

So amazing that you pointed that out. 🤣😂😂🤣😂🤣😂🤣😂🤣😂🤣

[@helenamannkopf8695]

HAHAHAH LOVE THAT

[@samsaw11]

Do you know what CRISPR is? Me: Yes I believe every potato chip could be CRISPR.

[@Vergil7799]

I like this joke.

[@zayonakbelfield]

im deaaaad

[@hipeople9856]

I'm deceased

[@rebeccaandersen9684]

Sam Saw i laughed way too much reading this

[@immissliss9843]

that’s me lol

[@lexodius]

Level 1: What is CRISPR Level 2: What is CRISPR Level 3: ETHICS Level 4: ETHICS Level 5: Dino's!

[@kennedylawless6259]

Spot on!

[@Omprakash-fd2pc]

Level 100 : i can edit by my sight

[@jasonophee6153]

and here I am wanting to use it to gain superpowers

[@B.Harper7]

GIVE US THE DINOS!!!!!!!!!!! 🌿 🦕 🦖

[@carter-dq1uo]

Level 1: he teaches Level 2: he teaches a little bit deeper Level 3: he has a basic conversation, but he knows a little more Level 4: they both know about the same and have a back and forth discussion Level 5: *he gets taught by the interviewee*

[@freshavocado8572]

Stolen comment

[@nelson8555]

Stolen

[@carter-dq1uo]

Idgaf

[@atleastimnotgae2124]

Donl Duck shameless

[@jonathanodude6660]

he did not know about the same as level 4 wtf

[@Draxis32]

"Well I'm allergic to Penicillin and Azithromycin" WOA WOA HOLD UP THERE! I THOUGHT YOU WERE THE KID NOT THE GRADUATE STUDENT

[@yeahkeen2905]

Draxis32 this deserves more likes. Honestly it surprised me that the kid could pronounce those words.

[@infinite5imal]

As a person with TONS of allergies I can tell you that it may be the parents' merit. Knowing your allergies at a young age can quite literally save your life

[@Helmy___]

I think the kids had a lot of experience with antibiotics. Maybe few series of internal bacterial infection. So I think he heard those a lot.

[@maureenlaneski4309]

Um, we call it AZT cause it' shard to say...

[@jacksonsingleton7572]

I’m allergic to those same things and more antibiotics. And TRUST ME, after having life threatening reactions to both of them at a young age, I definitely learned their names lol

[@resrevr]

I'm in the level between child and the exact moment before the teen mentioned P53

[@gauravgummaraju]

resrevr This comment needs to be on the top

[@nolan5386]

bruh

[@oreofatcat]

Gaurav Gummaraju this is a comment to help get OP on top.

[@LW123LW]

She almost certainly knows that from either a paper she wrote in science class or reading on her own. P53 is not generally mentioned even in college biology.

[@HKspec009]

Well first time I learned about P53 was my 2nd year in undergrad med.sci. I'd assume most people with physiology majors or even minors would know what P53 would be.

[@abhinavajith92]

Mitochondria are the powerhouses of the cell.

[@Niskiss]

I wrote this on my cell biology exam. I passed.

[@primodiscepolopingu373]

darkmanne

[@kaneminik]

*Are

[@wassolldasdenn]

Yea, that's exactly the thing that needs to be changed about our education system.

[@werderdley245]

OSMOSIS

[@m.g_0109]

Exactly how my biology degree is going, the more you learn the more it goes into ethics

[@DashonEugeneJerez]

In this specific conversation that’s good because science and ethics go hand and hand. If it didn’t it would only be a matter of time before man crosses the line.

[@wasordx3245]

​@@DashonEugeneJerezwhy does ethics even matter? It's just holding innovation back why does it even exist

[@PrinceTerrien]

​@@DashonEugeneJerezScience does NOT go hand and hand with ethics. Science doesn't believe in ethics.

[@cloroxbleach7554]

Level 1: Kid Level 2: Teen Level 3: College Level 4: Grad student Level 5: Expert Level 6: Random Chinese kid

[@inmessionante1722]

Clorox Bleach Best comment I’ve seen so far 😂

[@mirel4478]

😂😂😂😂😂😂✈️💥🏢🏢

[@Quoidx]

@@mirel4478 are YOU DESTROOOYING THE TWIN TOWERS

[@jayb6535]

😂😂😂

[@mirel4478]

maybe 👀

[@DhiaAbdelli]

I like how he changes his sitting position depending on the level. Also, the amount of information he's providing decreases by levels and it becomes more of a conversation than some kind of course. Great video!

[@flavioluiscc]

I believe that was unintentional. People just had more to say.

[@PongoXBongo]

Agreed. When you're less informed you're more hesitant to speak as you may "say something stupid". Whereas when you're more informed you're more confident in speaking up.

[@vancekangyishu]

He turned from the explainer to the explained

[@piteoswaldo]

This is inevitable, I think. When casually talking to persons with increasing level of understanding of the subject, it is expected that the conversation goes from explanations, questions, and answers, to ideas and perspectives.

[@danengo2]

yi shu From questioner to questioned.

[@jessicajnsm]

After the teen, these just became normal dual sided conversations rather than explanations 😂

[@taniani884]

jessicajnsm mostly because he doesn’t need to explain them, which I think is part of the point

[@hj2479]

why was the teen so uninformed. All students should be taught basic cell and molecular biology which covers the genome, DNA, Plasmids, etc. As a high school student, I had to learn all of these and more and used them in a professional lab setting aId i could keep up with the college students.

