Your ASMR Professor explains SN1 reactions to you

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Күн бұрын

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@paytonclare 3 ай бұрын

i’m back to your channel to prep my brain before i start orgo 2 next week! so eternally grateful for you and your videos and i’m so happy to be back enjoying them!! 💞✨

@ASMRChemistry 3 ай бұрын

@@paytonclare Woohoo! Glad to have you here! Are you excited for orgo? Or a little nervous? You got this!! Happy to be here for you!😃

@paytonclare 3 ай бұрын

⁠@@ASMRChemistry i’m super excited :)) i really enjoyed the first semester of orgo, and i had a nice relaxing summer break so i’m so ready to jump back in!! the farther i get into my chemistry courses the more i think about switching my major from bio to chem hahaha

@markboyle9941 4 ай бұрын

An overview of glycolysis, the Krebs cycle and the electron transport chain would be a lovely way to fall asleep... As a fellow chemist (physical), I live these videos, take me right back to my undergraduate days in the 90s!

@ASMRChemistry 4 ай бұрын

@@markboyle9941 Biochemistry FTW! I don’t get requests for that very often, so that would be fun. Physical chem - awesome! Inorganic is my specialty. Sounds like we are about the same age. Thanks for checking in to say hi and give a request!!

@swoss 5 ай бұрын

Hello Madam, how're you doing!? I missed your few videos. Chemistry isn't my subject but I really enjoy these videos, reminds me of my college studies haha And as always, absolute soothing voice you've! With really pretty handwriting❤️

@AG-nq6tt 5 ай бұрын

I do like the use of "you've". :D

@ASMRChemistry 5 ай бұрын

Hi there!! It’s been a while since I’ve heard from you, and it’s so nice to get a message from you again! How are you? I’m so glad you’re enjoying these videos!! I love making them. ☺️ Hope you’re well!

@ASMRChemistry 5 ай бұрын

@@AG-nq6tt me too!

@swoss 5 ай бұрын

@@ASMRChemistry I'm doing good ma'am😌 Was busy for a while with my university exams and internships :)

@KorenGreenberg 5 ай бұрын

ASMR edu-science. My favorite.

@ASMRChemistry 5 ай бұрын

Woohoo! So glad you found this! Let me know if you have requests for any particular topics.😃

@StaticBlaster 5 ай бұрын

This video from you is another one worthy of an Oscar. Btw, I was wondering if you could provide a description of the molecular structure of Sodium Nitrite?

@ASMRChemistry 5 ай бұрын

Why, thank you! Not so sure about an Oscar😆 but I very much appreciate the compliment as always!☺️ As for your question- yes I could absolutely do that. As a preview, it would be a fun combination of three topics - ionic compounds, polyatomic ions, and resonance structures!😃

@StaticBlaster 5 ай бұрын

@@ASMRChemistry You're so welcome and your videos are definitely top-notch. And, that would be awesome if you could go into those three topics. 🙂

@AG-nq6tt 5 ай бұрын

Thank-you! I loved the SN2 video as well! May I ask a quick question: Since you can have chiral inversion resulting from this type of reaction, would it be the case that any single enantiomer, capable of forming an sp2 hybridized intermediate, will eventually turn into the racemate given long enough? I can imagine a chiral alkyl halide, for instance, separating into carbocation and halide anion, and recombining with chiral inversion, eventually due to the entropy there would be equal proportions of each...?

@ASMRChemistry 5 ай бұрын

First off, thank you for the kind words! I’m so happy that you are loving these videos.😃 Great question! You are absolutely right, any one of these compounds that has some amount of inherent instability to lose one of the groups and form an sp2 hybridized intermediate, has a likelihood of forming a racemic mixture. One of the key aspects you pointed out in your message: “given long enough”. In terms of it being a 50-50 mix of products, it depends on the structure of the compound itself, specifically around the chiral center. If one of the groups is larger, the sterics will throw off the relative percentage of the R/S enantiomers. Thanks again for the question! Hope this helps confirm your suspicions and adds some more insight! @AG-nq6tt

@AG-nq6tt 5 ай бұрын

@@ASMRChemistry Thank you so much for the reply! We (your subscribers) really are blessed that you dedicate so much of your time to answering our ponderings! I have been searching for some time for an intuitive understanding of entropy, specifically as it applies to chemical reactions (not physical changes like gases mixing); Explanations along these lines tend to be rather elusive, so I thought perhaps I was on the wrong track entirely! :) Would it be fair to say that the "steric factor" contributes to a reaction being "favoured" (or otherwise) by entropy, that is, that larger molecules are favoured because it is less likely that collisions between them will result in a successful collision, hence for any given concentration the reverse reaction is less probable (if we ignore activation energy for the sake of the thought experiment)? An extreme example would be a bare proton which could theoretically react regardless of the orientation of the collision, vs a long molecule with the reacting group on the end that has to collide in just the right way. Anyway I've taken up too much of your time already! Thank you so much.

@BenjaminLu_ 4 ай бұрын

Hello, I think this is a great video and good review for the SN1 reaction. I do have a question though, which relates to the mixture of products at the end of the reaction. I’ve read in a textbook that while the H2O is free to attack the carbocation from both sides leading to both inversion and retention of configuration, but the chloride ion is still sort of attracted to the carbocation while floating around after loss of the LG, which creates some sort of steric hindrance effect, essentially causing the H2O to slightly favor backside attack over frontside. This would thus create a sort of favoring of inversion of configuration over retention. Is this effect negligible to the point where the resulting products would still be considered a racemix or would it lead to the production of major/minor products? Thank you!

@ASMRChemistry 4 ай бұрын

Great question, and yes, you are spot-on. In the cases where sterics don’t hinder one side over another, it’s close to 50/50. However, oftentimes the molecule is asymmetric or the leaving group is nearby enough to affect the rate of reaction with the incoming group. The rate of diffusion (how quickly the leaving group “floats away”) thus will be an issue, as you brought up. So, yes, often it won’t be exactly 50/50, but the exact ratio is difficult to predict. You can often make predictions that one will be preferred over another based on sterics. So, alas, each reaction must be considered on a case-by-case basis. Another person asked a similar question that’s in the comments here, too. I hope this is helpful! Thanks for being here and asking your question!