You Think You Understand Autophagy...You Don't. | Educational Video | Biolayne

James Smith Fasting Video:
/ c2pfasjviiw
Caloric restriction increases autophagy: pubmed.ncbi.nlm.nih.gov/37527766
pubmed.ncbi.nlm.nih.gov/30172...
pubmed.ncbi.nlm.nih.gov/21364...
pubmed.ncbi.nlm.nih.gov/32068...
Exercise increases autophagy:
pubmed.ncbi.nlm.nih.gov/35269...
pubmed.ncbi.nlm.nih.gov/29626...
pubmed.ncbi.nlm.nih.gov/30430...
Caloric restriction in monkeys increases lifespan
pubmed.ncbi.nlm.nih.gov/28094...
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[@jslull]

I’m suffering from excessive and perpetual autophagy. I’m basically immortal at this point

[@Lillypad3183]

😂😂😂😂😂

[@karlhungus5554]

People like simple explanations for complex processes. It's understandable and definitely a trap into which I've fallen. Now, decades older and after having read, watched, and listened to so much information from so many different perspectives, I'm convinced I know virtually nothing about anything.

[@nicktheodorou3474]

Yep! Same here.

[@royjames196]

I feel your pain 😢

[@dieppat]

The more you know, the more you know you don't know!

[@karlhungus5554]

@@dieppat Well said. That makes me think about Donald Rumsfeld's famous quote: "...as we know, there are known knowns; there are things we know we know. We also know there are known unknowns; that is to say, we know there are some things we do not know. But there are also unknown unknowns-the ones we don't know we don't know."

[@elisea.740]

The more you learn the less you know.

[@nikbiz]

Prolonged fasting has a direct correlation with bigger bank account.

[@mementomori29231]

Not if the person binges on huge meals after prolonged fasting.

[@limitisillusion7]

Nah, catering menus and cooking in bulk is cheaper.

[@propaycheque]

Hahaha literally just live off the fat of a time when groceries were cheaper

[@nattyfatty6.0]

I've noticed a similar phenomenon with Carnivore, Veganism, and other fad diets

[@rgh622]

Unfortunately, I also completed my graduate studies in autophagy and can say unequivocally that fasting will increase the length and girth of your protein straw if stimulated with the proper vigor. I say this with the utmost of respect for the algorithm.

[@JustWantedToGrill]

Lmao

[@elisea.740]

😂🤭🫣

[@kathleenhamilton4756]

😂

[@Physionic]

I know nothing about autophagy

[@dangallagher6176]

I was literally watching this thinking "I wonder what Physionic's take is on this?" then your lil name pops up in the comments

[@Dan-dg9pi]

Has this guy ever done a video that isn't obnoxious and full of unwarranted assumptions? But it is good to know that he and his buddy are the only two people with the answers.

[@peterkephart7955]

Ha! I just recommended your channel prior to seeing your comment.

[@grashoprsmith]

Some people are the .01%

[@Dan-dg9pi]

Just to be clear: Physionic is the gold standard. Mr KissesHisBiceps not so much. Mockery and loud braying because you took a graduate course in a subject is what is known as knowing enough to be dangerous. I'll stick with Physionic.

[@marcdaniels9079]

Categories of food crazies was GENIUS. 😅

[@Fvfm2000]

😂😂😂 yes, hilarious!!

[@AndreiPetcu_]

There is nothing crazy about not hurting animals. It's just common sense. Vegans are no crazy, we just follow the science. Maybe raw vegans are crazy but us, normal vegans, are not crazy.

[@TheFracturedfuture]

​@@AndreiPetcu_All vegans are crazy. We evolved to eat meat

[@marcdaniels9079]

@@AndreiPetcu_ In this context “crazies” is a figure of speech ie the word is not being used literally. However veganism is only one world view and there are many others, so it’s not common sense, rather it is a philosophy which you subscribe to and you are quite entitled to do that. Some of your fellow vegans do come across as somewhat evangelical to put it mildly

[@DAce-vu5ct]

​@@AndreiPetcu_shut the hell up

[@hardlylast]

I used your videos to study for my cell bio and metabolism class back in 2017 and got an A in a class I had no business being in I was just super interested. I have completely changed my mind on fasting because of videos like these. Thank you

[@daveramsay8115]

Haha love the energy!! Great content and very helpful! Thank you!!