[@PaulTheSkeptic]

Yeah, true but it would be an insult to explain how it works to a colleague. I could imagine explaining how to operate an 18 wheeler to a road veteren of 20 30 years.

[@yaboi6851]

@@hj2479 didnt it say the teen was 14 years old? most likely she just hadnt had a class on it yet

[@greatdanelegend7001]

Then the grad student started explaining the stuff to HIM

[@Skyjy10]

How an oversea student feels about this video clip: Level 1: English Beginners Level 2: English course textbooks Level 3: What IELTS/TOEFL will test on Level 4: Daily conversation Level 5: University Lectures

[@ItsAstie]

1. Easily Understandable 2. Easily Understandable 3. Easily Understandable 4. Understandable 5. Mostly Understandable

[@charlenef]

Level 3 is so true😂😂 ive taken toefl twice and this is golden

[@DianaDiana-kl2gm]

Tbh, level 5 was kinda easier to understand than level 4

[@alfredojoselito5108]

For me ia actually almost all understandble, because my mother tongue (portuguese) is a latin one and the english high vocabulary is mostly latin rip offs. So, it's actually really easy for a brazilian/portuguese person that speaks avarage english to understand the "expert" conversstion.

[@mischazimny4066]

@@charlenef Toefl is really easy IMO. No need to learn anything just basics.

[@asdfghyter]

Level 1: Biologist explains CRISPR to 7 year-old Level 2: Biologist explains CRISPR to 14 year-old Level 3: Collage student explains CRISPR to Biologist (who clarifies it a bit) Level 4: Biologist discusses ethical issues about CRISPR with grad student. Level 5: Biologist discusses CRISPR with expert (and explains some of the concepts they are talking about to the audience).

[@malisarai6516]

asdfghyter collage 😂

[@diol9313]

I feel like this is the spreadsheet of learning no matter what subject it is lol

[@Chiosucks]

collage

[@thecanucklehead3034]

asdfghyter honestly I like this way of explaining things. You get the layman's terms as well as in depth discussions including potentials and controversies. Not just the same thing with longer words every time

[@E_AA1941]

College*

[@akaashisbtch4138]

Professionals: You know what this is? Me as college student: Absolutely not

[@Manly-Tears]

Me IRL : dude you're supposed to explain this to ME.

[@anieee96]

I study medicine, and we’ve touched on this in medical genetics. If you’re not doing a biology or chemistry course with focus on genetics definitely do not feel bad. It’s a niche concept for most non-biology/medical geneticists/medical doctors:

[@terripricher6378]

peanut's daisy basically there’s this guide RNA and it matches up with a specific part in the DNA. The guide RNA is connected to a protein that’s like biological scissors called Cas9 and when the guide RNA makes that match, Cas9 can do it’s thing and cut the DNA, allowing for biologists to take out specific parts of the DNA or put in new DNA so as to fix mutations or cause new mutations and see whether they have a positive or negative effect on that cell’s DNA.

[@SLEEVEASMR]

FR 😭

[@matcha_]

@@thesamtomyfrodo Agreed. Even as a science major, CRISPR was covered very briefly in my general bio classes. Only when I started taking genetics classes my junior year did my professors talk about it in depth. So I'm not surprised people are unfamiliar with it.

[@enderninja319]

Level 1: who Level 2: whom Level 3: whomst Level 4: whomst'd Level 5: whomst'd've

[@LowkeyGungnir]

Level 5: whomstest

[@TheDarkblader39]

Whomst've'd

[@Gamesforus1]

All I think when I see this is Vinny Vinesauce

[@sneal8526]

Level 6: whomst'd've'ly Level 7: whomst'd've'ly'yaint Level 8: whomst'd've'ly'yaint'nt Level 9: whomst'd've'ly'yaint'nt'ed Level 10: whomst'd've'ly'yaint'nt'ed'ies Level 11: whomst'd've'ly'yaint'nt'ed'ies's Level 12: whomst'd've'ly'yaint'nt'ed'ies's'y Level 13: whomst'd've'ly'yaint'nt'ed'ies's'y'es

[@MM-vs2et]

Level 69 : whomst'd've'ly'yaint'nt'ed'ies's'y'es

[@cai3763]

Child: im allergic to penicillin Expert: i love jurassic park oH mY-

[@steelsaber54]

Jurassic Park is lit

[@sabrinathewitch6396]

His body language says a lot about him he's very ambitious willing to share and learn more but also he's really competitive

[@Ice.muffin]

It was more like really attentive to the matters discussed and willing to absorb but also self-confident in his own knowledge and status to me..

[@michelleobamafootcream9292]

yo is u the fbi

[@Nizana3]

@N. Am Lol! Always.

