the study spot

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@samankoli9579 2 күн бұрын

Can you explain pathology please ❤

@expectopeetrrronium7349 11 күн бұрын

SIMPLY THE BEST!!

@bipattarankhan6254 15 күн бұрын

Thankyou sir

@Alaa-cv8pj 23 күн бұрын

Thank you❤

@Reemessi1 Ай бұрын

Im the one who put the 1k like 😂🎉

@Antipsychotics2000 Ай бұрын

Ur explaination sucks

@umadhanesh172 Ай бұрын

No 1 cause of blindness in the world isn’t cataract?

@thae9116 2 ай бұрын

Between the 6 and 8 months window period will the viral load be detectable?

@lilianwu5651 2 ай бұрын

the best explanation about amenorrhea i've seen so far ! thank you

@tasneemwl8000 2 ай бұрын

Good lecture

@JulieW-p2c 3 ай бұрын

You’re right, feeling how it began to shrink and eventually disappear within 2 months was so liberating. I followed the steps I mentioned, and within the first 2 weeks the bloating was gone. I simply go'ogled Tilly Strankten's Ovarian Cyst Guide and it's like I hit the feel-good reset button lol.

@georgenassr6133 3 ай бұрын

Thank you so much! ❤❤

@theodor-games7487 3 ай бұрын

If I were to create a molecule to suppress the hepatitis B virus (HBV), I would develop a comprehensive drug targeting multiple key stages of the virus's life cycle simultaneously. This approach, based on combination therapy, would include the following components: ### 1. **Inhibitor of Viral DNA Replication (Nucleoside/Nucleotide Analog)** - The main component would be a **modified nucleoside analog**, similar to tenofovir or entecavir, which blocks the viral DNA polymerase. - In my version, I would focus on creating an **improved version** with stronger affinity for the polymerase and greater resistance to viral mutations, reducing the likelihood of the virus developing resistance. ### 2. **Inhibitor of Virus Entry into the Cell** - I would add a **modified NTCP receptor inhibitor**, such as mirsartan, which prevents the virus from entering liver cells (hepatocytes). - To enhance targeted action, I would encapsulate this component in nanoparticles or liposomes so the drug would be delivered directly to liver cells, minimizing systemic side effects. ### 3. **Capsid Assembly Inhibitor** - A key element of the molecule would be a **capsid assembly inhibitor**, which prevents the proper assembly of viral particles. This would stop the virus from completing its life cycle, reducing its reproductive capacity. - This molecule would specifically target core antigens (HBcAg), disrupting capsid assembly and rendering the virus inactive. ### 4. **Immune Response Modulator** - The drug could include an **immune-stimulating component** - for example, a peptide that activates the production of interferons (interferon-alpha or gamma) or a **molecule that stimulates NK cell and T-lymphocyte activity**. This would help the body more actively destroy infected cells. - Using low doses of pegylated interferon could boost the antiviral immune response, reducing the need for prolonged immunomodulator therapy. ### 5. **Nanotechnology for Targeted Delivery** - The entire composition could be enclosed in **lipid nanoparticles** for delivering components directly to the liver. This would reduce systemic exposure and ensure high concentrations of the drug in infected cells. ### Overall Molecular Structure: - **Active DNA Replication Inhibitor** - an improved version of tenofovir or entecavir. - **NTCP Receptor Inhibitor** - modified mirsartan, preventing the virus from entering cells. - **Capsid Inhibitor** - a molecule that blocks viral particle assembly. - **Immune Response Modulator** - a component that enhances interferon production and immune cell activity. - **Nanoparticle Delivery System** - liposomes for targeted delivery to the liver. ### Advantages of This Approach: 1. **Multi-Targeted Action**: The molecule acts on multiple stages of the virus's life cycle at once, making it more effective against the virus. 2. **Reduced Resistance**: Using a combination of components reduces the likelihood of the virus mutating and becoming resistant to treatment. 3. **Targeted Delivery**: Nanoparticles ensure that the main active components reach liver cells directly, minimizing side effects. 4. **Enhanced Immune Response**: Stimulating the immune system helps the body fight the virus on its own, reducing the risk of developing chronic infection. ### Conclusion: I would create a multifunctional molecule that targets key stages of the hepatitis B virus life cycle. Such a drug would have the potential to significantly reduce viral load, prevent replication, and strengthen the immune response, potentially leading to suppression of the infection and improved outcomes for patients.

@fiolasigia 4 ай бұрын

Thank u

@PauloRoberto-x7d 4 ай бұрын

I really want to appreciate #DrObulor @KZbin for helping me cured my Hepatitis B totally with his herb medicine I’m grateful sir!…

@amaliasrianjani8389 4 ай бұрын

THANKSSSSS💖

@lestaroberts2189 4 ай бұрын

really well explained looking forward to your next videos

@zainahziyad2036 4 ай бұрын

❤merci

@mohammmedahmedali9733 4 ай бұрын

جزاكم الله خيراً - May Allah reward you continue

@rockstarmax 5 ай бұрын

Great Video

@AyeshaSeerat 5 ай бұрын

bro u forgot 5 alpha reductase deficiency...

@rmari1811 5 ай бұрын

I have all the symptoms, i got a vaginal ultrasound that showed by endometrial thickness was 25mm so i got sent to get a biopsy & my results say ( ENDOMETRIUM: PROLIFERATIVE PHASE ENDOMETRIUM, NEGATIVE FOR HYPERPLASIA AND/OR MALIGNANCY. NOTE: THE IMMUNOSTAIN FOR CD138 IS POSITIVE, FINDING SUPPORTS THE ABOVE DIAGNOSIS. 0 CD138 POSITIVE CELLS ) i have yet to talk to my doctor about results .idk what my results mean but i think they came back negative for anything.

@blondie7341 5 ай бұрын

My 3 month old had this!! I'm in the UK and my GP fobbed me off for a week when my baby's skin started coming off. I took him to accident and emergency and was scolded for not bringing him sooner, but my GP was gaslighting me, saying i was an overwrought first time mother. But i took him everu day for a week abd it got to the point wjere i couldnt even put nappies (diapers) on him. He was prescribed oral antibiotics and told he wasnt in pain, but the ABs caused diarrhoea which then burnt his raw skin in the groin - even his little oenis was affected. THEN once he was admitted to the Paediatric ward, the nurses and doctors there completely dismissed it all and sent us home TWICE in 5 weeks, even though a third of his tiny body was covered in raw open weeping wounds. It was honestly the worst time of my life. We had to fight every inch of the way to be taken seriously and my baby to be treated appropriately. In the end we had to be referred to Great Ormond Street Hospital to get treated appropriately. Awful.

@simbah7723 6 ай бұрын

Thank you 🎉🎉🎉

@CCai-yr5gr 7 ай бұрын

Great great content wish the sound was on point

@ianmacdougall2467 7 ай бұрын

Too many errors

@Pkedya2boy 7 ай бұрын

Despite being an old video, I was able to present and diagnose this information during my internal med and ENT rotation to my doctors confidently. Thank you so much for the thorough presentation!