[@stevelegg9901]

Absolutely brilliant, thanks again for knowledge bombs Layne…..absolutely love your posts …..so so knowledgeable ❤

[@Claire-f]

As someone learning about lysosomes and autophagy right now this was interesting. Thanks for the help 🙏🏻

[@computerhelpcc]

Doc, a core part of your audience is already doing all the big stuff correctly for decade (s) so clarifying what else is worth doing is appreciated.

[@musclemaster8509]

I loved the content and the energy 💯💯

[@Lillypad3183]

As always great straight forward explanation.

[@michaelp5518]

Love IT! Love the presentation. Love the passion.

[@etherealreality2598]

Thank you for explaining this succinctly.

[@AlphaDad]

your analogies are phenomenal

[@DDHS_Podcast]

Hi Dr. Norton, thanks alot for making such a great educational video about autophagy. For someone working in the academic research, even for me it is difficutl to grasp sometimes the many layers this specific topic about autophagy has. So many interesting articles and reviews are out and still it is not really clear which amazing pathways are still hidden. Thanks for making this clear! I am looking forward to your next video!!!

[@ThommyB]

Hahah awesome. Love your video. I do intermittent fasting because it put you in a structure that can help you to get rid of bad habits. I quit alcool, energy drink and all snacking thx to that structure.

[@ivanorozco4274]

I so appreciate the sacrifice in revenue you and other warriors of truth make when deciding to post these educational, simple, straight-to-the-point kind of vids. It's so alluring to hear about "the magic of fasting" and "the secrets of autophagy" that for neophites as myself, your kind of work is a real life saver. Keep it up Doc!

[@lordjaraxxus663]

It seems to work strictly for weight loss very well for me because its easier to skip a meal of the day than to eat less on all meals. Also easier to cook a big portion meal once or twice than to cooke smaller portions 3 or 4 times a day, less opportunity to eat snacks.

[@theparadisesnare]

There’s nothing wrong with using IF if you’re using for personal preference reasons (although it’s probably better to spread protein out throughout the day for muscle maintenance). Biolayne is just calling out the ppl who are portraying IF and autophagy or any fad diet modalities as magic. They’re not

[@cynthianm1743]

Thank you for the explanation about rat and longevity aspect.

[@JaykleMusic]

Great video Layne, nicely put I actually understood it 😁😂😂

[@robertdipietro991]

really appreciate ur work man sent this to a friend as he was talking about doing a 72 hour fast recently which I was skeptical about.

[@amizan8653]

Good video. Learned a lot

[@wendywertz8828]

I literally was looking this up when your video came up and mtor info

[@medsidney]

🎯 Key Takeaways for quick navigation: 00:00 *🍎 Fasting and Autophagy Basics* - Autophagy defined as lysosomal protein degradation. - Fasting, exercise, and calorie restriction all increase autophagy. - Autophagy is not an on/off switch; it varies based on calorie intake. 02:15 *🔄 Autophagy Comparison: Fasting vs. Calorie Restriction* - Fasting zealots often overlook the role of calorie intake in autophagy. - Autophagy levels fluctuate with calorie intake, not just fasting duration. - No significant difference in autophagy between fasting and calorie restriction over a week. 03:37 *📉 Autophagy and Caloric Balance* - Autophagy levels are higher during fasting but lower on non-fasting days with compensatory eating. - Maintaining a calorie deficit leads to increased autophagy, regardless of fasting. - Argument against the notion of fasting having inherent magical benefits beyond calorie restriction. 05:15 *🐭 Longevity Studies and Fasting* - Limitations of rodent studies in assessing longevity benefits of fasting. - Rhesus monkey studies suggest calorie restriction, not fasting, as beneficial for longevity. - Clarification on the interpretation of "calorie restriction" in animal studies. 06:23 *🤔 Complexities of Caloric Regulation* - Understanding the nuances of calorie restriction in animal studies. - The importance of maintaining a healthy body weight for longevity. - Dispelling misconceptions about fasting and calorie restriction providing magical health benefits. Made with HARPA AI

[@factbots]

Just for the algorithm 💪 Love James also, best six-pack in industry 🤣

[@richardhaselwood9478]

Jesus, the analogies were on point.....

[@nikomak1813]

Hey man, don't change a thing! I love your stuff and the way you present and I find you very entertaining. The people who don't like it can go watch something else lol!