[@saisab1412]

I wanna like this but its at 420

[@ellayatchi3721]

@@saisab1412 its not anymore:(

[@digitaoru]

Child: Genomes Expert: Jurassic Park

[@vidivici9564]

Lol

[@kingdrew5083]

I was able to comprehend every level with full understanding and i am only 5 months old. The secret to becoming an intellectual is watching Rick and Morty

[@bookedroomer]

I watched rick and morty twice so I don’t have 200 iq I have 400 iq

[@ok-sj7bx]

@@bookedroomer Because that is how iq works. (Even tho iq max is 200, if i remember right)

[@ayaazbukhari8654]

ok ummm it was a joke

[@kingdrew5083]

Mithun Nathan Good stuff fellow intellectual brother. Keep it up and continue to fill your brain with knowledge and you will have the mind of a deity.

[@elliottscully]

ok 200 is not the maximum, just very uncommon for people to have an IQ above that. There have only been a handful of confirmed cases.

[@nder767]

"If you can't explain it simply, you don't understand it well enough" -Albert Einstein

[@ahmednedjmeeddineadnane8677]

I thought that this was feynman original

[@nabhchandra_]

this might be one of those few quotes that i dont like

[@oliverdiamond6594]

whoa...

[@oliverdiamond6594]

@@nabhchandra_ i love it

[@justsomeguy6545]

@@nabhchandra_ mind if I ask why

[@youtubian2500]

These 5 levels of difficulty videos are awesome.

[@KimiHayashi]

Erratic & Static 1st to comment a 1.2k liked comment. I feel wow

[@SnoFitzroy]

Zed The Master of Shadows you deserve more likes than the original comment tbh

[@majncriftgamapleys9928]

stfu @zed pleb

[@AliciaZapata]

I love them, I hope they keep making more and about different topics

[@starchaser28]

Agreed, such a great learning tool.

[@OmarDelawar]

So we are just going to ignore all the paintings in the background that are on tripods? Really people? lol

[@audreychapin9561]

Omar Delawar yeah there’s no way for them to be mounted on the wall

[@audreychapin9561]

Omar Delawar i think it looks kinda cool ;)

[@bananabonanza3562]

😂

[@purple.cube.]

There weren't there until you said it

[@AuntyAwesome]

@Taylor Ross actually if you look at the bottom of the video you will see a light brown flooring, and then white where the wall begins, so they could go on the wall.

[@momekh]

Why does a 14 year old know about p53 mutation... ? How can we have more 14 year olds like that?

[@cswess7256]

Momekh biology class? most kids take it in 9th grade, whether or not they remember it is a different question of course, and i guess she did. kids arent as dumb as you may think

[@Kerigen]

Yeaahhhh I'm a freshman and knew about that😂😅

[@florianwicher]

We can make more of those using CRISPR ;D

[@jamarihamilton1126]

AP Bio

[@gautam8072]

everyone knows that i think

[@zipity2782]

I love how at first he’s teaching them, by end he’s getting taught like literally just listening.

[@sarahctic1865]

I live how the expert gets half the video

[@theultimatereductionist7592]

I, too. Except, they end up talking at the dumbed down 0 level anyway.

[@michaelvenezia9673]

You have just clued yourself into what this video is....... it's not a normal conversation where LET'S JUST RECORD TWO PEOPLE CONVERSING ..... it's a commercial for something we need to get used to.....

[@AC_Blanco]

Those god damn changes! Everything is moving so fast, let's go backwards.

[@zakman246]

Maybe you should watch "Kids react to" as it may be more your cup of tea.

[@trenzinhodaalegria8012]

The expert already knew about it and instead of just listening to an unnecessary explanation he started to talk about it and basically trade ideas, predictions and etc with the biologist.

[@BellaDiDomenico]

Thank you for having me on this! I loved working with all of you!!

[@samithjay5569]

WOAH WHAT IS THAT YOU

[@yashagarwal3946]

Nice job

[@gauravgummaraju]

Bella DiDomenico The interviewer guy was really impressed you knew about p53. Great job

[@BellaDiDomenico]

I was the teen they interviewed!!

[@buttersXI]

Damn check you out

[@amedyr863]

I love this series, especially how they don't dumb things down from the very first level of difficulty.

[@tuomio5043]

Ann Wright "don't dumb things down"

[@TheRealOtakuEdits]

Emil Aaltonen All he does is use more accessible language while getting to the gist of things more concisely.

[@tuomio5043]

OtakuEdits really, he didn't bring almost anything up with the kid. obviously this is understandable.

[@linuxd]

Emil Aaltonen which is a great place to start especially for those who never went through modern schooling like I have, in which I was literally taught a little bit about all of these complex sciences that effect our society so much today, and also for those who need a brush up...like I did because I'm not looking at DNA, RNA, Proteins, and this kind of work on a daily basis. lol

[@tuomio5043]

Rory M that's the point. he's dumbing things down because the kid obviously doesn't know about crispr. I'm not saying it's a bad thing, just that the original comment was wrong.

[@viepng]

The teen is definitely in ap bio, sis knew what the p53 gene was lmao

[@alwaysprocrastinating355]

lmao and I was so shocked cause it said she was 14 meaning she was a freshman and I pretty sure most people don't even let freshmen take APs (mine didn't at least). I took AP bio sophomore year which to some is early but her being a freshman is super impressive

[@kojo6387]

@@alwaysprocrastinating355 I’m taking AP Bio as a freshman, since it’s virtual I barely understand much ;-;

[@chiffy755]

I'm taking normal biology, and I knew about CRISPR and how it works, at basically Level 3. I'm not actually sure it has to be AP Bio, although maybe I just have a good teacher - he gave us some really cool reading and it was very interesting, however it left me with a lot of questions, such as how guide RNA works. I'm just thinking she'd probably know about CRISPR if she was taking AP Bio

We are taught that at school

[@sarimkamal5649]

Lol i thought it was written 'play station 3'

[@hanifwardhana8633]

this guy is great. he really know how to start a conversation.

