Wounds and healing 1, Tissue regeneration or fibrosis

Wound healing occurs whenever there is injury to the tissues of the body. An injury describes an area of loss of continuity in any body tissue, this may occur as a result of trauma, infection or a pathological process. The mode of wound healing depends on the powers of regeneration a particular tissue possesses. The following are some examples at specific sites.
Liver
Liver is able to regenerate very well. For example, acute hepatic injury caused by viral hepatitis or toxin exposure, can regenerate completely restoring full form and function. However, chronic insults such as ongoing exposure to alcohol or hepatitis C virus, may result in the formation of collagen based scars and the development of cirrhosis. This latter process is associated with loss of functional liver tissue, so may progress to liver failure. This gives hope for heavy drinkers; liver function may be restored, sometimes after many years of abuse, as long as the person stops drinking before cirrhosis is established.
Kidneys
In the kidneys, epithelial tissues lining renal tubules may regenerate but whole nephrons do not. This means that mild damage to the kidneys will heal completely but more extensive injuries will result in scar formation. The glomeruli are the balls of capillaries within a Bowman's capsule and do not regenerate after injury. However, if one kidney is removed, the glomeruli in the other kidney enlarge to compensate.

[@anwarajaj6333]

I'm a biology major senior, and I have forgotten a lot of what I have learned in my earlier years, but with your videos and explanation, I understand everything again and I learn new things too in simple informative explanations . You are great!!

[@visionary87]

Dr Campbell thank you so very much. I study to become a nurse in Canada and I love reading and going in depth, particularly in the subjects of pathophysiology. I fell in love with your explanation of body fluid movement and the body fluid compartments and I never stopped watching your videos since. Thank you so much!!!

[@pataniki8034]

kudos dr john it took me 15 yrs of research to learn what you explained in this vid re regen starting at 2mins-some like kidneys can not in whole regen but i have found that pressure based movement therapy increases blood flow to organs and area and that in time it helps change the damaged nature of the situation-manythxsgr8shares

[@lihins435]

Thanks Dr Campbell, you are a excellent teacher and your videos are very, very helpful and has helped with my study so much. Thank you

[@ciarj25]

I love all your videos. Very helpful!!! Thank you so much!!!

[@kundaputs]

best way to learn. keep up the good work!!!

[@Cmielcahs]

Clear and to the point. Helpful, thank you!

[@giovannamead8270]

Thank you so helpful! In the future can you publish videos regarding transplants!

[@bothainah8420]

Thanks! very informative.

[@zeezeebo]

Great job! Thanks!

[@001971ful]

Informative...

[@lesaroderick5058]

Brilliant thank you for sharing

[@Docrashidahmad]

Nice,thanks doctor

[@abelincolnparth]

nice summary, thanks

[@danaghazaleh9117]

Many thanks

[@cherylenerantsedi1226]

Love your video’s, help me so much

[@jungsuli]

thank you

[@Dazzletoad]

Dr. Campbell is an incredible man, and incredible teacher. Just a curious question. Given that all the cells of the body that contain genetic material contain the same genetic material, our blueprint, and also code for cellular and therefore tissue repair, why is it that liver cells have a high capacity for regeneration but brain cells don't? As you have explained the liver can suffer extensive damage and yet, provided with respite, it can and will regenerate without a problem, but damage to the brain can lead to permanent loss of cells and therefore permanent functional problems of the organ.

[@Campbellteaching]

I wish I knew that one. Part of it is the present of stem cells in the tissue, but why some cells are capable of ongoing mitotic repair while others are not is a mystery to me. However, asking the question is a step forward.

[@juancarlosvegapacheco131]

True and you are great

[@pataniki8034]

so far this is one of the more complete overviews with exacting info-in case of trunk muscles cut to access inner organs what the verdict doc-will they ever completely heal back into a cohesive whole-personally i know its a very painful slow process and then if by accident that t12 nerves gets cut and that supply to those areas if effected-loss of electrical stimulation atrophy-and lastly if internal organs have been surgically cut to remove parts of organ-how is the internal healing process different in relation to epidermal external healing- and now lastly if after all this surgical exploratory cut and save stuff-with all those missing parts and separated pieces and moved internal organs what is the importance of the abdominal/front/back/side muscles in holding up and protecting those damaged internal organs-personally i have found nueroplastique regen therapy to be xtremely benificial but very slow-in the rebuild area-perhaps this is an american question of how it once was in the wild western medicine world-its changed somewhat but still these ops happen and damage is sustained but no one can give insight or answer human body rebuilding questions-so far in all this looking you have come the closest-i am aware of the answers being within your detailed explanations and those millineums of experience-training and as teacher-manythxsthisoneisgr8

[@oliverjames9922]

Aye John before people thought he was a covid puppet. ✌🏼 helpful video thanks

[@carolethomson7105]

Thank you Professor, I've just had surgery to my lower leg following a break in my fibula which required a plate and screws. My external wound is healing lovely and is at stage week 4. I am experiencing internal tingles though so I'm assuming that's the internal process. I'm due to see my surgeon again in two weeks so I'll discuss this with him. Thank you, your videos are brilliant.

[@Campbellteaching]

People do experience a range of sensations while wounds are healing, but of course you should always check with you local doctor.

[@carolethomson7105]

Dr. John Campbell thank you Doctor. I'll keep watching your videos, they are awesome 😌

[@maaan8494]

Are you from Stoke Dr Campbell

[@jamesthomas5993]

in secondary healings like in preasure ulcers ,why not draw fresh blood from the patient and put it in a freshly debribed ulcer and seal it a few times a day to get the extra cytokines to help out,especally if there not healing in stead of stuffing it which is very painfull on the exposed nerve endings,remember pain means its in the process of scarring no pain means no scarring will occur,i look at it with the eyes of Hippocrates,thank you doctor in one of my experments I stuffed a piece of gause in a wound and the skin not granulation tissue grew into the gause fibers and I had a mess and had to sand it all back out and start over in another experiment I trapped air bubbles in the wound and the skin had grown with airbubbles in side the skin, I even made a mold of a coin and placed it on the wound when the skin grew into the mold i had a perfect impression of the coin but it soon grew back to a scarless wound,i find the imflamation and destructive migratory fase of a wound unessessary in wound healing , the way I treat a wound it is nice and pink the whole time,im finishing another wound in a day or two scarless as usual good bye

[@the_unconventional_Indian77]

Hey need your help i have gastritis my stomach lining is inflammed

[@azouz5675]

but professor why After tooth extraction the Bone does not regenerate as well as other places so After extraction the alveolar Bone resorb and don't grow UP ?

[@Elections2013]

Peripheral nerve axon regenerate at rate of 1mm/day. Or 1inch per month.

[@btudrus]

I wonder how much of those tissues which are being thought 'not to regenerate' actually can regenerate if stemm-cells are in play (like after a prolonged fast)...

[@jennifercervantesd]

What about the stomach lining ? Am I doomed?

[@fhoo00dy2012]

thanks doctor

[@jamesthomas1753]

we have 10 times more lung than we need