[@TheYangoable]

Love your videos

[@nizarel-ahmar2810]

big man, amazing content

[@samuelcakar174]

Great video!

[@allyc311]

I fell for this the first time I heard it. Fasted and spent forever in the sauna. And told anyone who would listen. And it was way harder than just having a healthy, balanced diet

[@kimmoffat6429]

Loved the episode, mic is a bit scretchy thou pal x

[@michaelaneprasova]

Please, could you comment on the Fasting Mimicking Diet? I would love to know your opinion ❤

[@AngelGonzalez-ej9he]

Just the way he explained everything is so good he got data and real research you can't beat that

[@HSLSFirst]

Love your conclusion. Magic is in being lean.

[@mugflub]

THANK YOU for bringing sanity to the crazy interwebs

[@D.Fay_Coe]

glorious.

[@TeKStaTuS]

@biolayne1 hey layne, I had massive gut issues for years because of an undiagnosed hiatal hernia. My entire stomach migrated into my upper chest and eating was basically a monumental undertaking for me. That said, I had tons of damage done to my body because of the bacteria and stomach acids that were eroding my insides. After surgery and everything being repaired I was able to eat but the horrible symptoms that come with a ton of bacteria still living inside your guts was around for a while. It wasn't until I started doing a 20/4 fast that my body was able to repair itself. I did manage to lose about 60lbs within 2 months (insane and I understand caloric restriction is the prime mover here) but given that our gut micro- biome plays a large roll in our quality of life amongst other things. I wanted to ask you if you have any thoughts on the rest/break that fasting provides to our guts and how that could potentially provide a positive environment for our bodies. I agree with you 100% on your views about fasting and it's effects but I don't really ever hear anyone discussing its effect on our micro-biome. Thanks again for everything and I hope I hear back from you!!! Foooooooooor the ALGORITHM!!

[@santiagobodhi7075]

Interesting, I also wanna know more about this possible link

[@tuckstar]

I've fasted in the past but don't bother now for fat loss. However, if you have gut issues then fasting is one of the best tools to heal your gut issues. It allows the gut to rest from digesting food and heal from food issues. I'd combine that with a very restrictive diet removing gluten, dairy, eggs, nuts and nightshade veg. Look up AIP diet. These foods seem to give people the most amount of issues. After some time , reintroduce them one by one and see how you feel and see which foods seem to trigger issues. This was a game changer for my wife.

[@moaf2padventures757]

this is an interesting question. i wonder if you are actually giving your body a break from digestion when you fast. like if you consume your 2000 calories in 4 hours as opposed to 12 hours are you actually spending less time digesting? or are you just condensing the exact same amount of digesting into a shorter period of time? it seems plausible that it could be easier on your digestive system to spread out your calorie consumption over a longer time period so that your digestive system is not 'working as hard' when you do eat. just theorizing, i have no idea how this stuff works.

[@klocugh12]

I'd wager it is anecdotal. I mean, if it worked for you, awesome. But microbiome is complex and likely individual on certain level. What works for one may not work for another.

[@gafflation]

Studies show that people with the most variety in their diets have the healthiest gut microbiomes. I would assume people that do fasting or calorie restriction are likely to be eating a less diverse diet and so potentially have a less healthy gut microbiome.

[@tristinyaeger9222]

Great video

[@jdtransformation]

Layne, you continue to handle internet trolls w/ the best of them. Question tho - what about Rapamycin? Does it notably move the autophagy-needle?

[@triluve]

do we know anything about "letting the gut lining cells rest" while fasting hypothesis?

[@kevinwicklund9593]

Layne can you please do a video on what age resistance trained people typically cap their lean mass gains?

[@april9337]

Go off king👏👏

[@cristopherbrown2633]

@biolayne Not trying to argue. Am grateful for the truth. This is an honest question. What about the claims of “stem cell segregation increase” and “HGH” during prolonged fasts? I did a 72 hour fast 3 years ago motivated by those claims. Was it pointless?

[@sercan272727]

hgh doesnt do anything at natural levels. barely does anything at endogenous levels. eat 3 meals a day and inject hgh if you are doing it for hgh, its easier.