[@sebastiansebastian5270]

Hanif Wardhana Agreed

[@kevinkelly8896]

Shoulda seen how fast he got me in bed.

[@hxcAMBERhxc]

And he has great socks.

[@MoeMentos]

Hanif Wardhana Not really. His tone is really condescending. Talks to everyone like they're a child.

[@fatsacktony1]

CRISPR leads to hundreds of unwanted untargeted mutations. It is hardly safe.

[@flying_phanny5704]

The explanations just kept getting crisper and crisper...

[@hiffahyphae6707]

Omfg I hate you

[@sabrina3138]

Lol

[@niko-pp]

can you explain memes in 5 levels of difficulty

[@somespaghetti9301]

Niko i would be the expert

[@shannonbear8807]

Make this top comment 😂

[@nightangel3578]

No, you dumb shit.

[@ladynoluck]

Niko Memes are actually a real psychology/sociology concept, so they actually could talk about it (internet memes still fall under this concept of memes, btw).

[@epoch7136]

I am god-like in the deparment of Memeology

[@dishaaithal1223]

Lvl 1: I understood Lvl 2: hmm interesting Lvl 3: I am lost Lvl 4: still lost wait what Lvl 5: I am in space

[@Omprakash-fd2pc]

Lvl 6 : gone back to big bang

[@davieskamanda6622]

I understood all of it

[@wooooo0oo]

@@DSam-de1fr bye

[@cameronmartin7613]

@@DSam-de1fr I love u wish you the best but I'm not reading all of this see your smart I'm smart but I'm the type of smart person who dont like doing stuff (lazy) stay smart an dont be like me

[@voxtur__7]

@@DSam-de1fr As a high school graduate with particular interests in biology, I daresay the expert level conversation was not as incomprehensible as these people in the comments section consider it to be. They used terminology that I could understand. Further, they were just communing about concepts and possibilities, as opposed to "discussing" the actualities in detail, which I think is reasonable as deliberating on known and proven facts is not as productive as doing likewise with outcomes, or in general, more subjective matters. Albeit I did understand majority of the conversation, I would love to do more research on it. Wikipedia! Here I come.

[@nixel1324]

That blue cushion looks edited in.

[@Okay-vz3qw]

They added it in with CRISPR

[@meghanaroy16]

FEED ME omfg! This reply is underrated 😂

[@nixel1324]

@@meghanaroy16 Can you really call it underrated when it was only 5 hours old?

[@meghanaroy16]

Nixel well yeah..because sometimes you can get more likes even in 5 hrs and no seeing it has been 2 days and only 9 likes it is def underrated

[@susy14valentine]

The yellow one too😂😂😂

[@highonglucose1168]

You see how the biologists body language changed when the expert started talking 😂

[@RoyalRahim]

HighOnGlucose commenting so u know how many likes you have

[@medjov1061]

Because instead of explaining its more of discussing thoughts and ideas to each other and explaining it to us viewers

[@highonglucose1168]

@@RoyalRahim nope didn't realize

[@alextrevino1067]

HighOnGlucose indeed I saw that and at 6:24 he interrupted her because she was knowing to much and she went over the subject of what the biologist was talking about

[@yowisarias1433]

@@alextrevino1067 epigenetics or gene expression is relevant tho?

[@CommanderBalok]

While the ethical considerations are important, I wanted more about how it actually works.

[@haileywang3434]

CommanderBalok level 3 kinda already explained it well using gRNA and Cas9 protein to nick out a piece. Or iCRIPSR/aCRISPR for easy editing by phosphorylation

[@XMysticHerox]

It’s a complex between a protein called Cas9 and a short palindromic RNA sequence which corresponds to a repeated palindromic sequence (a CRISPR) in the DNA of the target organism. Using the guiding RNA Cas9 can find the sequence and make a cut allowing for various ways to insert something new in the gap or cutting something out.

[@boxelder9167]

It’s like a Ninja but for DNA.

[@SV-fq9kl]

Yes and the melatonin undergoes expohilyation, which deteriorates the plasmid solution , thus enabling the catarctrophylic sect to change the gremlin in the DNA

[@lorenbench3320]

@@SV-fq9kl word salid anyone?

[@princesoprano]

I’m doing a Master’s Degree in Genetics and CRISPR-Cas9 is my favorite subject. The level 5 conversation is music to my ears ❤️

[@peekabooo292]

i really find genetics interesting and would like to master in that. what did you study after your high school? do you need an mbbs degree?

[@princesoprano]

@@peekabooo292 Genetics is the best subject in the world so keep going on that path ;) You don't need a medicine degree at all to study genetics. I simply studied biology for my Bachelor's Degree, along with taking genetics, cell biology & molecular biology courses along the way. Good luck!

[@thedeviouspanda]

Genetics is so interesting but any amount of chemistry makes my brain shut all the way down 😔

[@peekabooo292]

@@princesoprano thank you sp much!!!