[@Berzan_007]

Let me know it too

[@GuidedHealthandPerformance]

To my knowledge Layne has covered this before. Regarding HGH increase, this is generally seen because of a compensatory mechanism. Eating less means your body has to work harder to do certain things, basically just increasing fuel mobilization. I believe the first part of the question regarding stem cells still falls under the autophagy argument but idk about all that.

[@DrAJ_LatinAmerica]

Not for everyone. Depends on the individual. In some cases HGH goes down. Case by case, person by person. Lots of variations in age, race, health status......

[@PSA78]

I'm not sure why anyone would focus on increasing HGH by a tiny amount, it's only anabolic to some tissue (not muscles). And we should probably look at the long term outcome, like getting enough stimulation of MPS vs short term low change of certain hormones.

[@user-ip9mw8yg9o]

Golden words

[@pauli2062]

I saw James in the thumbnail and got worried. I always liked his content and thought he may be on the wrong side of science for a moment. Glad it went the other way!

[@oleg.helgwar]

Do I get it right that Autophagy is just a part of a Catabolism (breaking of proteins/fats) which is going on all the time alongside with Anabolism (building of proteins/fats)? And thus Autophagy can happen even when one is in the "net anabolic" state?

[@jjbenjamin8488]

Autophagy is continuous.

[@wendywertz8828]

You should have a million subscribers!

[@biostaples]

Great information and I love that you include CURRENT scientific studies to support your conclusions. I'd love to see you list the full author/title citation and DOI as well in your works cited list. It's the educator in me ..... sorry. 😁😁

[@kimbattles938]

Are there potential downfalls to fasting though even when you’re trying to restrict calories i.e. getting enough protein? Especially if you are aging and trying to preserve muscle mass.

[@boatmandan9945]

Please do this style video for cholesterol! Damn that topic is confusing AF!!

[@wendywertz8828]

Thank you for all the excellent info ! I’m tired of hearing about fasting and AUTOPHAGY! Fasting only raises my cortisol and A-1C ! When I stopped fasting my A-1C lowered to 4.7 !

[@davidgreene8608]

First time watching you. Refreshing to hear your stance. Seems level headed and balanced

[@poshzombie]

I would be interested in your opinion of Dr. David Sinclair's, and other scientists, adherence to intermittent fasting, for its effects as a "mild stressor", in the following (oldish) video: kzbin.info/www/bejne/mp6npHmLa7yAiJY Would caloric restriction still be equivalently beneficial relative to intermittent fasting for this particular effect on the body? Thank you.

[@jeffb6979]

You’re right.. I had no idea what autophagy is or what exactly it does. 😂

[@Macgee826]

Of course you didn't know ,only layne knows.hes the big mad mental educator n he's the only one who can educate everybody because he's got a PhD .

[@aleck156]

Next time, please do video on ... COLD SHOWERS. Last time I checked literature it caused specific adaptations from strength training workouts to diminish returns, making your workouts less effective.

[@espenstoro]

Cold baths (more intense than showers) apparently lowers inflammation to some degree, and it can sort of "speed up" recovery, but it's the good inflammation that contributes to adaptation and muscle growth that gets reduced. Might be useful for certain athletes in season to get ready for the next performance quicker without excessive soreness, but probably not for the rest of us who want to grow muscle and get stronger. Anecdotally, some really enjoy doing the hot/cold contrast baths, and if that makes you feel better and gives you better sleep and lower stress, then I can't argue with that. Many pro strongmen do it consistently, maybe they have something figured out? I don't know. There wasn't a ton of research, and I've barely skimmed some of it, to be honest. On second thought, disregard this comment. 🤣

[@gregd4391]

Can you have a discussion/interview with Dr Rhonda Patrick amd discuss extended fast8ng and saunas?

[@jirihutecka9020]

Enzymes like lubrokinese on empty stomach should work like autophagy right? Ultimate regeneration should be fasting + taking enzymes. Can imagine it can work for all kinds of issues maybe cancer as well..

[@karlhungus5554]

Something else that I suspect may help increase longevity: Not being pulled into the latest health fads. Doing so has caused me a lot of grief over the years.

[@TheOne-pv4rz]

I fast because it's great against visceral fat, the increased autophagy is a very nice bonus on top.

[@Ocxlocxl]

I think that the idea of fasting being linked to traditional religions (lent, Ramadan etc…)in order to gain greater spiritual understanding may have added a magical component to the idea of fasting for some. For others who don’t make the connection it’s just another way of regulating one’s behaviour now and again. Just an early morning thought!

[@user-ij5ky4lr3x]

A school of thought on fasting stems from the idea that we evolved going long periods of time without a kill (days) for most of human history and ate large meals before going a few days with nothing - that the body adapted over time to this mechanic. Food wasn't always as readily available as it is now days. In fact, that is pretty new to the 20th and 21st century. Before that, only royalty were eating regularly 3 meals a day.

[@paulcox2447]

Multiple religions figured out that fasting has multiple benefits. That's really the key to religions, which ones succeed over time and which don't. The key is does it create/support a life structure that is fulfilling both mentally and physically. Muslims wash their hands and feet long before the germ theory of disease. Confessions, fasting, prayer, all of these things have mental/spiritual benefits or they wouldn't' have withstood the test of time.

[@arihaviv8510]

It's meant as a sacrifice, not something you do for gains

[@wendyvg1225]

But what about benefits of fasting with respect to decreasing oxidation and inflammation? Is there any benefit with respect to these 2 when you eat all of your daily calories in a smaller interval versus throughout say 14 to 16 hours as most non fasting folks tend to do?

[@WhatTheHex]

Well, Sample size 1, I have experienced that there is something extra going on when calories go down to certain limit that does not happen in steady moderate calorie limit.. I had "inflamed" wrist for 6 months, went to doctor, xray etc, no clear reason found, physical therapy -> did nothing, grip power was 50% compared to other hand.. after that measurement I just wanted to jumpstart 3-4kg fat loss with 3 day extremely low calorie food selection (600kcal/day) and to my surprise in those 3 days my wrist pain vanished and grip power returned to normal.. (measures just before and after) so it was very odd, 6 months pain, therapy and suddenly 3 days just fixed all that.. like wtf, and wrist has been fine since then, 6 years.. auto this and that, no idea but very low calorie state does something extra at least short term.

[@Themata]

Any downside to eating an orange or 2 after hard exercise?

[@scotchbarrel4429]

Give it up for Algor, for doing its job 😂👊

[@briangoodhealth]

All of that in less than 10 mins. Mind blown. Great video!

[@b-sideplank]

I think setting aside weight loss through fasting, just doing a fast every once in a while - once a week/month - is really good for feeling good. I'll leave what it does physiologically to actual experts like Layne. I fast in Ramadan (1 month) every year (sunrise to sunset - Ramadan fasting is "dry" fasting). And it feels really really great for your body and mind. If only we didn't stuff our face at breaking of the fast at sunset, it could be so much more healthy for sure.

[@user-ij5ky4lr3x]

You need to give your internal organs a rest from time to time, just like you'd give muscles a break to recover. When people say "Fasting isnt' about weight loss" they mean that losing weight isn't the reason why one would seek to fast. Layne throws out a strawman here claiming that they are saying that you won't lose weight fasting. Of course you lose weight fasting. You can gain it back afterwards by consuming more than your normal calories. It's funny that there's at on of medical literature on the topic of autophagy that clearly states that autophagy occurs 48-72 hours after fasting. Yet, Layne "I know everything" Norton is here to tell everyone that ... well he knows everything ... and the rest of the world is wrong. Dude has become an insufferable blow hard. But he's got his sycophant fan base here to defend him to the death.

[@axalius572]

Yes Layne, you are an expert on every single highly complex topic out there, but it's actually just those two numbers CI and CO.

[@LowHangingFruitForest]

I did a 60 day fast and I look ten years younger than I did previously. Don’t know the science or care about the science. I just think it’s good to do hard things.

[@terryhagen8171]

Thank you for the video. I love people who throw out the buzzwords and want to try to sound smart lol

[@AllenKim86]

I hear all these claims about increasing stem cells from 24 hour fasting, faster healing, and so on... can you do a video explaining if there is any special with fasting not in relation to weight loss or autophagy?

[@nicholasantoniou8291]

Interview bryan Johnson!

[@anthonyallred7264]

As an avid faster (5+ years of near weekly 36 hour fasts, and a handful of 3-5 day fasts) I appreciate the discussion and am aware that the benefits I've seen may be attributable solely to calorie restriction. But I am trying to reconcile some of this to what I've heard from people like Valter Longo at USC's Longevity Institute. Can you comment on his claims (I hope I'm not misattributing) that white blood cells don't begin autophagy until about hour 72 of a fast? I believe it was also implicated that other bodily systems/tissues also enter autophagy at different times. Maybe this is nonsense, but my layperson's brain is thinking that, despite a lack of clinical evidence (which can be hard to produce with humans as you mention), if different tissues begin autophagy at different lengths of fasting time it would imply that there is a benefit to fasting over just caloric restriction. Thanks DLN.