[@nullify2750]

@@thedeviouspanda ikr 😢

[@muzammilhalim3188]

LVL 6: KZbin COMMENTERS "Do you know what CRISPR is?" "THEY'RE TURNING THE FROGS GAY!"

[@anastasia.beaverhausen]

Omg who taught that child about p53? Bless her science teachers ...

[@JollyWanker]

We learned about p53 in high school biology, 6th grade during carcinogenesis lessons. Is it really that special in the USA to know about this? Lmao

[@MeganMarieT]

I took honors biology last year (my freshman year of highschool) and we learned a little bit about cancer but we didn’t learn anything about p53. We did a lot of DNA and genetics though

[@kathleenl1882]

@@JollyWanker yeah, it's that special. In 5th-6th grade, the "p" i knew wah photosynthesis. Then in junior high, the "p"I knew are photochemical reaction and pen*s. In my highschool, finally I knew "p" with some numbers, p680 & p700 photosystem. Yea, my whole point is, that's just how advanced you are, compared to most south east asians...

[@nuclearclarity3778]

p53 is taught in freshman biology in the US it’s really not that abnormal

[@jessicabraud3307]

Yeah I learned that last year in Freshman biology. It definitely depends on if they remember it or not lol. The school system sets it up to where you remember everything for the test and then forget it right after

[@LelouchVelvet]

Funny when you're the age of Level 5 but knowledge of Level 1.

[@aliceliddell8413]

And vice-versa #HumbleBrag

[@charlotted4642]

Alice Liddell you’re 7?

[@aliceliddell8413]

Not that literal, and also, that was only a joke ;-; I'm not that smart T-T

[@clashcrafter]

Yeah he's a 7 year old CRISPR Expert, who researches it in the lab. duh

[@eternaldesolution6205]

It's not about age, it is about education level and knowledge.

[@shreyassuresh7924]

I’m a biochem major, the level 5 was really interesting. CRISPR has huge possibilities, but it going wrong in a patient could have huge repercussions. Tread lightly scientists

[@ganjiraja9407]

Quantum computing or Quantum physics explained in 5 levels of difficulty.....That would really be interesting trust me.

[@lammy3055]

But you can't explain at levels 0-4, and at level 5 you just admit that you don't get it

[@zetharic1610]

Lamanite Flarpleston yeah..... that thing is complex.... even the logic behind gravitional waves is beyond me even though it seems perfectly logical :(

[@angeah.6555]

u sound stupid

[@themegacurly2]

Yesssss. Please. This is a promising idea

[@gardenofeden9217]

Ganji Raja its easier to do rocket science than quantum mechanics or any concept of quantum physics.

[@CRIZZIEE]

As a 9th grade biology teacher, I have enjoyed this so much! I am going to show it to my students.

[@bagelsaredonutswithoutambi7113]

Lequan LD Top 10 Most Shocking Anime Twists of All Time

[@justvibin7576]

C R I N G E

[@theclassicgamer965]

Bagels Are Donuts Without Ambition top 10anamie rights

[@Delayeed9]

You go grill!

[@Xtrodinary20]

They should make a lot more of these and turn it into a regular series. I see the Neuroscientist one in recommended so that's cool to see theres more. Also, I feel GATTACA maybe be more closer to reality than Jurassic Park.

[@brandasorus5096]

There's no way Gattaca is closer. I can't imagine people would be more open to doing it to themselves first than animals. A not so cool version of Jurassic park will come way before Gattaca

[@brandasorus5096]

Kahtrao I don't think you know how genetics works. A two headed sheep is not plausible let alone possible. And using gene therapy to mess with cosmetics is not possible either. And obviously people don't think cloning animals is bad because we've done it so much. Also people are definitely aware of the ethical and moral ideas behind genetic modification. There is already tons of coverage on those ideas in a large group of media

[@ApexHerbivore]

Shrek is closer to reality than Jurassic Park.

[@emeralddiscordian3116]

good to see GATTACA mentioned here and honestly as mentioned by the teen I think people will be be more then willing to use it to edit their children somewhat like GATTACA but no completely unlike dr moreau

[@emeralddiscordian3116]

and why we may not be at the scale of GATTACA yet we are more then close enough to start talking about the ethicalness of it all and that I think is the scariest part, everything has the potential to be misused and a crispr is inherently a bad thing all it takes is a mind looking only at profit and manipulation.

[@theemilyguy52]

First watched this video as a science-curious high schooler, now rewatching it as a junior molecular biology major who is actually doing CRISPR in the lab ❤

[@ajesusencounter8261]

Love how 9 whole minutes of this video is just the conversation with the expert. Really shows how much more in-depth you can get in a conversation with more knowledge

[@anthonyJones-ll4ei]

each interview is about the same amount of time, they just cut parts of it out so the video wouldn't be too long.

[@conradkai9705]

Yeah, that's right. Only expert level discussions involve Jurassic Park

[@lisilein2]

I think you'd be surprised how many movie's are referenced during a conversation between experts (of any field).

[@jinnie6292]

Amit Sethi I wAnT ScEcHwAn SaUcE!! XDXD

[@littlemisstoes]

OMG Rick and morty fanboys are insufferable. You don't need a high IQ to understand that show, get over yourself.