[@user-ij5ky4lr3x]

There's quite a bit of literature, studies, and medical institutions of prominence that are claiming stuff about autophagy that Layne here seems to be totally ignorant or in disagreement about. The consensus is that fasting beyond 24-48 hours is when autophagy really starts, and it will end when you start consuming calories again. Thus, a longer fast means your body will be in the state of autophagy for a longer, continuous period of time. But Layne knows everything, and the rest of the "fasting" community is clueless. Don't forget that. /s

[@Macgee826]

@@user-ij5ky4lr3x that's narcissism for ye !

[@pauljansen6650]

@@user-ij5ky4lr3x I mean did you watch the video???? He literally said autophagy is higher when fasting for longer periods but you can't just look at the fasting period because you need to eat too! So you need to take it all into account. You can't just cherry pick periods of fasting and ignore the overall timeframe for the week/month!

[@timsouthend]

Providing there isn't any follow-up questions, I know everything about autophagy.

[@LeanOnPlants]

Too good 😝

[@PinataOblongata]

Ok, I'll try to argue, but I'm not confident... You may have covered this previously, but does going for longer periods of time without spiking blood glucose help with insulin resistance/sensitivity? A fasted state is not metabolically the same as just being in a slight deficit - if you are mostly meeting your energy requirements with food and just need a little from fat/glycogen stores, surely that looks biochemically different from a situation where you are, say, in ketosis due to total lack of food. Perhaps autophagy is not much greater, but what about other systems that get up- or down-regulated in such a state? (I'm going to guess we just don't have the human studies to say anything significant about it). P.S. Could you please have a word to your mate Peter Attia about his interview with Stuart McGill and their bullshit about not deadlifting to avoid supposedly becoming a cripple, that was straight up misinformation.

[@wendywertz8828]

Been trying to lose 60 pounds the past 3 years …. Menopausal lost 30 of it but hit hard stall 😢

[@andresbosque4810]

We just don't like simple things. Also those things are harder to profit from.

[@cam-inf-4w5]

I had this suspicion bc why would autophagy not immediately start? If i did 48hr fast but drank a 5 calorie water flavor drink on the 25th hour would it really be a 47 hour fast or a 36 hour fast bc it takes hours to burn 5 calories? I dont think so. When the stomach is empty.....your body isnt gunna wait 16 hours and somehow survive on nothing then start consuming fat and muscle. Im glad i found this video

[@netizenkane2230]

The main benefit of fasting is appetite control. The most common reason people fail a diet is adherence. Hunger management is crucial for diet adherence. Time restricted eating can be quite useful in this regard.

[@ivanorozco4274]

Except for those individuals whose appetite is NOT controlled due to fasting, but actually have their appetite increased because of it. I know such individuals exist, I fasted for years both partially and for days at a time, and when it came time to eat I just couldn't get satisfied, wouldn't feel full no matter how much I ate. I do find it peculiar that no one seems to address common issues while going without food for more than 12 hours: Headaches, ill-temper bouts, fatigue and heartburn were commonplace for me during my last fasting periods. I totally dropped the practice now

[@pedrobarros2000]

The main disadvantage of fasting is loss of lean body mass, for those people who don't lift weights. Specially for older folk, this could become problematic.

[@keyman6385]

@@ivanorozco4274 Perhaps the macronutrients you consumed did not tide you over well enough relative to your needs? Fasting is more useful when you have a lot of excess fat to get rid off, where it forces your body to burn those fats. If you're already too lean, your body might compensate by triggering you to eat more. Otherwise, single 24 fasts are much easier and reduced window of eating even easier. As Dr. N says, pick and choose whatever approach suits your needs best. That way you get the benefits of fasting but (ideally) without the rebound pangs of hunger. Who knows, maybe more fiber might help to tide you over? Otherwise, my buddy just consumes foods with higher density nutrition - that seems to work for him.

[@Melesniannon]

Yes but remember, "it's not about weight loss".