[@olliveraira6122]

I got the idea of editing DNA (in humans as example) for Jurassic Park, today its really my biggest dream in my life, to change DNA, modify, make improvements/changes in different animal lifeforms EDIT: Im not a expert on anything within the medical world, Im just a dreamer (Referring to Tomorrowland, the movie)

[@shottotheface75]

littlemisstoes it's a joke

[@bungusgrumble7524]

Level 6: Rick and Morty viewer

[@kacesux7712]

Bungus Grumble 😂

[@nguyenchihieu7332]

Hmmm that gonna be hard :v

[@kingviper5700]

200 IQ too smert

[@CartoonKidOLLY]

Lol

[@armitage5855]

This is the only type of bullying I enjoy.

[@RuleroftheWorld]

I like how in most of these type of videos, when they get to a professional, it's someone they've met before and it's as if they're just catching up.

[@devSparkle]

It's interesting to note how the conversation begins with the near-infinite possibilities of CRISPR and slowly develops, as the levels progress, to a discussion on the ethics of using this new technology.

[@JakobPapirov]

Ricardo Loureiro and also the limitations.

[@iLuvTofu20]

Low key I'm pretty impressed this teenager knew about p53 hahaha

[@AndriyLinnyk]

it is something they probably went over in highschool

[@esnipopulate9607]

Gus She just has biology class. That's where she learned it.

[@hat12071997]

Gus maybe she had someone in her family with cancer caused by a p53 mutation or has an interest in genetics.

[@ellasnow3575]

We learn that in the molecular genetics portion of Biology (9th grade)

[@charltonlepkofker2711]

+ESN iPopulate nah I bet she just looked up some information online surrounding the topic she was told she'd be discussing. She appeared uncomfortable with the teens she was using.

[@therevolutionwillbecaffeinated]

I'd love to see a linguistic version of this 😊 these videos are great, I love them

[@Cmrang99]

Calum McGee -a--

[@Rolando_Cueva]

I second this

[@lukeburke8787]

Me as well

[@_tacins_]

YES

[@jiehanaldicho3710]

Indeed! Most people have misconception about linguistics

[@heartsdeprived]

This is why peer review is SO IMPORTANT. It’s a checks and balances system for both the primary scientist and the society as a whole.

[@theabrasileno1921]

Wow didn't know Sam Smith was a CRISPR scientist.

[@gf1x119]

Lol

[@ndpd7695]

Hahaha

[@SinoLegionaire]

A true renaissance man. www.realmadrid.com/img/vertical_380px/benzema_380x501_20191221090937.jpg; he also plays for Real Madrid.

[@ikz8439]

Lmao

[@beetlejuiceisreal238]

@@SinoLegionaire oh man, what a genius.

[@Ryukachoo]

holy shit make this a regular series, this is excellent stuff

[@valentinion6554]

Ryukachoo it is a serie

[@seamuscallaghan8851]

By the time he got to level 4, they were explaining the concept to him.

[@leorYJackanory]

The tables have turned

[@sizzlinsj8135]

Yeah also he started asking doubts to them... lol

They're in University level and what we do in classes in university level is more like that.

[@aon02b]

Level 3 actually :l

[@Cannongabang]

Well not really, more of a conversation; anyway, 666 likes, good

[@Trackpad_W4rri0r]

Job interviewer: so what made you want to be a bio engineer? Neville: Um I watched some movies on dinosaurs and stuff Interviewer: O.O you’re hired

[@risktaker7996]

Good idea

[@aaimaayub7713]

Its true.. Jurrasic park and cloning were definately the reasons why I chose this field😂

[@ianmathes5414]

Level 6: KZbin commenter

[@user-hi4sm3ig5j]

Ian Mathes I'm pretty sure that's level 0 for most of us.

[@SteamyMerlin]

lvl:-1

[@XxXNOSCOPEURASSXxX]

Level 1000000000: Roblox let's players

[@DanielRenardAnimation]

*(Level 6: KZbin commenter)* Hai crispur i wunna hitler t-rex with laz0r bim eyes 4 next xmas, kthx bai

that would be level 0

[@EatsRainbows15]

I love watching these as I can learn something new level by level; I slowly begin to learn it

[@ngand660]

AnOwlThatEatsRainbows that is how it works

[@antdx316]

Maybe the idea is to make a database DNA system for all people who are born and alive 1st before trying to modify it? You start modifying things before mastering how the base is you will have no idea what is truly going on.

[@TricksterRad]

We're actually already building extensive databases of the human genome.

[@nog5904]

No you don't, if you were to take a test from a course on relevant material you'd fail it

[@TheEnglishRogue]

lmao savage

[@witbyy]

Level 1: what your teacher teaches you Level 5: What they put in your test

[@risktaker7996]

So true

[@Clementine3107]

😂😂😂😂😂

[@MaddyBlu9724]

Woah, I have a biology degree and I have to say, the college student they picked had a waaay better understanding of CRISPR than your average randomly picked bio student would. I have to assume that either he learned it really recently or he specialized into more molec bio/genetics study. Or he is just way smarter than me and the people I've been around!

[@lilithlu929]

The first two kids’ area of knowledge are NOT representative of their age

[@jennadombroski1505]

In what sense? They seemed pretty on par to me.