[@AndrewBrownK]

the amount of discourse required to understand addition and subtraction

[@derfigurfluesterer]

thank you for this shot against all the wannabe gurus ofbthe fasting industry🙌🙌🔥🔥

[@MA-jj4lp]

I would recommand that Layne starts a open discussion with Dr. Sinclair. He is a big advocate of fasting.

[@justindie7543]

Great video!! Can you make a video about fasting and cognition? Having tried IF I felt less tired and more productive while fasted and I figured this was due the energy saved from being devoted to digestion, but the papers I've found on this relationship are mixed. I thought this aspect of fasting would be cut and dry given that it would help avoid glucose spikes during productive hours.

[@freeyourmind7538]

Basically, Ramadan has the perfect autophagy ❤❤❤ calorie deficit by only having 2 meals per dat, morning amd evening, fast lasts around 13 hours a day!!! Ive done some Ramadan fasta for 19 hours!!!

[@airplanebuilder8685]

A bunch of chiropractors disliked this video.😜

[@Caferramarta]

😂😂😂😂

[@Rob-me8vp]

Here I thought it was airplane builders

[@upholstery1995]

"Tickles your fasting funny bone" 😂

[@RHIMYM]

For the truth, science and the algorithm!

[@wickedah]

im curious how you get to the point where you say autophagy is equal if you fast 3 days and eat more 4 days to have no caloric deficit over the week or just at every day at your maintanence level. good work greets.

[@user-ij5ky4lr3x]

It's funny that the Mayo Clinic has something completely different to say about Autophagy, but I guess they didn't study Autophagy like Layne here

[@bobbyventon5015]

We need a description of the personality of the caloric deficit group to fit the angry ex analogy.

[@GayBearBro2]

For the algorithm!

[@heathergant0819]

All the rhythm

[@paddy3622]

so much of this is common sense. it's all behavioral. a person needs to find a program that they will be consistent with.

[@dyderich]

How dare you use logic and data in your argument! Another great informative video.

[@JemyM]

Thank you for this. I have lost 85 pounds with the help of Alternate Day Fasting and it truly allowed me to take control of my life and health at the age of 46. I have a background in societal psychology with a masters degree and as such I have always been research/science focused. The amount of nonsense in the fasting community really grind my gears.

[@douglasmurphy3266]

A lot of the "benefit" people see while fasting is just a reflection of the bad decisions they are making when they are not fasting. If you are eating garbage, not eating garbage will give you a sense of relief. That is why a lot of "fasts" that make no sense scientifically seem to work for people, such as a "only eat a certain thing" fast - This isn't even a fast because you are still ingesting calories - But forcing yourself to only eat potatoes or drink fruit juice is cutting off whatever garbage you were eating. If you focus on eating clean, mostly unprocessed foods, not eating literal poison essentially, and figure out your digestion and allergies, you should be consuming a diet that your body doesn't need an extended break from just to restore basic function.

[@user-ij5ky4lr3x]

Literally everything you consume damages your body's organs as they process it. It only makes sense that you'd give your organs a period of prolonged rest from time to time to recover from that damage. Just like you give your biceps a couple of days to heal the microtears from hypertrophy. Fasting once a quarter for 48-72 hours is easy and painless. Even if you are eating clean, organic, whatever, you should consider giving your internals a break from time to time.

[@Tyrantteemo]

I have been fasting (for 30 days straight) since I was 10 or something and I either gained weight in that month or did not lose any weight at all. Mostt people just cannot eat enough in the small period of time :)

[@sercan272727]

cool story bro. so you gained weight fasting 30 day days of the 30 day month huh. tell us more about it

[@Tangible_D]

🤔

[@Tyrantteemo]

​@@sercan272727I was eating from sunset until sunrise :) and since I was quite hungry throughout the day, I was eating like crazy in those few hours.. does not mean you have to, but I just wanted to say that it is certainly possible to gain weight in this way

[@Tyrantteemo]

@@sercan272727 Thought it'd be self-explanatory but I ate in the evening (hence the "eat enough in small period of time").. but yeah just wanted to say that just because people reduce the amount of time to eat during the day does not mean they will eat less overall and thus lose some weight :)

[@wallacebonner7939]

Is it possible that people who say they aren't making up their calories on non-fasting days aren't simply incrementally decreasing their metabolic base rate through loss of lean muscle on these fasts?