[@nuclearclarity3778]

Not really, the 7 year old didn’t know anything and the 14 year old had a basic grasp of freshman biology 😂

[@kalebsok2947]

a. i. What? Lol Britain and American curriculum aren’t they far off

[@StefV153]

I live in Belgium, soon I'm a junior and I haven't seen a single bit of genetics in biology.

[@genshinaddict435]

@@aishas8794 As a British 15 year old, she is pretty average.

[@bizzblooperz]

Oh please I beg you, make more of these please. This is educational in so, so many ways.

[@lightesque1407]

The only thing holding anyone back from understaning, even someone who can only understand basic concepts, is vocabulary and literary devices. -a kid

[@HassanPoyo]

Go back to Mario, Cappy

[@TheCarbonMirror]

to an extent, there's some stuff that requires years of dedication to memory, some concepts that are super complex and hard to follow, rules that you need to develop and logical patterns of thinking that a lot of people's brains haven't developed well at earlier ages. there's a lot more to being an expert than memorizing and understanding words, the really hard stuff is solving new problems. All I'm saying is get really good at math. especially algebra and multi variable calculus, computers can do all the memorizing and other math pretty easily.

[@ILikesexalot]

well, if you really understand something, you don't have to memorize anything in math or physics-- maybe biology.

[@angelmendez-rivera351]

DanKest Yes, but the point is that understanding goes beyond vocabulary. It's easy to see this once you've encountered enough nutjobs in your lifetime who throw word salads and logical fallacies at you. In fact, you really don't need much vocabulary to understand most concepts in physics. You do, however, need some very advanced geometrical and mathematical thinking, and you need to know how to carefully make generalizations.

[@zoom-zip3473]

Angel Mendez-Rivera as he throws a word salad

[@penguin0101]

Level 5: When Sam Smith altered his DNA and decided to be a scientist

[@mdadil1456]

Lol

[@gluedglued1252]

tranpshobia is not cute

[@flowerbed7757]

Transcareeria

[@user-gt1kd9rv1w]

Lmaoooooo

[@SirMinelli]

0:50 "It's kinda like an instruction manual" kid's mind: wtf is an instruction manual?

[@SLEEVEASMR]

Tulo Chavez 😭😭😭😭

[@Hyblup]

Imagine following instructions

[@yhctaw]

😂😂😂

[@thecomfyshirt]

Ummm.... I’m pretty sure kids still play with legos.

[@SirMinelli]

@@thecomfyshirt Yes, but not with instruction manuals.

[@thatlad27]

He seemed to actually start to learn stuff from the last guy, really cool video format.

[@gokenrocks]

Indeed

[@JM-us3fr]

Number Theory preferably

[@SciShorts]

Level 6: Biologist asks God if CRISPR is good or not

[@X606]

God: ofc its good, how do you think I made anything?

[@kerryhart9418]

Ask parents of children on the autism spectrum & many other diseases some fatal weather they would like a cure, easy for those not affected to say no leave it to god, but it's these god fearing people who select who they will allow into there circle & who they won't, try living the life of being ostracised by society. Bring on crisper.

[@ItsTornHD]

Angelo Consunji what God are we referring to?

[@LucyMusic1999]

@@ItsTornHD The Spaghetti Man

[@boxelder9167]

Torn V - It’s probably the God you find most objectionable. Nobody really cares if you talk about all the other gods because we know that they don’t have any real authority.

[@allisond.46]

When the guy said “mistakes... and people get sick”, he probably wasn’t talking about allergies, but he went with it anyway.

[@jonathanodude6660]

allergies are genetic but not really present in your genome

[@JerenVelletri]

crispr is the coolest thing to come out of science in the last decade

[@Donglator]

no one gives a fuck

[@hahafunny4538]

*cough*Nutella*cough*

[@Vyrilien]

I-I'm someone...:(

[@AuCafeDeLaMarmotte]

Nutella is from 1965

[@Jorjioo]

Linguine Snek uhmm, no, not terrifying at all. Try again please.

[@brahmse9409]

Expert: Do you know what CRISPR is? Me: Yeah, it's how I like my churros!

[@mtgsk5180]

🤣🤣🤣🤣 omg

[@AB-hq6kw]

Hahaha

[@clearlythuydoan]

Love this 5 Levels of Difficulty series. CONTINUE IT PLEASE.

[@gloriatrinh5559]

here they are only talking about the use of CRISPR in the medical field but it can be used in so much other ways like with crops to make them resistant to some pests, grow with less water, or improving their taste or lowering the impact of their gluten on gluten intolerant people. It's truly a precious tool that will revolutionize the future !

[@hollyjones3710]

Mitochondria isn’t the powerhouse of the cell. I am.

[@laurynpending6958]

ATP is what gives you that ENERGYY

[@dylankrejci9965]

I am the one who knocks

[@user-un6je1jh5g]

Russian has entered the chat

[@gwenshirebros4883]

Wrong

[@JeremiahWatkins-zv8bn]

Holly Jones I am inevitable

[@khl2445]

the grad student was like.. let ME explain it hah

[@bigmarv5656]

It's one of those things where you want to show off that you know something

[@YoursTruelyMe2]

I love hearing people who know a lot about a topic speak about it. They have dedicated their life to solving problems that most don't think about. Just Great!

[@DoctorJack16]

CRIPR and what Alphafold 2 just did with protein folding is going to change so much of the biomedical sciences and so much more. It made my list of most amazing scientific and technological breakthroughs that happened in 2020 in my KZbin video. This was really cool to watch the levels of understanding. So important to be able to explain things like this. Keep spreading the knowledge!

[@laxsplash78]

bruh im in college and the 14 year old is smarter than me

[@jmike1197]

olivia ik

[@glubglub5120]

Haha love this so much

[@VibrGames]

Why if my degree is in Dairy Production?

[@fuvet]

Consuela your degree is in Lemon Pledge

[@Atlas92936]

fuvet hahaha

[@coldclearkt]

Level 1 should have had level 5 on an earpiece, telling the kid what to say😂

[@MrsLynthia]

I think this is a very nice concept, but for me it was a bit misleading with the title. I hoped to actually learn something new about how CRISPR works since I expected that it would be a scientist EXPLAINING it at different levels, not DISCUSSING it. Of course the ethical issues are very important, but I had hoped it would be a video in which I could learn more about CRISPR and not listen to a discussion about ethics. It would have been nice to hear a less vague explanation.

[@Quintisence]

Äldi you’re just dumb

[@henkdesteen4299]

Everything that has to do with CRISPR has to do with ethics.

[@pepavasata6790]

I feel like it was explained fairly well. It uses RNA to deliver the thing that edits the genome.

[@Max-zf5vt]

Äldi As a university student who knows a lot about biology, the actual science behind CRISPR can’t be explained in a 20 minute video. There’s so much background and understanding needed to grasp CRISPR that the ethics side of it becomes a more productive discussion.

[@vishant98]

@@Max-zf5vt I get your point and I also totally agree with Äldi as I thought they would start discussing like what machines are for crispr or what chemicals are used for tests, like something totally practical they did in the labs regarding crispr. But they kept discussing what should be legal and illegal and ethics so yeah. And coming to your point, they could have given it in short the science behind crispr like they told about ethics in crispr (which I know is also not such a short topic that it can be discussed in a 20 min KZbin video, then it would have been a more interesting video. Don't mean any offense.

[@maryaurelio1835]

I attended high school in Italy and i learned about Crisper during biology class like it was at the same level of knowing the mitochondria is the power house of the cell. I think its really nice how they teach biotechnology in high school here!

[@stoutlager6325]

with kid: Hey we can do all sorts of crazy stuff! with expert: yeah, we're not actually there yet though.

[@sparklynarwhal7158]

5:25 by that logic you cant have children because they didn't consent to existing.

[@Ice.muffin]

Yeah I didn't consent either..

[@michelleobamafootcream9292]

I did not consent😤😤

[@sparklynarwhal7158]

@DejaVoodooDoll dude... it was a joke...

[@ItsAstie]

I surely didnt, how do i not exist

[@nellsea8086]

Fr bro them mfs didn't even ask me

[@jessicagomez1760]

The grad lady was not there to learn at all, props to the expert host for being emotionally intelligent and having the patience of a true teacher to listen and know when and how to answer back. Loved the final conversation where they where clearly giving us a lesson, stating probably pretty obvious arguments for them for the sake of teaching us a little of what and how they do what they do. Great video.

[@I_THE_ME]

That college student knew a lot more than people would have expected him to know. Actually every single person who were asked about CRISPR in the video had much more knowledge about biology/the subject than one should expect.

[@dreamgaming8471]

Physicists explain one concept in 5 level of difficulty. Quantum physics

[@araleker]

DreamGaming yessssssssss

[@CtrlAltDeliciousGaming]

yes please

[@Dexx1s]

Level 1-3: You're not knowledgeable enough to understand this. We're done here.

[@chrisczaja5384]

Dexx the Duck I'd agree with you on level 1 and 2, but a college student should be capable of understanding at least the fundamental basics of quantum physics...

[@Dexx1s]

Chris Czaja And what are these fundamental basics? Can that student sufficiently talk on a topic related to quantum mechanics based solely on that knowledge? Quantum mechanics is a rather large topic, and would probably require knowledge in other areas in order to have a conversation that could make for a video that's not incredibly boring. For example, I could understand most of what was being said in this video, as a CS degree holder with almost no knowledge of biology, because it wasn't just gritty biology and was a topic that was simple. Quantum computing took a decent bit of brain power to actually understand to the point where I could sufficiently hold an interesting conversation on it. Quantum mechanics is something you definitely wouldn't want to see done in this format.

[@ryanwsu4]

"Id love to visit jurassic park" Dude.... have you seen any of the movies.

[@andrebadillo8568]

This some Gattaca shit right here

[@vapeangel2953]

Andre Badillo the last guy even looks like Jude law !

[@brandasorus5096]

Andre Badillo this fucking comment made me laugh for 10 minutes

[@gokenrocks]

Andre Badillo My thoughts throughout the entire video.

[@andrewrobertson444]

Exactly, and that's why they talk about ethics all the way from level 2 to the top.

[@emmanuelmeris5841]

To people who think ethics issues are a genuine reason for denying access to therapeutic applications of gene editing. Fuck you very much - From the parents of a genetically sick children everywhere. #curerettsyndrome

[@jacksonh3457]

Love how the grad student only talked about the ethics of it but barely any of the actual science

[@geneie6050]

True. The college guy had most knowledge that was displayed atleast. Saying this as a biotech college student who has her exam on it tmrw